The schizosaccharomyces pombe rad3 checkpoint gene

EMBO Journal

Volumn 15, Issue 23, 1996, Pages 6641-6651

  Bentley, Nicola J ^a   Holtzman, Douglas A ^b   Flaggs, Gail ^b   Keegan, Kathleen S ^b   DeMaggio, Anthony ^b   Ford, Jon C ^a   Hoekstra, Merl ^b   Carr, Antony M ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Ataxia telangiectasia; Checkpoint; Fission yeast; Mec1; Rad3

Indexed keywords

FUNGAL DNA; FUNGAL PROTEIN; PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA STRUCTURE; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; EVOLUTION; FUNGAL GENETICS; GENE SEQUENCE; HUMAN; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

ATAXIA; ATAXIA TELANGIECTASIA; DROSOPHILA MELANOGASTER; MELANOGASTER; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0029827367     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01054.x     Document Type: Article

References (54)

1. 2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J., 11, 1343-1350.
2. Al-Khodairy, F., Fotou, E., Sheldrick, K.S., Griffiths, D.J.F., Lehmann, A.R. and Carr, A.M. (1994) Identification and characterisation of new elements involved in checkpoints and feedback controls in fission yeast. Mol. Biol. Cell, 5, 147-160.
3. Allen, J.B., Zhou, Z., Siede, W., Friedberg, E.C. and Elledge, S.J. (1994) The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev., 8, 2416-2428.
4. Barbet, N.C. and Carr, A.M. (1993) Fission yeast wee1 protein kinase is not required for DNA damage-dependent mitotic arrest. Nature, 364, 824-827.
5. Barbet, N.C., Muriel, W.J. and Carr, A.M. (1992) Versatile shuttle vectors and genomic libraries for use with Schizosaccharomyces pombe. Gene, 114, 59-66.
6. Basi, G., Schmid, E. and Maundrell, K. (1993) TATA box mutations in the Schizosaccharomyces pombe nmt1 promoter affect transcription efficiency but not the transcription start point or thiamine repressibility. Gene, 123, 131-136.
7. Beamish, H. and Lavin, M.F. (1994) Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay. Int. J. Radiat. Biol., 65, 175-184.
8. Berbee, M.L. and Taylor, J.W. (1993) Dating the evolutionary radiations of the true fungi, Can. J. Bot., 71, 1114-1127.
9. Carr, A.M. (1994) Radiation checkpoints in model systems. Int. J. Radiat. Biol., 66, S133-S139.
10. Carr, A.M. (1996) Checkpoints take the next step. Science, 271, 314-315.
11. Carr, A.M. and Hoekstra, M.F. (1995) The cellular responses to DNA damage. Trends Cell Biol., 5, 32-40.
12. Carr, A.M. et al. (1994) The rad16 gene of Schizosaccharomyces pombe: a homologue of the RAD1 gene of Saccharomyces cerevisiae. Mol. Cell. Biol., 14, 2029-2040.
13. Carr, A.M., Moudjou, M., Bentley, N.J. and Hagan, I.M. (1995) The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'. Curr. Biol., 5, 1179-1190.
14. Cimprich, K.A., Shin, T.B., Keith, C.T. and Schreiber, S.L. (1996) cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc. Natl Acad. Sci. USA, 93, 2850-2855.
15. Drwinga, H.L., Tojia, L.H., Kim, C.H., Greene, A.E. and Mulovor, R.A. (1993) NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2. Genomics, 16, 311-314.
16. Enoch, T. and Nurse, P. (1990) Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell, 60, 665-673.
17. + of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet., 238, 241-251.
18. Ford, J.C., Al-Khodairy, F., Fotou, E., Sheldrick, K.S., Griffiths, D.J.F. and Carr, A.M. (1994) 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Science, 265, 533-535.
19. Forsburg, S.L. (1993) Comparison of Schizosaccharomyces pombe expression systems. Nucleic Acids Res., 21, 2955-2956.
20. Greenwell, P.W., Kronmal, S.L., Porter, S.E., Gassenhuber, J., Obermaier, B. and Petes, T.D. (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell, 82, 823-829.
21. Griffiths, D.J.F., Barbet, N.C., McCready, S., Lehmann, A.R. and Carr, A.M. (1995) Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J., 14, 5812-5823.
22. Grimm, C., Kholi, J. Murray, J.M. and Maundrell, K. (1988) Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker. Mol. Gen. Genet., 215, 81-86.
23. Gutz, H., Heslot, H. Leupold, U. and Loprieno, N. (1974) Schizosaccharomyces pombe. In King, R.C. (ed.). Handbook of Genetics. Plenum Press, New York, Vol. 1, pp. 395-446.
24. Hari, K.L., Santerre, A., Sekelsky, J.J., McKim, K.S., Boyd, J.B. and Hawley, R.S. (1995) The mei-41 gene of D.melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell, 82, 815-821.
25. Hartley, K.O. et al. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell, 82, 849-856.
26. Hartwell, L.H. and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
27. Helliwell, S.B., Wagner, P., Kunz, J., Deuter-Reinhard, M., Henriquez, R. and Hall, M.N. (1994) TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol. Cell, 5, 105-118.
28. + gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc. Natl Acad. Sci. USA, 87, 4952-4956.
29. Kato, R. and Ogawa, H. (1994) An essential gene. ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res., 22, 3104-3112.
30. Keegan, K.S. et al. (1996) The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev., 10, 2423-2437.
31. Leach, R.J. et al. (1994) Regional localisation of 188 sequence tagged sites on a somatic cell hybrid mapping panel for human chromosome 3. Genomics, 24, 549-556.
32. Long, K.E., Sunnerhagen, P. and Subramani, S. (1994) The Schizosaccharomyces pombe rad1 gene consists of three exons and the cDNA sequence is partially homologous to the Ustilago maydis REC1 cDNA, Gene, 148, 155-159.
33. Lydall, D. and Weinert, T. (1995) Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science, 270 1488-1491.
34. Maundrell, K. (1990) nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine. J. Biol. Chem., 265, 10857-10864.
35. McCready, S.J., Burkill, H., Evans, S. and Cox, B.S. (1989) The Saccharomyces cerevisiae RAD2 gene complements a Schizosaccharomyces pombe repair mutation. Curr. Genet., 15, 27-30.
36. Morrow, D.M., Tagle, D.A., Shiloh, Y., Collins, F.S. and Hieter, P. (1995) TEL1, an S.cerevisiae homologue of the human gene mutated in ataxia-telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell, 82, 831-840.
37. Murakami, H. and Okayama, H. (1995) A kinase from fission yeast responsible for blocking mitosis in S phase. Nature, 374, 817-819.
38. Murray, J.M., Doe, C., Schenk, P., Carr, A.M., Lehmann, A.R. and Watts, F.Z. (1992) Cloning and characterization of the S.pombe rad15 gene, a homologue to the S.cerevisiae RAD3 and human ERCC2 genes. Nucleic Acids Res., 20, 2673-2678.
39. Paulovich, A.G. and Hartwell, L.H. (1995) A checkpoint regulates the rate of progression through S phase in S.cerevisiae in response to DNA damage. Cell, 82, 841-847.
40. Rowley, R., Subramani, S. and Young, P.G. (1992) Checkpoint controls in Schizosaccharomyces pombe, rad1. EMBO J., 11, 1335-1342.
41. Sabers, C.J., Martin, M.M., Brunn, G.J., Williams, J.M., Dumont, F.J., Wiederrecht, G. and Abraham, R.T. (1995) Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem., 270, 815-822.
42. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B. and Elledge, S.J. (1996) Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science, 271, 357-360.
43. Savitsky, K. et al. (1995a) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science, 286, 1749-1753.
44. Savitsky, K., Sfez, S., Tagle, D.A., Ziv, Y., Sartiel, A., Collins, F.S., Shiloh, Y. and Rotman, G. (1995b) The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet., 4, 2025-2032.
45. Schu, P.V., Takegawa, K., Fry, M.J., Stack, J.H., Waterfield, M.D. and Emr, S.D. (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science, 260, 88-91.
46. Seaton, B.L., Yucel, J., Sunnerhagen, P. and Subramani, S. (1992) Isolation and characterisation of the Schizosaccharomyces pombe rad3 gene which is involved in the DNA damage and DNA synthesis checkpoints. Gene, 119, 83-89.
47. Sheldrick, K.S. and Carr, A.M. (1993) Feedback controls and G2 checkpoints, fission yeast as a model system. BioEssays, 15, 775-782.
48. Siede, W., Friedberg, A.S., Dianova, I. and Friedberg, E.C. (1994) Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents. Genetics, 138, 271-281.
49. Sun, Z., Fay, D.S., Marini, F., Foiani, M. and Stern, D.F. (1996) Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev., 10, 395-406.
50. Walworth, N.C. and Bernards, R. (1996) rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science, 271, 353-356.
51. Walworth, N., Davey, S. and Beach, D. (1993) Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature, 363, 368-371.
52. Weinert, T.A. and Hartwell, L.H. (1988) The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science, 241, 317-322.
53. Weinert, T.A. and Hartwell, L.H. (1993) Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint. Genetics, 134, 63-80.
54. Weinert, T.A., Kiser, G.L. and Hartwell, L.H. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev., 8, 652-665.