-
1
-
-
0027210071
-
Gene regulation by IGF-1
-
Baserga, R. (1993). Gene regulation by IGF-1. Mol. Reprod. Dev. 35, 353-356.
-
(1993)
Mol. Reprod. Dev.
, vol.35
, pp. 353-356
-
-
Baserga, R.1
-
2
-
-
0027423419
-
Role of insulin-like growth factors in embryonic and postnatal growth
-
Baker, J., Liu, J.P., Robertson, E.J. and Efstratiadis, A. (1993). Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73-82.
-
(1993)
Cell
, vol.75
, pp. 73-82
-
-
Baker, J.1
Liu, J.P.2
Robertson, E.J.3
Efstratiadis, A.4
-
3
-
-
0029148591
-
Role of IRS-2 in insulin and cytokine signalling
-
Sun, X.J. et al. (1995). Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177.
-
(1995)
Nature
, vol.377
, pp. 173-177
-
-
Sun, X.J.1
-
4
-
-
0025813375
-
The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
Sun, X.J. et al. (1991). The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77.
-
(1991)
Nature
, vol.352
, pp. 73-77
-
-
Sun, X.J.1
-
5
-
-
0028876283
-
Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells
-
Johnson, J. et al. (1995). Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. J. Biol. Chem. 270, 1-4.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1-4
-
-
Johnson, J.1
-
6
-
-
0028980989
-
Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1
-
Argetsinger, L.S. et al. (1995). Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270, 14685-14692.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14685-14692
-
-
Argetsinger, L.S.1
-
7
-
-
0028982917
-
Interferon-alpha engages IRS-signaling proteins to regulate the phosphatidylinositol 3-kinase
-
Uddin, S., Yenush, L., Sun, X.J., Sweet, M.E., White, M.F. and Platanias, L.C. (1995). Interferon-alpha engages IRS-signaling proteins to regulate the phosphatidylinositol 3-kinase. J. Biol. Chem. 270, 15938-15941.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 15938-15941
-
-
Uddin, S.1
Yenush, L.2
Sun, X.J.3
Sweet, M.E.4
White, M.F.5
Platanias, L.C.6
-
8
-
-
0030043596
-
The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2
-
Platanias, L.C., Uddin, S., Yetter, A., Sun, X.J. and White, M.F. (1996). The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J. Biol. Chem. 271, 278-282.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 278-282
-
-
Platanias, L.C.1
Uddin, S.2
Yetter, A.3
Sun, X.J.4
White, M.F.5
-
9
-
-
0028582185
-
Crystal structure of the tyrosine kinase domain of the human insulin receptor
-
Hubbard, S.R., Wei, L., Ellis, L. and Hendrickson, W.A. (1994). Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372, 746-754.
-
(1994)
Nature
, vol.372
, pp. 746-754
-
-
Hubbard, S.R.1
Wei, L.2
Ellis, L.3
Hendrickson, W.A.4
-
10
-
-
0023814924
-
Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity
-
White, M.F. et al. (1988). Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity. Cell 54, 641-649.
-
(1988)
Cell
, vol.54
, pp. 641-649
-
-
White, M.F.1
-
11
-
-
0026655777
-
Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in FAO hepatoma cells
-
Miralpeix, M., Sun, X.J., Backer, J.M., Myers, M.G., Jr., Araki, E. and White, M.F. (1992). Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in FAO hepatoma cells. Biochemistry 31, 9031-9039.
-
(1992)
Biochemistry
, vol.31
, pp. 9031-9039
-
-
Miralpeix, M.1
Sun, X.J.2
Backer, J.M.3
Myers M.G., Jr.4
Araki, E.5
White, M.F.6
-
12
-
-
0027262352
-
Common elements in interleukin 4 and insulin signaling pathways in factor dependent hematopoietic cells
-
Wang, L.M. et al. (1993). Common elements in interleukin 4 and insulin signaling pathways in factor dependent hematopoietic cells. Proc. Natl Acad. Sci USA 90, 4032-4036.
-
(1993)
Proc. Natl Acad. Sci USA
, vol.90
, pp. 4032-4036
-
-
Wang, L.M.1
-
13
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki, E. et al. (1994). Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372, 186-190.
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
-
14
-
-
0028957037
-
Identification of a 190 kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1
-
Tobe, K., Tamemoto, H., Yamauchi, T., Aizawa, S., Yazaki, Y. and Kadowaki, T. (1995). Identification of a 190 kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J. Biol. Chem. 270, 5698-56701.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 5698-56701
-
-
Tobe, K.1
Tamemoto, H.2
Yamauchi, T.3
Aizawa, S.4
Yazaki, Y.5
Kadowaki, T.6
-
15
-
-
0027164156
-
Human skeletal muscle insulin receptor substrate-1: Characterization of the cDNA, gene and chromosomal localization
-
Araki, E. et al. (1993). Human skeletal muscle insulin receptor substrate-1: Characterization of the cDNA, gene and chromosomal localization. Diabetes 42, 1041-1054.
-
(1993)
Diabetes
, vol.42
, pp. 1041-1054
-
-
Araki, E.1
-
16
-
-
0000772655
-
The IRS-2 gene on murine chromosome 2 encodes a unique signaling adapter for insulin and cytokine signal trainsduction
-
Sun, X.J. et al. (1997). The IRS-2 gene on murine chromosome 2 encodes a unique signaling adapter for insulin and cytokine signal trainsduction. Mol. Endocrinol. 11, 251-262.
-
(1997)
Mol. Endocrinol.
, vol.11
, pp. 251-262
-
-
Sun, X.J.1
-
17
-
-
0030003293
-
Daughter of sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling
-
Herbst, R., Carroll, P.M., Allard, J.D., Schilling, J., Raabe, T. and Simon, M.A. (1996). Daughter of sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling. Cell 85, 899-909.
-
(1996)
Cell
, vol.85
, pp. 899-909
-
-
Herbst, R.1
Carroll, P.M.2
Allard, J.D.3
Schilling, J.4
Raabe, T.5
Simon, M.A.6
-
18
-
-
0030028790
-
A Grb2-associated docking protein in EGF- and insulin-receptor signalling
-
Holgado-Madruga, M., Emlet, D.R., Moscatello, D.K., Godwin, A.K. and Wong, A.J. (1996). A Grb2-associated docking protein in EGF-and insulin-receptor signalling. Nature 379, 560-563.
-
(1996)
Nature
, vol.379
, pp. 560-563
-
-
Holgado-Madruga, M.1
Emlet, D.R.2
Moscatello, D.K.3
Godwin, A.K.4
Wong, A.J.5
-
19
-
-
0028352043
-
The role of IRS-1/GRB2 complexes in insulin signaling
-
Myers, M.G. et al. (1994). The role of IRS-1/GRB2 complexes in insulin signaling. Mol. Cell. Biol. 14, 3577-3587.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 3577-3587
-
-
Myers, M.G.1
-
20
-
-
0027182367
-
The function of GRB2 in linking the insulin receptor to ras signaling pathways
-
Skolnik, E.Y. et al. (1993). The function of GRB2 in linking the insulin receptor to ras signaling pathways. Science 260, 1953-1955.
-
(1993)
Science
, vol.260
, pp. 1953-1955
-
-
Skolnik, E.Y.1
-
21
-
-
15844409347
-
The fyn tyrosine kinase binds IRS-1 and forms a distinct signaling complex during insulin stimulation
-
Sun, X.J., Pons, S., Asano, T., Myers, M.G., Jr., Glasheen, E.M. and White, M.F. (1996). The fyn tyrosine kinase binds IRS-1 and forms a distinct signaling complex during insulin stimulation. J. Biol. Chem. 271, 10583-10587.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10583-10587
-
-
Sun, X.J.1
Pons, S.2
Asano, T.3
Myers M.G., Jr.4
Glasheen, E.M.5
White, M.F.6
-
22
-
-
0027158159
-
The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp
-
Kuhne, M.R., Pawson, T., Lienhard, G.E. and Feng, G.S. (1993). The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J. Biol. Chem. 268, 11479-11481.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 11479-11481
-
-
Kuhne, M.R.1
Pawson, T.2
Lienhard, G.E.3
Feng, G.S.4
-
23
-
-
0342959179
-
The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS
-
Beitner-Johnson, D. et al. (1996). The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. J. Biol. Chem. 271, 287-290.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 287-290
-
-
Beitner-Johnson, D.1
-
24
-
-
0027143218
-
Nck associates with the SH2 domain docking proteins IRS-1 in insulin stimulated cells
-
Lee, C.H. et al. (1993). Nck associates with the SH2 domain docking proteins IRS-1 in insulin stimulated cells. Proc. Natl Acad. Sci. USA 90, 11713-11717.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 11713-11717
-
-
Lee, C.H.1
-
25
-
-
0029966086
-
Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles
-
Heller-Harrison, R.A., Morin, M., Guilherme, A. and Czech, M.P. (1996). Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles. J. Biol. Chem. 271, 10200-10204.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10200-10204
-
-
Heller-Harrison, R.A.1
Morin, M.2
Guilherme, A.3
Czech, M.P.4
-
26
-
-
0027969225
-
Characterization of an interaction between insulin receptor substrate-1 and the insulin receptor by using the two-hybrid system
-
O'Neill, T.J., Craparo, A. and Gustafson, T.A. (1994). Characterization of an interaction between insulin receptor substrate-1 and the insulin receptor by using the two-hybrid system. Mol. Cell. Biol. 14, 6433-6442.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6433-6442
-
-
O'Neill, T.J.1
Craparo, A.2
Gustafson, T.A.3
-
27
-
-
0028874953
-
The PTB domains of IRS-1 and Shc have distinct but overlapping specificities
-
Wolf, G. et al. (1995). The PTB domains of IRS-1 and Shc have distinct but overlapping specificities. J. Biol. Chem. 270, 27407-27410.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27407-27410
-
-
Wolf, G.1
-
28
-
-
0029939448
-
PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface
-
Lemmon, M.A., Ferguson, K.M. and Schlessinger, J. (1996). PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85, 621-624.
-
(1996)
Cell
, vol.85
, pp. 621-624
-
-
Lemmon, M.A.1
Ferguson, K.M.2
Schlessinger, J.3
-
29
-
-
0028219966
-
An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth
-
Keegan, A.D., Nelms, K., White, M., Wang, L.M., Pierce, J.H. and Paul, W.E. (1994). An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 76, 811-820.
-
(1994)
Cell
, vol.76
, pp. 811-820
-
-
Keegan, A.D.1
Nelms, K.2
White, M.3
Wang, L.M.4
Pierce, J.H.5
Paul, W.E.6
-
30
-
-
0030010590
-
Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor
-
Eck, M.J., Dhe-Paganon, S., Trub, T., Nolte, R.T. and Shoelson, S.E. (1996). Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell 85, 695-705.
-
(1996)
Cell
, vol.85
, pp. 695-705
-
-
Eck, M.J.1
Dhe-Paganon, S.2
Trub, T.3
Nolte, R.T.4
Shoelson, S.E.5
-
31
-
-
0029820085
-
The pleckstrin homology domain is the principle link between the insulin receptor and IRS-1
-
Yenush, L. et al. (1996). The pleckstrin homology domain is the principle link between the insulin receptor and IRS-1. J. Biol. Chem. 271, 24300-24306.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24300-24306
-
-
Yenush, L.1
-
32
-
-
0029039613
-
Pleckstrin homology domain-mediated membrane assocaition and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G-beta/gamma subunits and lipid
-
Pitcher, J.A., Touhara, K., Payne, E.S. and Lefkowitz, R.J. (1995) Pleckstrin homology domain-mediated membrane assocaition and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G-beta/gamma subunits and lipid. J. Biol. Chem. 270, 11707-11710.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11707-11710
-
-
Pitcher, J.A.1
Touhara, K.2
Payne, E.S.3
Lefkowitz, R.J.4
-
33
-
-
0029783037
-
The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting
-
Zheng, Y., Zangrilli, D., Cerione, R.A. and Eva, A. (1996). The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. J. Biol. Chem. 271, 19017-19020.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19017-19020
-
-
Zheng, Y.1
Zangrilli, D.2
Cerione, R.A.3
Eva, A.4
-
34
-
-
0029866195
-
IRS-2 binds to the insulin receptor through its PTB domain and through a newly identified domain comprising amino acids 591 to 786
-
Sawka-Verhelle, D., Tartare-Deckert, S., White, M.F. and Van Obberghen, E. (1996). IRS-2 binds to the insulin receptor through its PTB domain and through a newly identified domain comprising amino acids 591 to 786. J. Biol. Chem. 271, 5980-5983.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5980-5983
-
-
Sawka-Verhelle, D.1
Tartare-Deckert, S.2
White, M.F.3
Van Obberghen, E.4
-
35
-
-
0029898718
-
Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors
-
He, W. et al. (1996). Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. J. Biol. Chem. 271, 11641-11645.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 11641-11645
-
-
He, W.1
-
36
-
-
0029855280
-
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
-
Weidner, K.M. et al. (1996). Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176.
-
(1996)
Nature
, vol.384
, pp. 173-176
-
-
Weidner, K.M.1
-
37
-
-
0029984739
-
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and ras1 in Drosophila
-
Raabe, T. et al. (1996). DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and ras1 in Drosophila. Cell 85, 911-920.
-
(1996)
Cell
, vol.85
, pp. 911-920
-
-
Raabe, T.1
-
38
-
-
0028019361
-
Signal transduction in the early Drosophila embryo: When genetics meets biochemistry
-
Perrimon, N. and Desplan, C. (1994). Signal transduction in the early Drosophila embryo: when genetics meets biochemistry. Trends Biochem. Sci. 19, 509-513.
-
(1994)
Trends Biochem. Sci.
, vol.19
, pp. 509-513
-
-
Perrimon, N.1
Desplan, C.2
-
39
-
-
0030002820
-
The Drosophila insulin receptor activates multiple signaling pathways but requires IRS proteins for DNA synthesis
-
Yenush, L. et al. (1996). The Drosophila insulin receptor activates multiple signaling pathways but requires IRS proteins for DNA synthesis. Mol. Cell. Biol. 16, 2509-2517.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2509-2517
-
-
Yenush, L.1
-
40
-
-
0028641601
-
Association of insulin receptor substrate-1 with integrins
-
Vuori, K. and Ruoslahti, E. (1994). Association of insulin receptor substrate-1 with integrins. Science 266, 1576-1578.
-
(1994)
Science
, vol.266
, pp. 1576-1578
-
-
Vuori, K.1
Ruoslahti, E.2
-
41
-
-
0029038910
-
Association of insulin receptor substrate 1 with simian virus 40 large T antigen
-
Fei, Z.L., D'Ambrosio, C., Li, S., Surmacz, E. and Baserga, R. (1995). Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol. Cell. Biol. 15, 4232-4239.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4232-4239
-
-
Fei, Z.L.1
D'Ambrosio, C.2
Li, S.3
Surmacz, E.4
Baserga, R.5
-
42
-
-
0026544517
-
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation
-
Backer, J.M. et al. (1992). Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. J. Biol. Chem. 267, 1367-1374.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 1367-1374
-
-
Backer, J.M.1
-
43
-
-
0028909206
-
Regulation of phosphatidylinositol 3-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85 kDa regulatory subunit
-
Rordorf-Nikolic, T., Van Horn, D.J., Chen, D., White, M.F. and Backer, J.M. (1995). Regulation of phosphatidylinositol 3-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85 kDa regulatory subunit. J. Biol. Chem. 270, 3662-3666.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 3662-3666
-
-
Rordorf-Nikolic, T.1
Van Horn, D.J.2
Chen, D.3
White, M.F.4
Backer, J.M.5
-
44
-
-
0028018858
-
The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1 stimulation by insulin and inhibition by wortmannin
-
Lam, K., Carpenter, C.L., Ruderman, N.B., Friel, J.C. and Kelly, K.L. (1994). The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1 stimulation by insulin and inhibition by wortmannin. J. Biol. Chem. 269, 20648-20652.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 20648-20652
-
-
Lam, K.1
Carpenter, C.L.2
Ruderman, N.B.3
Friel, J.C.4
Kelly, K.L.5
-
45
-
-
8944240840
-
YMXM motifs and signaling by an insulin receptor substrate 1 molecule with tyrosine phosphorylation sites
-
Myers, M.G. et al. (1996). YMXM motifs and signaling by an insulin receptor substrate 1 molecule with tyrosine phosphorylation sites. Mol. Cell. Biol. 16, 4147-4155.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4147-4155
-
-
Myers, M.G.1
-
46
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke, T.F. et al. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736.
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
-
47
-
-
0028063391
-
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta
-
Diaz-Meco, M.T. et al. (1994). Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. J. Biol. Chem. 269, 31706-31710.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 31706-31710
-
-
Diaz-Meco, M.T.1
-
48
-
-
0030066325
-
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
-
Eck, M.J., Pluskey, S., Trub, T., Harrison, S.C. and Shoelson, S.E. (1996). Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature 379, 277-280.
-
(1996)
Nature
, vol.379
, pp. 277-280
-
-
Eck, M.J.1
Pluskey, S.2
Trub, T.3
Harrison, S.C.4
Shoelson, S.E.5
-
49
-
-
0029894305
-
Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3́-kinase activity via modulation of phosphorylation of insulin receptor substrate-1
-
Ugi, S., Maegawa, H., Kashiwagi, A., Adachi, M., Olefsky, J.M. and Kikkawa, R. (1996). Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3́-kinase activity via modulation of phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 271, 12595-12602.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12595-12602
-
-
Ugi, S.1
Maegawa, H.2
Kashiwagi, A.3
Adachi, M.4
Olefsky, J.M.5
Kikkawa, R.6
-
50
-
-
0027288587
-
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS-1 and Shc: Implications for insulin control of ras signalling
-
Skolnik, E.Y. et al. (1993). The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS-1 and Shc: Implications for insulin control of ras signalling. EMBO J. 12, 1929-1936.
-
(1993)
EMBO J.
, vol.12
, pp. 1929-1936
-
-
Skolnik, E.Y.1
-
51
-
-
0029897280
-
Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice
-
Yamauchi, T. et al. (1996). Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell. Biol. 16, 3074-3084.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 3074-3084
-
-
Yamauchi, T.1
-
52
-
-
0028938721
-
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
-
Songyang, Z. et al. (1995). Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 373, 536-539.
-
(1995)
Nature
, vol.373
, pp. 536-539
-
-
Songyang, Z.1
-
53
-
-
0028910216
-
Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes
-
Ridderstrale, M., Degerman, E. and Tornqvist, H.E. (1995). Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes. J. Biol. Chem. 270, 3471-3474.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 3471-3474
-
-
Ridderstrale, M.1
Degerman, E.2
Tornqvist, H.E.3
-
54
-
-
0029096408
-
Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases
-
Yin, T. et al. (1995). Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases. J. Biol. Chem. 270, 20497-20502.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20497-20502
-
-
Yin, T.1
-
55
-
-
0028818459
-
The insulin related substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13 mediated signal transduction
-
Wang, L.M. et al. (1995). The insulin related substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13 mediated signal transduction. Blood 86, 4218-4227.
-
(1995)
Blood
, vol.86
, pp. 4218-4227
-
-
Wang, L.M.1
-
56
-
-
0029147360
-
Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in the rat heart
-
Saad, M.J.A., Velloso, L.A. and Carvalho, C.R.O. (1995). Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in the rat heart. Biochem. J. 310, 741-744.
-
(1995)
Biochem. J.
, vol.310
, pp. 741-744
-
-
Saad, M.J.A.1
Velloso, L.A.2
Carvalho, C.R.O.3
-
57
-
-
0029959818
-
Cross-talk between the insulin and angiotensin signaling system
-
Velloso, L.A., Folli, F., Sun, X.J., White, M.F., Saad, M.J.A. and Kahn, C.R. (1996). Cross-talk between the insulin and angiotensin signaling system. Proc. Natl Acad. Sci. USA 93, 1249-12495.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1249-12495
-
-
Velloso, L.A.1
Folli, F.2
Sun, X.J.3
White, M.F.4
Saad, M.J.A.5
Kahn, C.R.6
-
58
-
-
0027202202
-
Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II
-
Tranisijevik, M. et al. (1993). Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II. J. Biol. Chem. 268, 18157-18166.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 18157-18166
-
-
Tranisijevik, M.1
-
59
-
-
0028023002
-
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling
-
Tanti, J.F., Gremeaux, T., Van Obberghen, E. and Le Marchand-Brustel, Y. (1994). Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. J. Biol. Chem. 269, 6051-6057.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6051-6057
-
-
Tanti, J.F.1
Gremeaux, T.2
Van Obberghen, E.3
Le Marchand-Brustel, Y.4
-
60
-
-
15844389443
-
Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 662, and 731 modulates insulin action
-
Mothe, I. and Van Obberghen, E. (1996) Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 662, and 731 modulates insulin action. J. Biol. Chem. 271, 11222-11227.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 11222-11227
-
-
Mothe, I.1
Van Obberghen, E.2
-
61
-
-
0030061922
-
IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance
-
Hotamisligil, G.S., Peraldi, P., Budvari, A., Ellis, R.W., White, M.F. and Spiegelman, B.M. (1996). IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance. Science 271, 665-668.
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budvari, A.3
Ellis, R.W.4
White, M.F.5
Spiegelman, B.M.6
-
62
-
-
0030605404
-
Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction
-
Saklatvala, J., Davis, W. and Guesdon, F. (1996). Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction. Phil. Trans. R. Soc. Lond. B 351, 151-157.
-
(1996)
Phil. Trans. R. Soc. Lond. B
, vol.351
, pp. 151-157
-
-
Saklatvala, J.1
Davis, W.2
Guesdon, F.3
-
63
-
-
0028587742
-
Tumor necrosis factor alpha: A key component of the obesity-diabetes link
-
Hotamisligil, G.S. and Spiegelman, B.M. (1994). Tumor necrosis factor alpha: A key component of the obesity-diabetes link. Diabetes 43, 1271-1278.
-
(1994)
Diabetes
, vol.43
, pp. 1271-1278
-
-
Hotamisligil, G.S.1
Spiegelman, B.M.2
-
64
-
-
0028931724
-
Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
-
Hotamisligil, G.S., Arner, P., Caro, J.F., Atkinson, R.L. and Spiegelman, B.M. (1995). Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J. Clin. Invest. 95, 2409-2415.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2409-2415
-
-
Hotamisligil, G.S.1
Arner, P.2
Caro, J.F.3
Atkinson, R.L.4
Spiegelman, B.M.5
-
65
-
-
0026555109
-
How cells absorb glucose
-
Lienhard, G.E., Slot, J.W., James, D.E. and Mueckler, M.M. (1992). How cells absorb glucose. Sci. Am. 266, 86-91.
-
(1992)
Sci. Am.
, vol.266
, pp. 86-91
-
-
Lienhard, G.E.1
Slot, J.W.2
James, D.E.3
Mueckler, M.M.4
-
66
-
-
0028226008
-
A role for raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport
-
Fingar, D.C. and Birnbaum, M.J. (1994). A role for raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport. J. Biol. Chem. 269, 10127-10132.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 10127-10132
-
-
Fingar, D.C.1
Birnbaum, M.J.2
-
67
-
-
0027981333
-
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells
-
Hara, K. et al. (1994). 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells. Proc. Natl Acad. Sci. USA 91, 7415-7419.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 7415-7419
-
-
Hara, K.1
-
68
-
-
0028124189
-
Essential role of phsophatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes - Studies with a selective inhibitor wortmannin
-
Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O. and Ui, M. (1994) Essential role of phsophatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes - Studies with a selective inhibitor wortmannin. J. Biol. Chem. 269, 3568-3573.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 3568-3573
-
-
Okada, T.1
Kawano, Y.2
Sakakibara, T.3
Hazeki, O.4
Ui, M.5
-
69
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross, D.A.E., Alessi, D.R., Cohen, P., Andjelkovich, M. and Hemmings, B.A. (1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
70
-
-
0025522071
-
The molecular mechanisms by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
-
Dent, P., Lavoinne, A., Nakielny, S., Caudwell, F.B., Watt, P. and Cohen, P. (1990). The molecular mechanisms by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature 348, 302-307.
-
(1990)
Nature
, vol.348
, pp. 302-307
-
-
Dent, P.1
Lavoinne, A.2
Nakielny, S.3
Caudwell, F.B.4
Watt, P.5
Cohen, P.6
-
71
-
-
0029157595
-
Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif
-
Chen, D., Van Horn, D.J., White, M.F. and Backer, J.M. (1995) Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif. Mol. Cell. Biol. 15, 4711-4717.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4711-4717
-
-
Chen, D.1
Van Horn, D.J.2
White, M.F.3
Backer, J.M.4
-
72
-
-
0030013326
-
Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-1 phosphorylation by insulin requires insulin receptor substrate-1 and phosphotidylinositol-3-kinase
-
Mendez, R., Myers, M.G. Jr., White, M.F. and Rhoads, R.E. (1996) Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-1 phosphorylation by insulin requires insulin receptor substrate-1 and phosphotidylinositol-3-kinase. Mol. Cell. Biol. 16, 2857-2864.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2857-2864
-
-
Mendez, R.1
Myers M.G., Jr.2
White, M.F.3
Rhoads, R.E.4
-
73
-
-
0038155702
-
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
-
Bruning, J.C., Winnay, J., Bonner-Weir, S., Taylor, S.I., Accili, D. and Kahn, C.R. (1997). Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561-572.
-
(1997)
Cell
, vol.88
, pp. 561-572
-
-
Bruning, J.C.1
Winnay, J.2
Bonner-Weir, S.3
Taylor, S.I.4
Accili, D.5
Kahn, C.R.6
-
74
-
-
0028810236
-
4PS/IRS-2 is the alternative substrate of the insulin receptor in IRS-1 deficient mice
-
Patti, M.E. et al. (1995). 4PS/IRS-2 is the alternative substrate of the insulin receptor in IRS-1 deficient mice. J. Biol. Chem. 270, 24670-24673.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24670-24673
-
-
Patti, M.E.1
-
75
-
-
0029893417
-
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies
-
Almind, K., Inoue, G., Pedersen, O. and Kahn, C.R. (1996). A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. J. Clin. Invest. 97, 2569-2575.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2569-2575
-
-
Almind, K.1
Inoue, G.2
Pedersen, O.3
Kahn, C.R.4
-
76
-
-
0029118510
-
Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1
-
Clausen, J.O. et al. (1995). Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1. Lancet 346, 397-402.
-
(1995)
Lancet
, vol.346
, pp. 397-402
-
-
Clausen, J.O.1
-
77
-
-
0027496895
-
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
-
Liu, J.P., Baker, J., Perkins, J.A., Robertson, E.J. and Efstratiadis, A. (1993). Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59-72.
-
(1993)
Cell
, vol.75
, pp. 59-72
-
-
Liu, J.P.1
Baker, J.2
Perkins, J.A.3
Robertson, E.J.4
Efstratiadis, A.5
-
78
-
-
13344277357
-
Early neonatal death in mice homozygous for a null alele of the insulin receptor gene
-
Accili, D. et al. (1996). Early neonatal death in mice homozygous for a null alele of the insulin receptor gene. Nature Genet. 12, 106-109.
-
(1996)
Nature Genet.
, vol.12
, pp. 106-109
-
-
Accili, D.1
-
79
-
-
0029044416
-
Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor
-
Surmacz, E., et al. (1995). Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. Exp. Cell Res. 218, 370-380.
-
(1995)
Exp. Cell Res.
, vol.218
, pp. 370-380
-
-
Surmacz, E.1
-
80
-
-
0028852556
-
Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis
-
Sell, C., Baserga, R. and Rubin, R. (1995). Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res. 55, 303-306.
-
(1995)
Cancer Res.
, vol.55
, pp. 303-306
-
-
Sell, C.1
Baserga, R.2
Rubin, R.3
-
81
-
-
0029024963
-
Transforming potential of the insulin receptor substrate 1
-
D'Ambrosio, C., Keller, S.R., Morrione, A., Lienhard, G.E. and Baserga, R., Surmacz, E. (1995). Transforming potential of the insulin receptor substrate 1. Cell Growth Differ. 6, 557-562.
-
(1995)
Cell Growth Differ.
, vol.6
, pp. 557-562
-
-
D'Ambrosio, C.1
Keller, S.R.2
Morrione, A.3
Lienhard, G.E.4
Baserga, R.5
Surmacz, E.6
|