Structural and functional diversity of phosphoinositide 3-kinases

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 351, Issue 1336, 1996, Pages 217-223

  Zvelebil, M J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE;

AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; ISOMERISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REVIEW; SEQUENCE HOMOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; CONSERVED SEQUENCE; ISOMERISM; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0030605392     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1996.0019     Document Type: Article

References (50)

1. Barton, G. G. & Sternberg, M. J. E. 1987 A strategy for the rapid multiple alignment of protein sequences confidence levels from tertiary structure comparisons. J. molec. Biol. 198, 327-337.
2. Boronenkov, I. V. & Anderson, R. A. 1995 The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases. J. Biol. Chem. 270, 2881-2884.
3. ++ adenyl imidodiphosphate and inhibitor peptide PKI(5-24). EMBO J 12, 849-859.
4. Brown, E. J., Albers, M. W., Shin, T. B. et al. 1994 A mammalian protein targeted by G1-arresting rapamycinreceptor complex. Nature, Lond. 369, 756-758.
5. DeBondt, H. L., Rosenblatt, J., Jancarik, J., Jones, H. D., Morgan, D. O. & Kim, S.-H. 1993 Crystal structure of cyclin-dependent protein kinase. Science, Wash. 253,414-420.
6. Dhand, R., Hara, K., Miles, I. et al. 1994a PI3-kinase: structural and functional analysis of intersubunit interactions. EMBO J. 13, 511-521.
7. Dhand, R., Hiles, R., Panayotou, G. et al. 1994b PI 3-kinase is a dual-specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J. 13, 522-533.
8. Flanagan, C. A., Schnieders, E. A., Emerick, A. W., Kunisawa, R., Admon, A. & Thorner, J. 1993 Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science, Wash. 262, 1444-1448.
9. Garcia-Bustos, J. F., Marini, F., Stevenson, I., Frei, C. & Hall, M. N. 1994 PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus. EMBO J 13, 2352-2361.
10. Gibson, T. J., Hyvonen, M., Musacchio, A. & Saraste, M. 1994 PH domain: the first anniversary. Trends Biochem. Sci. 19, 349-353.
11. Greenwell, P. W., Kronmal, S. L., Porter, S. E., Gassenhuber, J., Obermaier, B. & Petes, T. D. 1995 TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia (ATM) gene. Cell 82, 823-829.
12. Hanks, S. K. & Quinn, A. M. 1991 Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Meth. Enzymol. 200, 38-62.
13. Hari, K. L., Santerre, A., Sekelsky, J. J., McKim, K. S., Boyd, J. B. & Hawley, R. S. 1995 The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82, 815-821.
14. Hartley, K. O., Gell, D., Smith, G. C. M. et al. 1995 DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856.
15. Helliwell, S., Wagner, P., Kunz, J., Deuter-Reinhard, M., Henriquez, R. & Hall, M. N. 1994 TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Molec. Biol. Cell 5, 105-118.
16. Herman, P. K., Stack, J. H., DeModena, J. A. & Emr, S. D. 1991 A novel protein kinase homologue essential for protein sorting to the yeast lysosome-like vacuole. Cell 64, 425-437.
17. Hiles, I. D., Otsu, M., Volinia, S. et al. 1992 Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70, 419-429.
18. Hong, Z. & Verma, D. P. 1994 A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation. Proc. natn. Acad. Sci. U.S.A. 91, 9617-9621.
19. Horazdovsky, B., DeWald, D. & Emr, S. 1995 Protein transport in the yeast vacuole. Curr. Opin. Cell Biol. 7, 544-551.
20. Hu, P., Mondino, A., Skolnik, E. Y. & Schlessinger, J. 1993 Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Molec. Cell. Biol. 13, 7677-7688.
21. Hubbard, S. R., Wei, L., Ellis, L. & Hendrickson, W. A. 1994 Crystal structure of the tyrosine kinase of the human insulin receptor. Nature, Lond. 372, 746-754.
22. Kapeller, R. & Cantley, L. C. 1994 Phosphatidylinositol 3-kinase. BioEssays 16, 565-576.
23. Klippel, A., Escobedo, J. A., Hirano, M. & Williams, L. T. 1994 The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Molec. Cell. Biol. 14, 2675-2685.
24. Koga, H., Vanhaesebroeck, B., Zvelebil, M. J. J. M. & Waterfield, M. D. 1995 Phosphatidylinositol 3-kinase: recent progress in structure-function studies and thier implcations. Expl Med. 13, 794-801.
25. Knighton, D. R., Zheng, J., Ten Eyck, L. F. et al. 1991 Crystal structure of the catalytic adenosine monophosphate-dependent protein kinase. Science, Wash. 253, 407-413.
26. Kunz, J., Henriques, R., Schneider, U., Deuter-Reinhard, M., Movva, N. R. & Hall, M. N. 1993 Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homologue required for G1 progression.Cell 73, 586-596.
27. Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S. & Hieter, P. 1995 TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82, 831-840.
28. Nassar, N., Horn, G., Herrman, C., Scherer, A., McCormick, F. & Wittinghofer, A. 1995 The 2.2Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Rafl in complex with Rap1A and GTP analogue. Nature, Lond. 375, 554-560.
29. c-src complexes, and PI 3-kinase. Cell 65, 91-104.
30. Paulovich, A. G. & Hartwell, L. H. 1995 A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82, 841-847.
31. Rodriguez-Vicinia, P., Warne, P. H., Dhand, R. et al. 1994 Phosphatidylinositol 3-OH-kinase as a direct target of Ras. Nature, Lond. 370, 527-532.
32. Sabatini, D. M., Erdjument-Bromage, H., Lui, M., Tempst, P. & Snyder, S. H. 1994 RAFT1 : a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78, 35-43.
33. Savitsky, K., Bar-Shira, A., Gilad, S. et al. 1995 A single ataxia-telangiectasia gene with a product similar to PI 3-kinase. Science, Wash. 268, 1749-1752.
34. Schu, P. V., Takegawa, K., Fry, M. J., Stack, J. H., Waterfield, M. D. & Emr, S. D. 1993 Phosphatidylinositol 3-kinase encoded by yeast Vps34 gene essential for protein sorting. Science, Wash. 260, 88-91.
35. Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C. & Hawkins, P. T. 1994 a A novel phosphoinositide-3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell 77, 83-93.
36. Stephens, L., Cooke, F. T., Walters, R. et al. 1994b Charactarisation of a phosphatidylinositol-specific PI3-kinase in mammalian cells. Curr. Biol. 4, 203-214.
37. Stoyanov, B., Volinia, S., Hanck, T. et al. 1995 PI3-kinase: cloning, expression and characterisation of a human PI 3-kinase which is activated by G protein subunits. Science, Wash. 269, 690-693.
38. Takegawa, K., DeWald, D. B. & Emr, S. E. 1995 Phosphtidylinositol-specific phosphoinositide 3-kinase from Schizosaccharomyces pombe, SpVps34p, required for normal cell growth and vacuole function. U32583: GenBank. (Submitted.)
39. Valius, M. & Kazlauskas, A. 1993 Phospholipase C-gamma 1 and phosphatidylinositol 3-kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73, 321-34.
40. Volinia, S., Hiles, I., Ormondroyd, E. et al. 1994 Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene. Genomics 24, 472-477.
41. Weinert, T. A., Riser, G. L. & Hartwell, L. H. 1994 Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8, 652-665.
42. Welters, P., Takegawa, K., Emr, S. D. & Chrispeels, M. J. 1994 AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain. Proc. natn. Acad. Sci. U.S.A. 91, 11398-11402.
43. Whitman, M., Kaplan, D. R., Schaffhausen, B., Cantley, L. C. & Roberts, T. M. 1985 Association of phosphatidylinositol 3-kinase activity with polyoma middle-T component for transformation. Nature, Lond. 315, 239-242.
44. Wong, K. & Cantley, L. 1994 Cloning and characterization of a human phosphatidylinositol 4-kinase. J. Biol. Chem. 269, 28878-28884.
45. Yamakawa, A., Nishizawa, M., Fujiwara, K. T. et al. 1991 Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain. J. Biol. Chem. 266, 17580-17583.
46. Yoshida, S., Ohya, Y., Goebl, M., Nakano, A. & Anraku, Y. 1994a A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae. J. Biol. Chem. 269, 1166-1172.
47. Yoshida, S., Ohya, Y., Nakano, A. & Anraku, Y. 1994b Genetic interactions among genes involved the STT4-PKC1 pathway of Saccharomyces cerevisiae. Molec. Gen. Genet. 242, 631-640.
48. Zakian, V. A. 1995 ATM-related genes: what do they tell us about functions of the human gene? Cell 82, 685-687.
49. Zheng, J., Knighton, D. R., Ten Eyck, L. F. et al. 1993 Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 32, 2154-2161.
50. Zvelebil, M. J., Barton, G. J., Taylor, W. R., & Sternberg, M. J. 1987 Prediction of protein structure and active sites using the alignment of homologous sequences. J. molec. Biol. 195, 957-961.