Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin

Journal of Cell Biology

Volumn 132, Issue 4, 1996, Pages 595-605

  Shpetner, Howard ^a   Joly, Marguerite ^a   Hartley, David ^a   Corvera, Silvia ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM FLUORIDE; BREFELDIN A; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; LUCIFER YELLOW; PHOSPHATIDYLINOSITIDE; PHOSPHOTRANSFERASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; TRANSFERRIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CERCOPITHECIDAE; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTERNALIZATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; BIOLOGICAL TRANSPORT; CELL LINE; ENDOCYTOSIS; ENZYME INHIBITORS; FLUORESCENT DYES; HUMANS; ISOQUINOLINES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; TRANSFERRIN;

ANIMALIA; CERCOPITHECIDAE; MAMMALIA;

EID: 0030027394     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.132.4.595     Document Type: Article

References (40)

1. Auger, K., L. Serunian, S. Soltoff, P. Libby, and L. Cantley. 1989 PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell. 57:167-175.
2. Brown, H.A., S. Gutowski, C.R. Moomaw, C. Slaughter, and P.C Sternweis. 1993 Cell. 75:1137-1144.
3. Cantley, L.C., K.R. Auger, C. Carpenter, B Duckworth, A. Graziani R. Kapeller, and S. Soltoff. 1991. Oncogenes and signal transduction. Cell. 64:281-302.
4. Carrington, W , K.E. Fogarty, and F.S. Fay. 1990. 3D fluorescence imaging of single cells using image restoration. In Non-Invasive Techniques in Cell Biology K. Foster, editor. John Wiley-Liss, New York. 53-72.
5. s6k activation mediated by phosphatidylinositol-3-OH kinase. Nature (Lond.). 370:71-75.
6. Cockcroft, S., G.M.H. Thomas, A Fensome, B. Geny, E Cunningham, I Gout, I. Miles, N.F. Totty, O. Truong, J.J. Hsuan. 1994. Phospholipase D: a downstream effector of ARF in granulocytes. Science (Wash. DC). 263. 523-526.
7. D'Souza-Schorey, C., G. Li, M.I. Colombo, and P.D. Stahl. 1995. A regulatory role for ARF6 in receptor-mediated endocytosis. Science (Wash. DC). 267:1175-1177.
8. Donaldson, J.G., D. Finazzi, and R D. Klausner. 1992 Brefeldin-A inhibits Golgi membrane-catalyzed exchange of guanine-nucleotide onto ARF protein. Nature (Lond.). 360:350-352.
9. Finazzi, D., D. Cassel, J G. Donaldson, and R.D. Klausner. 1994 Aluminum Fluoride acts on the reversibility of ARF1-dependent coat protein binding to Golgi membranes. J. Biol. Chem. 269:13325-13330
10. Geuze, H.J., J.W. Slot, G.J.A.M. Strous, H.F. Lodish, and A L. Schwartz. 1983. Intracellular site of asialoglycoprotein receptor-Ligand uncoupling: double-label immunoelectron microscopy during receptor-mediated endocytosis. Cell 32.277-287.
11. Geuze, H.J., J.W. Slot, G.J A.M Strous, J. Peppard, K. von Figura, A. Hasilik, and A.L. Schwartz. 1984. Intracellular receptor sorting during endocytosis: comparative immunoelectron microscopy of multiple receptors in rat liver. Cell. 37:195-204
12. Helms, J B., and J.E. Rothman. 1993 Inhibition by brefeldin-A of a Golgi membrane enzyme that catalyzes exchange of guanine nucleotide bound to ARF. Nature (Lond.). 360:352-354.
13. Herman, P., J. Stack, and S. Emr. 1992. An essential role for a protein and lipid kinase complex in secretory protein sorting. Trends Cell Biol. 2:363-368.
14. Hues, I. M. Otsu, S. Volinia, M, Fry, I. Gout, R. Dhand, G Panayotou, F. Ruiz-Larrea. A Thompson, N. Totty, J.J Hsuan, S. Courtneidge, P Parker, and M. Waterfield. 1992. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70:419-429.
15. Hopkins, C.R., A. Gibson, M. Shipman, D.K. Strickland, and I.S. Trowbridge. 1994 In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella. J. Cell Biol. 125.1265-1274.
16. Joly, M., A. Kazlauskas, and S. Corvera. 1995. Phosphatidylinositol 3-kinase is required at a post-endocytic step in PDGF receptor trafficking. J. Biol. Chem. 270:13225-13230.
17. Joly, M., A. Kazlauskas, F. Fay, and S. Corvera. 1994. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science (Wash DC). 263:581-724.
18. Kapeller, R., R Chakrabarti, L. Cantley, F. Fay, and S. Corvera. 1993. Internalization of activated PDGF receptor-phosphatidylinositol-3 kinase complexes: potential interactions with the microtubule cytoskeleton. Mol. Cell Biol. 13:6052-6063.
19. Kapeller, R., and L. C. Cantley. 1994. Phosphatidylinositol 3-kinase. BioEssays. 16:565-576.
20. Klausner, R.D., J.G. Donaldson, and J.L. Schwartz. 1992. Brefeldin-A: insights into the control of membrane traffic and organelle structure. J. Cell Biol 116:1071-1080.
21. Lippincott-Schwartz, J , L. Yuan, C. Tipper, M. Amherdt, L Orci, and R.D. Klausner. 1991. Brefeldin A's effects on endosomes, lysosomes and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic Cell. 67:601-616.
22. Mayors, S., J.F. Presley, and R.R. Maxfield. 1993. Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk-flow process J. Cell Biol. 121:1257-1269.
23. +-ATPase-defective yeast: identification of six new END genes. J. Cell Biol. 127.373-386.
24. Okada, T., L. Sakuma, Y. Fukui, O. Hazeki, and M. Ui. 1994. Blockage of Chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase J. Biol. Chem 269:3563-3567
25. Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and M. Ui. 1994. Essential role of phosphatidylmositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes J. Biol. Chem. 269:3568-3573.
26. Orci, L., D.J. Palmer, M Amherdt, and J.E. Rothman. 1993. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol Nature (Lond.). 364:732-734.
27. Peters, P.J., V.W. Hsu, C.E. Ooi, D. Finazzi, S.B. Teal, V. Oorschot, J.G. Donaldson, and R.D. Klausner. 1995. Overexpression of wild-type and mutant ARF1 and ARF6: Distinct perturbations of nonoverlapping membrane compartments J. Cell Biol 128:1003-1017.
28. Randazzo, P.A., and R.A. Kahn. 1994. GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acidic phospholipids. J Biol. Chem. 269:10758-10763
29. Robinson, M.S., and T. Kreis. 1992. Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: effects of brefeldin A and G protein activators. Cell. 69:129-138.
30. Shurmann, A., M. Breiner, W. Becker, C Huppertz, H. Kainulainen, H. Kentrup, and H.G. Ioost 1994. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J. Biol. Chem. 269:15683-15688.
31. Stack, J.H., and S.D. Emr. 1994. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI-3 kinase activities. J Biol. Chem. 269:31552-31562.
32. Stephens, L, F.T. Cooke, R. Walkers, T. Jackson, S. Volinia, I. Gout, M.D. Waterfield, and P.T. Hawkins. 1994. Characterization of a phosphatidylinositol-specific phosphoinositide-3-kinase from mammalian cells. Curr. Biol. 4.203-214.
33. Stephens, L., A. Smrcka, F.T. Cooke, T.R. Jackson, P C. Sternweis, and P.T. Hawkins. 1994 A novel phosphoinositide-3-kinase activity in myeloid-derived cells is activated by G protein bg subunits Cell 77.83-93.
34. Tsai, S-C , R. Adamik, J. Moss, and M. Vaughan 1994. Identification of a brefeldin-A insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain. Proc Natl. Acad. Sci. USA. 91.3063-3066.
35. Tsuchiya, M., S.R. Price, S.C. Tsai, J. Moss, and M. Vaughan. 1991. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. J. Biol. Chem. 266:2772-2777.
36. Valius, M., and A. Kazlauskas. 1993. Phospholipase C-g1 and phosphatydylinositol-3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell. 73:321-334.
37. Whitman, M., C.P Downes, M. Keeler, T. Keller, and L. Cantley. 1988. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, pnosphatidylinositol-3-phosphate. Nature (Lond.). 332:644-646
38. Wood, S.A., and W.J. Brown. 1992. The morphology, but not the function of endosomes and lysosomes is altered by brefeldin-A. J. Cell Biol. 119: 273-285.
39. Wood, S.A , J E Park, and W.J Brown. 1991. Brefeldin-A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes. Cell. 67:591-600.
40. Yano, H., S. Nakanishi, K. Kimura, N. Hanai, Y. Saitoh, Y. Fukui, Y. Nonomura, and Y. Matsuda. 1993. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol Chem. 268:25846-25856.