Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin: Dependence on signal strength

Journal of Biological Chemistry

Volumn 272, Issue 44, 1997, Pages 27665-27670

  Duckworth, Brian C ^a,b,c,d   Cantley, Lewis C ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; ENZYME ACTIVATION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANDROSTADIENES; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CHO CELLS; CRICETINAE; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MICE; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030786202     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.44.27665     Document Type: Article

References (45)

1. Cantley, L. C., Auger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S. (1991) Cell 64, 281-302
2. Duckworth, B. C., and Cantley, L. C. (1996) in Lipid Second Messengers (Bell, R. M., ed) Vol. 8, pp. 125-175, Plenum Publishing Corp., New York
3. Chang, H. W., Aoki, M., Fruman, D., Auger, K. R., Bellacosa, A., Tsichlis, P. N., Cantley, L. C., and Vogt, P. K. (1997) Science 270, 1848-1850
4. Marais, R., Light, Y., Paterson, H. F., and Marshall, C. J., (1995) EMBO J. 14, 3136-3145
5. Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Science 268, 100-102
6. Klippel, A., Reinhard, C., Kavanaugh, W. M., Apell, G., Escobedo, M. A., and Williams, L. T. (1996) Mol. Cell. Biol. 16, 4117-4127
7. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. (1997) Nature 385, 544-548
8. Frevert, E. U., and Kahn, B. B. (1997) Mol. Cell. Biol. 17, 190-198
9. Lopez-Ilasaca, M., Crespo, P., Pellici, P. G., Gutkind, J. S., and Wetzker, R. (1997) Science 275, 394-397
10. Cross, D. A., Alessi, D. R., Vandenheede, J. R., McDowell, H. E., Hundal, H. S., and Cohen, P. (1994) Biochem. J. 303, 21-26
11. Chuang, L. M., Hausdorff, S. F., Myers, M. G., Jr., White, M. F., Birnbaum, M. J., and Kahn, C. R. (1994) J. Biol. Chem. 269, 27645-27649
12. Ferby, I. M., Waga, I., Sakanaka, C., Kume, K., and Shimizu, T. (1994) J. Biol. Chem. 269, 30485-30488
13. Marra, F., Pinzani, M., DeFranco, R., Laffi, G., and Gentilini, P. (1995) FEBS Lett. 376, 141-145
14. Nishioka, N., Hirai, S., Mizuno, K., Osada, S., Suzuki, A., Kosaka, K., and Ohno, S. (1995) FEBS Lett. 377, 393-398
15. Hu, Z. W., Shi, X. Y., Lin, R. Z., and Hoffman, B. B. (1996) J. Biol. Chem. 271, 8977-8982
16. Von Willebrand, M., Jascur, T., Bonnefoy-Berard, N., Yano, H., Altman, A., Matsuda, Y., and Mustelin, T. (1996) Eur. J. Biochem. 235, 828-835
17. Nakamura, K., Zhou, C. J., Parente, J., and Chew, C. S. (1996) Am. J. Physiol. 271, G640-G649
18. Scheid, M. P., and Duronio, V. (1996) J. Biol. Chem. 271, 18134-18139
19. Ferby, I. M., Waga, I., Hoshino, M., Kume, K., and Shimizu, T. (1996) J. Biol. Chem. 271, 11684-11688
20. Toker, A., Meyer, M., Reddy, K. K., Falck, J. R., Aneja, R., Aneja, S., Parra, A., Burns, D. J., Ballas, L. M., and Cantley, L. C. (1994) J. Biol. Chem. 269, 32358-32367
21. Toker, A., Bachelot, C., Chen, C.-S., Falck, J. R., Hartwig, J. H., Cantley, L. C., and Kovacsovics, T. J. (1995) J. Biol. Chem. 270, 29525-29531
22. Zhang, J., Falck, J. R., Reddy, K. K., Abrams, C. S., Zhao, W., and Rittenhouse, S. E. (1995) J. Biol. Chem. 270, 22807-22810
23. Moriya, S., Kazlauskas, A., Akimoto, K., Hirai, S., Mizuno, K., Takenawa, T., Fukui, Y., Watanabe, Y., Ozaki, S., and Ohno, S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 151-155
24. Akimoto, K., Takahashi, R., Moriya, S., Nishioka, N., Takayanagi, J., Kimura, K. Fukui, Y., Osada, S., Mizuno, K., Hirai, S., Kazlauskas, A., and Ohno, S. (1996) EMBO J. 15, 788-798
25. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marme, D., and Rapp, U. R. (1993) Nature 364, 249-252
26. Troppmair, J., Bruder, J. T., Munoz, H., Lloyd, P. A., Kyriakis, J., Banerjee, P., Avruch, J., and Rapp, U. R. (1994) J. Biol. Chem. 269, 7030-7035
27. Cai, H., Smola, U., Wixler, V., Eisenmann-Tappe, I., Diaz-Meco, M. T., Moscat, J., Rapp, U., and Cooper, G. M. (1997) Mol. Cell. Biol. 17, 732-741
28. Klippel, A., Kavanaugh, W. M., Pot, D., and Williams, L. T. (1997) Mol. Cell. Biol. 17, 338-344
29. Franke, T. F., Kaplan, D. R., Cantley, L. C., and Toker, A. (1997) Science 275, 665-658
30. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995) Cell 81, 727-736
31. Chung, J., Grammer, T. C., Lemon, K. P., Kazlauskas, A., and Blenis, J. (1994) Nature 370, 71-75
32. Serunian, L. A., Auger, K. R., and Cantley, L. C. (1991) Methods Enzymol. 198, 78-87
33. Claesson-Welsh, L., Eriksson, A., Moren, A., Severinsson, L., Ek, B., Ostman, A., Betsholtz C., and Heldin, C. H. (1988) Mol. Cell. Biol. 8, 3476-3486
34. Huang, J. S., Huang, S. S., Kennedy, B., and Deuel, T. F. (1982) J. Biol. Chem. 257, 8130-8136
35. Singh, J. P., Chaikin, M. A., and Stiles, C. D. (1982) J. Cell Biol. 95, 667-671
36. Moodie, S. A., Willumsen, B. M., Weber, M. J., and Wolfman, A. (1993) Science 260, 1658-1661
37. Koide, H., Satoh, T., Nakafuku, M., and Kaziro, Y. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 8683-8686
38. Van, A. L., Barr, M., Marcus, S., Polverino, A., and Wigler, M. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6213-6217
39. Hallberg, B., Rayter, S. I., and Downward, J. (1994) J. Biol. Chem. 269, 3913-3916
40. Stokoe, D., Macdonald, S. G., Cadwallader, K., Symons, M., and Hancock, J. F. (1994) Science 264, 1463-1467
41. Kimura, K., Hattori, S., Kabuyama, Y., Shizawa, Y., Takayanagi, J., Nakamura, S., Toki, S., Matsuda, Y., Onodera, K., and Fukui, Y. (1994) J. Biol. Chem. 269, 18961-18967
42. Kotani K., Yonezawa, K., Kara, K., Ueda, H., Kitamura, Y., Sakaue, H., Ando, A., Chavanieu A., Calas, B., Grigorescu, F., Nishiyama, M., Waterfield, M. D., and Kasuga, M. (1994) EMBO J. 13, 2313-2321
43. Nakanishi, S., Catt, K. J., and Balla, T. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5317-5321
44. Barker, S. A., Caldwell, K. K., Hall, A., Martinez, A. M., Pfeiffer, J. R., Oliver, J. M., and Wilson, B. S. (1995) Mol. Biol. Cell 6, 1145-1158
45. Morrison, D. K., and Cutler, R. E. (1997) Curr. Opin. Cell Biol. 9, 174-179