Multi-chain immune recognition receptors: Spatial organization and signal transduction

Seminars in Immunology

Volumn 17, Issue 1, 2005, Pages 51-64

  Sigalov, Alexander ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cell activation; Multi chain immune recognition receptors; Signal transduction

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN E RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MULTI CHAIN IMMUNE RECOGNITION RECEPTOR; NEF PROTEIN; RECEPTOR SUBUNIT; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; B LYMPHOCYTE; BASOPHIL; BINDING AFFINITY; CELL ACTIVATION; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; LIGAND BINDING; MAST CELL; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 9644259016     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2004.09.003     Document Type: Article

References (196)

1. A.D. Keegan, and W.E. Paul Multichain immune recognition receptors: similarities in structure and signaling pathways Immunol Today 13 1992 63 68
2. M.E. Call, J. Pyrdol, M. Wiedmann, and K.W. Wucherpfennig The organizing principle in the formation of the T cell receptor-CD3 complex Cell 111 2002 967 979
3. M.E. Call, J. Pyrdol, and K.W. Wucherpfennig Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum EMBO J 23 2004 2348 2357
4. M.E. Call, and K.W. Wucherpfennig Molecular mechanisms for the assembly of the T cell receptor-CD3 complex Mol Immunol 40 2004 1295 1305
5. M. Sanchez, Z. Misulovin, A.L. Burkhardt, S. Mahajan, T. Costa, and R. Franke Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta J Exp Med 178 1993 1049 1055
6. A.L. DeFranco, J.D. Richards, J.H. Blum, T.L. Stevens, D.A. Law, and V.W. Chan Signal transduction by the B-cell antigen receptor Ann N Y Acad Sci 766 1995 195 201
7. C.M. Pleiman, D. D'Ambrosio, and J.C. Cambier The B-cell antigen receptor complex: structure and signal transduction Immunol Today 15 1994 393 399
8. P. Cosson, S.P. Lankford, J.S. Bonifacino, and R.D. Klausner Membrane protein association by potential intramembrane charge pairs Nature 351 1991 414 416
9. M. Daeron Fc receptor biology Annu Rev Immunol 15 1997 203 234
10. M. Reth Antigen receptor tail clue Nature 338 1989 383 384
11. A. Weiss T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases Cell 73 1993 209 212
12. C.E. Rudd Adaptors and molecular scaffolds in immune cell signaling Cell 96 1999 5 8
13. P. Anton van der Merwe, S.J. Davis, A.S. Shaw, and M.L. Dustin Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition Semin Immunol 12 2000 5 21
14. P. Anton van der Merwe The TCR triggering puzzle Immunity 14 2001 665 668
15. T.M. Fahmy, J.G. Bieler, and J.P. Schneck Probing T cell membrane organization using dimeric MHC-Ig complexes J Immunol Methods 268 2002 93 106
16. Z. Reich, J.J. Boniface, D.S. Lyons, N. Borochov, E.J. Wachtel, and M.M. Davis Ligand-specific oligomerization of T-cell receptor molecules Nature 387 1997 617 620
17. M.F. Bachmann, and P.S. Ohashi The role of T-cell receptor dimerization in T-cell activation Immunol Today 20 1999 568 576
18. P.C. Cheng, B.K. Brown, W. Song, and S.K. Pierce Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling J Immunol 166 2001 3693 3701
19. E. Ortega, R. Schweitzer-Stenner, and I. Pecht Possible orientational constraints determine secretory signals induced by aggregation of IgE receptors on mast cells EMBO J 7 1988 4101 4109
20. E. Ortega, R. Schweitzer-Stenner, and I. Pecht Kinetics of ligand binding to the type 1 Fc epsilon receptor on mast cells Biochemistry 30 1991 3473 3483
21. R. Schweitzer-Stenner, I. Tamir, and I. Pecht Analysis of Fc(epsilon)RI-mediated mast cell stimulation by surface-carried antigens Biophys J 72 1997 2470 2478
22. I. Tamir, and J.C. Cambier Antigen receptor signaling: integration of protein tyrosine kinase functions Oncogene 17 1998 1353 1364
23. D. Holowka, and B. Baird Antigen-mediated IGE receptor aggregation and signaling: a window on cell surface structure and dynamics Annu Rev Biophys Biomol Struct 25 1996 79 112
24. Z.J. Liu, H. Haleem-Smith, H. Chen, and H. Metzger Unexpected signals in a system subject to kinetic proofreading Proc Natl Acad Sci USA 98 2001 7289 7294
25. B. Seed Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases Semin Immunol 7 1995 3 11
26. M.F. Bachmann, M. Salzmann, A. Oxenius, and P.S. Ohashi Formation of TCR dimers/trimers as a crucial step for T cell activation Eur J Immunol 28 1998 2571 2579
27. J.R. Cochran, T.O. Cameron, and L.J. Stern The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers Immunity 12 2000 241 250
28. C.H. Heldin Dimerization of cell surface receptors in signal transduction Cell 80 1995 213 223
29. A.L. DeFranco, M.R. Gold, and J.P. Jakway B-lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide Immunol Rev 95 1987 161 176
30. H. Metzger Transmembrane signaling: the joy of aggregation J Immunol 149 1992 1477 1487
31. J.J. Boniface, J.D. Rabinowitz, C. Wulfing, J. Hampl, Z. Reich, and J.D. Altman Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected] Immunity 9 1998 459 466
32. R.Z. Dintzis, M. Okajima, M.H. Middleton, G. Greene, and H.M. Dintzis The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence J Immunol 143 1989 1239 1244
33. J.D. Stone, J.R. Cochran, and L.J. Stern T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model Biophys J 81 2001 2547 2557
34. R. Thyagarajan, N. Arunkumar, and W. Song Polyvalent antigens stabilize B cell antigen receptor surface signaling microdomains J Immunol 170 12 2003 6099 6106
35. D. Maurer, E. Fiebiger, B. Reininger, C. Ebner, P. Petzelbauer, and G.P. Shi Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation J Immunol 161 1998 2731 2739
36. D. Gil, W.W. Schamel, M. Montoya, F. Sanchez-Madrid, and B. Alarcon Recruitment of Nek by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation Cell 109 2002 901 912
37. M.M. Davis A new trigger for T cells Cell 110 2002 285 287
38. B. Alarcon, D. Gil, P. Delgado, and W.W. Schamel Initiation of TCR signaling: regulation within CD3 dimers Immunol Rev 191 2003 38 46
39. M. Reth, J. Wienands, and W.W. Schamel An unsolved problem of the clonal selection theory and the model of an oligomeric B-cell antigen receptor Immunol Rev 176 2000 10 18
40. M. Reth Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes Trends Immunol 22 2001 356 360
41. V. Horejsi, K. Drbal, M. Cebecauer, J. Cerny, T. Brdicka, and P. Angelisova GPI-microdomains: a role in signalling via immunoreceptors Immunol Today 20 1999 356 361
42. P.W. Janes, S.C. Ley, A.I. Magee, and P.S. Kabouridis The role of lipid rafts in T cell antigen receptor (TCR) signalling Semin Immunol 12 2000 23 34
43. S. Ilangumaran, H.T. He, and D.C. Hoessli Microdomains in lymphocyte signalling: beyond GPI-anchored proteins Immunol Today 21 2000 2 7
44. C. Langlet, A.M. Bernard, P. Drevot, and H.T. He Membrane rafts and signaling by the multichain immune recognition receptors Curr Opin Immunol 12 2000 250 255
45. A. Cherukuri, M. Dykstra, and S.K. Pierce Floating the raft hypothesis: lipid rafts play a role in immune cell activation Immunity 14 2001 657 660
46. M. Dykstra, A. Cherukuri, and S.K. Pierce Rafts and synapses in the spatial organization of immune cell signaling receptors J Leukoc Biol 70 2001 699 707
47. M. Dykstra, A. Cherukuri, H.W. Sohn, S.J. Tzeng, and S.K. Pierce Location is everything: lipid rafts and immune cell signaling Annu Rev Immunol 21 2003 457 481
48. T. Harder Lipid raft domains and protein networks in T-cell receptor signal transduction Curr Opin Immunol 16 2004 353 359
49. J. Matko, and J. Szollosi Landing of immune receptors and signal proteins on lipid rafts: a safe way to be spatio-temporally coordinated? Immunol Lett 82 2002 3 15
50. O.O. Glebov, and B.J. Nichols Lipid raft proteins have a random distribution during localized activation of the T-cell receptor Nat Cell Biol 6 2004 238 243
51. S.K. Pierce To cluster or not to cluster: FRETting over rafts Nat Cell Biol 6 2004 180 181
52. A. Weiss, and D.R. Littman Signal transduction by lymphocyte antigen receptors Cell 76 1994 263 274
53. M. Reth, and J. Wienands Initiation and processing of signals from the B cell antigen receptor Annu Rev Immunol 15 1997 453 479
54. J.P. Kinet The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology Annu Rev Immunol 17 1999 931 972
55. D. Aivazian, and L.J. Stern Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition Nat Struct Biol 7 2000 1023 1026
56. J.C. Cambier Signal transduction by T- and B-cell antigen receptors: converging structures and concepts Curr Opin Immunol 4 1992 257 264
57. N.S. van Oers, P.E. Love, E.W. Shores, and A. Weiss Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs J Immunol 160 1998 163 170
58. N.S. van Oers, B. Tohlen, B. Malissen, C.R. Moomaw, S. Afendis, and C.A. Slaughter The 21- and 23-kD forms of TCR zeta are generated by specific ITAM phosphorylations Nat Immunol 1 2000 322 328
59. U. Blank, C. Ra, L. Miller, K. White, H. Metzger, and J.P. Kinet Complete structure and expression in transfected cells of high affinity IgE receptor Nature 337 1989 187 189
60. C. Ra, M.H. Jouvin, and J.P. Kinet Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells J Biol Chem 264 1989 15323 15327
61. S. Krishnan, V.G. Warke, M.P. Nambiar, G.C. Tsokos, and D.L. Farber The FcRgamma subunit and Syk kinase replace the CD3zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells J Immunol 170 2003 4189 4195
62. E.J. Enyedy, M.P. Nambiar, S.N. Liossis, G. Dennis, G.M. Kammer, and G.C. Tsokos Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus Arthritis Rheum 44 2001 1114 1121
63. D.M. Engelman Electrostatic fasteners hold the T cell receptor-CD3 complex together Mol Cell 11 2003 5 6
64. G.T. Williams, A.R. Venkitaraman, D.J. Gilmore, and M.S. Neuberger The sequence of the μ transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface J Exp Med 171 1990 947 952
65. G.T. Williams, P. Dariavach, A.R. Venkitaraman, D.J. Gilmore, and M.S. Neuberger Membrane immunoglobulin without sheath or anchor Mol Immunol 30 1993 1427 1432
66. J.H. Blum, T.L. Stevens, and A.L. DeFranco Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction J Biol Chem 268 1993 27236 27245
67. J.P. Kinet, G. Alcaraz, A. Leonard, S. Wank, and H. Metzger Dissociation of the receptor for immunoglobulin E in mild detergents Biochemistry 24 1985 4117 4124
68. S. Ono, H. Ohno, and T. Saito Rapid turnover of the CD3 zeta chain independent of the TCR-CD3 complex in normal T cells Immunity 2 1995 639 644
69. A. Sigalov, D. Aivazian, and L. Stern Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif Biochemistry 43 2004 2049 2061
70. W. Weissenhorn, M.J. Eck, S.C. Harrison, and D.C. Wiley Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro Eur J Biochem 238 1996 440 445
71. 1H-NMR analysis of CD3-epsilon reveals the presence of turn-helix structures around the ITAM motif in an otherwise random coil cytoplasmic tail Biopolymers 42 1997 75 88
72. I. Laczko, M. Hollosi, E. Vass, Z. Hegedus, E. Monostori, and G.K. Toth Conformational effect of phosphorylation on T cell receptor/CD3 zeta-chain sequences Biochem Biophys Res Commun 242 1998 474 479
73. L.M. Iakoucheva, C.J. Brown, J.D. Lawson, Z. Obradovic, and A.K. Dunker Intrinsic disorder in cell-signaling and cancer-associated proteins J Mol Biol 323 2002 573 584
74. V.N. Uversky, J.R. Gillespie, and A.L. Fink Why are "natively unfolded" proteins unstructured under physiologic conditions? Proteins 41 2000 415 427
75. A.K. Dunker, C.J. Brown, J.D. Lawson, L.M. Iakoucheva, and Z. Obradovic Intrinsic disorder and protein function Biochemistry 41 2002 6573 6582
76. A.K. Dunker, C.J. Brown, and Z. Obradovic Identification and functions of usefully disordered proteins Adv Protein Chem 62 2002 25 49
77. P. Tompa Intrinsically unstructured proteins Trends Biochem Sci 27 2002 527 533
78. A.B. Sigalov Multichain immune recognition receptor signaling: different players, same game? Trends Immunol 25 2004 582 588
79. J.D. Klemm, S.L. Schreiber, and G.R. Crabtree Dimerization as a regulatory mechanism in signal transduction Annu Rev Immunol 16 1998 569 592
80. B. Johansson, E. Palmer, and L. Bolliger The extracellular domain of the zeta-chain is essential for TCR function J Immunol 162 1999 878 885
81. T. Rutledge, P. Cosson, N. Manolios, J.S. Bonifacino, and R.D. Klausner Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell antigen receptor EMBO J 11 1992 3245 3554
82. A. Kupfer, and S.J. Singer Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples Annu Rev Immunol 7 1989 309 337
83. A. Grakoui, S.K. Bromley, C. Sumen, M.M. Davis, A.S. Shaw, and P.M. Allen The immunological synapse: a molecular machine controlling T cell activation Science 285 1999 221 227
84. J.B. Huppa, and M.M. Davis T-cell-antigen recognition and the immunological synapse Nat Rev Immunol 3 2003 973 983
85. J.B. Huppa, M. Gleimer, C. Sumen, and M.M. Davis Continuous T cell receptor signaling required for synapse maintenance and full effector potential Nat Immunol 4 2003 749 755
86. N.R. Gascoigne, and T. Zal Molecular interactions at the T cell-antigen-presenting cell interface Curr Opin Immunol 16 2004 114 119
87. T. Zal, M.A. Zal, and N.R. Gascoigne Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse Immunity 16 2002 521 534
88. T. Zal, and N.R. Gascoigne Photobleaching-corrected FRET efficiency imaging of live cells Biophys J 86 2004 3923 3939
89. S.A. Wetzel, T.W. McKeithan, and D.C. Parker Live-cell dynamics and the role of costimulation in immunological synapse formation J Immunol 169 2002 6092 6101
90. Y.R. Carrasco, S.J. Fleire, T. Cameron, M.L. Dustin, and F.D. Batista LFA-l/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation Immunity 20 2004 589 599
91. M.F. Krummel, M.D. Sjaastad, C. Wulfing, and M.M. Davis Differential clustering of CD4 and CD3zeta during T cell recognition Science 289 2000 1349 1352
92. C.R. Monks, B.A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer Three-dimensional segregation of supramolecular activation clusters in T cells Nature 395 1998 82 86
93. K.H. Lee, A.D. Holdorf, M.L. Dustin, A.C. Chan, P.M. Allen, and A.S. Shaw T cell receptor signaling precedes immunological synapse formation Science 295 2002 1539 1542
94. S.J. Lee, Y. Hori, J.T. Groves, M.L. Dustin, and A.K. Chakraborty Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation Trends Immunol 23 2002 492 499
95. F.D. Batista, D. Iber, and M.S. Neuberger B cells acquire antigen from target cells after synapse formation Nature 411 2001 489 494
96. M. Krogsgaard, J.B. Huppa, M.A. Purbhoo, and M.M. Davis Linking molecular and cellular events in T-cell activation and synapse formation Semin Immunol 15 2003 307 315
97. H. Kishimoto, R.T. Kubo, H. Yorifuji, T. Nakayama, Y. Asano, and T. Tada Physical dissociation of the TCR-CD3 complex accompanies receptor ligation J Exp Med 182 1995 1997 2006
98. H. Liu, M. Rhodes, D.L. Wiest, and D.A. Vignali On the dynamics of TCR:CD3 complex cell surface expression and downmodulation Immunity 13 2000 665 675
99. A. Kosugi, S. Saitoh, S. Noda, K. Yasuda, F. Hayashi, and M. Ogata Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation Int Immunol 11 1999 11395 11401
100. N.L. La Gruta, H. Liu, S. Dilioglou, M. Rhodes, D.L. Wiest, and D.A. Vignali Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation J Immunol 172 2004 3662 3669
101. B.J. Vilen, T. Nakamura, and J.C. Cambier Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization Immunity 10 1999 239 248
102. K. Asai, K. Fujimoto, M. Harazaki, T. Kusunoki, S. Korematsu, and C. Ide Distinct aggregation of beta- and gamma-chains of the highs-affinity IgE receptor on cross-linking J Histochem Cytochem 48 2000 1705 1716
103. T.W. McKeithan Kinetic proofreading in T-cell receptor signal transduction Proc Natl Acad Sci USA 92 1995 5042 5046
104. J.D. Rabinowitz, C. Beeson, D.S. Lyons, M.M. Davis, and H.M. McConnell Kinetic discrimination in T-cell activation Proc Natl Acad Sci USA 93 1996 1401 1405
105. J.D. Rabinowitz, C. Beeson, C. Wulfing, K. Tate, P.M. Allen, and M.M. Davis Altered T cell receptor ligands trigger a subset of early T cell signals Immunity 5 1996 125 135
106. G.J. Kersh, E.N. Kersh, D.H. Fremont, and P.M. Allen High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling Immunity 9 1998 817 826
107. C. Rosette, G. Werlen, M.A. Daniels, P.O. Holman, S.M. Alam, and P.J. Travers The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model Immunity 15 2001 59 70
108. S. Valitutti, S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia Serial triggering of many T-cell receptors by a few peptide-MHC complexes Nature 375 1995 148 151
109. Y. Itoh, B. Hemmer, R. Martin, and R.N. Germain Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events J Immunol 162 1999 2073 2080
110. P.D. Holler, A.R. Lim, B.K. Cho, L.A. Rund, and D.M. Kranz CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation J Exp Med 194 2001 1043 1052
111. Z. Borovsky, G. Mishan-Eisenberg, E. Yaniv, and J. Rachmilewitz Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates J Biol Chem 277 2002 21529 21536
112. J. Sousa, and J. Carneiro A mathematical analysis of TCR serial triggering and down-regulation Eur J Immunol 30 2000 3219 3227
113. P. Friedl, and M. Gunzer Interaction of T cells with APCs: the serial encounter model Trends Immunol 22 2001 187 191
114. J.M. Rojo, and CA. Janeway Jr. The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized J Immunol 140 1988 1081 1088
115. M. Krogsgaard, N. Prado, E.J. Adams, X.L. He, D.C. Chow, and D.B. Wilson Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation Mol Cell 12 2003 1367 1378
116. L. Kjer-Nielsen, M.A. Dunstone, L. Kostenko, L.K. Ely, T. Beddoe, and N.A. Mifsud Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3 Proc Natl Acad Sci USA 101 2004 7675 7680
117. R.N. Germain T-cell signaling: the importance of receptor clustering Curr Biol 7 1997 R640 R644
118. J. Buslepp, H. Wang, W.E. Biddison, E. Appella, and E.J. Collins A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection Immunity 19 2003 595 606
119. M.M. Davis, and Y. Chien Topology and affinity of T-cell receptor mediated recognition of peptide-MHC complexes Curr Opin Immunol 5 1993 45 49
120. Y.H. Ding, K.J. Smith, D.N. Garboczi, U. Utz, W.E. Biddison, and D.C. Wiley Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids Immunity 8 1998 403 411
121. J.H. Wang, and E.L. Reinherz Structural basis of T cell recognition of peptides bound to MHC molecules Mol Immunol 38 2002 1039 1049
122. I.A. Wilson Perspectives: protein structure. Class-conscious TCR? Science 286 1999 1867 1868
123. A. Fahmy, and G. Wagner TreeDock: a tool for protein docking based on minimizing van der Waals energies J Am Chem Soc. 124 2002 1241 1250
124. M.K. Teng, A. Smolyar, A.G. Tse, J.H. Liu, J. Liu, and R.E. Hussey Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes Curr Biol 8 1998 409 412
125. M.G. Rudolph, and I.A. Wilson The specificity of TCR/pMHC interaction Curr Opin Immunol 14 2002 52 65
126. A. Borroto, A. Mallabiabarrena, J.P. Albar, A.C. Martinez, and B. Alarcon Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex J Biol Chem 273 1998 12807 12816
127. J. Torres, J.A. Briggs, and I.T. Arkin Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta J Mol Biol 316 2002 375 384
128. J. Torres, J.A. Briggs, and I.T. Arkin Multiple site-specific infrared dichroism of CD3-zeta, a transmembrane helix bundle J Mol Biol 316 2002 365 374
129. U. D'Oro, I. Munitic, G. Chacko, T. Karpova, J. McNally, and J.D. Ashwell Regulation of constitutive TCR internalization by the zeta-chain J Immunol 169 2002 6269 6278
130. W.A. Jensen, C.M. Pleiman, P. Beaufils, A.M. Wegener, B. Malissen, and J.C. Cambier Qualitatively distinct signaling through T cell antigen receptor subunits Eur J Immunol 27 1997 707 716
131. L.A. Pitcher, and N.S. van Oers T-cell receptor signal transmission: who gives an ITAM? Trends Immunol 24 2003 554 560
132. M.M. Davis, J.J. Boniface, Z. Reich, D. Lyons, J. Hampl, and B. Arden Ligand recognition by alpha beta T cell receptors Annu Rev Immunol 16 1998 523 544
133. N.R. Gascoigne, T. Zal, and S.M. Alam T-cell receptor binding kinetics in T-cell development and activation Expert Rev Mol Med 2001 2001 1 17
134. R.N. Germain, and I. Stefanova The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation Annu Rev Immunol 17 1999 467 522
135. J. Sloan-Lancaster, and P.M. Allen Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology Annu Rev Immunol 14 1996 1 27
136. G. Werlen, B. Hausmann, D. Naeher, and E. Palmer Signaling life and death in the thymus: timing is everything Science 299 2003 1859 1863
137. J. Rachmilewitz, and A. Lanzavecchia A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding Trends Immunol 23 2002 592 595
138. C.M. Bonefeld, A.B. Rasmussen, J.P. Lauritsen, M. von Essen, N. Odum, and P.S. Andersen TCR comodulation of nonengaged TCR takes place by a protein kinase C and CD3 gamma di-leucine-based motif-dependent mechanism J Immunol 171 2003 3003 3009
139. F. Niedergang, A. Dautry-Varsat, and A. Alcover Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors J Immunol 159 1997 1703 1710
140. V. Legendre, A. Guimezanes, M. Buferne, M. Barad, A.M. Schmitt-Verhulst, and C. Boyer Antigen-induced TCR-CD3 down-modulation does not require CD3delta or CD3gamma cytoplasmic domains, necessary in response to anti-CD3 antibody Int Immunol 11 1999 1731 1738
141. F. Niedergang, E. San Jose, B. Rubin, B. Alarcon, A. Dautry-Varsat, and A. Alcover Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester Res Immunol 148 1997 231 245
142. B. Favier, N.J. Burroughs, L. Wedderburn, and S. Valitutti TCR dynamics on the surface of living T cells Int Immunol 13 2001 1525 1532
143. X.M. Wang, J.T. Djordjevic, V. Bender, and N. Manolios T cell antigen receptor (TCR) transmembrane peptides colocalize with TCR, not lipid rafts, in surface membranes Cell Immunol 215 2002 12 19
144. N. Manolios, S. Collier, J. Taylor, J. Pollard, L.C. Harrison, and V. Bender T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease Nat Med 3 1997 84 88
145. A.H. Enk, and J. Knop T cell receptor mimic peptides and their potential application in T-cell-mediated disease Int Arch Allergy Immunol 123 2000 275 281
146. K. Mahnke, Y. Qian, J. Knop, and A.H. Enk Dendritic cells, engineered to secrete a T-cell receptor mimic peptide, induce antigen-specific immunosuppression in vivo Nat Biotechnol 21 2003 903 908
147. X.M. Wang, J.T. Djordjevic, N. Kurosaka, S. Schibeci, L. Lee, and P. Williamson T-cell antigen receptor peptides inhibit signal transduction within the membrane bilayer Clin Immunol 105 2002 199 207
148. G.P. Gollner, G. Muller, R. Alt, J. Knop, and A.H. Enk Therapeutic application of T cell receptor mimic peptides or cDNA in the treatment of T cell-mediated skin diseases Gene Ther 7 2000 1000 1004
149. N.T. Huynh, R.A. Ffrench, R.A. Boadle, and N. Manolios Transmembrane T-cell receptor peptides inhibit B- and natural killer-cell function Immunology 108 2003 458 464
150. I. Bell, C. Ashman, J. Maughan, E. Hooker, F. Cook, and T.A. Reinhart Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation J Gen Virol 79 1998 2717 2727
151. T.M. Schaefer, I. Bell, B.A. Fallert, and T.A. Reinhart The T-cell receptor zeta chain contains two homologous domains with which simian immunodeficiency virus Nef interacts and mediates down-modulation J Virol 74 2000 3273 3283
152. T.M. Schaefer, I. Bell, M.E. Pfeifer, M. Ghosh, R.P. Trible, and C.L. Fuller The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs Virology 302 2002 106 122
153. J.A. Schrager, and J.W. Marsh HIV-1 Nef increases T cell activation in a stimulus-dependent manner Proc Natl Acad Sci USA 96 1999 8167 8172
154. A. Simmons, V. Aluvihare, and A. McMichael Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators Immunity 14 2001 763 777
155. J.T. Djordjevic, S.D. Schibeci, G.J. Stewart, and P. Williamson HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion ADDS Res Hum Retroviruses 20 2004 547 555
156. E. Krautkramer, S.I. Giese, J.E. Gasteier, W. Muranyi, and O.T. Fackler Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts J Virol 78 2004 4085 4097
157. X.N. Xu, B. Laffert, G.R. Screaton, M. Kraft, D. Wolf, and W. Kolanus Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain J Exp Med 189 1999 1489 1496
158. S. Arold, F. Hoh, S. Domergue, C. Birck, M.A. Delsuc, and M. Jullien Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein Protein Sci 9 2000 1137 1148
159. L.X. Liu, N. Heveker, O.T. Fackler, S. Arold, S. Le Gall, and K. Janvier Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions J Virol 74 2000 5310 5319
160. R. Geisberger, R. Crameri, and G. Achatz Models of signal transduction through the B-cell antigen receptor Immunology 110 2003 401 410
161. J.C. Cambier, C.M. Pleiman, and M.R. Clark Signal transduction by the B cell antigen receptor and its coreceptors Annu Rev Immunol 12 1994 457 486
162. F.D. Batista, and M.S. Neuberger Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate Immunity 8 1998 751 759
163. S. Casola, K.L. Otipoby, M. Alimzhanov, S. Humme, N. Uyttersprot, and J.L. Kutok B cell receptor signal strength determines B cell fate Nat Immunol 5 2004 317 327
164. R.J. Benschop, and J.C. Cambier B cell development: signal transduction by antigen receptors and their surrogates Curr Opin Immunol 11 1999 143 151
165. B.J. Vilen, K.M. Burke, M. Sleater, and J.C. Cambier Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells J Immunol 168 2002 4344 4351
166. G. Bannish, E.M. Fuentes-Panana, J.C. Cambier, W.S. Pear, and J.G. Monroe Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis J Exp Med 194 2001 1583 1596
167. B.J. Sutton, and H.J. Gould The human IgE network Nature 366 1993 421 428
168. H.J. Gould, B.J. Sutton, A.J. Beavil, R.L. Beavil, N. McCloskey, and H.A. Coker The biology of IGE and the basis of allergic disease Annu Rev Immunol 21 2003 579 628
169. I. Pecht, E. Ortega, and T.M. Jovin Rotational dynamics of the Fc epsilon receptor on mast cells monitored by specific monoclonal antibodies and IgE Biochemistry 30 1991 3450 3458
170. R. Schweitzer-Stenner, E. Ortega, and I. Pecht Kinetics of Fc epsilon RI dimer formation by specific monoclonal antibodies on mast cells Biochemistry 33 1994 8813 8825
171. A.M. Scharenberg, S. Lin, B. Cuenod, H. Yamamura, and J.P. Kinet Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering EMBO J 14 1995 3385 3394
172. M. Adamczewski, R. Paolini, and J.P. Kinet Evidence for two distinct phosphorylation pathways activated by high affinity immunoglobulin E receptors J Biol Chem 267 1992 18126 18132
173. E. Eiseman, and J.B. Bolen Signal transduction by the cytoplasmic domains of Fc epsilon RI-gamma and TCR-zeta in rat basophilic leukemia cells J Biol Chem 267 1992 21027 21032
174. M.H. Jouvin, M. Adamczewski, R. Numerof, O. Letourneur, A. Valle, and J.P. Kinet Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor J Biol Chem 269 1994 5918 5925
175. B.S. Wilson, N. Kapp, R.J. Lee, J.R. Pfeiffer, A.M. Martinez, and Y. Platt Distinct functions of the Fc epsilon R1 gamma and beta subunits in the control of Fc epsilon Rl-mediated tyrosine kinase activation and signaling responses in RBL-2H3 mast cells J Biol Chem 270 1995 4013 4022
176. L. Shiue, J. Green, O.M. Green, J.L. Karas, J.P. Morgenstern, and M.K. Ram Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI Mol Cell Biol 15 1995 272 281
177. S. Lin, C. Cicala, A.M. Scharenberg, and J.P. Kinet The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon) RIgamma-mediated cell activation signals Cell 85 1996 985 995
178. D. Dombrowicz, S. Lin, V. Flamand, A.T. Brini, B.H. Roller, and J.P. Kinet Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses Immunity 8 1998 517 529
179. B. Goldstein, J.R. Faeder, W.S. Hlavacek, M.L. Blinov, A. Redondo, and C. Wofsy Modeling the early signaling events mediated by FcepsilonRI Mol Immunol 38 2002 1213 1219
180. J.R. Faeder, W.S. Hlavacek, I. Reischl, M.L. Blinov, H. Metzger, and A. Redondo Investigation of early events in Fc epsilon Rl-mediated signaling using a detailed mathematical model J Immunol 170 2003 3769 3781
181. W.S. Hlavacek, J.R. Faeder, M.L. Blinov, A.S. Perelson, and B. Goldstein The complexity of complexes in signal transduction Biotechnol Bioeng 84 2003 783 794
182. H. Metzger, S. Eglite, H. Haleem-Smith, I. Reischl, and C. Torigoe Quantitative aspects of signal transduction by the receptor with high affinity for IgE Mol Immunol 38 2002 1207 1211
183. M.J. Nadler, S.A. Matthews, H. Turner, and J.P. Kinet Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function Adv Immunol 76 2000 325 355
184. G. Jiang, and T. Hunter Receptor signaling: when dimerization is not enough Curr Biol 9 1999 R568 R571
185. O. Livnah, D.L. Johnson, E.A. Stura, F.X. Farrell, F.P. Barbone, and Y. You An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation Nat Struct Biol 5 1998 993 1004
186. R.S. Syed, S.W. Reid, C. Li, J.C. Cheetham, K.H. Aoki, and B. Liu Efficiency of signalling through cytokine receptors depends critically on receptor orientation Nature 395 1998 511 516
187. J.S. Greiser, C. Stross, P.C. Heinrich, I. Behrmann, and H.M. Hermanns Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling J Biol Chem 277 2002 26959 26965
188. E. Ortega How do multichain immune recognition receptors signal? A structural hypothesis Mol Immunol 32 1995 941 945
189. Y. Chen, C. Birck, J.P. Samama, and F.M. Hulett Residue R113 is essential for PhoP dimerization and function: a residue buried in the asymmetric PhoP dimer interface determined in the PhoPN three-dimensional crystal structure J Bacteriol 185 2003 262 273
190. Y.I. Kim, S. Park, D.I. Jeoung, and H. Lee Point mutations affecting the oligomeric structure of Nm23-H1 abrogates its inhibitory activity on
191. D.J. Moore, L. Zhang, T.M. Dawson, and V.L. Dawson A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization J Neurochem 87 2003 1558 1567
192. P. Hernanz-Falcon, J.M. Rodriguez-Frade, A. Serrano, D. Juan, A. del Sol, and S.F. Soriano Identification of amino acid residues crucial for chemokine receptor dimerization Nat Immunol 5 2004 216 223
193. W.S. Alexander, D. Metcalf, and A.R. Dunn Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity EMBO J 14 1995 5569 5578
194. T. Zal, and N.R. Gascoigne Using live FRET imaging to reveal early protein-protein interactions during T cell activation Curr Opin Immunol 16 2004 418 427
195. H. Abken, A. Hombach, and C. Heuser Immune response manipulation: recombinant immunoreceptors endow T-cells with predefined specificity Curr Pharm Des 9 2003 1992 2001
196. A. Hombach, C. Heuser, and H. Abken The recombinant T cell receptor strategy: insights into structure and function of recombinant immunoreceptors on the way towards an optimal receptor design for cellular immunotherapy Curr Gene Ther 2 2002 211 226