Fcε receptor type I γ chain replaces the deficient T cell receptor ζ chain in T cells of patients with systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 44, Issue 5, 2001, Pages 1114-1121

  Enyedy, Edith J ^a,b   Nambiar, Madhusoodana P ^a,b   Liossis, Stamatis Nick C ^a,b   Dennis, Gregory ^c   Kammer, Gary M ^d   Tsokos, George C ^a,b,e  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c WALTER REED ARMY MEDICAL CENTER   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e Waller Reed Army Institute of Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FC RECEPTOR; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; ANTIBODY; CD3 ANTIGEN, ZETA CHAIN; ENZYME PRECURSOR; IMMUNOGLOBULIN E RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; PROTEIN KINASE SYK; SIGNAL PEPTIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DENSITOMETRY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; WESTERN BLOTTING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; ENZYMOLOGY; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; ENZYME PRECURSORS; FEMALE; GENE EXPRESSION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IGE; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0034744286     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200105)44:5<1114::AID-ANR192>3.0.CO;2-B     Document Type: Article

References (36)

1. Tsokos GC, Liossis SN. Immune cell signaling defects in lupus: activation, anergy and death. Immunol Today 1999;20:119-24.
2. Tsokos GC. Overview of cellular immune function in systemic lupus erythematosus. In: Lahita RG, editor. Systemic lupus erythematosus. San Diego: Academic Press; 1999. p. 17-54.
3. Khan IU, Laxminarayana D, Kammer GM. A genetic mechanism underlying deficient type I protein kinase A activity in systemic lupus erythematosus T lymphocytes. In: Kammer GM, Tsokos GC, editors. Lupus: molecular and cellular pathogenesis. Totowa (NJ): Humana Press; 1999. p. 231-56.
4. Scott JM, Richardson BC. Impaired DNA methylation in lupus T cells. In: Kammer GM, Tsokos GC, editors. Lupus: molecular and cellular pathogenesis. Totowa (NJ): Humana Press; 1999. p. 278-98.
5. Vassilipoulos D, Kovacs B, Tsokos GC. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J Immunol 1995;155:2269-81.
6. Liossis SN, Hoffman RW, Tsokos GC. Abnormal early TCR/CD3-mediated signaling events of a snRNP-autoreactive lupus T cell clone. Clin Immunol Immunopathol 1998;88:305-10.
7. Liossis S-NC, Ding XZ, Dennis GJ, Tsokos GC. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus: deficient expression of the T cell receptor zeta chain. J Clin Invest 1998;101: 1448-57.
8. Maurice MM, Lankester AC, Bezemer AC, Geertsma MF, Tak PP, Breedveld FC, et al. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. J Immunol 1997;159: 2973-8.
9. Geertsma MF, Wengen-Stevenhagen A, van Dam EM, Risberg K, Kroon FP, Groeneveld PH, et al. Decreased expression of ζ molecules by T lymphocytes is correlated with disease progression in human immunodeficiency virus-infected persons. J Infect Dis 1999;180:649-58.
10. Whiteside TL. Signaling defects in T lymphocytes of patients with malignancy. Cancer Immunol Immunother 1999;48:346-52.
11. Capron M, Soussi GA, Morita M, Truong MJ, Prin L, Kinet JP, et al. Eosinophils: from low-to high-affinity immunoglobulin E receptors. Allergy 1995;50 Suppl 25:20-3.
12. Pan XQ, Darby C, Indik ZK, Schreiber AD. Activation of three classes of nonreceptor tyrosine kinases following Fc γ receptor crosslinking in human monocytes. Clin Immunol 1999;90:55-64.
13. Shine L, Green J, Green OM, Karas JL, Morgenstern JP, Ram MK, et al. Interaction of p72syk with the γ and β subunits of the high-affinity receptor for immunoglobulin E, Fc ε RI. Mol Cell Biol 1995;15:272-81.
14. Shiue L, Zoller MJ, Brugge JS. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J Biol Chem 1995;270:10498-502.
15. Oliver JM, Burg D, Wilson BS, McLaughlin JL, Geahlen RL. Inhibition of mast cell FcεRI-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem 1994;269:29697-703.
16. Taylor N, Jahn T, Smith S, Lamkin T, Uribe L, Liu Y, et al. Differential activation of the tyrosine kinases ZAP-70 and Syk after FcγRI stimulation. Blood 1997;89:388-96.
17. Koyasu S, d'Adamio L, Arulanandam AR, Abraham S, Clayton LK, Reinherz EL. T cell receptor complexes containing Fc epsilon RI γ homodimers in lieu of CD3 ζ and CD3 η components: a novel isoform expressed on large granular lymphocytes. J Exp Med 1992;175:203-9.
18. Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW, Ochoa AC. Alterations in signal transduclion molecules in T lymphocytes from tumor-bearing mice. Science 1992;258:1795-8.
19. Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, et al. TCR-γ δ cells in CD3 ζ-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen. J Immunol 1996;157:2320-7.
20. Shores E, Flamand V, Tran T, Grinberg A, Kinet J-P, Love PE. FcεR1γ can support T cell development and function in mice lacking endogenous TCR ζ-chain. J Immunol 1997;159:222-30.
21. Qian D, Sperling AI, Lancki DW, Tatsumi Y, Barrett TA, Bluestone JA, et al. The γ chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in γ δ T lymphocytes. Proc Natl Acad Sci U S A 1993;90:11875-9.
22. Howard FD, Rodewald HR, Kinet JP, Reinherz EL. CD3 ζ subunit can substitute for the γ subunit of Fc ε receptor type I in assembly and functional expression of the high-affinity IgE receptor: evidence for interreceptor complementation. Proc Natl Acad Sci U S A 1990;87:7015-9.
23. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
24. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH, and the Committee on Prognosis Studies in SLE. Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum 1992;35:630-40.
25. Letourneur O, Kennedy IC, Brini AT, Ortaldo JR, O'Shea JJ, Kinet JP. Characterization of the family of dimers associated with Fc receptors (Fc ε RI and Fc γ RIII). J Immunol 1991;147:2652-6.
26. Kuester H, Thompson H, Kinet JP. Characterization and expression of the gene for the human receptor γ subunit: definition of a new gene family. J Biol Chem 1990;265:6448-52.
27. Takeuchi T, Tsuzaka K, Pang M, Amano K, Koide J, Abe T. TCR ζ chain lacking exon 7 in two patients with systemic lupus erythematosus. Int Immunol 1998;10:911-21.
28. Brundula V, Rivas LJ, Blasini AM, Paris M, Salazar S, Stekman IL, et al. Diminished levels of T cell receptor ζ chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 1999;42:1908-16.
29. Orloff DG, Ra CS, Frank SJ, Klausner RD, Kinet JP. Family of disulphide-linked dimers containing the ζ and η chains of the T-cell receptor and the γ chain of Fc receptors. Nature 1990;347: 189-91.
30. Paolini R, Renard V, Vivier E, Ochiai K, Jouvin M-H, Malissen B, et al. Different roles for the Fcε RI 7 chain as a function of the receptor context. J Exp Med 1995;181:247-55.
31. Chen T, Repetto B, Chizzonite R, Pullar C, Burghardt C, Dharm E, et al. Interaction of phosphorylated FcεRIγ immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk: assessment of binding parameters and real time binding kinetics. J Biol Chem 1996;271:25308-15.
32. Shores EW, Ono M, Kawabe T, Sommers CL, Tran T, Lui K, et al. T cell development in mice lacking all T cell receptor ζ family members (ζ, η. and FcεRIγ). J Exp Med 1998;187:1093-101.
33. Brini AT, Lee GM, Kinet JP. Involvement of Alu sequences in the cell-specific regulation of transcription of the γ chain of Fc and T cell receptors. J Biol Chem 1993;268:1355-61.
34. Kersh EN, Kersh GJ, Allen PM. Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation. J Exp Med 1999;190:1627-36.
35. Kimura T, Sakamoto H, Appella E, Siraganian RP. Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. Mol Cell Biol 1996;16:1471-8.
36. Turner I, Schweighoffer I, Colucci I, di Santo JP, Tybulewicz VL. Tyrosine kinase SYK: essential functions for immunoreceptor signalling. Immunol Today 2000;21:148-54.