HIV type 1 Nef increases the association of T Cell Receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion

AIDS Research and Human Retroviruses

Volumn 20, Issue 5, 2004, Pages 547-555

  Djordjevic, Julianne T ^a   Schibeci, Stephen D ^a   Stewart, Graeme J ^a,b   Williamson, Peter ^a,b  

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; HYBRID PROTEIN; NEF PROTEIN; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOSOL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MYRISTYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; WILD TYPE;

EID: 2642557101     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922204323087804     Document Type: Article

References (50)

1. Mohri H et al.: Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. J Exp Med 2001;194:1277-1287.
2. Kovacs JA et al.: Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. J Exp Med 2001;194:1731-1741.
3. Grossman Z et al.: CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause? Nat Med 2002;8:319-323.
4. Emerman M and Malim MH: HIV-1 regulatory/accessory genes: Keys to unraveling viral and host cell biology. Science 1998;280:1880-1884.
5. Peter F: HIV nef: The mother of all evil? Immunity 1998;9:433-437.
6. Arold ST and Baur AS: Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein. Trends Biochem Sci 2001;26:356-363.
7. Hanna Z et al.: Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 1998;95:163-175.
8. Schibeci SD et al.: HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line. AIDS 2000;14:1701-1707.
9. Wang JK et al.: The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci USA 2000;97:394-399.
10. Schrager JA and Marsh JW: HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc Natl Acad Sci USA 1999;96:8167-8172.
11. Monks CR et al.: Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;395:82-86.
12. Dustin ML and Cooper JA: The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling. Nat Immunol 2000;1:23-29.
13. Samelson LE: Signal transduction mediated by the T cell antigen receptor: The role of adapter proteins. Annu Rev Immunol 2002;20:371-394.
14. Howe AY et al.: Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2. J Virol 1998;72:9827-9834.
15. Xu XN et al.: Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain. J Exp Med 1999;189:1489-1496.
16. Schaefer TM et al.: The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs. Virology 2002;302:106-122.
17. Dutartre H et al.: The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism. Virology 1998;247:200-211.
18. Kovacs B et al.: Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. Proc Natl Acad Sci USA 2002;99:15006-15011.
19. Drevot P et al.: TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. Embo J 2002;21:1899-1908.
20. Brown DA and London E: Structure and function of sphingolipid-and cholesterol-rich membrane rafts. J Biol Chem 2000;275:17221-17224.
21. Xavier R and Seed B: Membrane compartmentation and the response to antigen. Curr Opin Immunol 1999;11:265-269.
22. Montixi C, et al.: Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. Embo J 1998;17:5334-5348.
23. Valensin S, et al.: F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts. Eur J Immunol 2002;32:435-446.
24. Janes PW et al.: Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 1999;147:447-461.
25. Wulfing C and Davis MM: A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 1998;282:2266-2269.
26. Penninger JM and Crabtree GR: The actin cytoskeleton and lymphocyte activation. Cell 1999;96:9-12.
27. Burack WR, et al.: Cutting edge: Quantitative imaging of raft accumulation in the immunological synapse. J Immunol 2002;169:2837-2841.
28. Villalba M et al.: Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J Cell Biol 2001;155:331-338.
29. Fackler OT et al.: Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell 1999;3:729-739.
30. Manninen A et al.: SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. Virology 1998;250:273-282.
31. Goldsmith MA et al.: Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J Virol 1995;69:4112-4121.
32. Pandori MW et al.: Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J Virol 1996;70:4283-4290.
33. Peng B and Robert-Guroff M: Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation. Immunol Lett 2001;78:195-200.
34. Aiken C et al.: Mutational analysis of HIV-1 Nef: Identification of two mutants that are temperature-sensitive for CD4 downregulation. Virology 1996;217:293-300.
35. Macreadie IG et al.: Expression of HIV-1 nef in yeast causes membrane perturbation and release of the myristylated Nef protein. J Biomed Sci 1998;5:203-210.
36. Macreadie IG et al.: Cytotoxicity resulting from addition of HIV-1 Nef N-terminal peptides to yeast and bacterial cells. Biochem Biophys Res Commun 1997;232:707-711.
37. Wang JK et al.: The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci USA 2000;97:394-399.
38. Grossman Z and Paul WE: Self-tolerance: Context dependent tuning of T cell antigen recognition. Semin Immunol 2000;12:197-203; discussion 257-344.
39. Holdorf AD et al.: Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat Immunol 2002;3:259-264.
40. Viola A et al.: T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 1999;283:680-682.
41. Curtain CC et al.: Fusogenic activity of amino-terminal region of HIV type 1 Nef protein. AIDS Res Hum Retroviruses 1994;10:1231-1240.
42. Fackler OT et al.: Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization. Eur J Biochem 1997;247:843-851.
43. Lu X et al.: CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr Biol 1996;6:1677-1684.
44. Manes S et al.: Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection. EMBO Rep 2000;1:190-196.
45. Liao Z et al.: Lipid rafts and HIV pathogenesis: Host membrane cholesterol is required for infection by HIV type 1. AIDS Res Hum Retroviruses 2001;17:1009-1019.
46. Liao Z et al.: Lipid rafts and HIV pathogenesis: Viron-associated cholesterol is required for fusion and infection of susceptible cells AIDS Res Hum Retroviruses 2003;19:675-687.
47. Mandic R et al.: Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity. Mol Biol Cell 2001;12:463-473.
48. Lindwasser OW and Resh MD: Myristoylation as a target for inhibiting HIV assembly: Unsaturated fatty acids block viral budding. Proc Natl Acad Sci USA 2002;99:13037-13042.
49. Zheng YH et al.: Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc Natl Acad Sci USA 2003;100:8460-8465.
50. Popik W and Alce TM: CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4. J Biol Chem 2003;279:704-712.