Location is everything: Lipid rafts and immune cell signaling

Annual Review of Immunology

Volumn 21, Issue , 2003, Pages 457-481

  Dykstra, Michelle ^a   Cherukuri, Anu ^a   Sohn, Hae Won ^a   Tzeng, Shiang Jong ^a   Pierce, Susan K ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Antigen receptors; B cells; Coreceptors; Mast cells; T cells

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; CD2 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD48 ANTIGEN; CELL RECEPTOR; CHOLESTEROL; COMPLEMENT COMPONENT C3D RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; FC RECEPTOR; FC RECEPTOR 2 B 1; GLUCOCORTICOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN E RECEPTOR; LIGAND; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NATURAL KILLER CELL RECEPTOR; POLYUNSATURATED FATTY ACID; PROTEIN TYROSINE KINASE; SPHINGOLIPID; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR;

ANTIGEN RECOGNITION; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MATURATION; CELL MEMBRANE; CELLULAR IMMUNITY; CROSS LINKING; DRUG TARGETING; EVALUATION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; MICROENVIRONMENT; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; B LYMPHOCYTE; BIOLOGICAL MODEL; CHEMISTRY; IMMUNOLOGY; INFECTION; METABOLISM; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; HUMANS; INFECTION; MEMBRANE MICRODOMAINS; MODELS, IMMUNOLOGICAL; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0042470559     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.21.120601.141021     Document Type: Review

References (149)

1. Simons K, Toomre D. 2000. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1:31-41
2. Cherukuri A, Dykstra ML, Pierce SK. 2001. Floating the raft hypothesis: lipid rafts play a role in immune cell activation. Immunity 14:657-60
3. Langlet C, Bernard A-M, Drevot P, He H-T. 2000. Membrane rafts and signaling by the multichain immune recognition receptors. Curr. Opin. Immunol. 12:250-55
4. Brown DA, London E. 2000. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 275:17221-24
5. Simons K, Ikonen E. 2000. How cells handle cholesterol. Science 290:1721-26
6. Mukherjee S, Maxfield FR. 2000. Role of membrane organization and membrane domains in endocytic lipid trafficking. Traffic 1:203-11
7. van der Goot FG, Harder T. 2001. Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack. Semin. Immunol. 13:89-97
8. Horejsi V, Drbal K, Cebecauer J, Cerny J, Brdicka T, et al. 1999. GPI-micro-domains: a role in signalling via immuno-receptors. Immunol. Today 20:356-61
9. Brown DA, London E. 1998. Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol. 14:111-36
10. Melkonian KA, Ostermeyer AG, Chen JZ, Roth MG, Brown DA. 1999. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. J. Biol. Chem. 274:3910-17
11. Rodgers W, Crise B, Rose JK. 1994. Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction. Mol. Cell. Biol. 14:5384-91
12. fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins. Mol. Cell. Biol. 13:6385-92
13. Koegl M, Zlatkine P, Ley SC, Courtneidge SA, Magee AI. 1994. Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem. J. 303:749-53
14. Prior IA, Harding A, Yan J, Sluimer J, Parton RG, Hancock JF. 2001. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell Biol. 3:368-75
15. Webb Y, Hermida-Matsumoto L, Resh MD. 2000. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and poly-unsaturated fatty acids. J. Biol. Chem. 275:261-70
16. Liang X, Nazarian A, Erdjument-Bromage H, Bornmann W, Tempst P, Resh MD. 2001. Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction. J. Biol. Chem. 276:30987-94
17. Zhang W, Trible RP, Samelson LE. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9:239-46
18. Parolini I, Topa S, Sorice M, Pace A, Ceddia P, et al. 1999. Phorbol ester-induced disruption of the CD4-Lck complex occurs within a detergent-resistant microdomain of the plasma membrane. J. Biol. Chem. 274:14176-87
19. Arcaro A, Gregoire C, Boucheron N, Stotz S, Palmer E, et al. 2000. Essential role of CD8 palmitoylation in CD8 coreceptor function. J. Immunol. 165:2068-76
20. Dykstra ML, Longnecker R, Pierce SK. 2001. Epstein-Barr virus co-opts lipid rafts to block the signaling and antigen transport functions of the BCR. Immunity 14:57-67
21. Field KA, Holowka D, Baird B. 1999. Structural aspects of the association of FcεRI with detergent-resistant membranes. J. Biol. Chem. 274:1753-58
22. Scheiffele P, Roth MG, Simons K. 1997. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J. 16:5501-8
23. Hooper NM. 1999. Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae. Mol. Membr. Biol. 16:145-56
24. Janes PW, Ley SC, Magee AI, Kabouridis PS. 2000. The role of lipid rafts in T cell antigen receptor (TCR) signaling. Semin. Immunol. 12:23-34
25. Friedrichson T, Kurzchalla TV. 1998. Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature 394:802-5
26. Varma R, Mayor S. 1998. GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394:798-801
27. Pralle A, Keller P, Florin E-L, Simons K, Horber JKH. 2000. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J. Cell Biol. 148:997-1007
28. Schutz GJ, Kada G, Pastushenko VP, Schindler H. 2000. Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy. EMBO J. 19:892-901
29. Zacharias DA, Violin JIB, Newton AC, Tsien RY. 2002. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296:913-16
30. Gidwam A, Holowka D, Baird B. 2001. Fluorescence anisotropy measurements of lipid order in plasma membranes and lipid rafts from RBL-2H3 mast cells. Biochemistry 40:12422-29
31. Levis GM, Evangelatos GP. 1976. Lipid composition of lymphocyte plasma membrane from pig mesenteric lymph node. Biochem. J. 156:103-10
32. Harder T, Scheiffele P, Verkade P, Simons K. 1998. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141:929-42
33. Janes PW, Ley SC, Magee AI. 1999. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147:447-61
34. lck associated with glycolipid-enriched membrane domains. J. Cell Biol. 135:1515-23
35. Xavier R, Brennan T, Li Q, McCormack C, Seed B. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity 8:723-32
36. Montixi C, Langlet C, Bernard A-M, Thimonier J, Dubois C, et al. 1998. Engagement oft cell receptor triggers its recruitment of low-density detergent-insoluble membrane domains. EMBO J. 17:5334-48
37. Sheets ED, Holowka D, Baird B. 1999. Membrane organization in immunoglobulin E receptor signaling. Curr. Opin. Chem. Biol. 3:95-99
38. Viola A. 2001. The amplification of TCR signaling by dynamic membrane microdomains. Trends Immunol. 22:322-27
39. Miceli MC, Moran M, Chung CD, Patel VP, Low T, Zinnanti W. 2001. Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes. Semin. Immunol. 13:115-28
40. Bromley SK, Burack WR, Johnson KG, Sims TN, Sumen C, et al. 2001. The immunological synapse. Annu. Rev. Immunol. 19:375-96
41. Batista FD, Iber D, Neuberger MS. 2001. B cells acquire antigen from target cells after synapse formation. Nature 411:489-94
42. Delon J, Germain RN. 2000. Information transfer at the immunological synapse. Curr. Biol. 10:R923-33
43. Dustin ML. 2002. Membrane domains and the immunological synapse: keeping T cells resting and ready. J. Clin. Invest. 109:155-60
44. Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, et al. 2000. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation. J. Exp. Med. 191:1591-1604
45. Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, et al. 2000. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 404:999-1003
46. Boerth NJ, Sadler JJ, Bauer DE, Clements JL, Gheith SM, Koretzky GA. 2000. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling. J. Exp. Med. 192:1047-58
47. Bi K, Yoshihiko T, Coudronniere N, Sugie K, Hong S, et al. 2001. Antigen-induced translocation of PKC- to membrane rafts is required for T cell activation. Nat. Immunol. 2:556-63
48. Moran M, Miceli MC. 1998. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation. Immunity 9:787-96
49. von Haller PD, Donohoe S, Goodlett DR, Aebersold R, Watts D. 2001. Mass spectrometric characterization of proteins extracted from Jurkat T cell detergentresistant membrane domains. Proteomics 1:1010-21
50. Gomez-Mouton C, Abad JL, Mira E, Lacalle RA, Gallardo E, et al. 2001. Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc. Natl. Acad. Sci. USA 98:9642-47
51. Schade AE, Levine AD. 2002. Lipid raft heterogeneity in human peripheral blood T lymphoblasts: a mechanism for regulating the initiation of TCR signal transduction. J. Immunol. 168:2233-39
52. Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. 2002. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat. Immunol. 3:48388
53. Delgado P, Fernandez E, Dave V, Kappes D, Alarcon B. 2000. CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature 406:426-30
54. Kabouridis PS, Janzen J, Magee AL, Ley SC. 2000. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur. J. Immunol. 30:954-63
55. Stoffel B, Bauer P, Nix M, Deres K, Stoffel W. 1998. Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingo-myelinase-deficient mice. Eur. J. Immunol. 28:874-80
56. Kabouridis PS, Magee AI, Ley SC. 1997. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:4983-98
57. Lin J, Weiss A, Finco TS. 1999. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J. Biol. Chem. 274:28861-64
58. Kosugi A, Sakakura J, Yasuda K, Ogata M, Hamaoka T. 2001. Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 14:669-80
59. Ilangumaran S, Ami S, van Echten-Deckert G, Borisch B, Hoessli DC. 1999. Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes. Mol. Biol. Cell 10:891-905
60. Kosugi A, Saitoh S, Noda S, Yasuda K, Hayashi F, et al. 1999. Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation. Int. Immunol. 11:1395-1401
61. Sedwick CE, Altman A. 2002. Ordered just so: lipid rafts and lymphocyte function. Sci. STKE 2002:RE2
62. Valensin S, Paccani SR, Ulivieri C, Mercati D, Pacini S, et al. 2002. F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts. Eur. J. Immunol. 32:435-46
63. Drevot P, Langlet C, Guo X-J, Bernard A-M, Colard O, et al. 2002. TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J. 21:1899-1908
64. Kinet JP. 1999. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu. Rev. Immunol. 17:931-72
65. Holowka D, Sheets ED, Baird B. 2000. Interactions between FcεRI and lipid raft components are regulated by the actin cytoskeleton. J. Cell Sci. 113:1009-19
66. Pyenta PS, Holowka D, Baird B. 2001. Cross-correlation analysis of inner-leaflet-anchored green fluorescent protein co-redistributed with IgE receptors and outer leaflet lipid raft components. Biophys. J. 80:2120-32
67. Stauffer TP, Meyer T. 1997. Compartmentalized IgE receptor-mediated signal transduction in living cells. J. Cell Biol. 139:1447-54
68. Arudchandran R, Brown MJ, Peirce MJ, Song JS, Zhang J, et al. The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J. Exp. Med. 191:47-60
69. lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc. Natl. Acad. Sci. USA 92:9201-5
70. Field KA, Holowka D, Baird B. 1997. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J. Biol. Chem. 272:4276-80
71. Wilson BS, Pfeiffer JR, Oliver JM. 2000. Observing FcεRI signaling from the inside of the mast cell membrane. J. Cell Biol. 149:1131-42
72. Sheets ED, Holowka D, Baird B. 1999. Critical role for cholesterol in Lynmediated tyrosine phosphorylation of FcεRI and their assication with detergent-resistant membranes. J. Cell Biol. 145:877-87
73. Lara M, Ortega E, Pecht I, Pfeiffer JR, Martinez AM, et al. 2001. Overcoming the signaling defect of lyn-sequestering, signal-curtailing FcεRI dimers: aggregated dimers can dissociate from lyn and form signaling complexes with syk. J. Immunol. 167:4329-37
74. Cheng PC, Dykstra ML, Mitchell RN, Pierce SK. 1999. A role for lipid rafts in BCR signaling and antigen targeting. J. Exp. Med. 190:1549-60
75. Petrie RJ, Schnetkamp PPM, Patel KD, Awasthi-Kalia M, Deans JP. 2000. Transient translocation of the B cell receptor and src homology 2 domain-containing inositol phosphatase to lipid rafts: Evidence toward a role in calcium regulation. J. Immunol. 165:1220-27
76. 2+ flux. Curr. Biol. 10:393-96
77. Cheng P, Brown BK, Song W, Pierce SK. 2001. Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J. Immunol. 166:3693-3701
78. Weintraub BC, Jun JE, Bishop AC, Shokat KM, Thomas ML, Goodnow CC. 2000. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells. J. Exp. Med. 191:1443-48
79. Awasthi-Kalia M, Schnetkamp PP, Deans JP. 2001. Differential effects of filipin and methyl-beta-cyclodextrin on B cell receptor signaling. Biochem. Biophys. Res. Commun. 287:77-82
80. Lanier LL. 1998. NK cell receptors. Annu. Rev. Immunol. 16:359-93
81. Lou BZ, Jevremovic D, Billadeau DD, Leibson PJ. 2000. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing. J. Exp. Med. 191:347-54
82. Fassett MS, Davis DM, Valter MM, Cohen GB, Strominger JL. 2001. Signaling at the inhibitory natural killer immune synapse regulates lipid raft polarization but not the class I MHC clustering. Proc. Natl. Acad. Sci. USA 98:14547-52
83. Huby RDJ, Dearman RJ, Kimber I. 1999. Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. J. Biol. Chem. 274:22591-96
84. Anderson HA, Hiltbold EM, Roche PA. 2000. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat. Immunol. 1:156-62
85. Kropshofer H, Spindelreher S, Rotm TA, Platania N, Grygar C, et al. 2002. Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Nat. Immunol. 3:61-68
86. Grewal IS, Flavell RA. 1998. CD40 and CD 154 in cell-mediated immunity. Ann u. Rev. Immunol. 16:111-35
87. Hostager BS, Catlett IM, Bishop GA. 2000. Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling. J. Biol. Chem. 275:15392-98
88. Malapati S, Pierce SK. 2001. The influence of CD40 on the association of the B cell antigen receptor with lipid rafts in mature and immature cells. Eur. J. Immunol. 31:3789-97
89. Pham LV, Tamayo AT, Yoshimura LC, Lo P, Terry N, et al. 2002. A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas. Immunity 16:37-50
90. Vidalain P-O, Azocar O, Servet-Delprat C, Rabourdin-Combe C, Gerlier D, Manie S. 2000. CD40 signaling in human dendritic cells is initiated within membrane rafts. EMBO J. 19:3304-13
91. Spiegel S, Cuvillier O, Edsall LC, Kohama T, Menzeleev R, et al. 1998. Sphingosine-1-phosphate in cell growth and cell death. Ann. NY Acad. Sci. 845:11-18
92. Grassme H, Jekle A, Riehle A, Schwarz H, Berger J, et al. 2001. CD95 signaling via ceramide-rich membrane rafts. J. Biol. Chem. 276:20589-96
93. Carreno BM, Collins M. 2002. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 20:29-53
94. Tuosto L, Parolini I, Schroder S, Sargiacomo M, Lanzavecchia A, Viola A. 2001. Organization of plasma membrane functional rafts upon T cell activation. Eur. J. Immunol. 31:345-49
95. Martin M, Schneider H, Azouz A, Rudd CE. 2001. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J. Exp. Med. 194:1675-81
96. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680-82
97. Rudd CE, Martin M, Schneider H. 2002. CTLA-4 negative signaling via lipid rafts: A new perspective. Sci. STKE 2002:PE18
98. Yang H, Reinherz EL. 2001. Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transduction. J. Biol. Chem. 276:18775-85
99. Yashiro-Ohtani Y, Zhou XY, Toyo-Oka K, Tai XG, Park CS, et al. 2000. Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts. J. Immunol. 164:1251-59
100. Fearon DT, Carroll MC. 2000. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu. Rev. Immunol. 18:393-422
101. Cherukuri A, Cheng PC, Sohn HW, Pierce SK. 2001. The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts. Immunity 14:169-79
102. Maecker HT, Todd SC, Levy S. 1997. The tetraspanin superfamily: molecular facilitators. FASEB J. 11:428-42
103. Claas C, Stipp CS, Hemler ME. 2001. Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts. J. Biol. Chem. 276:7974-84
104. Ravetch IV. 1997. Fc receptors. Curr. Opin. Immunol. 9:121-25
105. Aman MJ, Tosello-Trampont AC, Ravichandran K. 2001. Fc> RIIB1/SHIP-mediated inhibitory signaling in B cells involves lipid rafts. J. Biol. Chem. 279:46371-78
106. Ashman RF, Peckham D, Stunz LL. 1996. Fc receptor off-signal in the B cell involves apoptosis. J. Immunol. 157:5-11
107. Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ. 2000. Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. Immunity 13:243-53
108. Saint-Ruf C, Panigada M, Azogui O, Debey P, von Boehmer H, Grassi F. 2000. Different initiation of pre-TCR and gamma-delta TCR signalling. Nature 406:524-27
109. Sproul TW, Malapati S, Kim J, Pierce SK. 2000. B cell antigen receptor signaling occurs outside lipid rafts in immature B cells. J. Immunol. 165:6020-23
110. Chung JB, Baumeister MA, Monroe JG. 2001. Differential sequestration of plasma membrane-associated B cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains. J. Immunol. 166:736-40
111. Ebert PJR, Baker JF, Punt JA. 2000. Immature CD4+CD8+ thymocytes do not polarize lipid rafts in response to TCR-mediated signals. J. Immunol. 165:5435-42
112. Leitenberg D, Balamuth F, Bottomly K. 2001. Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation. Semin. Immunol. 13:129-38
113. Balamuth F, Leitenberg D, Unternaehrer J, Mellman I, Bottomly K. 2001. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 15:729-38
114. Harder T, Simons K. 1999. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. 29:556-62
115. Mitchell JS, Kanca O, McIntyre BW. 2002. Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes. J. Immunol. 168:2737-44
116. Khan AA, Bose C, Yam LS, Soloski MJ, Rupp F, 2001. Physiological regulation of the immunological synapse by agrin. Science 292:1681-86
117. Chung CD, Patel VP, Moran M, Lewis LA, Miceli MC, 2000. Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction. J. Immunol. 165:3722-29
118. Kozak SL, Heard JM, Kabat D. 2002. Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus. J. Virol. 76:1802-15
119. Popik W, Alce TM, Au WC. 2002. Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells. J. Virol. 76:4709-22
120. Manes S, del Real G, Lacalle RA, Lucas P, Gomez-Mouton C, et al. 2000. Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection. EMBO Rep. 1:190-96
121. Hug P, Lin HM, Korte T, Xiao X, Dimitrov DS, et al. 2000. Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5. J. Virol. 74:6377-85
122. Liao Z, Cimakasky LM, Hampton R, Nguyen DH, Hildreth JE. 2001. Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1. AIDS Res. Hum. Retroviruses 17:1009-19
123. Lindwasser OW, Resh MD. 2001. Multimerization of human immunodeficiency virus type 1 Gag promotes its localization to barges, raft-like membrane microdomains. J. Virol. 75:7913-24
124. Ono A, Freed EO. 2001. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc. Natl. Acad. Sci. USA 98:13925-30
125. Rousso I, Mixon MB, Chen BK, Kim PS. 2000. Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proc. Natl. Acad. Sci. USA 97:13523-25
126. Nguyen DH, Hildreth JE. 2000. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J. Virol. 74:3264-72
127. Clausse B, Fizazi K, Walczak V, Tetaud C, Wiels J, et al. 1997. High concentration of EBV latent membrane protein 1 in glycosphingolipid-rich complexes from both epithelial and lymphoid cells. Virology 228:285-93
128. Higuchi M, Izumi KM, Kieff E. 2001. Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors. Proc. Natl. Acad. Sci. USA 98:4675-80
129. Kaykas A, Worringer K, Sugden B. 2001. CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex. EMBO J. 20:2641-54
130. Merchant M, Swart R, Katzman RB, Ikeda M, Ikeda A, et al. 2001. The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function. Int. Rev. Immunol. 20:805-35
131. Liu Y, Casey L, Pike LJ. 1998. Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin. Biochem. Biophys. Res. Commun. 245:684-90
132. Martin TF. 2001. PI(4,5)P(2) regulation of surface membrane traffic. Curr. Opin. Cell Biol. 13:493-99
133. Lafont F, Simons K. 2001. Raft-partitioning of the ubiquitin ligases Cb1 and Nedd4 upon IgE-triggered cell signaling. Proc. Natl. Acad. Sci. USA 98:3180-84
134. Stuermer CA, Lang DM, Kitsch F, Wiechers M, Deininger SO, et al. 2001. Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in non-caveolar plasma membrane microdomains defined by reggie-1 and -2. Mol. Biol. Cell 12:3031-45
135. Solomon S, Masilamani M, Rajendran L, Bastmeyer M, Stuermer CA, et al. 2002. The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs. Immunobiology 205:108-19
136. Dermine JF, Duclos S, Garin J, St-Louis F, Rea S, et al. 2001. Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes. J. Biol. Chem. 276:18507-12
137. Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, et al. 2000. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407:202-7
138. Van Laethem F, Baus E, Andris F, Urbain J, Leo O. 2001. A novel aspect of the anti-inflammatory actions of glucocorticoids: inhibition of proximal steps of signaling cascades in lymphocytes. Cell Mol. Life Sci. 58:1599-1606
139. Van Laethem F, Baus E, Smyth LA, Andris F, Bex F, et al. 2001. Glucocorticoids attenuate T cell receptor signaling. J. Exp. Med. 193:803-14
140. Kelley DS. 2001. Modulation of human immune and inflammatory responses by dietary fatty acids. Nutrition 17:669-73
141. Stulnig TM, Berger M, Sigmund T, Raederstorff D, Stockinger H, Waldhausl W. 1998. Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains. J. Cell Biol. 143:637-44
142. Goldman F, Hohl RJ, Crabtree J, Lewis-Tibesar K, Koretzky G. 1996. Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras. Blood 88:4611-19
143. Zipfel PA, Grove M, Blackburn K, Fujimoto M, Tedder TF, Pendergast AM. 2000. The c-Abl tyrosine kinase is regulated downstream of the B cell receptor and interacts with CD19. J. Immunol. 165:6872-79
144. Shan X, Wange RL. 1999. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment. J. Biol. Chem. 274:29323-30
145. Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, et al. 2001. Requirements for activation and raft localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2:3-17
146. Ling P, Meyer CF, Redmond LP, Shui J-W, Davis B, et al. 2001. Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. J. Biol. Chem. 276:18908-14
147. Khoshnan A, Bae D, Tindell CA, Nel AE. 2000. The physical association of protein kinase C θ with a lipid raft-associated inhibitor of κB factor kinase (IKK) complex plays a role in the activation of the NF-κB cascade by TCR and CD28. J. Immunol. 165:6933-40
148. Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, et al. 2001. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. J. Exp. Med. 193:497-507
149. Wilson BS, Pfeiffer JR, Surviladze Z, Gaudet EA, Oliver JM. 2001. High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT. J. Cell Biol. 154:645-58