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Volumn 162, Issue 4, 1999, Pages 2073-2080

Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: Relationship to the quality of individual TCR signaling events

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; T LYMPHOCYTE RECEPTOR; THYMIDINE; TRITIUM;

EID: 0033558278     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (106)

References (49)
  • 1
    • 0027315182 scopus 로고
    • T-cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases
    • Weiss, A. 1993. T-cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell 73:209.
    • (1993) Cell , vol.73 , pp. 209
    • Weiss, A.1
  • 2
    • 0030008145 scopus 로고    scopus 로고
    • Variant TCR ligands: New insights into the molecular basis of antigen-dependent signal transduction and T-cell activation
    • Madrenas, J., and R. N. Germain. 1996. Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Semin. Immunol. 8:83.
    • (1996) Semin. Immunol. , vol.8 , pp. 83
    • Madrenas, J.1    Germain, R.N.2
  • 3
    • 0030914290 scopus 로고    scopus 로고
    • Understanding the mechanisms of sustained signaling and T-cell activation
    • Lanzavecchia, A. 1997. Understanding the mechanisms of sustained signaling and T-cell activation. J. Exp. Mol. 185:1717.
    • (1997) J. Exp. Mol. , vol.185 , pp. 1717
    • Lanzavecchia, A.1
  • 7
    • 0003104975 scopus 로고    scopus 로고
    • A TCR binds to agonist ligands with lower affinities and faster dissociation rates than to agonists
    • Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to agonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5:53.
    • (1996) Immunity , vol.5 , pp. 53
    • Lyons, D.S.1    Lieberman, S.A.2    Hampl, J.3    Boniface, J.J.4    Chien, Y.5    Berg, L.J.6    Davis, M.M.7
  • 8
    • 0025182003 scopus 로고
    • The minimal number of class II MHC-antigen complexes needed for T-cell activation
    • Demotz, S., H. M. Grey, and A. Sette. 1990. The minimal number of class II MHC-antigen complexes needed for T-cell activation. Science 249:1028.
    • (1990) Science , vol.249 , pp. 1028
    • Demotz, S.1    Grey, H.M.2    Sette, A.3
  • 9
    • 0025286210 scopus 로고
    • Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
    • Harding, C. V., and E. R. Unanue. 1990. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature 346: 574.
    • (1990) Nature , vol.346 , pp. 574
    • Harding, C.V.1    Unanue, E.R.2
  • 10
    • 0026715263 scopus 로고
    • Identification and quantification of a naturally presented peptide as recognized by cytotoxic T lymphocytes specific for an immunogenic tumor variant
    • Wallny, H. J., K. Deres, S. Faath, G. Jung, A. Van Pel, T. Boon, and H.-G. Rammensee. 1992. Identification and quantification of a naturally presented peptide as recognized by cytotoxic T lymphocytes specific for an immunogenic tumor variant. Int. Immunol. 4:1085.
    • (1992) Int. Immunol. , vol.4 , pp. 1085
    • Wallny, H.J.1    Deres, K.2    Faath, S.3    Jung, G.4    Van Pel, A.5    Boon, T.6    Rammensee, H.-G.7
  • 11
    • 0030176270 scopus 로고    scopus 로고
    • Evidence that a single peptide-MHC complex on a target T-cell can elicit a cytolytic T-cell response
    • Sykulev, Y., M. Joo, I. Vturina, T. J. Tsomides, and H. N. Eisen. 1996. Evidence that a single peptide-MHC complex on a target T-cell can elicit a cytolytic T-cell response. Immunity. 4:565.
    • (1996) Immunity , vol.4 , pp. 565
    • Sykulev, Y.1    Joo, M.2    Vturina, I.3    Tsomides, T.J.4    Eisen, H.N.5
  • 12
    • 0030219704 scopus 로고    scopus 로고
    • Correlation between the number of T-cell receptors required for T-cell activation and TCR-ligand affinity
    • Schodin, B. A., T. J. Tsomides, and D. M. Kranz. 1996. Correlation between the number of T-cell receptors required for T-cell activation and TCR-ligand affinity. Immunity 5:137.
    • (1996) Immunity , vol.5 , pp. 137
    • Schodin, B.A.1    Tsomides, T.J.2    Kranz, D.M.3
  • 13
    • 0030849769 scopus 로고    scopus 로고
    • Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody
    • Porgador, A., J. W. Yewdell, Y. Deng, J. R. Bennink, and R. N. Germain. 1997. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 6:715.
    • (1997) Immunity , vol.6 , pp. 715
    • Porgador, A.1    Yewdell, J.W.2    Deng, Y.3    Bennink, J.R.4    Germain, R.N.5
  • 14
    • 0030707645 scopus 로고    scopus 로고
    • Quantitative contribution of CD4 and CD8 to T-cell antigen receptor serial triggering
    • Viola, A., M. Salio, L. Tuosto, S. Linkert, O. Acuto, and A. Lanzavecchia. 1997. Quantitative contribution of CD4 and CD8 to T-cell antigen receptor serial triggering. J. Exp. Med. 186:1775.
    • (1997) J. Exp. Med. , vol.186 , pp. 1775
    • Viola, A.1    Salio, M.2    Tuosto, L.3    Linkert, S.4    Acuto, O.5    Lanzavecchia, A.6
  • 15
    • 0028797801 scopus 로고
    • CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes
    • Luescher, I. F., E. Vivier, A. Layer, J. Mahiou, F. Godeau, B. Malissen, and P. Romero. 1995. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature 373:353.
    • (1995) Nature , vol.373 , pp. 353
    • Luescher, I.F.1    Vivier, E.2    Layer, A.3    Mahiou, J.4    Godeau, F.5    Malissen, B.6    Romero, P.7
  • 17
    • 0028125972 scopus 로고
    • Evidence for differential intracellular signaling via CD4 and CD8 molecules
    • Ravichandran, K. S., and S. J. Burakoff. 1994. Evidence for differential intracellular signaling via CD4 and CD8 molecules. J. Exp. Med. 179:727.
    • (1994) J. Exp. Med. , vol.179 , pp. 727
    • Ravichandran, K.S.1    Burakoff, S.J.2
  • 18
    • 0031048822 scopus 로고    scopus 로고
    • The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/ partial agonist properties of peptide-MHC molecule ligands
    • Madrenas, J., L. A. Chau, J. Smith, J. A. Bluestone, and R. N. Germain. 1997. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/ partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185: 219.
    • (1997) J. Exp. Med. , vol.185 , pp. 219
    • Madrenas, J.1    Chau, L.A.2    Smith, J.3    Bluestone, J.A.4    Germain, R.N.5
  • 19
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
    • (1995) Nature , vol.375 , pp. 148
    • Valitutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 20
    • 0028038426 scopus 로고
    • MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
    • Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 74:287.
    • (1994) Cell , vol.74 , pp. 287
    • Germain, R.N.1
  • 22
    • 0028290315 scopus 로고
    • Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 internalization and surface redistribution
    • Luton, F., M. Buferne, J. Davoust, A.-M. Schmitt-Verhulst, and C. Boyer. 1994. Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 internalization and surface redistribution. J. Immunol. 153:63.
    • (1994) J. Immunol. , vol.153 , pp. 63
    • Luton, F.1    Buferne, M.2    Davoust, J.3    Schmitt-Verhulst, A.-M.4    Boyer, C.5
  • 23
    • 0031448209 scopus 로고    scopus 로고
    • Activation of the Lck tyrosine kinase targets cell surface T-cell antigen receptors for lysosomal degradation
    • D'Oro, U., M. S. Vacchio, A. M. Weissman, and J. D. Ashwell. 1997. Activation of the Lck tyrosine kinase targets cell surface T-cell antigen receptors for lysosomal degradation. Immunity 7:619.
    • (1997) Immunity , vol.7 , pp. 619
    • D'Oro, U.1    Vacchio, M.S.2    Weissman, A.M.3    Ashwell, J.D.4
  • 24
    • 0029840935 scopus 로고    scopus 로고
    • Dual T-cell receptor T-cells have a decreased sensitivity to physiological ligands due to reduced density of each T-cell receptor
    • Blichfeldt, E., L. A. Munthe, J. S. Rotnes, and B. Bogen. 1996. Dual T-cell receptor T-cells have a decreased sensitivity to physiological ligands due to reduced density of each T-cell receptor. Eur. J. Immunol. 26:2876.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2876
    • Blichfeldt, E.1    Munthe, L.A.2    Rotnes, J.S.3    Bogen, B.4
  • 26
    • 0030772120 scopus 로고    scopus 로고
    • Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation
    • Bachmann, M. F., A. Oxenius, D. E. Speiser, S. Mariathasan, H. Hengartner, R. M. Zinkernagel, and P. S. Ohashi. 1997. Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation. Eur. J. Immunol. 27:2195.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2195
    • Bachmann, M.F.1    Oxenius, A.2    Speiser, D.E.3    Mariathasan, S.4    Hengartner, H.5    Zinkernagel, R.M.6    Ohashi, P.S.7
  • 27
    • 0032526345 scopus 로고    scopus 로고
    • Relationships among T cell receptor ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells
    • Hemmer, B., I. Stefanova, M. Vergelli, R. N. Germain, and R. Martin. 1998. Relationships among T cell receptor ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J. Immunol. 160:5807.
    • (1998) J. Immunol. , vol.160 , pp. 5807
    • Hemmer, B.1    Stefanova, I.2    Vergelli, M.3    Germain, R.N.4    Martin, R.5
  • 28
    • 0030002902 scopus 로고    scopus 로고
    • Different responses are elicited in cytotoxic T lymphocytes by different levels of T-cell receptor occupancy
    • Valitutti, S., S. Müller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T-cell receptor occupancy. J. Exp. Med. 183:1917.
    • (1996) J. Exp. Med. , vol.183 , pp. 1917
    • Valitutti, S.1    Müller, S.2    Dessing, M.3    Lanzavecchia, A.4
  • 29
    • 0030057218 scopus 로고    scopus 로고
    • T-cell activation determined by T-cell receptor number and tunable threshold
    • Viola, A., and A. Lanzavecchia. 1996. T-cell activation determined by T-cell receptor number and tunable threshold. Science 273:104.
    • (1996) Science , vol.273 , pp. 104
    • Viola, A.1    Lanzavecchia, A.2
  • 31
    • 0020506697 scopus 로고
    • The relationship between immune interferon production and proliferation in antigen-specific. MHC-restricted T cell lines and clones
    • Hecht, T. T., D. L. Longo, and L. A. Matis. 1983. The relationship between immune interferon production and proliferation in antigen-specific. MHC-restricted T cell lines and clones. J. Immunol. 131:1049.
    • (1983) J. Immunol. , vol.131 , pp. 1049
    • Hecht, T.T.1    Longo, D.L.2    Matis, L.A.3
  • 32
    • 0027239842 scopus 로고
    • IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
    • Ding, L., P. S. Linsley, L.-Y. Huang, R. N. Germain, and E.M. Shevach. 1993. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151:1224.
    • (1993) J. Immunol. , vol.151 , pp. 1224
    • Ding, L.1    Linsley, P.S.2    Huang, L.-Y.3    Germain, R.N.4    Shevach, E.M.5
  • 35
    • 0023732130 scopus 로고
    • The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens
    • Pullen, A. M., P. Marrack, and J. W. Kappler. 1988. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335:796.
    • (1988) Nature , vol.335 , pp. 796
    • Pullen, A.M.1    Marrack, P.2    Kappler, J.W.3
  • 36
    • 0028064781 scopus 로고
    • Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T-cell antigen receptor engagement
    • Burkhardt, A. L., B. Stealey, R. B. Rowley, S. Mahajan, M. Prendergast, J. Fargnoli, and J. B. Bolen. 1994. Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T-cell antigen receptor engagement. J. Biol. Chem. 269:23642.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23642
    • Burkhardt, A.L.1    Stealey, B.2    Rowley, R.B.3    Mahajan, S.4    Prendergast, M.5    Fargnoli, J.6    Bolen, J.B.7
  • 37
    • 0025107356 scopus 로고
    • Detection of peptide-MHC class II complexes on the surface of intact cells
    • Busch, R., and J. B. Rothbard. 1990. Detection of peptide-MHC class II complexes on the surface of intact cells. J. Immunol. Methods 134:1.
    • (1990) J. Immunol. Methods , vol.134 , pp. 1
    • Busch, R.1    Rothbard, J.B.2
  • 38
    • 0027941809 scopus 로고
    • MHC class II function preserved by low-affinity peptide interactions preceding stable binding
    • Sadegh-Nasseri, S., L. J. Stern, D. C. Wiley, and R. N. Germain. 1994. MHC class II function preserved by low-affinity peptide interactions preceding stable binding. Nature 370:647.
    • (1994) Nature , vol.370 , pp. 647
    • Sadegh-Nasseri, S.1    Stern, L.J.2    Wiley, D.C.3    Germain, R.N.4
  • 40
    • 0032521903 scopus 로고    scopus 로고
    • Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology
    • Hemmer, B., M. Vergelli, B. Gran, N. Ling, P. Conlon, C. Pinilla, R. Houghten, H. F. McFarland, and R. Martin. 1998. Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. J. Immunol. 160:3631.
    • (1998) J. Immunol. , vol.160 , pp. 3631
    • Hemmer, B.1    Vergelli, M.2    Gran, B.3    Ling, N.4    Conlon, P.5    Pinilla, C.6    Houghten, R.7    McFarland, H.F.8    Martin, R.9
  • 41
    • 0025886797 scopus 로고
    • Molecular and cellular mechanisms of receptor-mediated endocytosis
    • Brown, V. I., and M. I. Greene. 1991. Molecular and cellular mechanisms of receptor-mediated endocytosis. DNA Cell Biol. 10:399.
    • (1991) DNA Cell Biol. , vol.10 , pp. 399
    • Brown, V.I.1    Greene, M.I.2
  • 42
    • 0020197844 scopus 로고
    • Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex
    • Reinherz, E. L., S. Meuer, K. A. Fitzgerald, R. E. Hussey, H. Levine, and S. F. Schlossman. 1982. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell 30:735.
    • (1982) Cell , vol.30 , pp. 735
    • Reinherz, E.L.1    Meuer, S.2    Fitzgerald, K.A.3    Hussey, R.E.4    Levine, H.5    Schlossman, S.F.6
  • 43
    • 0023256274 scopus 로고
    • Endocytosis and recycling of the T3-T-cell receptor complex: The role of T3 phosphorylation
    • Krangel, M. S. 1987. Endocytosis and recycling of the T3-T-cell receptor complex: the role of T3 phosphorylation. J. Exp. Med. 165:1141.
    • (1987) J. Exp. Med. , vol.165 , pp. 1141
    • Krangel, M.S.1
  • 44
    • 0030584796 scopus 로고    scopus 로고
    • Quantitative analysis of T-cell activation: Role of TCR/ligand density and TCR affinity
    • Kim, D. T., J. B. Rothbard, D. D. Bloom, and C. G. Fathman. 1996. Quantitative analysis of T-cell activation: role of TCR/ligand density and TCR affinity. J. Immunol. 156:2737.
    • (1996) J. Immunol. , vol.156 , pp. 2737
    • Kim, D.T.1    Rothbard, J.B.2    Bloom, D.D.3    Fathman, C.G.4
  • 45
    • 0024502789 scopus 로고
    • The induction of T-cell unresponsiveness by rapidly modulating CD3
    • Davis, L. S., M. C. Wacholtz, and P. E. Lipsky. 1989. The induction of T-cell unresponsiveness by rapidly modulating CD3. J. Immunol. 142:1084.
    • (1989) J. Immunol. , vol.142 , pp. 1084
    • Davis, L.S.1    Wacholtz, M.C.2    Lipsky, P.E.3
  • 46
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T-cell activation: Molecular mechanisms and role in T-cell biology
    • Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T-cell activation: molecular mechanisms and role in T-cell biology. Annu. Rev. Immunol. 14:1.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 1
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 49
    • 0031935753 scopus 로고    scopus 로고
    • Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity
    • Nicholson, L. B., H. Waldner, A. M. Carrizosa, A. Sette, M. Collins, and V. K. Kuchroo. 1998. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc. Natl. Acad. Sci. USA 95:264.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 264
    • Nicholson, L.B.1    Waldner, H.2    Carrizosa, A.M.3    Sette, A.4    Collins, M.5    Kuchroo, V.K.6


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