Three-dimensional segregation of supramolecular activation clusters in T cells

Nature

Volumn 395, Issue 6697, 1998, Pages 82-86

  Monks, Colin R F ^a   Freiberg, Benjamin A ^a,b   Kupfer, Hannah ^a   Sciaky, Noah ^a   Kupfer, Abraham ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ANTIGEN PRESENTING CELL; ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; THREE DIMENSIONAL IMAGING;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD3; CELL LINE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, TRANSGENIC; PEPTIDES; PROTEIN KINASE C; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TALIN;

EID: 0032480279     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/25764     Document Type: Article

References (17)

1. Weiss, A. & Littman, D. R. Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274 (1994).
2. Qian, D. & Weiss, A. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9, 205-212 (1997).
3. Monks, C. R., Kupfer, H., Tamir, I., Barlow, A. & Kupfer, A. Selective modulation of protein kinase C-θ during T-cell activation. Nature 385, 83-86 (1997).
4. Podack, E. R. & Kupfer, A. T-cell effector functions: mechanisms for delivery of cytotoxkity and help. Annu. Rev. Cell Biol. 7, 479-504 (1991).
5. Singer, S. J. Intercellular communication and cell-cell adhesion. Science 255, 1671-1677 (1992).
6. Kupfer, A. & Singer, S. J. Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol. 7, 309-337 (1989).
7. Hiraoka, Y., Sedat, J. W. & Agard, D. A. Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. Biophys. J. 57, 325-333 (1990).
8. Kupfer, A. & Singer, S. J. The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose. J. Exp. Med. 170, 1697-1713 (1989).
9. Kupfer, A., Burn, P. & Singer, S. J. The PMA-induced specific association of LFA-1 and talin in intact cloned T helper cells. J. Mol. Cell. Immunol. 4, 317-325 (1990).
10. McCloskey, M. A. & Poo, M. M. Contact-induced redistribution of specific membrane components: local accumulation and development of adhesion. J. Cell Biol. 102, 2185-2196 (1986).
11. Harding, C. V. & Unanue, E. R. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature 346, 574-576 (1990).
12. Anderson, M. S., Swier, K., Arneson, L. & Miller, J. Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal. J. Exp. Med. 178, 1959-1969 (1993).
13. Dittel, B. N., Sant'Angelo, D. B. & Janeway, C. A. Jr Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR. J. Immunol. 158, 4065-4073 (1997).
14. Schlessinger, J. SH2/SH3 signaling proteins. Curr. Opin. Genet. Dev. 4, 25-30 (1994).
15. Lemmon, M. A., Ferguson, K. M. & Schlessinger, J. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85, 621-624 (1996).
16. Pawson, T. & Scott, J. D. Signaling through scaffold, anchoring, and adaptor proteins. Science 278, 2075-2080 (1997).
17. Kupfer, H., Monks, C. R. & Kupfer, A. Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B-antigen presenting cell interactions. J. Exp. Med. 179, 1507-1515 (1994).