Oligomeric antigen receptors: A new view on signaling for the selection of lymphocytes

Trends in Immunology

Volumn 22, Issue 7, 2001, Pages 356-360

  Reth, Michael ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; B LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN; OLIGOMER; T LYMPHOCYTE RECEPTOR;

B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL SELECTION; COMPLEX FORMATION; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; HUMANS; LYMPHOCYTES; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 0034914677     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)01964-0     Document Type: Review

References (48)

1. Clonal selection and learning in the antibody system
2. B-cell-receptor-dependent positive and negative selection in immature B cells
3. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
4. An unsolved problem of the clonal selection theory and the model of an oligomeric B-cell antigen receptor
5. Genetic analysis of B-cell antigen receptor signaling
6. Positive versus negative signaling by lymphocyte antigen receptors
7. Protein tyrosine phosphatase 1C negatively regulates antigen-receptor signaling in B lymphocytes and determines thresholds for negative selection
8. Monomeric and oligomeric complexes of the B-cell antigen receptor
9. Antigen receptors on B lymphocytes
10. The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface
11. A mutation of the mu transmembrane that disrupts endoplasmic reticulum retention. Effects on association with accessory proteins and signal transduction
12. Homodimerization of erythropoietin receptor by a bivalent monoclonal antibody triggers cell proliferation and differentiation of erythroid precursors
13. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
14. B-cell antigen receptor signalling in the balance of tolerance and immunity
15. A truncated heavy-chain protein relieves the requirement for surrogate light chains in early B-cell development
16. Molecular components of the B-cell antigen receptor complex of the IgM class
17. The B-cell antigen receptor of class IgD induces a stronger and more prolonged protein tyrosine phosphorylation than that of class IgM
18. Aberrant B-cell development and immune response in mice with a compromised BCR complex
19. B-cell development is arrested at the immature B-cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin β
20. A negative regulatory role for Igα during B-cell development
21. Ig-α cytoplasmic truncation renders immature B cells more sensitive to antigen contact
22. The germinal-center reaction
23. Role of Syk in B-cell development and antigen-receptor signaling
24. Evidence for a preformed transducer complex organized by the B-cell antigen receptor
25. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
26. BLNK: A central linker protein in B-cell activation
27. BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius
28. Induction of antigen-receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk
29. γ 2b provides only some of the signals normally given via mu in B-cell development
30. Gene dose-dependent maturation and receptor editing of B cells expressing immunoglobulin (Ig)G1 or IgM/IgG1 tail antigen receptors
31. Revealing mechanisms for SH2 domain-mediated regulation of the protein tyrosine phosphatase SHP-2
32. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE
33. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Igα/Igγ immunoreceptor tyrosine-based activation motif binding and autophosphorylation
34. Signal transduction by the B-cell antigen receptor
35. Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B-cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells
36. Identification of the tyrosine phosphatase PTP1C as a B-cell antigen receptor-associated protein involved in the regulation of B-cell signaling
37. Different patterns of calcium signaling triggered through two components of the B-lymphocyte antigen receptor
38. A role for lipid rafts in B-cell antigen receptor signaling and antigen targeting
39. Membrane rafts and signaling by the multichain immune recognition receptors
40. Syk activation by the Src-family tyrosine kinase in B-cell receptor signaling
41. Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B-cell activation includes a site that negatively regulates signaling
42. Defective negative regulation of antigen-receptor signaling in Lyn-deficient B lymphocytes
43. Calcium/calmodulin-dependent protein kinases
44. Structural basis of T-cell recognition
45. Assembly of the TCR/CD3 complex: CD3ε/δ and CD3ε/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer model
46. A kinetic window constricts the T-cell receptor repertoire in the thymus
47. From TCR engagement to T-cell activation: A kinetic view of T-cell behavior
48. Calcium/calmodulin-dependent protein kinases