Therapeutic application of T cell receptor mimic peptides or cDNA in the treatment of T cell-mediated skin diseases

Gene Therapy

Volumn 7, Issue 12, 2000, Pages 1000-1004

  Gollner G P ^a   Muller G ^a   Alt, R ^a   Knop, J ^a   Enk, A H ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Allergical contact dermatitis; DNA vaccination; T cell function; T cell mediated disease; TCR

Indexed keywords

COMPLEMENTARY DNA; CONTACT ALLERGEN; PEPTIDE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CONTACT DERMATITIS; CONTACT SENSITIVITY; CONTROLLED STUDY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LICHEN PLANUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; SKIN DISEASE; T LYMPHOCYTE ACTIVATION;

ANIMALIA; MURINAE;

EID: 0343091295     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301183     Document Type: Article

References (14)

1. Klausner RD, Lippincott-Schwarz J, Bonifacino JS. The T-cell antigen receptor: insights into organell biology. Annu Rev Cell Biol 1990; 6: 403-431.
2. Manolios N, Bonifacino JS, Klausner RD. Transmembrane helical interactions and the assembly of the T-cell receptor complex. Science 1990; 249: 274-277.
3. John S, Banting GS, Goodfellow PN, Owen MJ. Surface expression of the T-cell receptor complex requires charged residues within the alpha chain transmembrane region. Eur J Immunol 1989; 19: 335-339.
4. Blumberg RS et al. Assembly and function of the T-cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain. J Biol Chem 1990; 265: 14036-14043.
5. Manolios N, Letourneur F, Bonifacino JS, Klausner RD. Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor. EMBO J 1991; 10: 1643-1651.
6. Manolios N et al. T-cell antigen receptor transmembrane peptides modulate T-cell function and T-cell-mediated disease. Nature Med 1997; 3: 84-88.
7. Grabbe S, Schwarz T. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today 1998; 19: 37-44.
8. Lappin MB, Kimber I, Norval M. The role of dendritic cells in cutaneous immunity. Arch Dermatol Res 1996; 288: 109-121.
9. Hengge UR et al. Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nat Genet 1995; 10: 161-166.
10. Hengge UR, Walker PS, Vogel JC. Expression of naked DNA in human, pig, and mouse skin. J Clin Invest 1996; 97: 2911-2916.
11. Hengge UR et al. Efficient expression of naked plasmid DNA in mucosal epithelium: prospective for treatment of skin lesions. J Invest Dermatol 1998; 111: 605-608.
12. Forg P, von Hoegen P, Dalemans W, Schirrmacher V. Superiority of the ear pinna over muscle tissue as site for DNA vaccination. Gene Therapy 1998; 5: 789-797.
13. Janknecht R et al. Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc Natl Acad Sci USA 1991; 88: 8972-8976.
14. Jonuleit H et al. Proinflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 1997; 27: 3135-3142.