Dimerization as a regulatory mechanism in signal transduction

Annual Review of Immunology

Volumn 16, Issue , 1998, Pages 569-592

  Klemm, Juli D ^a   Schreiber, Stuart L ^b   Crabtree, Gerald R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Cell surface receptors; DNA binding proteins; Dominant negative; Oligomerization; Proximity

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; CELL SURFACE RECEPTOR; CYTOKINE RECEPTOR; PROTEIN TYROSINE KINASE;

BINDING AFFINITY; BIODIVERSITY; CHEMICAL MODIFICATION; DIMERIZATION; ORIENTATION; PARAMETER; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; DIMERIZATION; HUMANS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 0031892994     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.16.1.569     Document Type: Review

References (16)

1. Jones S, Thornton JM. 1995. Protein-protein interactions: a review of protein dimer structures. Prog. Biophys. Mol. Biol. 63:31-65
2. Heldin CH. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80:213-23
3. Jones N. 1990. Transcriptional regulation by dimerization: two sides to an incestuous relationship. Cell 61:9-11
4. Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H. 1990. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61:49-59
5. van Doren M, Ellis HM, Posakony JW. 1991. The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development 113:245-55
6. van Doren M, Powell PA, Pasternak D, Singson A, Posakony JW. 1992. Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev. 6:2592-2605
7. Hai T. Curran T. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720-24
8. Ptashne, M. 1986. A Genetic Switch. Boston: Blackwell Sci.
9. Schlessinger J. 1988. Signal transduction by allosteric receptor oligomerization. Trends Biol. Sci. 13:443-47
10. Weiner DB, Liu J, Cohen JA, Williams WV, Greene MI. 1989. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature 339:230-31
11. Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR. 1993. Controlling signal transduction with synthetic ligands. Science 262:1019-24
12. Kanakaraj P, Raj S, Khan SA, Bishayee S. 1991. Ligand-induced interaction between alpha- and beta-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation. Biochemistry 30:1761-67
13. Wells JA. 1996. Binding in the growth hormone receptor complex. Proc. Natl. Acad. Sci. USA 93:1-6
14. Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Crumley G, Schlessinger J, Lax I. 1994. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell 79:1015-24
15. Banner DW, D'Arcy A, Janes W, Gentz R, Schoenfeld HJ, Broger C, Loetscher H, Lesslauer W. 1993. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell 73:431-45
16. Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J. 1996. Kit receptor dimerization is driven by bivalent binding of stem cell factor. J. Biol. Chem. 272:6311-17