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Volumn 16, Issue 3, 2004, Pages 353-359

Lipid raft domains and protein networks in T-cell receptor signal transduction

Author keywords

B cell antigen receptor; BCR; carboxy terminal Src kinase; Csk; detergent resistant membrane; DRM; GFP; glycosylphosphatidylinositol; GPI; green fluorescent protein; HA; influenza haemagglutinin; LAT; Ld; linker for activation of T cells; liquid disordered; Lo

Indexed keywords

CHOLESTEROL; DETERGENT; LIPID; MEMBRANE PROTEIN; RAS PROTEIN; SPHINGOLIPID; T LYMPHOCYTE RECEPTOR;

EID: 2342492829     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.03.013     Document Type: Article
Times cited : (132)

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    • Glebov OO, Nichols BJ: Lipid raft proteins have a random distribution during localized activation of the T-cell receptor. Nat Cell Biol 2004 (published online 8 February 2004) DOI:10.1038/ncb1103 AOP.
    • (2004) Nat Cell Biol
    • Glebov, O.O.1    Nichols, B.J.2
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    • 0346103675 scopus 로고    scopus 로고
    • Visualizing lipid structure and raft domains in living cells with two-photon microscopy
    • This study makes use of the lipid dye Laurdan, which displays a spectral shift depending on the degree of order of its lipid environment. This spectral shift was used to monitor the phase behaviour of macrophage plasma membranes. These experiments revealed distinct ordered and disordered regions providing the first direct evidence for segregated physical phases in cell plasma membranes as predicted by a raft-non-raft equilibrium.
    • Gaus K., Gratton E., Kable E.P., Jones A.S., Gelissen I., Kritharides L., Jessup W. Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proc Natl Acad Sci USA. 100:2003;15554-15559 This study makes use of the lipid dye Laurdan, which displays a spectral shift depending on the degree of order of its lipid environment. This spectral shift was used to monitor the phase behaviour of macrophage plasma membranes. These experiments revealed distinct ordered and disordered regions providing the first direct evidence for segregated physical phases in cell plasma membranes as predicted by a raft-non-raft equilibrium.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15554-15559
    • Gaus, K.1    Gratton, E.2    Kable, E.P.3    Jones, A.S.4    Gelissen, I.5    Kritharides, L.6    Jessup, W.7


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