Architectural Changes in the TCR:CD3 Complex Induced by MHC:Peptide Ligation

Journal of Immunology

Volumn 172, Issue 6, 2004, Pages 3662-3669

  La Gruta, Nicole L ^a,d   Liu, Haiyan ^a,b,e   Dilioglou, Smaroula ^a   Rhodes, Michele ^c   Wiest, David L ^c   Vignali, Dario A A ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD3 ZETA ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEPTIDE DERIVATIVE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL SURFACE; COMPLEX FORMATION; DOWN REGULATION; EMBRYO; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FAMILY; T LYMPHOCYTE;

EID: 1542724435     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.6.3662     Document Type: Article

References (54)

1. Zanders, E. D., J. R. Lamb, M. Feldmann, N. Green, and P. C. Beverley. 1983. Tolerance of T-cell clones is associated with membrane antigen changes. Nature 303:625.
2. Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.
3. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
4. Valitutti, S., and A. Lanzavecchia. 1997. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today 18:299.
5. Liu, H. Y., M. Rhodes, D. L. Wiest, and D. A. A. Vignali. 2000. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 13:665.
6. Weiss, A., R. Shields, M. Newton, B. Manger, and J. Imboden. 1987. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. J. Immunol. 138:2169.
7. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy: role of T cell actin cytoskeleton. J. Exp. Med. 181:577.
8. Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8:89.
9. Grakoui, A., S. K. Bromley, C. Sumen, M. M. Davis, A. S. Shaw, P. M. Allen, and M. L. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science 285:221.
10. Clevers, H., B. Alarcon, T. Wileman, and C. Terhorst. 1988. The T cell receptor/CD3 complex: a dynamic protein ensemble. Annu. Rev. Immunol. 6:629.
11. Klausner, R. D., J. Lippincott-Schwartz, and J. S. Bonifacino. 1990. The T cell antigen receptor: insights into organelle biology. Annu. Rev. Cell Biol. 6:403.
12. Reth, M. 1987. Antigen receptor tail clue. Nature 38:383.
13. Minami, Y., A. M. Weissman, L. E. Samelson, and R. D. Klausner. 1987. Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 84:2688.
14. Klausner, R. D., A. M. Weissman, M. Baniyash, J. S. Bonifacino, and L. E. Samelson. 1989. The role of the zeta chain in the expression, structure and function of the T cell receptor. Adv. Exp. Med. Biol. 254:21.
15. Sussman, J. J., J. S. Bonifacino, J. Lippincott-Schwartz, A. M. Weissman, T. Saito, R. D. Klausner, and J. D. Ashwell. 1988. Failure to synthesize the T cell CD3-ζ chain: structure and function of a partial T cell receptor complex. Cell 52:85.
16. Weissman, A. M., S. J. Frank, D. G. Orloff, M. Mercep, J. D. Ashwell, and R. D. Klausner. 1989. Role of the ζ chain in the expression of the T cell antigen receptor: genetic reconstitution studies. EMBO J. 8:3651.
17. Manolios, N., F. Letourneur, J. S. Bonifacino, and R. D. Klausner. 1991. Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor. EMBO J. 10:1643.
18. Love, P. E., E. W. Shores, M. D. Johnson, M. L. Tremblay, E. J. Lee, A. Grinberg, S. P. Huang, A. Singer, and H. Westphal. 1993. T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. Science 261:918.
19. Malissen, M., A. Gillet, B. Rocha, J. Trucy, E. Vivier, C. Boyer, F. Kontgen, N. Brun, G. Mazza, and E. Spanopoulou. 1993. T cell development in mice lacking the CD3-ζ/η gene. EMBO J. 12:4347.
20. -/- mutant mice and identification of a novel T cell population in the intestine. EMBO J. 12:4863.
21. Liu, H. Y., and D. A. Vignali. 1999. Differential CD3ζ phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands. J. Immunol. 163:599.
22. Letourneur, F., and R. D. Klausner. 1992. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69:1143.
23. Dietrich, J., X. Hou, A.-M. K. Wegener, and C. Geisler. 1994. CD3γ contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor. EMBO J. 13:2156.
24. Dietrich, J., and C. Geisler. 1998. T cell receptor ζ allows stable expression of receptors containing the CD3γ leucine-based receptor-sorting motif. J. Biol. Chem. 273:26281.
25. Dietrich, J., J. Kastrup, J. P. Lauritsen, C. Menne, F. von Bulow, and C. Geisler. 1999. TCRζ is transported to and retained in the Golgi apparatus independently of other TCR chains: implications for TCR assembly. Eur. J. Immunol. 29:1719.
26. Ono, S., H. Ohno, and T. Saito. 1995. Rapid turnover of the CD3 zeta chain independent of the TCR-CD3 complex in normal T cells. Immunity 2:639.
27. Vignali, D. A. A., and K. M. Vignali. 1999. Profound enhancement of T cell activation mediated by the interaction between the T cell receptor and the D3 domain of CD4. J. Immunol. 162:1431.
28. Vignali, D. A. A., R. T. Carson, B. Chang, R. S. Mittler, and J. L. Strominger. 1996. The two membrane proximal domains of CD4 interact with the T cell receptor. J. Exp. Med. 183:2097.
29. Carson, R. T., K. M. Vignali, D. L. Woodland, and D. A. A. Vignali. 1997. T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage. Immunity 7:387.
30. Carson, R. T., and D. A. A. Vignali. 1999. Simultaneous quantitation of fifteen cytokines using a multiplexed flow cytometric assay. J. Immunol. Methods 227:41.
31. Eolliger, L., B. Johansson, and E. Palmer. 1997. The short extracellular domain of the T cell receptor ζ chain is involved in assembly and signal transduction. Mol. Immunol. 34:819.
32. Wange, R. L., and L. E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity 5:197.
33. Qian, D., and A. Weiss. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205.
34. Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollok, and P. A. Connelly. 1996. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor: study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:695.
35. Krangel, M. S. 1987. Endocytosis and recycling of the T3-T cell receptor complex: the role of T3 phosphorylation. J. Exp. Med. 165:1141.
36. Bachmann, M. F., A. Oxenius, D. E. Speiser, S. Mariathasan, H. Hengarmer, R. M. Zinkernagel, and P. S. Ohashi. 1997. Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation. Eur. J. Immunol. 27:2195.
37. Itoh, Y., B. Hemmer, R. Martin, and R. N. Germain. 1999. Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events. J. Immunol. 162:2073.
38. Valitutti, S., S. Muller, M. Salio, and A. Lanzavecchia. 1997. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation. J. Exp. Med. 185:1859.
39. D'Oro, U., M. S. Vacchio, A. M. Weissman, and J. D. Ashwell. 1997. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 7:619.
40. San Jose, E., A. Borroto, F. Niedergang, A. Alcover, and B. Alarcon. 2000. Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism. Immunity 12:161.
41. Coombs, D., A. M. Kalergis, S. G. Nathenson, C. Wofsy, and B. Goldstein. 2002. Activated TCRs remain marked for internalization after dissociation from pMHC. Nat. Immunol. 3:926.
42. D'Oro, U., I. Munitic, G. Chacko, T. Karpova, J. McNally, and J. D. Ashwell. 2002. Regulation of constitutive TCR internalization by the ζ-chain. J. Immunol. 169:6269.
43. Legendre, V., A. Guimezanes, M. Buferne, M. Barad, A. M. Schmitt-Verhulst, and C. Boyer. 1999. Antigen-induced TCR-CD3 down-modulation does not require CD3δ or CD3γ cytoplasmic domains, necessary in response to anti-CD3 antibody. Int. Immunol. 11:1731.
44. Borroto, A., J. Lama, F. Niedergang, A. Dautry-Varsat, B. Alarcon, and A. Alcover. 1999. The CD3ε subunit of the TCR contains endocytosis signals. J. Immunol. 163:25.
45. Gil, D., W. W. Schamel, M. Montoya, F. Sanchez-Madrid, and B. Alarcon. 2002. Recruitment of Nck by CD3ε reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109:901.
46. Orloff, D. G., C. S. Ra, S. J. Frank, R. D. Klausner, and J. P. Kinet. 1990. Family of disulphide-linked dimers containing the ζ and η chains of the T-cell receptor and the γ chain of Fc receptors. Nature 347:189.
47. Vivier, E., N. Rochet, J. P. Kochan, D. H. Presky, S. F. Schlossman, and P. Anderson. 1991. Structural similarity between Fc receptors and T cell receptors: expression of the γ-subunit of FcεRI in human T cells, natural killer cells and thymocytes. J. Immunol. 147:4263.
48. Rodewald, H. R., A. R. Arulanandam, S. Koyasu, and E. L. Reinherz. 1991. The high affinity Fcε receptor γ subunit (FcεRIγ) facilitates T cell receptor expression and antigen/major histocompatibility complex-driven signaling in the absence of CD3ζ and CD3η. J. Biol. Chem. 266:15974.
49. Ravetch, J. V., and J. P. Kinet. 1991. Fc receptors. Annu. Rev. Immunol. 9:457.
50. Lanier, L. L., B. C. Corliss, J. Wu. C. Leong, and J. H. Phillips. 1998. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391:703.
51. Lanier, L. L., B. Corliss, J. Wu, and J. H. Phillips. 1998. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity 8:693.
52. Wu, J., Y. Song, A. B. Bakker, S. Bauer, T. Spies, L. L. Lanier. and J. H. Phillips. 1999. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285:730.
53. Chang, C., J. Dietrich, A. G. Harpur, J. A. Lindquist, A. Haude, Y. W. Loke, A. King, M. Colonna, J. Trowsdale, and M. J. Wilson. 1999. Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J. Immunol. 163:4651.
54. Huh, G. S., L. M. Boulanger, H. Du, P. A. Riquelme, T. M. Brotz, and C. J. Shatz. 2000. Functional requirement for class I MHC in CNS development and plasticity. Science 290:2155.