Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) ζ chain leads to TCR down-modulation

Journal of General Virology

Volumn 79, Issue 11, 1998, Pages 2717-2727

  Bell, Ian ^a   Ashman, Claire ^a   Maughan, Juanita ^a   Hooker, Elizabeth ^a   Cook, Fiona ^a   Reinhart, Todd A ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; NEF PROTEIN; T LYMPHOCYTE RECEPTOR;

ARTICLE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0031791917     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-79-11-2717     Document Type: Article

References (51)

1. Alexander, L., Du, Z., Rosenzweig, M., Jung, J. U. & Desrosiers, R. C. (1997). Role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation. Journal of Virology 71, 6094-6099.
2. Allan, J. S., Coligan, J. E., Lee, T.-H., McLane, M. F., Kanki, P. J., Groopman, J. E. & Essex, M. (1985). A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients. Science 230, 810-813.
3. Almond, N., Kent, K., Cranage, M., Rud, E., Clarke, B. & Stott, E. J. (1995). Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells. Lancet 345, 1342-1344.
4. Baur, A. S., Sawai, E. T., Bazin, P., Fantl, W. J., Cheng-Mayer, C. & Peterlin, B. M. (1994). HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1, 373-384.
5. Benichou, S., Bomsel, M., Bodeus, M., Durand, H., Doute, M., Letourneur, F., Camonis, J. & Benarous, R. (1994). Physical interaction of the HIV-1 Nef protein with β-COP, a component of non-clathrin-coated vesicles essential for membrane traffic. Journal of Biological Chemistry 269, 30073-30076.
6. Benson, R. E., Sanfridson, A., Ottinger, J. S., Doyle, C. & Cullen, B. R. (1993). Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral superinfection. Journal of Experimental Medicine 177, 1561-1566.
7. Chapman, B. S., Thayer, R. M., Vincent, K. A. & Haigwood, N. L. (1991). Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells. Nucleic Acids Research 19, 3979-3986.
8. Chowers, M. Y., Spina, C. A., Kwoh, T. J., Fitch, N. J. S., Richman, D. D. & Guatelli, J. C. (1994). Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. Journal of Virology 68, 2906-2914.
9. Collete, Y., Dutartre, H., Benziane, A., RamosMorales, F., Benarous, R., Harris, M. & Olive, D. (1996). Physical and functional interaction of Nef with Lck: HIV-1 Nef-induced T-cell signaling defects. Journal of Biological Chemistry 271, 6333-6341.
10. Collins, K. L., Chen, B. K., Kalams, S. A., Walker, B. D. & Baltimore, D. (1998). HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397-401.
11. Cranage, M. P., Whatmore, A. M., Sharpe, S. A., Cook, N., Polyanskaya, N., Leech, S., Smith, J. D., Rud, E. W., Dennis, M. J. & Hall, G. A. (1997). Macaques infected with live attenuated SIVmac are protected against superinfection via the rectal mucosa. Virology 229, 143-154.
12. Daniel, M. D., Kirchoff, F., Czajak, S. D., Sehgal, P. K. & Desrosiers, R. C. (1992). Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938-1941.
13. Du, Z., Lang, S. M., Sasseville, V. G., Lackner, A. A., Ilyinskii, P. O., Daniel, M. D., Jung, J. U. & Desrosiers, R. C. (1995). Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82, 665-674.
14. Fuller, K. J., Morse, M. A., White, J. H. M., Dowell, S. J. & Sims, M. J. (1998). Development of a yeast tri-hybrid screen using stable yeast strains and regulated protein expression. Biotechniques 25, 85-92.
15. Fultz, P. N. (1991). Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes. Journal of Virology 65, 4902-4909.
16. Fultz, P. N. & Zack, P. (1994). Unique lentivirus-host interactions: SIV smmPBj14 infection of macaques. Virus Research 32, 205-225.
17. Greenberg, M. E., Iafrate, A. J. & Skowronski, J. (1998). The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO Journal 17, 2777-2789.
18. Greenway, A., Azad, A. & McPhee, D. (1995). Human immunodeficiency virus type 1 Nef inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. Journal of Virology 69, 1842-1850.
19. Greenway, A., Azad, A., Mills, J. & McPhee, D. (1996). Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity. Journal of Virology 70, 6701-6708.
20. Guy, B., Kieny, M. P., Riviere, Y., Le Peuch, C., Dott, K., Girard, M., Montagnier, L. & Lecocq, J. (1987). HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 330, 266-269.
21. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
22. Harris, M. & Coates, K. (1993). Identification of cellular proteins that bind to the human immunodeficiency virus type 1 nef gene product in vitro: a role for myristylation. Journal of General Virology 74, 1581-1589.
23. Harshman, K. D., Moye-Rowley, W. S. & Parker, C. S. (1988). Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4. Cell 53, 321-330.
24. Iafrate, A. J., Bronson, S. & Skowronski, J. (1997). Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO Journal 16, 673-684.
25. Johnston, J. R. (1994). Molecular Genetics of Yeast: A Practical Approach. New York: Oxford University Press.
26. Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N. C., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N. & Desrosiers, R. (1990). Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science 248, 1109-1112.
27. Kestler, H. W., Ringler, D. J., Mori, K., Panicali, D. L., Sehgal, P. K., Daniel, M. D. & Desrosiers, R. C. (1991). Importance of the nef gene for maintenance of high virus load and development of AIDS. Cell 65, 651-662.
28. Le Gall, S., Erdtmann, L., Benichou, S., Berlioz-Torrent, C., Liu, L., Benarous, R., Heard, J.-M. & Schwartz, O. (1998). Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 8, 463-495.
29. Lennon, G., Auffray, C., Polymeropoulos, M. & Soares, M. B. (1996). The I.M.A.G.E. consortium: an integrated molecular analysis of genomes and their expression. Genomics 33, 151-152.
30. Liu, L. X., Margottin, F., Le Gall, S., Schwartz, O., Selig, L., Benarous, R. & Benichou, S. (1997). Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. Journal of Biological Chemistry 272, 13779-13785.
31. Lu, X., Yu, H., Lui, S.-H., Brodsky, F. M. & Peterlin, B. M. (1998). Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8, 647-656.
32. Luo, W. & Peterlin, B. M. (1997). Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus. Journal of Virology 71, 9531-9537.
33. Luria, S., Chambers, I. & Berg, P. (1991). Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. Proceedings of the National Academy of Sciences, USA 88, 5326-5330.
34. Mangasarian, A., Foti, M., Aiken, C., Chin, D., Carpentier, J.-L. & Trono, D. (1997). The HIV-1 Nef protein acts as a connector with sorting pathways in the golgi and at the plasma membrane. Immunity 6, 67-77.
35. Page, K. A., van Schooten, W. C. & Feinberg, M. B. (1997). Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation. Journal of Virology 71, 1774-1785.
36. Piguet, V., Yen-Liang, C., Mangasarian, A., Foti, M., Carpentier, J.-L. & Trono, D. (1998). Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes. EMBO Journal 17, 2472-2481.
37. Robinson, M. A. (1994). The role of clathrin, adaptors, and dynamin in endocytosis. Current Biology 6, 538-544.
38. Rossi, F., Gallina, A. & Milanesi, G. (1996). Nef-CD4 physical interaction sensed with the yeast two-hybrid system. Virology 217, 397-403.
39. Rossi, F., Evstafieva, A., Pedrali-Noy, G., Ballina, A. & Milanesi, G. (1997). HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein. Virology 237, 33-45.
40. Rud, E. W., Cranage, M., Yon, J., Quirk, J., Ogilvie, L., Cook, N., Webster, S., Dennis, M. & Clarke, B. E. (1994). Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants. Journal of General Virology 75, 529-543.
41. Saksela, K., Cheng, G. & Baltimore, D. (1995). Proline-rich (PXXP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO Journal 3, 484-491.
42. Sasseville, V. G., Du, Z., Chalifoux, L. V., Pauley, D. R., Young, H. L., Sehgal, P. K., Desrosiers, R. C. & Lackner, A. A. (1996). Induction of lymphocyte proliferation and severe gastrointestinal disease in macaques by a Nef gene variant of SIVmac239. American Journal of Pathology 149, 163-176.
43. Sawai, E. T., Baur, A., Struble, H., Peterlin, B. M., Levy, J. A. & Cheng-Mayer, C. (1994). Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proceedings of the National Academy of Sciences, USA 91, 1539-1543.
44. Sawai, E. T., Baur, A., Peterlin, B. M., Levy, J. A. & Cheng-Mayer, C. (1995). A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. Journal of Biological Chemistry 270, 15307-15314.
45. Schwartz, O., Marechal, V., Le Gall, S., Lemonnier, F. & Heard, J.-M. (1996). Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nature Medicine 2, 338-342.
46. Spina, C. A., Kwoh, T. J., Chowers, M. Y., Guatelli, J. C. & Richman, D. D. (1994). The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. Journal of Experimental Medicine 179, 115-123.
47. Wange, R. L. & Samelson, L. E. (1996). Complex complexes: signaling at the TCR. Immunity 5, 197-205.
48. Watanabe, H., Shiratori, T., Shoji, H., Miyatake, S., Okazaki, Y., Ikuta, K., Sato, T. & Saito, T. (1997). A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef. Biochemical and Biophysical Research Communications 238, 234-239.
49. Weissman, A. M., Hou, D., Orloff, D. G., Modi, W. S., Seuanez, H., O'Brien, S. J. & Klausner, R. D. (1988). Molecular cloning and chromosomal localization of the human T-cell receptor ζ chain: distinction from the molecular CD3 complex. Proceedings of the National Academy of Sciences, USA 85, 9709-9713.
50. Welker, R., Kottler, H., Kalbitzer, H. R. & Krausslich, H.-G. (1996). Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. Virology 219, 228-236.
51. Whatmore, A. M., Cook, N., Hall, G. A., Sharpe, S., Rud, E. W. & Cranage, M. P. (1995). Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence. Journal of Virology 69, 5117-5123.