Signaling life and death in the thymus: Timing is everything

Science

Volumn 299, Issue 5614, 2003, Pages 1859-1863

  Werlen, Guy ^a   Hausmann, Barbara ^a   Naeher, Dieter ^a   Palmer, Ed ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPLEXATION; ERGONOMICS; PROTEINS;

LYMPHOCYTES;

IMMUNOLOGY;

CD4 ANTIGEN; CD8 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

BIOLOGY; LIFE CYCLE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CELL DEATH; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS; ANTIGENS, CD; APOPTOSIS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; ENZYME ACTIVATION; HUMANS; LIGANDS; MAJOR HISTOCOMPATIBILITY COMPLEX; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SELECTION (GENETICS); SELF TOLERANCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0037459321     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1067833     Document Type: Review

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69. We are indebted to the efforts of many laboratories that have contributed to this field. A Medline search found 35,090 publications that are relevant to TCR signaling and T cell development; we apologize to those whose work was not cited. We thank I. Luescher for sharing unpublished data; G. de Libero, K. Hogquist, D. Gil-Pagès, and E. Jacinto for reading the manuscript;and M. Cohn for discussions. The authors laboratory is supported by grants from the Swiss National Science Foundation and Hoffmann-La Roche, Ltd., and a generous gift from Novartis, AG. This review is dedicated to the memory of Rod Langman.