An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

Nature Structural Biology

Volumn 5, Issue 11, 1998, Pages 993-1004

  Livnah, Oded ^a,f   Johnson, Dana L ^b   Stura, Enrico A ^a,g   Farrel, Francis X ^b   Barbone, Francis P ^b   You, Yun ^d   Liu, Kathleen D ^d   Goldsmith, Mark A ^c,d   He, Wen ^e   Krause, Christopher D ^e   Pestka, Sidney ^e   Jolliffe, Linda K ^b   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Drug Discovery Raritan   (United States)

^c GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^f HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^g CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; ERYTHROPOIETIN RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; PHOSPHOTYROSINE;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; CYTOPLASM; DIMERIZATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA-BINDING PROTEINS; ERYTHROPOIETIN; HUMANS; MICE; MILK PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PHOSPHORYLATION; PROTEIN CONFORMATION; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRYPTOPHAN; TYROSINE;

EID: 0031766635     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/2965     Document Type: Article

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