High- and low-potency ligands with similar affinities for the TCR: The importance of kinetic in TCR signaling

Immunity

Volumn 9, Issue 6, 1998, Pages 817-826

  Kersh, Gilbert J ^a   Kersh, Ellen N ^a   Fremont, Daved H ^a   Allen, Paul M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; T LYMPHOCYTE RECEPTOR;

ARTICLE; BINDING AFFINITY; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0032438551     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80647-0     Document Type: Article

References (37)

1. Alam, S.M., Travers, P.J., Wung, J.L., Nasholds, W., Redpath, S., Jameson, S.C., and Gascoigne, N.R.J. (1996). T-cell-receptor affinity and thymocyte positive selection. Nature 381, 616-620.
2. Ashton-Rickardt, P.G., Bandeira, A., Delaney, J.R., Van Kaer, L., Pircher, H.-P., Zinkernagel, R.M., and Tonegawa, S. (1994). Evidence for a differential avidity model of T cell selection in the thymus. Cell 76, 651-663.
3. Corr, M., Slantez, A.E., Boyd, L.F., Jelonek, M.T., Khilko, S., AlRamadi, B.K., Kim, Y.S., Maher, S.E., Bothwell, A.L.M., and Margulies, D.H. (1994). T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity. Science 265, 946-949.
4. Daniel, C., Horvath, S., and Allen, P.M. (1998). A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR. Immunity 8, 543-552.
5. Evavold, B.D., Williams, S.G., Hsu, B.L., Buus, S., and Allen, P.M. (1992). Complete dissection of the Hb(64-76) determinant using Th1, Th2 clones, and T cell hybridomas. J. Immunol. 148, 347-353.
6. Fremont, D.H., Hendrickson, W.A., Marrack, P., and Kappler, J. (1996). Structures of an MHC class II molecule with covalently bound single peptides. Science 272, 1001-1004.
7. Garboczi, D.N., Ghosh, P., Utz, U., Fan, Q.R., Biddison, W.E., and Wiley, D.C. (1996). Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134-141.
8. Garcia, K.C., Degano, M., Stanfield, R.L., Brunmark, A., Jackson, M.R., Peterson, P.A., Teyton, L., and Wilson, I.A. (1996). An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science 274, 209-219.
9. Gavin, M.A., Dere, B., Grandea, A.G., III, Hogquist, K.A., and Bevan, M.J. (1994). Major histocompatibility complex class I allele-specific peptide libraries: identification of peptides that mimic an H-Y T cell epitope. Eur. J. Immunol. 24, 2124-2133.
10. Hampl, J., Chien, Y.-H., and Davis, M.M. (1997). CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7, 379-385.
11. + CTL clones is determined by the frequency of serial TCR engagement. J. Immunol. 161, 553-562.
12. Janeway, C.A., Jr. (1992). The T cell receptor as a multicomponent signaling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10, 645-674.
13. Kappler, J., White, J., Kozono, H., Clements, J., and Marrack, P. (1994). Binding of a soluble αβ T-cell receptor to superantigen/major histocompatibility complex ligands. Proc. Natl. Acad. Sci. USA 91, 8462-8466.
14. Kersh, G.J., and Allen, P.M. (1996a). Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184, 1259-1268.
15. Kersh, G.J., and Allen, P.M. (1996b). Essential flexibility in the T-cell recognition of antigen. Nature 222, 495-498.
16. Kersh, E.N., Shaw, A.S., and Allen, P.M. (1998a). Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281, 572-575.
17. Kersh, G.J., Donermeyer, D.L., Frederick, K.E., White, J.M., Hsu, B.L., and Allen, P.M. (1998b). TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand. J. Immunol. 161, 585-593.
18. Koyasu, S., McConkey, D.J., Clayton, L.K., Abraham, S., Yandava, B., Katagiri, T., Moingeon, P., Yamamoto, T., and Reinherz, E.L. (1992). Phosphorylation of multiple CD3ζ tyrosine residues leads to formation of pp21 in vitro and in vivo. J. Biol. Chem. 267, 3375-3381.
19. Kozono, H., White, J., Clements, J., Marrack, P., and Kappler, J. (1994). Production of soluble MHC class II proteins with covalently bound single peptides. Nature 369, 151-154.
20. Lesage, S., Charron, J., Winslow, G., and Hugo, P. (1997). Induction of thymocyte deletion by purified single peptide/major histocompatibility complex ligands. J. Immunol. 159, 2078-2081.
21. Liu, C.-P., Crawford, F., Marrack, P., and Kappler, J. (1998). T cell postitive selection by a high density, low affinity ligand. Proc. Natl. Acad. Sci. USA 95, 4522-4526.
22. Lyons, D.S., Lieberman, S.A., Hampl, J., Boniface, J.J., Chien, Y.-H., Berg, L.J., and Davis, M.M. (1996). ATCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5, 53-61.
23. Madrenas, J., Wange, R.L., Wang, J.L., Isakov, N., Samelson, L.E., and Germain, R.N. (1995). ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267, 515-518.
24. Madrenas, J., Chau, L.A., Smith, J., Bluestone, J.A., and Germain, R.N. (1997). The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185, 219-229.
25. Manning, T.C., Schlueter, C.J., Brodnicki, T.C., Parke, E.A., Speir, J.A., Garcia, K.C., Teyton, L., Wilson, I.A., and Kranz, D.M. (1998). Alanine scanning mutagenesis of an αβ T cell receptor: mapping the energy of antigen recognition. Immunity 8, 413-425.
26. k complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 91, 12862-12866.
27. McKeithan, T.W. (1995). Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92, 5042-5046.
28. Rabinowitz, J.D., Beeson, C., Lyons, D.S., Davis, M.M., and McConnell, H.M. (1996). Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA 93, 1401-1405.
29. Samelson, L.E., Harford, J.B., and Klausner, R.D. (1985). Identification of the components of the murine T cell antigen receptor complex. Cell 43, 223-231.
30. Samelson, L.E., Patel, M.D., Weissman, A.M., Harford, J.B., and Klausner, R.D. (1986). Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46, 1083-1090.
31. Schodin, B.A., Tsomides, T.J., and Kranz, D.M. (1996). Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity. Immunity 5, 137-146.
32. Sloan-Lancaster, J., and Allen, P.M. (1996). Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14, 1-27.
33. Sloan-Lancaster, J., Shaw, A.S., Rothbard, J.B., and Allen, P.M. (1994). Partial T cell signaling: altered phospho-ζ and lack of Zap 70 recruitment in APL-induced T cell anergy. Cell 79, 913-922.
34. + cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 92, 11990-11992.
35. Sykulev, Y., Vugmeyster, Y., Brunmark, A., Ploegh, H.L., and Eisen, H.N. (1998). Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity 9, 475-483.
36. Valitutti, S., Müller, S., Cella, M., Padovan, E., and Lanzavecchia, A. (1995). Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151.
37. van der Merwe, P.A., Barclay, N.A., Mason, D.W., Davies, E.A., Morgan, B.P., Tone, M., Krishnam, A.K.C., Ianelli, C., and Davis, S.J. (1994). Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59. Biochemistry 33, 10149-10160.