Natural prebiotic carbohydrates, carotenoids and flavonoids as ingredients in food systems

Current Opinion in Food Science

Volumn 33, Issue , 2020, Pages 98-107

  Neri Numa, Iramaia Angélica ^a   Arruda, Henrique Silvano ^a   Geraldi, Marina Vilar ^a   Maróstica Júnior, Mário Roberto ^a   Pastore, Glaucia Maria ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85083294725     PISSN: 22147993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cofs.2020.03.004     Document Type: Review

References (81)

1. Cruz, R.M.S., Alves, V., Khmelinskii, I., Vieira, M.C., New food packaging systems. Grumezescu, A.M., Holban, A.M., (eds.) Food Packaging and Preservation, 2018, Academic Press, 63–85.
2. Chai, J., Jiang, P., Wang, P., Jiang, Y., Li, D., Bao, W., Liu, B., Liu, B., Zhao, L., Norde, W., et al. The intelligent delivery systems for bioactive compounds in foods: physicochemical and physiological conditions, absorption mechanisms, obstacles and responsive strategies. Trends Food Sci Technol 78 (2018), 144–154 This comprehensive review highlights how intelligent delivery systems can be applied to enhance bioavailability of bioactive compounds in food industry.
3. Petzold, G., Moreno, J., Gianelli, M.P., Cerda, F., Mella, K., Zúñiga, P., Orellana-Palma, P., Food technology approaches for improvement of organoleptic properties through preservation and enrichment of bioactive compounds. Grumezescu, A.M., Holban, A.M., (eds.) Food Processing for Increased Quality and Consumption, 2018, Academic Press, 67–92 In this book chapter, it is presented a summary of the industrial innovative technologies for preservation and/or enrichment of bioactive compounds in a food matrix.
4. Recharla, N., Riaz, M., Ko, S., Park, S., Novel technologies to enhance solubility of food-derived bioactive compounds: a review. J Funct Foods 39 (2017), 63–73.
5. Artiga-Artigas, M., Odriozola-Serrano, I., Oms-Oliu, G., Martín-Belloso, O., Nanostructured systems to increase bioavailability of food ingredients. Rubio, A.L., Rovira, M.J.F., Sanz, M.M., Gómez-Mascaraque, L.G., (eds.) Nanomaterials for Food Applications, 2019, Elsevier, 13–33.
6. Gibson, G.R., Hutkins, R., Sanders, M.E., Prescott, S.L., Reimer, R.A., Salminen, S.J., Scott, K., Stanton, C., Swanson, K.S., Cani, P.D., et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14 (2017), 491–502.
7. Scott, K.P., Grimaldi, R., Cunningham, M., Sarbini, S.R., Wijeyesekera, A., Tang, M.L.K., Lee, J.C.-Y., Yau, Y.F., Ansell, J., Theis, S., et al. Developments in understanding and applying prebiotics in research and practice-an ISAPP conference paper. J Appl Microbiol 128 (2019), 934–949.
8. Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S.J., Berenjian, A., Ghasemi, Y., Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods, 8, 2019, 92.
9. Arruda, H.S., Pereira, G.A., Almeida, M.E.F., Neri-Numa, I.A., Sancho, R.A.S., Molina, G., Pastore, G.M., Current knowledge and future perspectives of oligosaccharides research. Atta-ur-Rahman, F.R.S., (eds.) Frontiers in Natural Product Chemistry, vol 3, 2017, Bentham Science Publishers, 91–175 This book chapter describes several aspects from prebiotic carbohydrates, including chemical structure, physicochemical properties, sources, emerging trends in production, applications in science and technology and beneficial health effects.
10. Borewicz, K., Suarez-Diez, M., Hechler, C., Beijers, R., de Weerth, C., Arts, I., Penders, J., Thijs, C., Nauta, A., Lindner, C., et al. The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life. Sci Rep, 9, 2019, 2434 This research paper investigates the effect of infant formulas fortified with prebiotic carbohydrates (scGOS or scGOS/lcFOS (9:1)) on infant microbiota composition and dynamics in the first 12 weeks of life.
11. Mantzourani, I., Terpou, A., Bekatorou, A., Mallouchos, A., Alexopoulos, A., Kimbaris, A., Bezirtzoglou, E., Koutinas, A.A., Plessas, S., Functional pomegranate beverage production by fermentation with a novel synbiotic L. paracasei biocatalyst. Food Chem, 308, 2020, 125658.
12. Xavier dos Santos, D., Casazza, A.A., Aliakbarian, B., Bedani, R., Saad, S.M.I., Perego, P., Improved probiotic survival to in vitro gastrointestinal stress in a mousse containing Lactobacillus acidophilus La-5 microencapsulated with inulin by spray drying. LWT 99 (2019), 404–410.
13. Poletto, G., Raddatz, G.C., Cichoski, A.J., Zepka, L.Q., Lopes, E.J., Barin, J.S., Wagner, R., de Menezes, C.R., Study of viability and storage stability of Lactobacillus acidophillus when encapsulated with the prebiotics rice bran, inulin and Hi-maize. Food Hydrocoll 95 (2019), 238–244.
14. Liao, N., Luo, B., Gao, J., Li, X., Zhao, Z., Zhang, Y., Ni, Y., Tian, F., Oligosaccharides as co-encapsulating agents: effect on oral Lactobacillus fermentum survival in a simulated gastrointestinal tract. Biotechnol Lett 41 (2019), 263–272 This research paper evaluates the impact of four kinds of prebiotic carbohydrates (GOS, FOS, XOS and IMOS) as co-encapsulating agents on microencapsulation efficiency and protection of Lactobacillus fermentum L7 against exposure to simulated gastric and intestinal juices as well as long-term refrigeration storage.
15. Wang, Y., Zheng, Z., Wang, K., Tang, C., Liu, Y., Li, J., Prebiotic carbohydrates: effect on physicochemical stability and solubility of algal oil nanoparticles. Carbohydr Polym, 228, 2020, 115372.
16. Rios-Mera, J.D., Saldaña, E., Ramírez, Y., Auquiñivín, E.A., Alvim, I.D., Contreras-Castillo, C.J., Encapsulation optimization and pH- and temperature-stability of the complex coacervation between soy protein isolate and inulin entrapping fish oil. LWT, 116, 2019, 108555.
17. Korma, S.A., Wei, W., Ali, A.H., Abed, S.M., Zheng, L., Jin, Q., Wang, X., Spray-dried novel structured lipids enriched with medium-and long-chain triacylglycerols encapsulated with different wall materials: characterization and stability. Food Res Int 116 (2019), 538–547.
18. Gomes, S., Finotelli, P.V., Sardela, V.F., Pereira, H.M.G., Santelli, R.E., Freire, A.S., Torres, A.G., Microencapsulated Brazil nut (Bertholletia excelsa) cake extract powder as an added-value functional food ingredient. LWT, 116, 2019, 108495.
19. Guimarães, J.T., Silva, E.K., Arruda, H.S., Freitas, M.Q., Pastore, G.M., Meireles, M.A.A., Cruz, A.G., How does the degree of inulin polymerization affect the bioaccessibility of bioactive compounds from soursop whey beverage during in vitro gastrointestinal digestion?. Food Hydrocoll, 101, 2020, 105511.
20. Ozturkoglu-Budak, S., Akal, H.C., Buran, İ., Yetişemiyen, A., Effect of inulin polymerization degree on various properties of synbiotic fermented milk including Lactobacillus acidophilus La-5 and Bifidobacterium animalis Bb-12. J Dairy Sci 102 (2019), 6901–6913.
21. Li, Y., Shabani, K.I., Qin, X., Yang, R., Jin, X., Ma, X., Liu, X., Effects of cross-linked inulin with different polymerisation degrees on physicochemical and sensory properties of set-style yoghurt. Int Dairy J 94 (2019), 46–52.
22. Sarwar, A., Aziz, T., Al-Dalali, S., Zhao, X., Zhang, J., ud Din, J., Chen, C., Cao, Y., Yang, Z., Physicochemical and microbiological properties of synbiotic yogurt made with probiotic yeast Saccharomyces boulardii in combination with inulin. Foods, 8, 2019, 468.
23. Langa, S., van den Bulck, E., Peirotén, A., Gaya, P., Schols, H.A., Arqués, J.L., Application of lactobacilli and prebiotic oligosaccharides for the development of a synbiotic semi-hard cheese. LWT, 114, 2019, 108361.
24. Codină, G.G., Dabija, A., Stroe, S.G., Ropciuc, S., Optimization of iron–oligofructose formulation on wheat flour dough rheological properties. J Food Process Preserv, 43, 2019, e13857.
25. Codină, G.G., Ropciuc, S., Dabija, A., Optimization of calcium–magnesium–inulin formulation on wheat flour dough rheological properties. J Food Process Eng, 42, 2019, e13219.
26. Alizadeh, A., Oskuyi, A.S., Amjadi, S., The optimization of prebiotic sucrose-free mango nectar by response surface methodology: the effect of stevia and inulin on physicochemical and rheological properties. Food Sci Technol Int 25 (2019), 243–251.
27. Mohebbi, Z., Azizi-Lalabadi, M., Hosseini, S.J., Abdi Nowrouzani, S., Alizadeh, M., Homayouni, A., The effects of prebiotic bread containing oat β-glucan and resistant starch on the glycemic index and glycemic load in healthy individuals. Nutr Food Sci 49 (2019), 1029–1038.
28. Costa, M.F., Pimentel, T.C., Guimaraes, J.T., Balthazar, C.F., Rocha, R.S., Cavalcanti, R.N., Esmerino, E.A., Freitas, M.Q., Raices, R.S.L., Silva, M.C., et al. Impact of prebiotics on the rheological characteristics and volatile compounds of Greek yogurt. LWT 105 (2019), 371–376.
29. Souza, F.P., Balthazar, C.F., Guimarães, J.T., Pimentel, T.C., Esmerino, E.A., Freitas, M.Q., Raices, R.S.L., Silva, M.C., Cruz, A.G., The addition of xyloligoosaccharide in strawberry-flavored whey beverage. LWT 109 (2019), 118–122.
30. López-Castejón, M.L., Bengoechea, C., Espinosa, S., Carrera, C., Characterization of prebiotic emulsions stabilized by inulin and β-lactoglobulin. Food Hydrocoll 87 (2019), 382–393 This research paper studies the effect of inulin concentration on the physical stability of the food emulsions. The mechanisms of stabilization are also described.
31. Bis-Souza, C.V., Pateiro, M., Domínguez, R., Lorenzo, J.M., Penna, A.L.B., da Silva Barretto, A.C., Volatile profile of fermented sausages with commercial probiotic strains and fructooligosaccharides. J Food Sci Technol 56 (2019), 5465–5473.
32. Glisic, M., Baltic, M., Glisic, M., Trbovic, D., Jokanovic, M., Parunovic, N., Dimitrijevic, M., Suvajdzic, B., Boskovic, M., Vasilev, D., Inulin-based emulsion-filled gel as a fat replacer in prebiotic- and PUFA-enriched dry fermented sausages. Int J Food Sci Technol 54 (2019), 787–797.
33. Xu, J., Xia, R., Yuan, T., Sun, R., Use of xylooligosaccharides (XOS) in hemicelluloses/chitosan-based films reinforced by cellulose nanofiber: effect on physicochemical properties. Food Chem, 298, 2019, 125041.
34. Bersaneti, G.T., Garcia, S., Mali, S., Pedrine Colabone Celligoi, M.A., Evaluation of the prebiotic activities of edible starch films with the addition of nystose from Bacillus subtilis natto. LWT, 116, 2019, 108502.
35. Fernández, J., Ledesma, E., Monte, J., Millán, E., Costa, P., de la Fuente, V.G., García, M.T.F., Martínez-Camblor, P., Villar, C.J., Lombó, F., Traditional processed meat products re-designed towards inulin-rich functional foods reduce polyps in two colorectal cancer animal models. Sci Rep, 9, 2019, 14783.
36. Pérez-Burillo, S., Mehta, T., Pastoriza, S., Kramer, D.L., Paliy, O., Rufián-Henares, J.Á, Potential probiotic salami with dietary fiber modulates antioxidant capacity, short chain fatty acid production and gut microbiota community structure. LWT 105 (2019), 355–362.
37. Krithika, B., Preetha, R., Formulation of protein based inulin incorporated synbiotic nanoemulsion for enhanced stability of probiotic. Mater Res Express, 6, 2019, 114003.
38. Sevim, S., Topal, G.G., Tengilimoglu-Metin, M.M., Sancak, B., Kizil, M., Effects of inulin and lactic acid bacteria strains on aflatoxin M1 detoxification in yoghurt. Food Control 100 (2019), 235–239.
39. Rodriguez-Amaya, D.B., Update on natural food pigments - a mini-review on carotenoids, anthocyanins, and betalains. Food Res Int 124 (2019), 200–205.
40. Rodriguez-Concepcion, M., Avalos, J., Bonet, M.L., Boronat, A., Gomez-Gomez, L., Hornero-Mendez, D., Limon, M.C., Meléndez-Martínez, A.J., Olmedilla-Alonso, B., Palou, A., et al. A global perspective on carotenoids: metabolism, biotechnology, and benefits for nutrition and health. Prog Lipid Res 70 (2018), 62–93.
41. Tan, B.L., Norhaizan, M.E., Carotenoids: how effective are they to prevent age-related diseases?. Molecules, 24, 2019, 1801.
42. Wurtzel, E.T., Changing form and function through carotenoids and synthetic biology. Plant Physiol 179 (2019), 830–843.
43. Liang, M.-H., Zhu, J., Jiang, J.-G., Carotenoids biosynthesis and cleavage related genes from bacteria to plants. Crit Rev Food Sci Nutr 58 (2018), 2314–2333.
44. von Lintig, J., Babino, D., Vitamin A and other carotenoids. De, Caterina R., Martinez, J.A., Kohlmeier, M., (eds.) Principles of Nutrigenetics and Nutrigenomics, 2020, Academic Press, 237–244.
45. Khalid, M., Saeed-ur-Rahman, Bilal, M., Iqbal, H.M.N., Huang, D., Biosynthesis and biomedical perspectives of carotenoids with special reference to human health-related applications. Biocatal Agric Biotechnol 17 (2019), 399–407.
46. Bohn, T., Carotenoids and markers of oxidative stress in human observational studies and intervention trials: implications for chronic diseases. Antioxidants, 8, 2019, 179.
47. Li, Z., Zhang, T., Jia, D., Sun, W., Wang, C., Gu, A., Yang, X., Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling. Oncol Lett 15 (2018), 2619–2624.
48. Goupy, P., Genot, C., Hammaz, F., Halimi, C., Caris-Veyrat, C., Borel, P., Mechanisms governing the transfer of pure and plant matrix carotenoids toward emulsified triglycerides. Mol Nutr Food Res, 2020, 1900911.
49. Huang, J.J., Lin, S., Xu, W., Cheung, P.C.K., Occurrence and biosynthesis of carotenoids in phytoplankton. Biotechnol Adv 35 (2017), 597–618.
50. dos Santos, P.P., Andrade, L.de A., Flôres, S.H., Rios, A.de O., Nanoencapsulation of carotenoids: a focus on different delivery systems and evaluation parameters. J Food Sci Technol 55 (2018), 3851–3860 This review provides an overview of the carotenoids delivery systems and the techniques currently used to assess the efficacy of these compounds in the food, cosmetic and pharmaceutical fields.
51. Xavier, A.A.O., Mercadante, A.Z., The bioaccessibility of carotenoids impacts the design of functional foods. Curr Opin Food Sci 26 (2019), 1–8.
52. Fu, D., Deng, S., McClements, D.J., Zhou, L., Zou, L., Yi, J., Liu, C., Liu, W., Encapsulation of β-carotene in wheat gluten nanoparticle-xanthan gum-stabilized Pickering emulsions: enhancement of carotenoid stability and bioaccessibility. Food Hydrocoll 89 (2019), 80–89.
53. Ursache, F.M., Andronoiu, D.G., Ghinea, I.O., Barbu, V., Ioniţă, E., Cotârleţ, M., Dumitraşcu, L., Botez, E., Râpeanu, G., Stănciuc, N., Valorizations of carotenoids from sea buckthorn extract by microencapsulation and formulation of value-added food products. J Food Eng 219 (2018), 16–24.
54. Cardoso, L.A.C., Karp, S.G., Vendruscolo, F., Kanno, K.Y.F., Zoz, L.I.C., Carvalho, J.C., Biotechnological production of carotenoids and their applications in food and pharmaceutical products. Cvetkovic, D.J., (eds.) Carotenoids, 2017, IntechOpen, Nikolic GS, 125–141.
55. Selig, M.J., Mehrad, B., Zamani, H., Kierulf, A., Licker, J., Abbaspourrad, A., Distribution of oil solubilized β-carotene in stabilized locust bean gum powders for the delivery of orange colorant to food products. Food Hydrocoll 84 (2018), 34–37.
56. Sobral, D., Bueno Costa, R.G., Machado, G.M., Jacinto de Paula, J.C., Martins Teodoro, V.A., Nunes, N.M., dos Santos Pires, A.C., Pinto, M.S., Can lutein replace annatto in the manufacture of Prato cheese?. LWT - Food Sci Technol 68 (2016), 349–355.
57. Díaz-Gómez, J., Moreno, J.A., Angulo, E., Sandmann, G., Zhu, C., Ramos, A.J., Capell, T., Christou, P., Nogareda, C., High-carotenoid biofortified maize is an alternative to color additives in poultry feed. Anim Feed Sci Technol 231 (2017), 38–46.
58. Ao, X., Kim, I.H., Effects of astaxanthin produced by Phaffia rhodozyma on growth performance, antioxidant activities, and meat quality in Pekin ducks. Poult Sci 98 (2019), 4954–4960.
59. Moreno, J.A., Díaz-Gómez, J., Fuentes-Font, L., Angulo, E., Gosálvez, L.F., Sandmann, G., Portero-Otin, M., Capell, T., Zhu, C., Christou, P., et al. Poultry diets containing (keto)carotenoid-enriched maize improve egg yolk color and maintain quality. Anim Feed Sci Technol, 260, 2020, 114334.
60. Carballo, D.E., Giráldez, F.J., Andrés, S., Caro, I., Fernández-Gutiérrez, M., Mateo, J., Effects of dietary astaxanthin supplementation on the oxidative stability of meat from suckling lambs fed a commercial milk-replacer containing butylated hydroxytoluene. Meat Sci 156 (2019), 68–74.
61. Pal, S., Bhattacharjee, P., Lutein-fortified potato soup and freeze-dried lutein powder designed with supercritical carbon dioxide extract of yellow corn kernels are promising nutraceutical foods. J Food Process Preserv, 43, 2019, e14005.
62. Pinheiro Bruni, G., de Oliveira, J.P., Gómez-Mascaraque, L.G., Fabra, M.J., Guimarães Martins, V., Zavareze E da, R., López-Rubio, A., Electrospun β-carotene–loaded SPI:PVA fiber mats produced by emulsion-electrospinning as bioactive coatings for food packaging. Food Packag Shelf Life, 23, 2020, 100426.
63. Stoll, L., Rech, R., Flôres, S.H., Nachtigall, S.M.B., de Oliveira Rios, A., Poly(acid lactic) films with carotenoids extracts: release study and effect on sunflower oil preservation. Food Chem 281 (2019), 213–221.
64. Martins, A.J., Cerqueira, M.A., Cunha, R.L., Vicente, A.A., Fortified beeswax oleogels: effect of β-carotene on the gel structure and oxidative stability. Food Funct 8 (2017), 4241–4250.
65. Chen, L., Teng, H., Xie, Z., Cao, H., Cheang, W.S., Skalicka-Woniak, K., Georgiev, M.I., Xiao, J., Modifications of dietary flavonoids towards improved bioactivity: an update on structure–activity relationship. Crit Rev Food Sci Nutr 58 (2018), 513–527.
66. He, B., Ge, J., Yue, P., Yue, X.Y., Fu, R., Liang, J., Gao, X., Loading of anthocyanins on chitosan nanoparticles influences anthocyanin degradation in gastrointestinal fluids and stability in a beverage. Food Chem 221 (2017), 1671–1677.
67. Khan, H., Jawad, M., Kamal, M.A., Baldi, A., Xiao, J., Nabavi, S.M., Daglia, M., Evidence and prospective of plant derived flavonoids as antiplatelet agents: strong candidates to be drugs of future. Food Chem Toxicol 119 (2018), 355–367.
68. Xiao, J., Stability of dietary polyphenols: It's never too late to mend?. Food Chem Toxicol 119 (2018), 3–5.
69. González-Barrio, R., Borges, G., Mullen, W., Crozier, A., Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J Agric Food Chem 58 (2010), 3933–3939.
70. Liu, Y., Zhang, D., Wu, Y., Wang, D., Wei, Y., Wu, J., Ji, B., Stability and absorption of anthocyanins from blueberries subjected to a simulated digestion process. Int J Food Sci Nutr 65 (2014), 440–448.
71. Xiong, K., Zhou, L., Wang, J., Ma, A., Fang, D., Xiong, L., Sun, Q., Construction of food-grade pH-sensitive nanoparticles for delivering functional food ingredients. Trends Food Sci Technol 96 (2020), 102–113.
72. Hribar, U., Ulrih, N., The metabolism of anthocyanins. Curr Drug Metab 15 (2014), 3–13 This review provide an overview of the bioavailability, metabolic products, and transport processes of anthocyanins.
73. Bernardes, A.L., Moreira, J.A., Tostes M das, G.V., Costa, N.M.B., Silva, P.I., Costa, A.G.V., In vitro bioaccessibility of microencapsulated phenolic compounds of jussara (Euterpe edulis Martius) fruit and application in gelatine model-system. LWT 102 (2019), 173–180 This study demonstrated that anthocyanin-rich extracts can be a promising natural dye for the food industry. Moreover, it is described the effect of microencapsulation on colour and anthocyanins stability during storage and in vitro simulated gastrointestinal digestion.
74. Gómez-Mascaraque, L.G., Hernández-Rojas, M., Tarancón, P., Tenon, M., Feuillère, N., Vélez Ruiz, J.F., Fiszman, S., López-Rubio, A., Impact of microencapsulation within electrosprayed proteins on the formulation of green tea extract-enriched biscuits. LWT 81 (2017), 77–86.
75. Girard, A.L., Awika, J.M., Sorghum polyphenols and other bioactive components as functional and health promoting food ingredients. J Cereal Sci 84 (2018), 112–124.
76. Queiroz, V.A.V., da Silva Aguiar, A., de Menezes, C.B., de Carvalho, C.W.P., Paiva, C.L., Fonseca, P.C., da Conceição, R.R.P., A low calorie and nutritive sorghum powdered drink mix: influence of tannin on the sensorial and functional properties. J Cereal Sci 79 (2018), 43–49.
77. Souza, M.C., Santos, M.P., Sumere, B.R., Silva, L.C., Cunha, D.T., Martínez, J., Barbero, G.F., Rostagno, M.A., Isolation of gallic acid, caffeine and flavonols from black tea by on-line coupling of pressurized liquid extraction with an adsorbent for the production of functional bakery products. LWT, 117, 2020, 108661.
78. Świeca, M., Gawlik-Dziki, U., Dziki, D., Baraniak, B., Wheat bread enriched with green coffee – in vitro bioaccessibility and bioavailability of phenolics and antioxidant activity. Food Chem 221 (2017), 1451–1457.
79. Fang, J., Bioavailability of anthocyanins. Drug Metab Rev 46 (2014), 508–520.
80. Papillo, V.A., Locatelli, M., Travaglia, F., Bordiga, M., Garino, C., Arlorio, M., Coïsson, J.D., Spray-dried polyphenolic extract from Italian black rice (Oryza sativa L., var. Artemide) as new ingredient for bakery products. Food Chem 269 (2018), 603–609.
81. Montibeller, M.J., de Lima Monteiro, P., Tupuna-Yerovi, D.S., Rios A de, O., Manfroi, V., Stability assessment of anthocyanins obtained from skin grape applied in kefir and carbonated water as a natural colorant. J Food Process Preserv, 42, 2018, e13698.