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Volumn , Issue , 2017, Pages 145-185

Taxol® biosynthesis and production: From forests to fermenters

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EID: 85043673001     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-319-67903-7_7     Document Type: Chapter
Times cited : (51)

References (225)
  • 1
    • 0037256419 scopus 로고    scopus 로고
    • Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling
    • Abe H, Urao T, Ito T, Seki M, Shinozaki K, Yamaguchi-Shinozaki K. Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling. Plant Cell. 2003;15(1):63-78. https://doi.org/10.1105/tpc.006130.
    • (2003) Plant Cell. , vol.15 , Issue.1 , pp. 63-78
    • Abe, H.1    Urao, T.2    Ito, T.3    Seki, M.4    Shinozaki, K.5    Yamaguchi-Shinozaki, K.6
  • 5
    • 85127687495 scopus 로고
    • Taxol: clinical results and current issues in development
    • In: Suffness M, editor. Boca Raton: CRC Press
    • Arbuck SG, Blaylock BA. Taxol: clinical results and current issues in development. In: Suffness M, editor. Taxol: science and applications. Boca Raton: CRC Press; 1995. p. 379.
    • (1995) Taxol: science and applications , pp. 379
    • Arbuck, S.G.1    Blaylock, B.A.2
  • 6
    • 0032790361 scopus 로고    scopus 로고
    • A new semisynthesis of paclitaxel from baccatin III
    • Baloglu E, Kingston DG. A new semisynthesis of paclitaxel from baccatin III. J Nat Prod. 1999;62(7):1068-71. https://doi.org/10.1021/np990040k.
    • (1999) J Nat Prod. , vol.62 , Issue.7 , pp. 1068-1071
    • Baloglu, E.1    Kingston, D.G.2
  • 7
    • 79953800166 scopus 로고    scopus 로고
    • Recent advances in plant transformation. Plant chromosome engineering: methods and protocols
    • Barampuram S, Zhang ZJ. Recent advances in plant transformation. In: Plant chromosome engineering: methods and protocols. Methods Mol Biol. 2011;701:1-35. https://doi. org/10.1007/978-1-61737-957-4_1.
    • (2011) Methods Mol Biol. , vol.701 , pp. 1-35
    • Barampuram, S.1    Zhang, Z.J.2
  • 8
    • 0025994649 scopus 로고
    • Expression and enzymatic-activity of recombinant cytochrome-P450 17-alpha-hydroxylase in Escherichia coli
    • Barnes HJ, Arlotto MP, Waterman MR. Expression and enzymatic-activity of recombinant cytochrome-P450 17-alpha-hydroxylase in Escherichia coli. P Natl Acad Sci USA. 1991;88(13):5597-601. https://doi.org/10.1073/pnas.88.13.5597.
    • (1991) P Natl Acad Sci USA. , vol.88 , Issue.13 , pp. 5597-5601
    • Barnes, H.J.1    Arlotto, M.P.2    Waterman, M.R.3
  • 9
    • 0003765809 scopus 로고
    • Morphologie und Physiologie der Pilze, Flechten, und Myxomyceten. Vol. 2
    • Engelmann W, Leipzig
    • Barry DA. Morphologie und Physiologie der Pilze, Flechten, und Myxomyceten. Vol. 2. In: Hofmeister's Handbook of Physiological Botany. Engelmann W, Leipzig; 1866.
    • (1866) Hofmeister's Handbook of Physiological Botany
    • Barry, D.A.1
  • 10
    • 84966417264 scopus 로고    scopus 로고
    • Accessing low-oxidation state taxanes: is taxadiene-4 (5)-epoxide on the taxol biosynthetic pathway?
    • Barton NA, Marsh BJ, Lewis W, Narraidoo N, Seymour GB, Fray R, Hayes CJ. Accessing low-oxidation state taxanes: is taxadiene-4 (5)-epoxide on the taxol biosynthetic pathway? Chem Sci. 2016;7(5):3102-7. https://doi.org/10.1039/C5SC03463A.
    • (2016) Chem Sci. , vol.7 , Issue.5 , pp. 3102-3107
    • Barton, N.A.1    Marsh, B.J.2    Lewis, W.3    Narraidoo, N.4    Seymour, G.B.5    Fray, R.6    Hayes, C.J.7
  • 11
    • 16344367973 scopus 로고    scopus 로고
    • Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata
    • Bentebibel S, Moyano E, Palazon J, Cusido RM, Bonfill M, Eibl R, Pinol MT. Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata. Biotechnol Bioeng. 2005;89(6):647-55. https://doi.org/10.1002/bit.20321.
    • (2005) Biotechnol Bioeng. , vol.89 , Issue.6 , pp. 647-655
    • Bentebibel, S.1    Moyano, E.2    Palazon, J.3    Cusido, R.M.4    Bonfill, M.5    Eibl, R.6    Pinol, M.T.7
  • 12
    • 6444235290 scopus 로고    scopus 로고
    • Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of taxol
    • Besumbes O, Sauret-Gueto S, Phillips MA, Imperial S, Rodriguez-Concepcion M, Boronat A. Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of taxol. Biotechnol Bioeng. 2004;88(2):168-75. https://doi.org/10.1002/bit.20237.
    • (2004) Biotechnol Bioeng. , vol.88 , Issue.2 , pp. 168-175
    • Besumbes, O.1    Sauret-Gueto, S.2    Phillips, M.A.3    Imperial, S.4    Rodriguez-Concepcion, M.5    Boronat, A.6
  • 13
    • 84962250132 scopus 로고    scopus 로고
    • Overcoming heterologous protein interdependency to optimize P450-mediated taxol precursor synthesis in Escherichia coli
    • Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK. Overcoming heterologous protein interdependency to optimize P450-mediated taxol precursor synthesis in Escherichia coli. P Natl Acad Sci USA. 2016;113(12):3209-14. https:// doi.org/10.1073/pnas.1515826113.
    • (2016) P Natl Acad Sci USA. , vol.113 , Issue.12 , pp. 3209-3214
    • Biggs, B.W.1    Lim, C.G.2    Sagliani, K.3    Shankar, S.4    Stephanopoulos, G.5    De Mey, M.6    Ajikumar, P.K.7
  • 15
    • 0002502917 scopus 로고
    • Recent progress in the synthesis of taxanes
    • Boa A, Jenkins P, Lawrence N. Recent progress in the synthesis of taxanes. Contemp Org Synth. 1994;1(1):47-75. https://doi.org/10.1039/CO9940100047.
    • (1994) Contemp Org Synth. , vol.1 , Issue.1 , pp. 47-75
    • Boa, A.1    Jenkins, P.2    Lawrence, N.3
  • 16
    • 70350734276 scopus 로고    scopus 로고
    • Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria
    • Bomke C, Tudzynski B. Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria. Phytochemistry. 2009;70(15-16):1876-93. https://doi.org/10.1016/j.phytochem.2009.05.020.
    • (2009) Phytochemistry. , vol.70 , Issue.15-16 , pp. 1876-1893
    • Bomke, C.1    Tudzynski, B.2
  • 17
    • 33845744840 scopus 로고    scopus 로고
    • Manipulation by culture mixing and elicitation of paclitaxel and baccatin III production in Taxus baccata suspension cultures
    • Bonfill M, Exposito O, Moyano E, Cusido RM, Palazon J, Pinol MT. Manipulation by culture mixing and elicitation of paclitaxel and baccatin III production in Taxus baccata suspension cultures. Vitro Cell Dev-Pl. 2006;42(5):422-6. https://doi.org/10.1079/Ivp2006761.
    • (2006) Vitro Cell Dev-Pl. , vol.42 , Issue.5 , pp. 422-426
    • Bonfill, M.1    Exposito, O.2    Moyano, E.3    Cusido, R.M.4    Palazon, J.5    Pinol, M.T.6
  • 18
    • 36448982128 scopus 로고    scopus 로고
    • Paclitaxel and baccatin III production induced by methyl jasmonate in free and immobilized cells of Taxus baccata
    • Bonfill M, Bentebibel S, Moyano E, Palazon J, Cusido RM, Eibl R, Pinol MT. Paclitaxel and baccatin III production induced by methyl jasmonate in free and immobilized cells of Taxus baccata. Biol Plant. 2007;51(4):647-52. https://doi.org/10.1007/s10535-007-0137-2.
    • (2007) Biol Plant. , vol.51 , Issue.4 , pp. 647-652
    • Bonfill, M.1    Bentebibel, S.2    Moyano, E.3    Palazon, J.4    Cusido, R.M.5    Eibl, R.6    Pinol, M.T.7
  • 20
    • 0022412949 scopus 로고
    • The potential role of immobilization in plant-cell biotechnology
    • Brodelius P. The potential role of immobilization in plant-cell biotechnology. Trends Biotechnol. 1985;3(11):280-5. https://doi.org/10.1016/0167-7799(85)90003-4.
    • (1985) Trends Biotechnol. , vol.3 , Issue.11 , pp. 280-285
    • Brodelius, P.1
  • 21
    • 0000442819 scopus 로고
    • Permeabilization of plant-cells for release of intracellularly stored products -viability studies
    • Brodelius P. Permeabilization of plant-cells for release of intracellularly stored products -viability studies. Appl Microbiol Biotechnol. 1988;27(5-6):561-6. https://doi.org/10.1007/ BF00451632.
    • (1988) Appl Microbiol Biotechnol. , vol.27 , Issue.5-6 , pp. 561-566
    • Brodelius, P.1
  • 22
    • 7944223010 scopus 로고    scopus 로고
    • Selection of callus cultures of Taxus baccata L. as a potential source of paclitaxel production
    • Brunáková K, Babincova Z, Cellárová E. Selection of callus cultures of Taxus baccata L. as a potential source of paclitaxel production. Eng Life Sci. 2004;4(5):465-9. https://doi. org/10.1002/elsc.200420050.
    • (2004) Eng Life Sci. , vol.4 , Issue.5 , pp. 465-469
    • Brunáková, K.1    Babincova, Z.2    Cellárová, E.3
  • 23
    • 84856972328 scopus 로고    scopus 로고
    • Exudation: an expanding technique for continuous production and release of secondary metabolites from plant cell suspension and hairy root cultures
    • Cai Z, Kastell A, Knorr D, Smetanska I. Exudation: an expanding technique for continuous production and release of secondary metabolites from plant cell suspension and hairy root cultures. Plant Cell Rep. 2012;31(3):461-77. https://doi.org/10.1007/s00299-011-1165-0.
    • (2012) Plant Cell Rep. , vol.31 , Issue.3 , pp. 461-477
    • Cai, Z.1    Kastell, A.2    Knorr, D.3    Smetanska, I.4
  • 24
    • 85043672466 scopus 로고    scopus 로고
    • Celgene 2016 Annual Report
    • Celgene Corporation. Celgene 2016 Annual Report. 2016. Retrieved from http://files.shareholder. com/downloads/AMDA-262QUJ/4420895141x0x939757/E2F8A415-6D24-4387-9CEA-D0620358E8E1/Celgene_2016_Annual_Report.pdf
    • (2016)
  • 25
    • 33751120932 scopus 로고    scopus 로고
    • Production of isoprenoid pharmaceuticals by engineered microbes
    • Chang MC, Keasling JD. Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol. 2006;2(12):674-81. https://doi.org/10.1038/nchembio836.
    • (2006) Nat Chem Biol. , vol.2 , Issue.12 , pp. 674-681
    • Chang, M.C.1    Keasling, J.D.2
  • 26
    • 34247182988 scopus 로고    scopus 로고
    • Engineering Escherichia coli for production of functionalized terpenoids using plant P450s
    • Chang MCY, Eachus RA, Trieu W, Ro DK, Keasling JD. Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol. 2007;3(5):274-7. https://doi.org/10.1038/nchembio875.
    • (2007) Nat Chem Biol. , vol.3 , Issue.5 , pp. 274-277
    • Chang, M.C.Y.1    Eachus, R.A.2    Trieu, W.3    Ro, D.K.4    Keasling, J.D.5
  • 27
    • 2642547256 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a cytochrome P450 taxoid 2 alpha-hydroxylase involved in taxol biosynthesis
    • Chau M, Croteau R. Molecular cloning and characterization of a cytochrome P450 taxoid 2 alpha-hydroxylase involved in taxol biosynthesis. Arch Biochem Biophys. 2004;427(1):48-57. https://doi.org/10.1016/j.abb.2004.04.016.
    • (2004) Arch Biochem Biophys. , vol.427 , Issue.1 , pp. 48-57
    • Chau, M.1    Croteau, R.2
  • 28
    • 2642550828 scopus 로고    scopus 로고
    • Taxol biosynthesis: molecular cloning and of a cytochrome p450 characterization taxoid 7 beta-hydroxylase
    • Chau M, Jennewein S, Walker K, Croteau R. Taxol biosynthesis: molecular cloning and of a cytochrome p450 characterization taxoid 7 beta-hydroxylase. Chem Biol. 2004;11(5):663-72. https://doi.org/10.1016/j.chembiol.2004.02.025.
    • (2004) Chem Biol. , vol.11 , Issue.5 , pp. 663-672
    • Chau, M.1    Jennewein, S.2    Walker, K.3    Croteau, R.4
  • 31
    • 33846339293 scopus 로고    scopus 로고
    • The ins and outs of cytochrome P450s
    • Cojocaru V, Winn PJ, Wade RC. The ins and outs of cytochrome P450s. Biochim Biophys Acta-Gen Subj. 2007;1770(3):390-401. https://doi.org/10.1016/j.bbagen.2006.07.005.
    • (2007) Biochim Biophys Acta-Gen Subj. , vol.1770 , Issue.3 , pp. 390-401
    • Cojocaru, V.1    Winn, P.J.2    Wade, R.C.3
  • 32
    • 84886382912 scopus 로고    scopus 로고
    • cDNA-AFLP-based transcript profiling for genome-wide expression analysis of jasmonate-treated plants and plant cultures
    • Colling J, Pollier J, Makunga NP, Goossens A cDNA-AFLP-based transcript profiling for genome-wide expression analysis of jasmonate-treated plants and plant cultures. Jasmonate Signal Methods Protocols. 2013; 287-303. doi:https://doi. org/10.1007/978-1-62703-414-2_23.
    • (2013) Jasmonate Signal Methods Protocols , pp. 287-303
    • Colling, J.1    Pollier, J.2    Makunga, N.P.3    Goossens, A.4
  • 33
    • 77954414058 scopus 로고    scopus 로고
    • Climate change effects on beneficial plant-microorganism interactions
    • Compant S, van der Heijden MGA, Sessitsch A. Climate change effects on beneficial plant-microorganism interactions. FEMS Microbiol Ecol. 2010;73(2):197-214. https:// doi.org/10. 1111/j.1574-6941.2010.00900.
    • (2010) FEMS Microbiol Ecol. , vol.73 , Issue.2 , pp. 197-214
    • Compant, S.1    van der Heijden, M.G.A.2    Sessitsch, A.3
  • 35
    • 0033618872 scopus 로고    scopus 로고
    • Production of taxol((R)) and baccatin III by a selected Taxus baccata callus line and its derived cell suspension culture
    • Cusido RM, Palazon J, Navia-Osorio A, Mallol A, Bonfill M, Morales C, Pinol MT. Production of taxol((R)) and baccatin III by a selected Taxus baccata callus line and its derived cell suspension culture. Plant Sci. 1999;146(2):101-7. https://doi.org/10.1016/ S0168-9452(99)00093-X.
    • (1999) Plant Sci. , vol.146 , Issue.2 , pp. 101-107
    • Cusido, R.M.1    Palazon, J.2    Navia-Osorio, A.3    Mallol, A.4    Bonfill, M.5    Morales, C.6    Pinol, M.T.7
  • 36
    • 33846469337 scopus 로고    scopus 로고
    • Source of isopentenyl diphosphate for taxol and baccatin III biosynthesis in cell cultures of Taxus baccata
    • Cusido RM, Palazon J, Bonfill M, Exposito O, Moyano E, Pinol MT. Source of isopentenyl diphosphate for taxol and baccatin III biosynthesis in cell cultures of Taxus baccata. Biochem Eng J. 2007;33(2):159-67. https://doi.org/10.1016/j.bej.2006.10.016.
    • (2007) Biochem Eng J. , vol.33 , Issue.2 , pp. 159-167
    • Cusido, R.M.1    Palazon, J.2    Bonfill, M.3    Exposito, O.4    Moyano, E.5    Pinol, M.T.6
  • 38
    • 84861889349 scopus 로고    scopus 로고
    • Transcriptional machineries in jasmonate-elicited plant secondary metabolism
    • De Geyter N, Gholami A, Goormachtig S, Goossens A. Transcriptional machineries in jasmonate-elicited plant secondary metabolism. Trends Plant Sci. 2012;17(6):349-59. https://doi.org/10.1016/j.tplants.2012.03.001.
    • (2012) Trends Plant Sci. , vol.17 , Issue.6 , pp. 349-359
    • De Geyter, N.1    Gholami, A.2    Goormachtig, S.3    Goossens, A.4
  • 40
    • 84878935096 scopus 로고    scopus 로고
    • Endophytes versus biotrophic and necrotrophic pathogens -are fungal lifestyles evolutionarily stable traits?
    • Delaye L, García-Guzmán G, Heil M. Endophytes versus biotrophic and necrotrophic pathogens -are fungal lifestyles evolutionarily stable traits? Fungal Divers. 2013;60(1):125-35. https://doi.org/10.1007/s13225-013-0240-y.
    • (2013) Fungal Divers. , vol.60 , Issue.1 , pp. 125-135
    • Delaye, L.1    García-Guzmán, G.2    Heil, M.3
  • 42
    • 0000748967 scopus 로고
    • Instability of indole alkaloid production in Catharanthus roseus cellsuspension cultures
    • Deusneumann B, Zenk MH. Instability of indole alkaloid production in Catharanthus roseus cellsuspension cultures. Planta Med. 1984;50(5):427-31. https://doi.org/10.1055/s-2007-969755.
    • (1984) Planta Med. , vol.50 , Issue.5 , pp. 427-431
    • Deusneumann, B.1    Zenk, M.H.2
  • 43
    • 84907822164 scopus 로고    scopus 로고
    • Biosynthesis of taxadiene in Saccharomyces cerevisiae: selection of geranylgeranyl diphosphate synthase directed by a computer-aided docking strategy
    • Ding MZ, Yan HF, Li LF, Zhai F, Shang LQ, Yin Z, Yuan YJ. Biosynthesis of taxadiene in Saccharomyces cerevisiae: selection of geranylgeranyl diphosphate synthase directed by a computer-aided docking strategy. PLoS One. 2014;9(10). https://doi.org/10.1371/journal. pone.0109348.
    • (2014) PLoS One. , vol.9 , Issue.10
    • Ding, M.Z.1    Yan, H.F.2    Li, L.F.3    Zhai, F.4    Shang, L.Q.5    Yin, Z.6    Yuan, Y.J.7
  • 44
    • 0029088428 scopus 로고
    • Strategies for the improvement of secondary metabolite production in plant cell cultures
    • Dornenburg H, Knorr D. Strategies for the improvement of secondary metabolite production in plant cell cultures. Enzym Microb Technol. 1995;17(8):674-84. https://doi. org/10.1016/0141-0229(94)00108-4.
    • (1995) Enzym Microb Technol. , vol.17 , Issue.8 , pp. 674-684
    • Dornenburg, H.1    Knorr, D.2
  • 45
    • 84959378627 scopus 로고    scopus 로고
    • Mechanistic insights into taxadiene epoxidation by taxadiene-5 alpha-hydroxylase
    • Edgar S, Zhou K, Qao KJ, King JR, Simpson JH, Stephanopoulos G. Mechanistic insights into taxadiene epoxidation by taxadiene-5 alpha-hydroxylase. ACS Chem Biol. 2016;11(2):460-9. https://doi.org/10.1021/acschembio.5b00767.
    • (2016) ACS Chem Biol. , vol.11 , Issue.2 , pp. 460-469
    • Edgar, S.1    Zhou, K.2    Qao, K.J.3    King, J.R.4    Simpson, J.H.5    Stephanopoulos, G.6
  • 46
    • 0030003383 scopus 로고    scopus 로고
    • Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin
    • Eisenreich W, Menhard B, Hylands PJ, Zenk MH, Bacher A. Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. P Natl Acad Sci USA. 1996;93(13):6431-6. https://doi.org/10.1073/pnas.93.13.6431.
    • (1996) P Natl Acad Sci USA. , vol.93 , Issue.13 , pp. 6431-6436
    • Eisenreich, W.1    Menhard, B.2    Hylands, P.J.3    Zenk, M.H.4    Bacher, A.5
  • 48
    • 0028190717 scopus 로고
    • Sensitivity of plant pathogenic fungi to taxane extracts from ornamental yews
    • Elmer W, Mattina M, MacEachern G. Sensitivity of plant pathogenic fungi to taxane extracts from ornamental yews. Phytopathology. 1994;84(10):1179-85. https://doi.org/10.1094/ Phyto-84-1179.
    • (1994) Phytopathology. , vol.84 , Issue.10 , pp. 1179-1185
    • Elmer, W.1    Mattina, M.2    MacEachern, G.3
  • 49
    • 44749083814 scopus 로고    scopus 로고
    • Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards taxol (Paclitaxel) production
    • Engels B, Dahm P, Jennewein S. Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards taxol (Paclitaxel) production. Metab Eng. 2008;10(3-4):201-6. https:// doi.org/10.1016/j.ymben.2008.03.001.
    • (2008) Metab Eng. , vol.10 , Issue.3-4 , pp. 201-206
    • Engels, B.1    Dahm, P.2    Jennewein, S.3
  • 50
    • 84873800970 scopus 로고    scopus 로고
    • Genome-scale engineering for systems and synthetic biology
    • Esvelt KM, Wang HH. Genome-scale engineering for systems and synthetic biology. Mol Syst Biol. 2013;9(1):641. https://doi.org/10.1038/msb.2012.66.
    • (2013) Mol Syst Biol. , vol.9 , Issue.1 , pp. 641
    • Esvelt, K.M.1    Wang, H.H.2
  • 51
    • 67349119921 scopus 로고    scopus 로고
    • Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures
    • Exposito O, Bonfill M, Onrubia M, Jane A, Moyano E, Cusido RM, Palazon J, Pinol MT. Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures. New Biotechnol. 2009;25(4):252-9. https://doi.org/10.1016/j.nbt.2008.11.001.
    • (2009) New Biotechnol. , vol.25 , Issue.4 , pp. 252-259
    • Exposito, O.1    Bonfill, M.2    Onrubia, M.3    Jane, A.4    Moyano, E.5    Cusido, R.M.6    Palazon, J.7    Pinol, M.T.8
  • 52
  • 53
    • 84896405585 scopus 로고    scopus 로고
    • Precision genetic modifications: a new era in molecular biology and crop improvement
    • Fichtner F, Castellanos RU, Ülker B. Precision genetic modifications: a new era in molecular biology and crop improvement. Planta. 2014;239(4):921-39. https://doi.org/10.1007/ s00425-014-2029-y.
    • (2014) Planta. , vol.239 , Issue.4 , pp. 921-939
    • Fichtner, F.1    Castellanos, R.U.2    Ülker, B.3
  • 55
    • 0027638752 scopus 로고
    • Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequencing, complementation and co-suppression
    • Fray RG, Grierson D. Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequencing, complementation and co-suppression. Plant Mol Biol. 1993;22(4):589-602. https://doi.org/10.1007/BF00047400.
    • (1993) Plant Mol Biol. , vol.22 , Issue.4 , pp. 589-602
    • Fray, R.G.1    Grierson, D.2
  • 56
    • 0034031131 scopus 로고    scopus 로고
    • Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression
    • Fujimoto SY, Ohta M, Usui A, Shinshi H, Ohme-Takagi M. Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. Plant Cell. 2000;12(3):393-404. https://doi.org/10.1105/tpc.12.3.393.
    • (2000) Plant Cell. , vol.12 , Issue.3 , pp. 393-404
    • Fujimoto, S.Y.1    Ohta, M.2    Usui, A.3    Shinshi, H.4    Ohme-Takagi, M.5
  • 57
    • 84919723245 scopus 로고    scopus 로고
    • Effects of polysaccharide elicitors on secondary metabolite production and antioxidant response in Hypericum perforatum L. shoot cultures
    • Gadzovska Simic S, Tusevski O, Maury S, Delaunay A, Joseph C, Hagège D. Effects of polysaccharide elicitors on secondary metabolite production and antioxidant response in Hypericum perforatum L. shoot cultures. ScientificWorldJ. 2014. https://doi.org/10.1155/2014/609649.
    • (2014) ScientificWorldJ
    • Gadzovska Simic, S.1    Tusevski, O.2    Maury, S.3    Delaunay, A.4    Joseph, C.5    Hagège, D.6
  • 58
    • 67650649429 scopus 로고    scopus 로고
    • Bioprocessing of plant cell cultures for mass production of targeted compounds
    • Georgiev MI, Weber J, Maciuk A. Bioprocessing of plant cell cultures for mass production of targeted compounds. Appl Microbiol Biotechnol. 2009;83(5):809-23. https://doi. org/10.1007/s00253-009-2049-x.
    • (2009) Appl Microbiol Biotechnol. , vol.83 , Issue.5 , pp. 809-823
    • Georgiev, M.I.1    Weber, J.2    Maciuk, A.3
  • 59
    • 0001472945 scopus 로고
    • Initiation and growth of cell lines of Taxus brevifolia (Pacific yew)
    • Gibson D, Ketchum R, Vance N, Christen A. Initiation and growth of cell lines of Taxus brevifolia (Pacific yew). Plant Cell Rep. 1993;12(9):479-82. https://doi.org/10.1007/BF00236091.
    • (1993) Plant Cell Rep. , vol.12 , Issue.9 , pp. 479-482
    • Gibson, D.1    Ketchum, R.2    Vance, N.3    Christen, A.4
  • 61
    • 84925134466 scopus 로고    scopus 로고
    • It is easy to get huge candidate gene lists for plant metabolism now, but how to get beyond?
    • Goossens A. It is easy to get huge candidate gene lists for plant metabolism now, but how to get beyond? Mol Plant. 2015;8(1):2-5. https://doi.org/10.1016/j.molp.2014.08.001.
    • (2015) Mol Plant. , vol.8 , Issue.1 , pp. 2-5
    • Goossens, A.1
  • 62
    • 84884376873 scopus 로고    scopus 로고
    • In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories
    • Gruchattka E, Hadicke O, Klamt S, Schutz V, Kayser O. In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories. Microb Cell Factories. 2013;12. https:// doi.org/10.1186/1475-2859-12-84.
    • (2013) Microb Cell Factories. , vol.12
    • Gruchattka, E.1    Hadicke, O.2    Klamt, S.3    Schutz, V.4    Kayser, O.5
  • 64
    • 0028217953 scopus 로고
    • Chemical and biological studies on taxol (Paclitaxel) and Taxotere (Docetaxel), new antineoplastic agents
    • Gueritte-Voegelein F, Guenard D, Dubois J, Wahl A, Potier P. Chemical and biological studies on taxol (Paclitaxel) and Taxotere (Docetaxel), new antineoplastic agents. J Pharm Belg. 1993;49(3):193-205.
    • (1993) J Pharm Belg. , vol.49 , Issue.3 , pp. 193-205
    • Gueritte-Voegelein, F.1    Guenard, D.2    Dubois, J.3    Wahl, A.4    Potier, P.5
  • 65
    • 84861303184 scopus 로고    scopus 로고
    • The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites
    • Guerra-Bubb J, Croteau R, Williams RM. The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites. Nat Prod Rep. 2012;29(6):683-96. https://doi.org/10.1039/c2np20021j.
    • (2012) Nat Prod Rep. , vol.29 , Issue.6 , pp. 683-696
    • Guerra-Bubb, J.1    Croteau, R.2    Williams, R.M.3
  • 67
    • 0000837640 scopus 로고
    • Intercellular and intercultural heterogeneity in secondary metabolite accumulation in cultures of Catharanthus roseus following cell-line selection
    • Hall RD, Yeoman MM. Intercellular and intercultural heterogeneity in secondary metabolite accumulation in cultures of Catharanthus roseus following cell-line selection. J Exp Bot. 1987;38(193):1391-8. https://doi.org/10.1093/jxb/38.8.1391.
    • (1987) J Exp Bot. , vol.38 , Issue.193 , pp. 1391-1398
    • Hall, R.D.1    Yeoman, M.M.2
  • 69
    • 85021901676 scopus 로고    scopus 로고
    • Taxol producing fungi
    • Springer
    • Hao X, Pan J, Zhu X. Taxol producing fungi. In: Natural products: Springer; 2013. p. 2797-812.
    • (2013) Natural products , pp. 2797-2812
    • Hao, X.1    Pan, J.2    Zhu, X.3
  • 70
    • 0032422236 scopus 로고    scopus 로고
    • Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol production
    • Hefner J, Ketchum REB, Croteau R. Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol production. Arch Biochem Biophys. 1998;360(1):62-74. https://doi.org/10.1006/abbi.1998.0926.
    • (1998) Arch Biochem Biophys. , vol.360 , Issue.1 , pp. 62-74
    • Hefner, J.1    Ketchum, R.E.B.2    Croteau, R.3
  • 71
    • 84878932326 scopus 로고    scopus 로고
    • Getting to the bottom of taxol biosynthesis by fungi
    • Heinig U, Scholz S, Jennewein S. Getting to the bottom of taxol biosynthesis by fungi. Fungal Divers. 2013;60(1):161-70. https://doi.org/10.1007/s13225-013-0228-7.
    • (2013) Fungal Divers. , vol.60 , Issue.1 , pp. 161-170
    • Heinig, U.1    Scholz, S.2    Jennewein, S.3
  • 73
    • 0031568221 scopus 로고    scopus 로고
    • Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures
    • Hezari M, Ketchum REB, Gibson DM, Croteau R. Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures. Arch Biochem Biophys. 1997;337(2):185-90. https://doi.org/10.1006/abbi.1996.9772.
    • (1997) Arch Biochem Biophys. , vol.337 , Issue.2 , pp. 185-190
    • Hezari, M.1    Ketchum, R.E.B.2    Gibson, D.M.3    Croteau, R.4
  • 74
    • 0032918558 scopus 로고    scopus 로고
    • Plant cis-acting regulatory DNA elements (PLACE) database: 1999
    • Higo K, Ugawa Y, Iwamoto M, Korenaga T. Plant cis-acting regulatory DNA elements (PLACE) database: 1999. Nucleic Acids Res. 1999;27(1):297-300.
    • (1999) Nucleic Acids Res. , vol.27 , Issue.1 , pp. 297-300
    • Higo, K.1    Ugawa, Y.2    Iwamoto, M.3    Korenaga, T.4
  • 75
    • 84920452257 scopus 로고    scopus 로고
    • Formal total synthesis of (-)-taxol through Pd-catalyzed eight-membered carbocyclic ring formation
    • Hirai S, Utsugi M, Iwamoto M, Nakada M. Formal total synthesis of (-)-taxol through Pd-catalyzed eight-membered carbocyclic ring formation. Chem Eur J. 2015;21(1):355-9. https://doi.org/10.1002/chem.201404295.
    • (2015) Chem Eur J. , vol.21 , Issue.1 , pp. 355-359
    • Hirai, S.1    Utsugi, M.2    Iwamoto, M.3    Nakada, M.4
  • 78
    • 85127651620 scopus 로고
    • Semisynthesis of taxol and taxotere
    • In: Suffness M, editor. Boca Raton: CRC Press
    • Holton R, Biediger RJ, Boatman PD. Semisynthesis of taxol and taxotere. In: Suffness M, editor. Taxol: science and applications, vol. 22. Boca Raton: CRC Press; 1995. p. 97-121.
    • (1995) Taxol: science and applications , vol.22 , pp. 97-121
    • Holton, R.1    Biediger, R.J.2    Boatman, P.D.3
  • 81
    • 0034838359 scopus 로고    scopus 로고
    • Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol
    • Huang QL, Roessner CA, Croteau R, Scott AI. Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol. Bioorg Med Chem. 2001;9(9):2237-42. https://doi.org/10.1016/S0968-0896(01)00072-4.
    • (2001) Bioorg Med Chem. , vol.9 , Issue.9 , pp. 2237-2242
    • Huang, Q.L.1    Roessner, C.A.2    Croteau, R.3    Scott, A.I.4
  • 85
    • 0035923612 scopus 로고    scopus 로고
    • Taxol biosynthesis: Taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase
    • Jennewein S, Rithner CD, Williams RM, Croteau RB. Taxol biosynthesis: Taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase. P Natl Acad Sci USA. 2001;98(24):13595-600. https://doi.org/10.1073/pnas.251539398.
    • (2001) P Natl Acad Sci USA. , vol.98 , Issue.24 , pp. 13595-13600
    • Jennewein, S.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.B.4
  • 86
    • 0242669969 scopus 로고    scopus 로고
    • Taxoid metabolism: Taxoid 14 beta-hydroxylase is a cytochrome P450-dependent monooxygenase
    • Jennewein S, Rithner CD, Williams RM, Croteau R. Taxoid metabolism: Taxoid 14 beta-hydroxylase is a cytochrome P450-dependent monooxygenase. Arch Biochem Biophys. 2003;413(2):262-70. https://doi.org/10.1016/S0003-9861(03)00090-0.
    • (2003) Arch Biochem Biophys. , vol.413 , Issue.2 , pp. 262-270
    • Jennewein, S.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.4
  • 87
    • 2642518854 scopus 로고    scopus 로고
    • Cytochrome P450 taxadiene 5 alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis
    • Jennewein S, Long RM, Williams RM, Croteau R. Cytochrome P450 taxadiene 5 alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem Biol. 2004;11(3):379-87. https://doi.org/10.1016/j. chembiol.2004.02.022.
    • (2004) Chem Biol. , vol.11 , Issue.3 , pp. 379-387
    • Jennewein, S.1    Long, R.M.2    Williams, R.M.3    Croteau, R.4
  • 88
    • 2942656782 scopus 로고    scopus 로고
    • Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in taxol biosynthesis
    • Jennewein S, Wildung MR, Chau M, Walker K, Croteau R. Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in taxol biosynthesis. P Natl Acad Sci USA. 2004;101(24):9149-54. https://doi.org/10.1073/pnas.0403009101.
    • (2004) P Natl Acad Sci USA. , vol.101 , Issue.24 , pp. 9149-9154
    • Jennewein, S.1    Wildung, M.R.2    Chau, M.3    Walker, K.4    Croteau, R.5
  • 89
    • 15944383707 scopus 로고    scopus 로고
    • Coexpression in yeast of Taxus cytochrome p450 reductase with cytochrorne P450 oxygenases involved in taxol biosynthesis
    • Jennewein S, Park H, DeJong JM, Long RM, Bollon AP, Croteau RB. Coexpression in yeast of Taxus cytochrome p450 reductase with cytochrorne P450 oxygenases involved in taxol biosynthesis. Biotechnol Bioeng. 2005;89(5):588-98. https://doi.org/10.1002/bit.20390.
    • (2005) Biotechnol Bioeng. , vol.89 , Issue.5 , pp. 588-598
    • Jennewein, S.1    Park, H.2    DeJong, J.M.3    Long, R.M.4    Bollon, A.P.5    Croteau, R.B.6
  • 90
    • 73649131594 scopus 로고    scopus 로고
    • Plant NADPH-cytochrome P450 oxidoreductases
    • Jensen K, Møller BL. Plant NADPH-cytochrome P450 oxidoreductases. Phytochemistry. 2010;71(2):132-41. https://doi.org/10.1016/j.phytochem.2009.10.017.
    • (2010) Phytochemistry. , vol.71 , Issue.2 , pp. 132-141
    • Jensen, K.1    Møller, B.L.2
  • 91
    • 0014450643 scopus 로고
    • The effect of some treatment conditions on the radiomimetic activity of 1-methyl-3-nitro-1-nitrosoguanidine in plants
    • Kaul BL. The effect of some treatment conditions on the radiomimetic activity of 1-methyl-3-nitro-1-nitrosoguanidine in plants. Mutat Res. 1969;7(1):43-9.
    • (1969) Mutat Res. , vol.7 , Issue.1 , pp. 43-49
    • Kaul, B.L.1
  • 92
    • 0033524365 scopus 로고    scopus 로고
    • The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate
    • Ketchum RE, Gibson DM, Croteau RB, Shuler ML. The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol Bioeng. 1999;62(1):97-105. https://doi.org/10.1002/ (SICI)1097-0290(19990105)62:1<97::AID-BIT11>3.0.CO;2-C.
    • (1999) Biotechnol Bioeng. , vol.62 , Issue.1 , pp. 97-105
    • Ketchum, R.E.1    Gibson, D.M.2    Croteau, R.B.3    Shuler, M.L.4
  • 93
    • 34548431347 scopus 로고    scopus 로고
    • Stable transformation and long-term maintenance of transgenic Taxus cell suspension cultures
    • Ketchum REB, Wherland L, Croteau RB. Stable transformation and long-term maintenance of transgenic Taxus cell suspension cultures. Plant Cell Rep. 2007;26(7):1025-33. https:// doi.org/10.1007/s00299-007-0323-x.
    • (2007) Plant Cell Rep. , vol.26 , Issue.7 , pp. 1025-1033
    • Ketchum, R.E.B.1    Wherland, L.2    Croteau, R.B.3
  • 94
    • 84855577720 scopus 로고    scopus 로고
    • Endophytic fungal association via gibberellins and indole acetic acid can improve plant growth under abiotic stress: an example of Paecilomyces formosus LHL10
    • Khan AL, Hamayun M, Kang SM, Kim YH, Jung HY, Lee JH, Lee IJ. Endophytic fungal association via gibberellins and indole acetic acid can improve plant growth under abiotic stress: an example of Paecilomyces formosus LHL10. BMC Microbiol. 2012;12. https://doi. org/10.1186/1471-2180-12-3.
    • (2012) BMC Microbiol. , vol.12
    • Khan, A.L.1    Hamayun, M.2    Kang, S.M.3    Kim, Y.H.4    Jung, H.Y.5    Lee, J.H.6    Lee, I.J.7
  • 95
  • 96
    • 10044255335 scopus 로고    scopus 로고
    • Effect of subculture and elicitation on instability of taxol production in Taxus sp suspension cultures
    • Kim BJ, Gibson DM, Shuler ML. Effect of subculture and elicitation on instability of taxol production in Taxus sp suspension cultures. Biotechnol Prog. 2004;20(6):1666-73. https:// doi.org/10.1021/bp034274c.
    • (2004) Biotechnol Prog. , vol.20 , Issue.6 , pp. 1666-1673
    • Kim, B.J.1    Gibson, D.M.2    Shuler, M.L.3
  • 97
    • 33748432538 scopus 로고    scopus 로고
    • Effect of the plant peptide regulator, phytosulfokine-alpha on the growth and taxol production from Taxus sp suspension cultures
    • Kim BJ, Gibson DM, Shuler ML. Effect of the plant peptide regulator, phytosulfokine-alpha on the growth and taxol production from Taxus sp suspension cultures. Biotechnol Bioeng. 2006;95(1):8-14. https://doi.org/10.1002/bit.20934.
    • (2006) Biotechnol Bioeng. , vol.95 , Issue.1 , pp. 8-14
    • Kim, B.J.1    Gibson, D.M.2    Shuler, M.L.3
  • 98
    • 0028904573 scopus 로고
    • Production of taxol and related Taxanes in Taxus brevifolia cell cultures: effect of sugar
    • Kim JH, Yun JH, Hwang YS, Byun SY, Kim DI. Production of taxol and related Taxanes in Taxus brevifolia cell cultures: effect of sugar. Biotechnol Lett. 1995;17(1):101-6. https://doi. org/10.1007/Bf00134204.
    • (1995) Biotechnol Lett. , vol.17 , Issue.1 , pp. 101-106
    • Kim, J.H.1    Yun, J.H.2    Hwang, Y.S.3    Byun, S.Y.4    Kim, D.I.5
  • 99
    • 23044497194 scopus 로고    scopus 로고
    • Taxol and its analogs
    • In: Cragg GM, Kingston DG, Newman DJ, editors. Boca Raton: CRC press
    • Kingston DG. Taxol and its analogs. In: Cragg GM, Kingston DG, Newman DJ, editors. Anticancer agents from natural products. Boca Raton: CRC press; 2011. p. 123-76.
    • (2011) Anticancer agents from natural products , pp. 123-176
    • Kingston, D.G.1
  • 100
    • 78650991785 scopus 로고    scopus 로고
    • Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis
    • Koksal M, Jin YH, Coates RM, Croteau R, Christianson DW. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature. 2011;469(7328):116-U138. https://doi.org/10.1038/nature09628.
    • (2011) Nature. , vol.469 , Issue.7328 , pp. 116-U138
    • Koksal, M.1    Jin, Y.H.2    Coates, R.M.3    Croteau, R.4    Christianson, D.W.5
  • 101
    • 80053917393 scopus 로고    scopus 로고
    • Analysis of aggregate size as a process variable affecting paclitaxel accumulation in taxus suspension cultures
    • Kolewe ME, Henson MA, Roberts SC. Analysis of aggregate size as a process variable affecting paclitaxel accumulation in taxus suspension cultures. Biotechnol Prog. 2011;27(5):1365-72. https://doi.org/10.1002/btpr.655.
    • (2011) Biotechnol Prog. , vol.27 , Issue.5 , pp. 1365-1372
    • Kolewe, M.E.1    Henson, M.A.2    Roberts, S.C.3
  • 102
    • 0000750804 scopus 로고
    • Three phenolic acid derivatives from stromata of Epichloe typhina on Phleum pratense
    • Koshino H, Terada S-I, Yoshihara T, Sakamura S, Shimanuki T, Sato T, Tajimi A. Three phenolic acid derivatives from stromata of Epichloe typhina on Phleum pratense. Phytochemistry. 1988;27(5):1333-8. https://doi.org/10.1016/0031-9422(88)80188-2.
    • (1988) Phytochemistry. , vol.27 , Issue.5 , pp. 1333-1338
    • Koshino, H.1    Terada, S.-I.2    Yoshihara, T.3    Sakamura, S.4    Shimanuki, T.5    Sato, T.6    Tajimi, A.7
  • 103
    • 33846058003 scopus 로고    scopus 로고
    • Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit
    • Kovacs K, Zhang L, Linforth RST, Whittaker B, Hayes CJ, Fray RG. Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit. Transgenic Res. 2007;16(1):121-6. https://doi.org/10.1007/s11248-006-9039-x.
    • (2007) Transgenic Res. , vol.16 , Issue.1 , pp. 121-126
    • Kovacs, K.1    Zhang, L.2    Linforth, R.S.T.3    Whittaker, B.4    Hayes, C.J.5    Fray, R.G.6
  • 104
    • 84901061244 scopus 로고    scopus 로고
    • Rethinking production of taxol (R) (paclitaxel) using endophyte biotechnology
    • Kusari S, Singh S, Jayabaskaran C. Rethinking production of taxol (R) (paclitaxel) using endophyte biotechnology. Trends Biotechnol. 2014;32(6):304-11. https://doi.org/10.1016/j. tibtech.2014.03.011.
    • (2014) Trends Biotechnol. , vol.32 , Issue.6 , pp. 304-311
    • Kusari, S.1    Singh, S.2    Jayabaskaran, C.3
  • 105
    • 0242554088 scopus 로고
    • Somaclonal variationa-novel source of variability from cell cultures for plant improvement
    • Larkin PJ, Scowcroft WR. Somaclonal variationa-novel source of variability from cell cultures for plant improvement. Theor Appl Genet. 1981;60(4):197-214. https://doi.org/10.1007/ BF02342540.
    • (1981) Theor Appl Genet. , vol.60 , Issue.4 , pp. 197-214
    • Larkin, P.J.1    Scowcroft, W.R.2
  • 106
    • 0027263576 scopus 로고
    • Taxotere: from yew's needles to clinical practice
    • Lavelle F, Gueritte-Voegelein F, Guenard D. Taxotere: from yew's needles to clinical practice. Bull Cancer. 1993;80(4):326-38.
    • (1993) Bull Cancer. , vol.80 , Issue.4 , pp. 326-338
    • Lavelle, F.1    Gueritte-Voegelein, F.2    Guenard, D.3
  • 107
    • 84951014894 scopus 로고    scopus 로고
    • Developing fermentative terpenoid production for commercial usage
    • Leavell MD, McPhee DJ, Paddon CJ. Developing fermentative terpenoid production for commercial usage. Curr Opin Biotechnol. 2016;37:114-9. https:// doi.org/10.1016/j. copbio.2015.10.007.
    • (2016) Curr Opin Biotechnol. , vol.37 , pp. 114-119
    • Leavell, M.D.1    McPhee, D.J.2    Paddon, C.J.3
  • 108
    • 84925048969 scopus 로고    scopus 로고
    • Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4
    • Lenka SK, Nims NE, Vongpaseuth K, Boshar RA, Roberts SC, Walker EL. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6. https://doi.org/10.3389/fpls.2015.00115.
    • (2015) Front Plant Sci. , vol.6
    • Lenka, S.K.1    Nims, N.E.2    Vongpaseuth, K.3    Boshar, R.A.4    Roberts, S.C.5    Walker, E.L.6
  • 109
    • 36649037393 scopus 로고    scopus 로고
    • Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli
    • Leonard E, Koffas MA. Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Appl Environ Microbiol. 2007;73(22):7246-51. https://doi.org/10.1128/AEM.01411-07.
    • (2007) Appl Environ Microbiol. , vol.73 , Issue.22 , pp. 7246-7251
    • Leonard, E.1    Koffas, M.A.2
  • 110
    • 80051759996 scopus 로고    scopus 로고
    • Antisense-induced suppression of taxoid 14ß-hydroxylase gene expression in transgenic Taxus× media cells
    • Li F-L, Ma X-J, X-L H, Hoffman A, Dai J-G, D-Y Q. Antisense-induced suppression of taxoid 14ß-hydroxylase gene expression in transgenic Taxus× media cells. Afr J Biotechnol. 2013;10(44):8720-8. https://doi.org/10.5897/AJB11.319.
    • (2013) Afr J Biotechnol. , vol.10 , Issue.44 , pp. 8720-8728
    • Li, F.-L.1    Ma, X.-J.2    Hoffman, A.3    Dai, J.-G.4    D-Y, Q.5
  • 111
    • 0029824617 scopus 로고    scopus 로고
    • Endophytic taxol-producing fungi from bald cypress, Taxodium distichum
    • Li JY, Strobel G, Sidhu R, Hess WM, Ford EJ. Endophytic taxol-producing fungi from bald cypress, Taxodium distichum. Microbiol-UK. 1996;142:2223-6. https://doi. org/10.1099/13500872-142-8-2223.
    • (1996) Microbiol-UK. , vol.142 , pp. 2223-2226
    • Li, J.Y.1    Strobel, G.2    Sidhu, R.3    Hess, W.M.4    Ford, E.J.5
  • 112
    • 84924064136 scopus 로고    scopus 로고
    • Engineering isoprenoid biosynthesis in Artemisia annua L. for the production of Taxadiene: a key intermediate of taxol
    • Li MY, Jiang FS, Yu XL, Miao ZQ. Engineering isoprenoid biosynthesis in Artemisia annua L. for the production of Taxadiene: a key intermediate of taxol. Biomed Res Int. 2015. https:// doi.org/10.1155/2015/504932.
    • (2015) Biomed Res Int.
    • Li, M.Y.1    Jiang, F.S.2    Yu, X.L.3    Miao, Z.Q.4
  • 113
    • 84870433755 scopus 로고    scopus 로고
    • Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis
    • Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol. 2013;15(1):19-26. https://doi.org/10.1111/j.1438-8677.2012.00611.
    • (2013) Plant Biol. , vol.15 , Issue.1 , pp. 19-26
    • Li, S.1    Zhang, P.2    Zhang, M.3    Fu, C.4    Yu, L.5
  • 114
    • 84865406854 scopus 로고    scopus 로고
    • Enhancing taxol biosynthesis by overexpressing a 9-cis-epoxycarotenoid dioxygenase gene in transgenic cell lines of Taxus chinensis
    • Li ST, CH F, Zhang M, Zhang Y, Xie S, LJ Y. Enhancing taxol biosynthesis by overexpressing a 9-cis-epoxycarotenoid dioxygenase gene in transgenic cell lines of Taxus chinensis. Plant Mol Biol Report. 2012;30(5):1125-30. https://doi.org/10.1007/s11105-012-0436-4.
    • (2012) Plant Mol Biol Report. , vol.30 , Issue.5 , pp. 1125-1130
    • Li, S.T.1    Zhang, M.2    Zhang, Y.3    Xie, S.4
  • 115
    • 84937538704 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing
    • Li YF, Lin ZQ, Huang C, Zhang Y, Wang ZW, Tang YJ, Chen T, Zhao XM. Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing. Metab Eng. 2015;31:13-21. https://doi.org/10.1016/j.ymben.2015.06.006.
    • (2015) Metab Eng. , vol.31 , pp. 13-21
    • Li, Y.F.1    Lin, Z.Q.2    Huang, C.3    Zhang, Y.4    Wang, Z.W.5    Tang, Y.J.6    Chen, T.7    Zhao, X.M.8
  • 116
    • 0029979356 scopus 로고    scopus 로고
    • Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew
    • Lin XY, Hezari M, Koepp AE, Floss HG, Croteau R. Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew. Biochemistry-US. 1996;35(9):2968-77. https://doi.org/10.1021/bi9526239.
    • (1996) Biochemistry-US. , vol.35 , Issue.9 , pp. 2968-2977
    • Lin, X.Y.1    Hezari, M.2    Koepp, A.E.3    Floss, H.G.4    Croteau, R.5
  • 117
    • 0034623096 scopus 로고    scopus 로고
    • Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis
    • Linden JC, Phisalaphong M. Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis. Plant Sci. 2000;158(1-2):41-51. https://doi. org/10.1016/S0168-9452(00)00306-X.
    • (2000) Plant Sci. , vol.158 , Issue.1-2 , pp. 41-51
    • Linden, J.C.1    Phisalaphong, M.2
  • 118
    • 69249232197 scopus 로고    scopus 로고
    • Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis
    • Liu KH, Ding XW, Deng BW, Chen WQ. Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis. J Ind Microbiol Biotechnol. 2009;36(9):1171-7. https://doi.org/10.1007/s10295-009-0598-8.
    • (2009) J Ind Microbiol Biotechnol. , vol.36 , Issue.9 , pp. 1171-1177
    • Liu, K.H.1    Ding, X.W.2    Deng, B.W.3    Chen, W.Q.4
  • 119
    • 27544457332 scopus 로고    scopus 로고
    • Preliminary assessment of the C13-side chain 2'-hydroxylase involved in taxol biosynthesis
    • Long RM, Croteau R. Preliminary assessment of the C13-side chain 2'-hydroxylase involved in taxol biosynthesis. Biochem Bioph Res Commun. 2005;338(1):410-7. https://doi. org/10.1016/j.bbrc.2005.08.119.
    • (2005) Biochem Bioph Res Commun. , vol.338 , Issue.1 , pp. 410-417
    • Long, R.M.1    Croteau, R.2
  • 120
    • 50149089756 scopus 로고    scopus 로고
    • Specificity of the N-benzoyl transferase responsible for the last step of taxol biosynthesis
    • Long RM, Lagisetti C, Coates RM, Croteau RB. Specificity of the N-benzoyl transferase responsible for the last step of taxol biosynthesis. Arch Biochem Biophys. 2008;477(2):384-9. https://doi.org/10.1016/j.abb.2008.06.021.
    • (2008) Arch Biochem Biophys. , vol.477 , Issue.2 , pp. 384-389
    • Long, R.M.1    Lagisetti, C.2    Coates, R.M.3    Croteau, R.B.4
  • 121
    • 78650254061 scopus 로고    scopus 로고
    • Production of the anticancer drug taxol in Taxus baccata suspension cultures: a review
    • Malik S, Cusido RM, Mirjalili MH, Moyano E, Palazon J, Bonfill M. Production of the anticancer drug taxol in Taxus baccata suspension cultures: a review. Process Biochem. 2011;46(1):23-34. https://doi.org/10.1016/j.procbio.2010.09.004.
    • (2011) Process Biochem. , vol.46 , Issue.1 , pp. 23-34
    • Malik, S.1    Cusido, R.M.2    Mirjalili, M.H.3    Moyano, E.4    Palazon, J.5    Bonfill, M.6
  • 122
    • 0038391517 scopus 로고    scopus 로고
    • Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
    • Martin VJJ, Pitera DJ, Withers ST, Newman JD, Keasling JD. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol. 2003;21(7):796-802. https://doi.org/10.1038/nbt833.
    • (2003) Nat Biotechnol. , vol.21 , Issue.7 , pp. 796-802
    • Martin, V.J.J.1    Pitera, D.J.2    Withers, S.T.3    Newman, J.D.4    Keasling, J.D.5
  • 125
    • 84855193582 scopus 로고    scopus 로고
    • Recent progress in research on small post-translationally modified peptide signals in plants
    • Matsubayashi Y. Recent progress in research on small post-translationally modified peptide signals in plants. Genes Cells. 2012;17(1):1-10. https://doi.org/10.1111/j.1365-2443.2011.01569.x.
    • (2012) Genes Cells. , vol.17 , Issue.1 , pp. 1-10
    • Matsubayashi, Y.1
  • 127
    • 0029049401 scopus 로고
    • Gas phase composition effects on suspension cultures of Taxus cuspidata
    • Mirjalili N, Linden JC. Gas phase composition effects on suspension cultures of Taxus cuspidata. Biotechnol Bioeng. 1995;48(2):123-32. https://doi.org/10.1002/bit.260480206.
    • (1995) Biotechnol Bioeng. , vol.48 , Issue.2 , pp. 123-132
    • Mirjalili, N.1    Linden, J.C.2
  • 128
    • 0030060485 scopus 로고    scopus 로고
    • Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: ethylene interaction and induction models
    • Mirjalili N, Linden JC. Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: ethylene interaction and induction models. Biotechnol Prog. 1996;12(1):110-8. https://doi.org/10.1021/bp9500831.
    • (1996) Biotechnol Prog. , vol.12 , Issue.1 , pp. 110-118
    • Mirjalili, N.1    Linden, J.C.2
  • 129
    • 0031913115 scopus 로고    scopus 로고
    • Elicitation kinetics of taxane production in suspension cultures of Taxus baccata Pendula
    • Moon WJ, Yoo BS, Kim DI, Byun SY. Elicitation kinetics of taxane production in suspension cultures of Taxus baccata Pendula. Biotechnol Tech. 1998;12(1):79-81. https://doi.org/10.10 23/A:1008867828951.
    • (1998) Biotechnol Tech. , vol.12 , Issue.1 , pp. 79-81
    • Moon, W.J.1    Yoo, B.S.2    Kim, D.I.3    Byun, S.Y.4
  • 130
    • 0038486022 scopus 로고    scopus 로고
    • A novel bioassay for screening and quantification of taxanes
    • Morais S, Pandey PC, Chen W, Mulchandani A. A novel bioassay for screening and quantification of taxanes. Chem Commun. 2003;10:1188-9.
    • (2003) Chem Commun. , vol.10 , pp. 1188-1189
    • Morais, S.1    Pandey, P.C.2    Chen, W.3    Mulchandani, A.4
  • 131
    • 0003090417 scopus 로고
    • Regulation of product synthesis in cell cultures of Catharanthus roseus. V. Long-term maintenance of cells on a production medium
    • Morris P, Rudge K, Cresswell R, Fowler M. Regulation of product synthesis in cell cultures of Catharanthus roseus. V. Long-term maintenance of cells on a production medium. Plant Cell Tissue Organ Cult. 1989;17(2-3):79-90. https://doi.org/10.1007/BF00046853.
    • (1989) Plant Cell Tissue Organ Cult. , vol.17 , Issue.2-3 , pp. 79-90
    • Morris, P.1    Rudge, K.2    Cresswell, R.3    Fowler, M.4
  • 132
    • 84861376526 scopus 로고    scopus 로고
    • The taxol® story-development ofa green synthesis via plant cell fermentation
    • Mountford PG. The taxol® story-development ofa green synthesis via plant cell fermentation. Green Chem Pharmaceut Ind. 2010. https://doi.org/10.1002/9783527629688.ch7.
    • (2010) Green Chem Pharmaceut Ind
    • Mountford, P.G.1
  • 133
    • 85126712585 scopus 로고    scopus 로고
    • The diversity of ant microbial secondary metabolites produced by fungal endophytes: an interdisciplinary perspective
    • Mousa WK, Raizada MN. The diversity of ant microbial secondary metabolites produced by fungal endophytes: an interdisciplinary perspective. Front Microbiol. 2013;4. https://doi. org/10.3389/fmicb.2013.00065.
    • (2013) Front Microbiol. , vol.4
    • Mousa, W.K.1    Raizada, M.N.2
  • 134
    • 85027248723 scopus 로고    scopus 로고
    • Abiotic and biotic elicitors-role in secondary metabolites production through in vitro culture of medicinal plants
    • In: Shanker AK and Shankar C (eds). InTech, Croatia
    • Naik PM, Al-Khayri JM. Abiotic and biotic elicitors-role in secondary metabolites production through in vitro culture of medicinal plants. In: Shanker AK and Shankar C (eds). Abiotic and biotic stress in plants-recent advances and future perspectives. InTech, Croatia. 2016: 247-77. https://doi.org/10.5772/61442.
    • (2016) Abiotic and biotic stress in plants-recent advances and future perspectives , pp. 247-277
    • Naik, P.M.1    Al-Khayri, J.M.2
  • 136
    • 33748226949 scopus 로고
    • Chemistry and biology of taxol
    • Nicolaou KC, Dai WM, Guy RK. Chemistry and biology of taxol. Angew Chem Int Ed Engl. 1994;33(1):15-44. https://doi.org/10.1002/anie.199400151.
    • (1994) Angew Chem Int Ed Engl. , vol.33 , Issue.1 , pp. 15-44
    • Nicolaou, K.C.1    Dai, W.M.2    Guy, R.K.3
  • 137
    • 33747787434 scopus 로고    scopus 로고
    • Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering
    • Nims E, Dubois CP, Roberts SC, Walker EL. Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering. Metab Eng. 2006;8(5):385-94. https:// doi.org/10.1016/j.ymben.2006.04.001.
    • (2006) Metab Eng. , vol.8 , Issue.5 , pp. 385-394
    • Nims, E.1    Dubois, C.P.2    Roberts, S.C.3    Walker, E.L.4
  • 138
    • 84874954483 scopus 로고    scopus 로고
    • The emerging field of transport engineering of plant specialized metabolites
    • Nour-Eldin HH, Halkier BA. The emerging field of transport engineering of plant specialized metabolites. Curr Opin Biotechnol. 2013;24(2):263-70. https://doi.org/10.1016/j. copbio.2012.09.006.
    • (2013) Curr Opin Biotechnol. , vol.24 , Issue.2 , pp. 263-270
    • Nour-Eldin, H.H.1    Halkier, B.A.2
  • 139
    • 0023812476 scopus 로고
    • Taxus (yews)-a highly toxic plant
    • Ogden L. Taxus (yews)-a highly toxic plant. Vet Hum Toxicol. 1988;30(6):563-4.
    • (1988) Vet Hum Toxicol. , vol.30 , Issue.6 , pp. 563-564
    • Ogden, L.1
  • 140
    • 84878002829 scopus 로고    scopus 로고
    • Bioprocessing of plant in vitro Systems for the Mass Production of pharmaceutically important metabolites: paclitaxel and its derivatives
    • Onrubia M, Cusido RM, Ramirez K, Hernandez-Vazquez L, Moyano E, Bonfill M, Palazon J. Bioprocessing of plant in vitro Systems for the Mass Production of pharmaceutically important metabolites: paclitaxel and its derivatives. Curr Med Chem. 2013;20(7):880-91. https://doi.org/10.2174/092986713805219064.
    • (2013) Curr Med Chem. , vol.20 , Issue.7 , pp. 880-891
    • Onrubia, M.1    Cusido, R.M.2    Ramirez, K.3    Hernandez-Vazquez, L.4    Moyano, E.5    Bonfill, M.6    Palazon, J.7
  • 141
    • 84871694307 scopus 로고    scopus 로고
    • Coronatine, a more powerful elicitor for inducing taxane biosynthesis in Taxus media cell cultures than methyl jasmonate
    • Onrubia M, Moyano E, Bonfill M, Cusido RM, Goossens A, Palazon J. Coronatine, a more powerful elicitor for inducing taxane biosynthesis in Taxus media cell cultures than methyl jasmonate. J Plant Physiol. 2013;170(2):211-9. https://doi.org/10.1016/j.jplph.2012.09.004.
    • (2013) J Plant Physiol. , vol.170 , Issue.2 , pp. 211-219
    • Onrubia, M.1    Moyano, E.2    Bonfill, M.3    Cusido, R.M.4    Goossens, A.5    Palazon, J.6
  • 143
    • 84941343975 scopus 로고    scopus 로고
    • Taxane production induced by methyl jasmonate in free and immobilized cell cultures of Mexican yew (Taxus globosa Schltdl)
    • Osuna L, Tapia N, Cusido R, Palazon J, Bonfill M, Zamilpa A, Lopez-Upton J, Cruz-Sosa F. Taxane production induced by methyl jasmonate in free and immobilized cell cultures of Mexican yew (Taxus globosa Schltdl). Acta Physiol Plant. 2015;37(10). https://doi. org/10.1007/s11738-015-1947-z.
    • (2015) Acta Physiol Plant. , vol.37 , Issue.10
    • Osuna, L.1    Tapia, N.2    Cusido, R.3    Palazon, J.4    Bonfill, M.5    Zamilpa, A.6    Lopez-Upton, J.7    Cruz-Sosa, F.8
  • 145
    • 84899051891 scopus 로고    scopus 로고
    • Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
    • Paddon CJ, Keasling JD. Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development. Nat Rev Microbiol. 2014;12(5):355-67. https://doi. org/10.1038/nrmicro3240.
    • (2014) Nat Rev Microbiol. , vol.12 , Issue.5 , pp. 355-367
    • Paddon, C.J.1    Keasling, J.D.2
  • 146
    • 84961125909 scopus 로고    scopus 로고
    • Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems/synthetic biology
    • Pandey RP, Parajuli P, Koffas MA, Sohng JK. Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems/synthetic biology. Biotechnol Adv. 2016. https://doi.org/10.1016/j.biotechadv.2016.02.012.
    • (2016) Biotechnol Adv
    • Pandey, R.P.1    Parajuli, P.2    Koffas, M.A.3    Sohng, J.K.4
  • 147
    • 79952127110 scopus 로고    scopus 로고
    • Isolation and detection of taxol, an anticancer drug produced from Lasiodiplodia theobromae, an endophytic fungus of the medicinal plant Morinda citrifolia
    • Pandi M, Kumaran RS, Choi YK, Kim HJ, Muthumary J. Isolation and detection of taxol, an anticancer drug produced from Lasiodiplodia theobromae, an endophytic fungus of the medicinal plant Morinda citrifolia. Afr J Biotechnol. 2011;10(8):1428-35. https://doi. org/10.5897/AJB10.950.
    • (2011) Afr J Biotechnol. , vol.10 , Issue.8 , pp. 1428-1435
    • Pandi, M.1    Kumaran, R.S.2    Choi, Y.K.3    Kim, H.J.4    Muthumary, J.5
  • 148
    • 0001120062 scopus 로고
    • Variation in tropane alkaloid accumulation within the Solanaceae and strategies for its exploitation
    • Parr AJ, Payne J, Eagles J, Chapman BT, Robins RJ, Rhodes MJC. Variation in tropane alkaloid accumulation within the Solanaceae and strategies for its exploitation. Phytochemistry. 1990;29(8):2545-50. https://doi.org/10.1016/0031-9422(90)85185-I.
    • (1990) Phytochemistry. , vol.29 , Issue.8 , pp. 2545-2550
    • Parr, A.J.1    Payne, J.2    Eagles, J.3    Chapman, B.T.4    Robins, R.J.5    Rhodes, M.J.C.6
  • 150
    • 84907470389 scopus 로고    scopus 로고
    • The Plant List Version 1.1
    • Published on the Internet, Accessed 9 Mar 2016
    • The Plant List Version 1.1. Published on the Internet. http://www.theplantlist.org/. 2013. Accessed 9 Mar 2016.
    • (2013)
  • 151
    • 51549112366 scopus 로고    scopus 로고
    • The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense
    • Pre M, Atallah M, Champion A, De Vos M, Pieterse CMJ, Memelink J. The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense. Plant Physiol. 2008;147(3):1347-57. https://doi.org/10.1104/pp.108.117523.
    • (2008) Plant Physiol. , vol.147 , Issue.3 , pp. 1347-1357
    • Pre, M.1    Atallah, M.2    Champion, A.3    De Vos, M.4    Pieterse, C.M.J.5    Memelink, J.6
  • 153
    • 84901769672 scopus 로고    scopus 로고
    • Metabolomic strategies for the identification of new enzyme functions and metabolic pathways
    • Prosser GA, Larrouy-Maumus G, de Carvalho LPS. Metabolomic strategies for the identification of new enzyme functions and metabolic pathways. EMBO Rep. 2014;15(6):657-69. 10.15252/embr.201338283.
    • (2014) EMBO Rep. , vol.15 , Issue.6 , pp. 657-669
    • Prosser, G.A.1    Larrouy-Maumus, G.2    de Carvalho, L.P.S.3
  • 154
    • 84931263702 scopus 로고    scopus 로고
    • Changes in gene transcription and taxane production in elicited cell cultures of Taxus x media and Taxus globosa
    • Ramirez-Estrada K, Osuna L, Moyano E, Bonfill M, Tapia N, Cusido RM, Palazon J. Changes in gene transcription and taxane production in elicited cell cultures of Taxus x media and Taxus globosa. Phytochemistry. 2015;117:174-84. https://doi.org/10.1016/j. phytochem.2015.06.013.
    • (2015) Phytochemistry. , vol.117 , pp. 174-184
    • Ramirez-Estrada, K.1    Osuna, L.2    Moyano, E.3    Bonfill, M.4    Tapia, N.5    Cusido, R.M.6    Palazon, J.7
  • 156
    • 84963679928 scopus 로고    scopus 로고
    • Elicitation, an effective strategy for the biotechnological production of bioactive high-added value compounds in plant cell factories
    • Ramirez-Estrada K, Vidal-Limon H, Hidalgo D, Moyano E, Golenioswki M, Cusido RM, Palazon J. Elicitation, an effective strategy for the biotechnological production of bioactive high-added value compounds in plant cell factories. Molecules. 2016;21(2). https://doi. org/10.3390/molecules21020182.
    • (2016) Molecules. , vol.21 , Issue.2
    • Ramirez-Estrada, K.1    Vidal-Limon, H.2    Hidalgo, D.3    Moyano, E.4    Golenioswki, M.5    Cusido, R.M.6    Palazon, J.7
  • 157
    • 0033621479 scopus 로고    scopus 로고
    • Characterization of the taxol binding site on the microtubule identification of Arg282 in ß-tubulin as the site of photoincorporation of a 7-benzophenone analogue of taxol
    • Rao S, He L, Chakravarty S, Ojima I, Orr GA, Horwitz SB. Characterization of the taxol binding site on the microtubule identification of Arg282 in ß-tubulin as the site of photoincorporation of a 7-benzophenone analogue of taxol. J Biol Chem. 1999;274(53):37990-4. https://doi.org/10.1074/jbc.274.53.37990.
    • (1999) J Biol Chem. , vol.274 , Issue.53 , pp. 37990-37994
    • Rao, S.1    He, L.2    Chakravarty, S.3    Ojima, I.4    Orr, G.A.5    Horwitz, S.B.6
  • 159
    • 0032415449 scopus 로고    scopus 로고
    • Himalayan yew: stand structure, canopy damage, regeneration and conservation strategy
    • Rikhari HC, Palni LMS, Sharma S, Nandi SK. Himalayan yew: stand structure, canopy damage, regeneration and conservation strategy. Environ Conserv. 1998;25(4):334-41. https:// doi.org/10.1017/S0376892998000411.
    • (1998) Environ Conserv. , vol.25 , Issue.4 , pp. 334-341
    • Rikhari, H.C.1    Palni, L.M.S.2    Sharma, S.3    Nandi, S.K.4
  • 160
    • 85043673155 scopus 로고    scopus 로고
    • Roche Finance Report 2016
    • Roche Holdings Ltd. Roche Finance Report 2016. 2016. Retrieved from http://www.roche. com/dam/jcr:6ddcec16-c658-48b2-82b5-4ed426c14ac8/en/fb16e.pdf
    • (2016)
  • 161
    • 63449129221 scopus 로고    scopus 로고
    • Fungal endophytes: diversity and functional roles
    • Rodriguez R, White J Jr, Arnold A, Redman R. Fungal endophytes: diversity and functional roles. New Phytol. 2009;182(2):314-30. https://doi.org/10.1111/j.1469-8137.2009.02773.
    • (2009) New Phytol. , vol.182 , Issue.2 , pp. 314-330
    • Rodriguez, R.1    White, J.2    Arnold, A.3    Redman, R.4
  • 162
    • 84947638057 scopus 로고
    • Production de cals par les gamétophytes mâles de Taxus baccata L. cultivés sur un milieu artificiel. Etude en microscopie photonique et électronique
    • Rohr R. Production de cals par les gamétophytes mâles de Taxus baccata L. cultivés sur un milieu artificiel. Etude en microscopie photonique et électronique. Caryologia. 1973;25(sup1):177-89. https://doi.org/10.1080/00087114.1973.10797122.
    • (1973) Caryologia. , vol.25 , pp. 177-189
    • Rohr, R.1
  • 163
    • 44449085997 scopus 로고    scopus 로고
    • CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane
    • Rontein D, Onillon S, Herbette G, Lesot A, Werck-Reichhart D, Sallaud C, Tissier A. CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane. J Biol Chem. 2008;283(10):6067-75. https://doi.org/10.1074/jbc.M708950200.
    • (2008) J Biol Chem. , vol.283 , Issue.10 , pp. 6067-6075
    • Rontein, D.1    Onillon, S.2    Herbette, G.3    Lesot, A.4    Werck-Reichhart, D.5    Sallaud, C.6    Tissier, A.7
  • 164
    • 84925941198 scopus 로고    scopus 로고
    • Synergistic effect of cyclodextrins and methyl jasmonate on taxane production in Taxus x media cell cultures
    • Sabater-Jara AB, Onrubia M, Moyano E, Bonfill M, Palazon J, Pedreno MA, Cusido RM. Synergistic effect of cyclodextrins and methyl jasmonate on taxane production in Taxus x media cell cultures. Plant Biotechnol J. 2014;12(8):1075-84. https://doi.org/10.1111/ pbi.12214.
    • (2014) Plant Biotechnol J. , vol.12 , Issue.8 , pp. 1075-1084
    • Sabater-Jara, A.B.1    Onrubia, M.2    Moyano, E.3    Bonfill, M.4    Palazon, J.5    Pedreno, M.A.6    Cusido, R.M.7
  • 165
    • 85043671354 scopus 로고    scopus 로고
    • Sanofi annual report on form 20-F 2016
    • Sanofi. Sanofi annual report on form 20-F 2016. 2016. Retrieved from http://en.sanofi.com/ Images/49288_20-F_2016.pdf
    • (2016)
    • Sanofi1
  • 166
    • 0000297058 scopus 로고
    • Taxol stabilizes microtubules in mouse fibroblast cells
    • Schiff PB, Horwitz SB. Taxol stabilizes microtubules in mouse fibroblast cells. P Natl Acad Sci-Biol. 1980;77(3):1561-5. https://doi.org/10.1073/pnas.77.3.1561.
    • (1980) P Natl Acad Sci-Biol. , vol.77 , Issue.3 , pp. 1561-1565
    • Schiff, P.B.1    Horwitz, S.B.2
  • 167
    • 0035852639 scopus 로고    scopus 로고
    • Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast
    • Schoendorf A, Rithner CD, Williams RM, Croteau RB. Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast. P Natl Acad Sci USA. 2001;98(4):1501-6. https://doi.org/10.1073/pnas.98.4.1501.
    • (2001) P Natl Acad Sci USA. , vol.98 , Issue.4 , pp. 1501-1506
    • Schoendorf, A.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.B.4
  • 168
    • 0026755830 scopus 로고
    • Search for factors related to the indole alkaloid production in cell suspension cultures of Tabernaemontana divaricata
    • Schripsema J, Verpoorte R. Search for factors related to the indole alkaloid production in cell suspension cultures of Tabernaemontana divaricata. Planta Med. 1992;58(3):245-9. https:// doi.org/10.1055/s-2006-961445.
    • (1992) Planta Med. , vol.58 , Issue.3 , pp. 245-249
    • Schripsema, J.1    Verpoorte, R.2
  • 169
    • 0142103950 scopus 로고    scopus 로고
    • Functional genomics of P450s
    • Schuler MA, Werck-Reichhart D. Functional genomics of P450s. Annu Rev Plant Biol. 2003;54:629-67. https://doi.org/10.1146/annurev.arplant.54.031902.134840.
    • (2003) Annu Rev Plant Biol. , vol.54 , pp. 629-667
    • Schuler, M.A.1    Werck-Reichhart, D.2
  • 170
    • 42049102779 scopus 로고    scopus 로고
    • Mutualistic interactions with fungal root endophytes
    • In: Schulz BJE, Boyle CJC, Sieber TN, editors. Berlin/Heidelberg: Springer
    • Schulz B. Mutualistic interactions with fungal root endophytes. In: Schulz BJE, Boyle CJC, Sieber TN, editors. Microbial root endophytes. Berlin/Heidelberg: Springer; 2006. p. 261-79. https://doi.org/10.1007/3-540-33526-9_15.
    • (2006) Microbial root endophytes , pp. 261-279
    • Schulz, B.1
  • 171
    • 39749107888 scopus 로고    scopus 로고
    • Regulation of secondary metabolite production in filamentous ascomycetes
    • Shwab EK, Keller NP. Regulation of secondary metabolite production in filamentous ascomycetes. Mycol Res. 2008;112(2):225-30.
    • (2008) Mycol Res. , vol.112 , Issue.2 , pp. 225-230
    • Shwab, E.K.1    Keller, N.P.2
  • 172
    • 84879429119 scopus 로고    scopus 로고
    • A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant
    • Soliman SS, Trobacher CP, Tsao R, Greenwood JS, Raizada MN. A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant. BMC Plant Biol. 2013;13(1):1. https://doi.org/10.1186/1471-2229-13-93.
    • (2013) BMC Plant Biol. , vol.13 , Issue.1 , pp. 1
    • Soliman, S.S.1    Trobacher, C.P.2    Tsao, R.3    Greenwood, J.S.4    Raizada, M.N.5
  • 173
  • 175
    • 0029361226 scopus 로고
    • Taxol production in bioreactors: kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata
    • Srinivasan V, Pestchanker L, Moser S, Hirasuna TJ, Taticek RA, Shuler ML. Taxol production in bioreactors: kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata. Biotechnol Bioeng. 1995;47(6):666-76. https://doi. org/10.1002/bit.260470607.
    • (1995) Biotechnol Bioeng. , vol.47 , Issue.6 , pp. 666-676
    • Srinivasan, V.1    Pestchanker, L.2    Moser, S.3    Hirasuna, T.J.4    Taticek, R.A.5    Shuler, M.L.6
  • 176
    • 73949148697 scopus 로고    scopus 로고
    • Taxomyces andreanae: a presumed paclitaxel producer demystified?
    • Staniek A, Woerdenbag HJ, Kayser O. Taxomyces andreanae: a presumed paclitaxel producer demystified? Planta Med. 2009;75(15):1561-6. https://doi.org/10.1055/s-0029-1186181.
    • (2009) Planta Med. , vol.75 , Issue.15 , pp. 1561-1566
    • Staniek, A.1    Woerdenbag, H.J.2    Kayser, O.3
  • 177
    • 0027270462 scopus 로고
    • Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew
    • Stierle A, Strobel G, Stierle D. Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science. 1993;260(5105):214-6. https://doi.org/10.1126/ science.8097061.
    • (1993) Science. , vol.260 , Issue.5105 , pp. 214-216
    • Stierle, A.1    Strobel, G.2    Stierle, D.3
  • 178
    • 0002716951 scopus 로고    scopus 로고
    • Bioactive compounds from four endophytic Penicillium sp. of a northwest Pacific yew tree
    • Stierle A, Stierle D. Bioactive compounds from four endophytic Penicillium sp. of a northwest Pacific yew tree. Stud Nat Prod Chem. 2000;24:933-77. https://doi.org/10.1016/ S1572-5995(00)80058-7.
    • (2000) Stud Nat Prod Chem. , vol.24 , pp. 933-977
    • Stierle, A.1    Stierle, D.2
  • 179
    • 84927920113 scopus 로고    scopus 로고
    • CRISPR-Cas system enables fast and simple genome editing of industrial Saccharomyces cerevisiae strains
    • Stovicek V, Borodina I, Forster J. CRISPR-Cas system enables fast and simple genome editing of industrial Saccharomyces cerevisiae strains. Metabol Eng Commun. 2015;2:13-22. https://doi.org/10.1016/j.meteno.2015.03.001.
    • (2015) Metabol Eng Commun. , vol.2 , pp. 13-22
    • Stovicek, V.1    Borodina, I.2    Forster, J.3
  • 180
    • 0028010252 scopus 로고
    • The stimulation of taxol production in Taxus brevifolia by various growth-retardants
    • Strobel G, Stierle A, Hess WM. The stimulation of taxol production in Taxus brevifolia by various growth-retardants. Plant Sci. 1994;101(2):115-24. https://doi. org/10.1016/0168-9452(94)90247-X.
    • (1994) Plant Sci. , vol.101 , Issue.2 , pp. 115-124
    • Strobel, G.1    Stierle, A.2    Hess, W.M.3
  • 181
    • 0038367945 scopus 로고    scopus 로고
    • Endophytes as sources of bioactive products
    • Strobel GA. Endophytes as sources of bioactive products. Microbes Infect. 2003;5(6):535-44. https://doi.org/10.1016/S1286-4579(03)00073-X.
    • (2003) Microbes Infect. , vol.5 , Issue.6 , pp. 535-544
    • Strobel, G.A.1
  • 182
    • 0040148644 scopus 로고
    • Mutagenesis of cultured plant cells
    • Sung ZR. Mutagenesis of cultured plant cells. Genetics. 1976;84(1):51-7.
    • (1976) Genetics. , vol.84 , Issue.1 , pp. 51-57
    • Sung, Z.R.1
  • 183
    • 2942619780 scopus 로고    scopus 로고
    • Paclitaxel production by plant-cell-culture technology
    • Springer Berlin Heidelberg
    • Tabata, H. (2004). Paclitaxel production by plant-cell-culture technology. In Biomanufacturing (pp. 1-23). Springer Berlin Heidelberg.
    • (2004) Biomanufacturing , pp. 1-23
    • Tabata, H.1
  • 184
    • 74149088519 scopus 로고    scopus 로고
    • Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function
    • Tang ZM, Salamanca-Pinzon SG, ZL W, Xiao Y, Guengerich FP. Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function. Arch Biochem Biophys. 2010;494(1):86-93. https://doi.org/10.1016/j.abb.2009.11.017.
    • (2010) Arch Biochem Biophys. , vol.494 , Issue.1 , pp. 86-93
    • Tang, Z.M.1    Salamanca-Pinzon, S.G.2    Xiao, Y.3    Guengerich, F.P.4
  • 185
    • 84962460393 scopus 로고    scopus 로고
    • Taxus brevifolia
    • Accessed 29 Apr 2016
    • Thomas, P. Taxus brevifolia. The IUCN red list of threatened species 2013. 2013. https://doi. org/10.2305/IUCN.UK.2013-1.RLTS.T34041A2841142.en. Accessed 29 Apr 2016.
    • (2013) The IUCN red list of threatened species 2013
    • Thomas, P.1
  • 186
    • 84901997761 scopus 로고    scopus 로고
    • Live cell imaging reveals extensive intracellular cytoplasmic colonization of banana by normally non-cultivable endophytic bacteria
    • Thomas P, Sekhar AC. Live cell imaging reveals extensive intracellular cytoplasmic colonization of banana by normally non-cultivable endophytic bacteria. Aob Plants. 2014;6. https:// doi.org/10.1093/aobpla/plu002.
    • (2014) Aob Plants. , vol.6
    • Thomas, P.1    Sekhar, A.C.2
  • 189
    • 84887622083 scopus 로고    scopus 로고
    • From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals
    • Van Dien S. From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals. Curr Opin Biotechnol. 2013;24(6):1061-8. https://doi. org/10.1016/j.copbio.2013.03.002.
    • (2013) Curr Opin Biotechnol. , vol.24 , Issue.6 , pp. 1061-1068
    • Van Dien, S.1
  • 190
    • 0025605649 scopus 로고
    • Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species
    • Vidensek N, Lim P, Campbell A, Carlson C. Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species. J Nat Prod. 1990;53(6):1609-10. https://doi. org/10.1021/np50072a039.
    • (1990) J Nat Prod. , vol.53 , Issue.6 , pp. 1609-1610
    • Vidensek, N.1    Lim, P.2    Campbell, A.3    Carlson, C.4
  • 191
    • 35348818665 scopus 로고    scopus 로고
    • Development of a particle bombardment-mediated transient transformation system for Taxus spp
    • Vongpaseuth K, Nims E, Amand MS, Walker EL, Roberts SC. Development of a particle bombardment-mediated transient transformation system for Taxus spp. cells in culture. Biotechnol Prog. 2007;23(5):1180-5. https://doi.org/10.1021/bp0700307.
    • (2007) cells in culture. Biotechnol Prog. , vol.23 , Issue.5 , pp. 1180-1185
    • Vongpaseuth, K.1    Nims, E.2    Amand, M.S.3    Walker, E.L.4    Roberts, S.C.5
  • 192
    • 34548323861 scopus 로고    scopus 로고
    • Advancements in the understanding of paclitaxel metabolism in tissue culture
    • Vongpaseuth K, Roberts SC. Advancements in the understanding of paclitaxel metabolism in tissue culture. Curr Pharm Biotechnol. 2007;8(4):219-36. https://doi. org/10.2174/138920107781387393.
    • (2007) Curr Pharm Biotechnol. , vol.8 , Issue.4 , pp. 219-236
    • Vongpaseuth, K.1    Roberts, S.C.2
  • 193
    • 0034610386 scopus 로고    scopus 로고
    • Taxol biosynthesis: molecular cloning of a benzoyl-CoA: taxane 2 alpha-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. P
    • Walker K, Croteau R. Taxol biosynthesis: molecular cloning of a benzoyl-CoA: taxane 2 alpha-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. P Natl Acad Sci USA. 2000a;97(25):13591-6. https://doi.org/10.1073/pnas.250491997.
    • (2000) Natl Acad Sci USA. , vol.97 , Issue.25 , pp. 13591-13596
    • Walker, K.1    Croteau, R.2
  • 194
    • 0034681193 scopus 로고    scopus 로고
    • Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
    • Walker K, Croteau R. Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. P Natl Acad Sci USA. 2000b;97(2):583-7. https://doi.org/10.1073/pnas.97.2.583.
    • (2000) P Natl Acad Sci USA. , vol.97 , Issue.2 , pp. 583-587
    • Walker, K.1    Croteau, R.2
  • 195
    • 0034652139 scopus 로고    scopus 로고
    • Molecular cloning of a taxa-4(20),11(12)-dien-5 alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
    • Walker K, Schoendorf A, Croteau R. Molecular cloning of a taxa-4(20),11(12)-dien-5 alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Arch Biochem Biophys. 2000;374(2):371-80. https://doi.org/10.1006/abbi.1999.1609.
    • (2000) Arch Biochem Biophys. , vol.374 , Issue.2 , pp. 371-380
    • Walker, K.1    Schoendorf, A.2    Croteau, R.3
  • 196
    • 0036789932 scopus 로고    scopus 로고
    • Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in taxol biosynthesis
    • Walker K, Fujisaki S, Long R, Croteau R. Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in taxol biosynthesis. P Natl Acad Sci USA. 2002;99(20):12715-20. https://doi.org/10.1073/pnas.192463699.
    • (2002) P Natl Acad Sci USA. , vol.99 , Issue.20 , pp. 12715-12720
    • Walker, K.1    Fujisaki, S.2    Long, R.3    Croteau, R.4
  • 197
    • 0037047151 scopus 로고    scopus 로고
    • The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus
    • Walker K, Long R, Croteau R. The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. P Natl Acad Sci USA. 2002;99(14):9166-71. https://doi.org/10.1073/pnas.082115799.
    • (2002) P Natl Acad Sci USA. , vol.99 , Issue.14 , pp. 9166-9171
    • Walker, K.1    Long, R.2    Croteau, R.3
  • 198
    • 11144225850 scopus 로고    scopus 로고
    • Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in taxol biosynthesis
    • Walker KD, Klettke K, Akiyama T, Croteau R. Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in taxol biosynthesis. J Biol Chem. 2004;279(52):53947-54. https://doi.org/10.1074/jbc.M411215200.
    • (2004) J Biol Chem. , vol.279 , Issue.52 , pp. 53947-53954
    • Walker, K.D.1    Klettke, K.2    Akiyama, T.3    Croteau, R.4
  • 199
    • 0028896166 scopus 로고
    • Camptothecin and taxol: discovery to clinic-thirteenth Bruce F. Cain Memorial Award Lecture
    • Wall ME, Wani MC. Camptothecin and taxol: discovery to clinic-thirteenth Bruce F. Cain Memorial Award Lecture. Cancer Res. 1995;55(4):753-60.
    • (1995) Cancer Res. , vol.55 , Issue.4 , pp. 753-760
    • Wall, M.E.1    Wani, M.C.2
  • 200
    • 0035121651 scopus 로고    scopus 로고
    • Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding
    • Wang CG, JY W, Mei XG. Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding. Biotechnol Prog. 2001;17(1):89-94. https://doi.org/10.1021/bp0001359.
    • (2001) Biotechnol Prog. , vol.17 , Issue.1 , pp. 89-94
    • Wang, C.G.1    Mei, X.G.2
  • 201
    • 0036210394 scopus 로고    scopus 로고
    • Repeated elicitation enhances taxane production in suspension cultures of Taxus chinensis in bioreactors
    • Wang ZY, Zhong JJ. Repeated elicitation enhances taxane production in suspension cultures of Taxus chinensis in bioreactors. Biotechnol Lett. 2002;24(6):445-8. https://doi.org/10.102 3/A:1014549008516.
    • (2002) Biotechnol Lett. , vol.24 , Issue.6 , pp. 445-448
    • Wang, Z.Y.1    Zhong, J.J.2
  • 202
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971;93(9):2325-7. https://doi.org/10.1021/ja00738a045.
    • (1971) J Am Chem Soc. , vol.93 , Issue.9 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 203
    • 84908375133 scopus 로고    scopus 로고
    • Nature as a remarkable chemist: a personal story of the discovery and development of taxol
    • Wani MC, Horwitz SB. Nature as a remarkable chemist: a personal story of the discovery and development of taxol. Anti-Cancer Drug. 2014;25(5):482-7. https://doi.org/10.1097/ Cad.0000000000000063.
    • (2014) Anti-Cancer Drug. , vol.25 , Issue.5 , pp. 482-487
    • Wani, M.C.1    Horwitz, S.B.2
  • 204
    • 84866912607 scopus 로고    scopus 로고
    • Endophytic fungi produce gibberellins and indoleacetic acid and promotes host-plant growth during stress
    • Waqas M, Khan AL, Kamran M, Hamayun M, Kang SM, Kim YH, Lee IJ. Endophytic fungi produce gibberellins and indoleacetic acid and promotes host-plant growth during stress. Molecules. 2012;17(9):10754-73. https://doi.org/10.3390/molecules170910754.
    • (2012) Molecules. , vol.17 , Issue.9 , pp. 10754-10773
    • Waqas, M.1    Khan, A.L.2    Kamran, M.3    Hamayun, M.4    Kang, S.M.5    Kim, Y.H.6    Lee, I.J.7
  • 205
    • 27244462261 scopus 로고    scopus 로고
    • Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells
    • Wheeler AL, Long RM, Ketchum REB, Rithner CD, Williams RM, Croteau R. Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells. Arch Biochem Biophys. 2001;390(2):265-78. https://doi.org/10.1006/abbi.2001.2377.
    • (2001) Arch Biochem Biophys. , vol.390 , Issue.2 , pp. 265-278
    • Wheeler, A.L.1    Long, R.M.2    Ketchum, R.E.B.3    Rithner, C.D.4    Williams, R.M.5    Croteau, R.6
  • 208
    • 84936865611 scopus 로고    scopus 로고
    • An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain
    • Wilding B, Vesela AB, Perry JJB, Black GW, Zhang M, Martinkova L, Klempier N. An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain. Org Biomol Chem. 2015;13(28):7803-12. https://doi.org/10.1039/c5ob01191d.
    • (2015) Org Biomol Chem. , vol.13 , Issue.28 , pp. 7803-7812
    • Wilding, B.1    Vesela, A.B.2    Perry, J.J.B.3    Black, G.W.4    Zhang, M.5    Martinkova, L.6    Klempier, N.7
  • 209
    • 0029873176 scopus 로고    scopus 로고
    • A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis
    • Wildung MR, Croteau R. A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis. J Biol Chem. 1996;271(16):9201-4. https://doi.org/10.1074/jbc.271.16.9201.
    • (1996) J Biol Chem. , vol.271 , Issue.16 , pp. 9201-9204
    • Wildung, M.R.1    Croteau, R.2
  • 210
    • 0034234699 scopus 로고    scopus 로고
    • Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction
    • Williams DC, Wildung MR, Jin AQ, Dalal D, Oliver JS, Coates RM, Croteau R. Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction. Arch Biochem Biophys. 2000;379(1):137-46. https://doi.org/10.1006/abbi.2000.1865.
    • (2000) Arch Biochem Biophys. , vol.379 , Issue.1 , pp. 137-146
    • Williams, D.C.1    Wildung, M.R.2    Jin, A.Q.3    Dalal, D.4    Oliver, J.S.5    Coates, R.M.6    Croteau, R.7
  • 211
    • 0028836170 scopus 로고
    • Endophyte: the evolution of a term, and clarification of its use and definition
    • Wilson D. Endophyte: the evolution of a term, and clarification of its use and definition. Oikos. 1995:274-6. https://doi.org/10.2307/3545919.
    • (1995) Oikos , pp. 274-276
    • Wilson, D.1
  • 212
    • 84857917000 scopus 로고    scopus 로고
    • Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules
    • Wilson SA, Roberts SC. Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules. Plant Biotechnol J. 2012;10(3):249-68. https://doi.org/10.1111/j.1467-7652.2011.00664.x.
    • (2012) Plant Biotechnol J. , vol.10 , Issue.3 , pp. 249-268
    • Wilson, S.A.1    Roberts, S.C.2
  • 213
    • 0002587066 scopus 로고    scopus 로고
    • Study on enhanced production of taxol from Taxus chinensis var. mairei in biphasic-liquid culture
    • ZL W, Yuan YJ, Liu JX, Xuan HY, ZD H, Sun AC, CX H. Study on enhanced production of taxol from Taxus chinensis var. mairei in biphasic-liquid culture. Acta Bot Sin. 1999;41(10):1108-13.
    • (1999) Acta Bot Sin. , vol.41 , Issue.10 , pp. 1108-1113
    • Z.L, W.1    Yuan, Y.J.2    Liu, J.X.3    Xuan, H.Y.4    Sun, A.C.5
  • 214
    • 84911886445 scopus 로고    scopus 로고
    • Unraveling the multispecificity and catalytic promiscuity of taxadiene monooxygenase
    • Yadav VG. Unraveling the multispecificity and catalytic promiscuity of taxadiene monooxygenase. J Mol Catal B-Enzym. 2014;110:154-64. https://doi.org/10.1016/j. molcatb.2014.10,004.
    • (2014) J Mol Catal B-Enzym. , vol.110 , pp. 154-164
    • Yadav, V.G.1
  • 216
    • 84892688705 scopus 로고    scopus 로고
    • Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431
    • Yang Y, Zhao H, Barrero RA, Zhang B, Sun G, Wilson IW, Xie F, Walker KD, Parks JW, Bruce R. Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431. BMC Genomics. 2014;15(1):1. https://doi. org/10.1186/1471-2164-15-69.
    • (2014) BMC Genomics. , vol.15 , Issue.1 , pp. 1
    • Yang, Y.1    Zhao, H.2    Barrero, R.A.3    Zhang, B.4    Sun, G.5    Wilson, I.W.6    Xie, F.7    Walker, K.D.8    Parks, J.W.9    Bruce, R.10
  • 217
    • 0003147906 scopus 로고
    • Ampelomyces quisqualis on clover mildew
    • Yarwood C. Ampelomyces quisqualis on clover mildew. Phytopathology. 1932;22:31.
    • (1932) Phytopathology. , vol.22 , pp. 31
    • Yarwood, C.1
  • 218
    • 84913587392 scopus 로고    scopus 로고
    • Metabolic engineering to enhance the value of plants as green factories
    • Yuan L, Grotewold E. Metabolic engineering to enhance the value of plants as green factories. Metab Eng. 2015;27:83-91. https://doi.org/10.1016/j.ymben.2014.11.005.
    • (2015) Metab Eng. , vol.27 , pp. 83-91
    • Yuan, L.1    Grotewold, E.2
  • 219
    • 0029737648 scopus 로고    scopus 로고
    • Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
    • Yukimune Y, Tabata H, Higashi Y, Hara Y. Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nat Biotechnol. 1996;14(9):1129-32. https://doi.org/10.1038/nbt0996-1129.
    • (1996) Nat Biotechnol. , vol.14 , Issue.9 , pp. 1129-1132
    • Yukimune, Y.1    Tabata, H.2    Higashi, Y.3    Hara, Y.4
  • 220
    • 84887616479 scopus 로고    scopus 로고
    • Effects of different elicitors on 10-deacetylbaccatin III-10-O-acetyltransferase activity and cytochrome P450 monooxygenase content in suspension cultures of Taxus cuspidata cells
    • Zhang JF, Gong S, Guo ZG. Effects of different elicitors on 10-deacetylbaccatin III-10-O-acetyltransferase activity and cytochrome P450 monooxygenase content in suspension cultures of Taxus cuspidata cells. Cell Biol Int Rep. 2011;18(1):7-13. https://doi.org/10.1042/ CBR20110001.
    • (2011) Cell Biol Int Rep. , vol.18 , Issue.1 , pp. 7-13
    • Zhang, J.F.1    Gong, S.2    Guo, Z.G.3
  • 221
    • 84946489357 scopus 로고    scopus 로고
    • Two jasmonate-responsive factors, TcERF12 and TcERF15, respectively act as repressor and activator of tasy gene of taxol biosynthesis in Taxus chinensis
    • Zhang M, Li ST, Nie L, Chen QP, XP X, LJ Y, CH F. Two jasmonate-responsive factors, TcERF12 and TcERF15, respectively act as repressor and activator of tasy gene of taxol biosynthesis in Taxus chinensis. Plant Mol Biol. 2015;89(4-5):463-73. https://doi.org/10.1007/ s11103-015-0382-2.
    • (2015) Plant Mol Biol. , vol.89 , Issue.4-5 , pp. 463-473
    • Zhang, M.1    Li, S.T.2    Nie, L.3    Chen, Q.P.4
  • 222
    • 62549162577 scopus 로고    scopus 로고
    • An endophytic taxol-producing fungus from Taxus x media, Aspergillus candidus MD3
    • Zhang P, Zhou P-P, L-J Y. An endophytic taxol-producing fungus from Taxus x media, Aspergillus candidus MD3. FEMS Microbiol Lett. 2009;293(2):155-9. https://doi. org/10.1111/j.1574-6968.2009.01481.x.
    • (2009) FEMS Microbiol Lett. , vol.293 , Issue.2 , pp. 155-159
    • Zhang, P.1    Zhou, P.-P.2    L-J, Y.3
  • 223
    • 79957975598 scopus 로고    scopus 로고
    • Overexpression of a 10-deacetylbaccatin III-10 ß-O-acetyltransferase gene leads to increased taxol yield in cells of Taxus chinensis
    • Zhang P, Li S-T, Liu T-T, C-H F, Zhou P-P, Zhao C-F, L-J Y. Overexpression of a 10-deacetylbaccatin III-10 ß-O-acetyltransferase gene leads to increased taxol yield in cells of Taxus chinensis. Plant Cell Tissue Organ Cult (PCTOC). 2011;106(1):63-70. https://doi. org/10.1007/s11240-010-9894-2.
    • (2011) Plant Cell Tissue Organ Cult (PCTOC). , vol.106 , Issue.1 , pp. 63-70
    • Zhang, P.1    Li, S.-T.2    Liu, T.-T.3    Zhou, P.-P.4    Zhao, C.-F.5
  • 224
    • 70349128489 scopus 로고    scopus 로고
    • Aspergillus niger var. taxi, a new species variant of taxol-producing fungus isolated from Taxus cuspidata in China
    • Zhao K, Ping W, Li Q, Hao S, Zhao L, Gao T, Zhou D. Aspergillus niger var. taxi, a new species variant of taxol-producing fungus isolated from Taxus cuspidata in China. J Appl Microbiol. 2009;107(4):1202-7. https://doi.org/10.1111/j.1365-2672.2009.04305.x.
    • (2009) J Appl Microbiol. , vol.107 , Issue.4 , pp. 1202-1207
    • Zhao, K.1    Ping, W.2    Li, Q.3    Hao, S.4    Zhao, L.5    Gao, T.6    Zhou, D.7
  • 225
    • 84926646130 scopus 로고    scopus 로고
    • Distributing a metabolic pathway among a microbial consortium enhances production of natural products
    • Zhou K, Qiao KJ, Edgar S, Stephanopoulos G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat Biotechnol. 2015;33(4):377-U157. https://doi.org/10.1038/nbt.3095.
    • (2015) Nat Biotechnol. , vol.33 , Issue.4 , pp. 377-U157
    • Zhou, K.1    Qiao, K.J.2    Edgar, S.3    Stephanopoulos, G.4


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