Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in taxol biosynthesis

Journal of Biological Chemistry

Volumn 279, Issue 52, 2004, Pages 53947-53954

  Walker, Kevin D ^a   Klettke, Karin ^a   Akiyama, Takumi ^b,c   Croteau, Rodney ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; BIOSYNTHESIS; DNA; DRUG PRODUCTS; ENZYMES; ESCHERICHIA COLI; GENES; PH EFFECTS; TUMORS;

HETEROLOGOUS EXPRESSION; PLANT ENZYMES; REVERSE GENETICS;

CLONING;

ALPHA PHENYLALANINE; COMPLEMENTARY DNA; MUTASE; PACLITAXEL; PHENYLALANINE; PHENYLALANINE AMINOMUTASE; PHENYLALANINE AMMONIA LYASE; RECOMBINANT ENZYME; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; DNA LIBRARY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; ISOMERISM; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PH MEASUREMENT; PLANT GENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; STEREOCHEMISTRY; TAXUS; TAXUS CUSPIDATA;

AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA, PLANT; ESCHERICHIA COLI; GENE EXPRESSION; GENE LIBRARY; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; OPEN READING FRAMES; PACLITAXEL; PHENYLALANINE AMMONIA-LYASE; RECOMBINANT PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TAXUS;

CUSPIDATA; ESCHERICHIA COLI; TAXUS; TAXUS CHINENSIS; TAXUS CUSPIDATA;

EID: 11144225850     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411215200     Document Type: Article

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