메뉴 건너뛰기




Volumn 12, Issue 1, 2013, Pages

In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories

Author keywords

Constrained minimal cut sets; Elementary mode analysis; Escherichia coli; In silico; Isoprenoids; Metabolic engineering; Saccharomyces cerevisiae; Terpenoids

Indexed keywords

ACETYL COENZYME A; CARBON; TERPENOID;

EID: 84884376873     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-12-84     Document Type: Article
Times cited : (76)

References (86)
  • 1
    • 84864186953 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries
    • 10.1007/s00018-012-0945-1, 22388689
    • Hong KK, Nielsen J. Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries. Cell Mol Life Sci 2012, 69:2671-2690. 10.1007/s00018-012-0945-1, 22388689.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2671-2690
    • Hong, K.K.1    Nielsen, J.2
  • 2
    • 67651030513 scopus 로고    scopus 로고
    • Biosynthesis of plant isoprenoids: perspectives for microbial engineering
    • 10.1146/annurev.arplant.043008.091955, 19575586
    • Kirby J, Keasling JD. Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu Rev Plant Biol 2009, 60:335-355. 10.1146/annurev.arplant.043008.091955, 19575586.
    • (2009) Annu Rev Plant Biol , vol.60 , pp. 335-355
    • Kirby, J.1    Keasling, J.D.2
  • 3
    • 14144252096 scopus 로고    scopus 로고
    • Artemisinins
    • 10.1136/pgmj.2004.028399, 1743191, 15701735
    • Woodrow CJ, Haynes RK, Krishna S. Artemisinins. Postgrad Med J 2005, 81:71-78. 10.1136/pgmj.2004.028399, 1743191, 15701735.
    • (2005) Postgrad Med J , vol.81 , pp. 71-78
    • Woodrow, C.J.1    Haynes, R.K.2    Krishna, S.3
  • 4
    • 67149140350 scopus 로고    scopus 로고
    • Organic chemistry: Synthetic lessons from nature
    • 10.1038/459786a, 19516330
    • Davies HM. Organic chemistry: Synthetic lessons from nature. Nature 2009, 459:786-787. 10.1038/459786a, 19516330.
    • (2009) Nature , vol.459 , pp. 786-787
    • Davies, H.M.1
  • 5
    • 84861128941 scopus 로고    scopus 로고
    • Toward biosynthetic design and implementation of Escherichia coli-derived paclitaxel and other heterologous polyisoprene compounds
    • 10.1128/AEM.07391-11, 3318847, 22287010
    • Jiang M, Stephanopoulos G, Pfeifer BA. Toward biosynthetic design and implementation of Escherichia coli-derived paclitaxel and other heterologous polyisoprene compounds. Appl Environ Microbiol 2012, 78:2497-2504. 10.1128/AEM.07391-11, 3318847, 22287010.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 2497-2504
    • Jiang, M.1    Stephanopoulos, G.2    Pfeifer, B.A.3
  • 6
    • 48149106189 scopus 로고    scopus 로고
    • Metabolic engineering of microorganisms for isoprenoid production
    • 10.1039/b802939c, 18663389
    • Kirby J, Keasling JD. Metabolic engineering of microorganisms for isoprenoid production. Nat Prod Rep 2008, 25:656-661. 10.1039/b802939c, 18663389.
    • (2008) Nat Prod Rep , vol.25 , pp. 656-661
    • Kirby, J.1    Keasling, J.D.2
  • 8
    • 84856389651 scopus 로고    scopus 로고
    • Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
    • 10.1073/pnas.1110740109, 3271868, 22247290
    • Westfall PJ, Pitera DJ, Lenihan JR, Eng D, Woolard FX, Regentin R, Horning T, Tsuruta H, Melis DJ, Owens A, et al. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc Natl Acad Sci U S A 2012, 109:E111-E118. 10.1073/pnas.1110740109, 3271868, 22247290.
    • (2012) Proc Natl Acad Sci U S A , vol.109
    • Westfall, P.J.1    Pitera, D.J.2    Lenihan, J.R.3    Eng, D.4    Woolard, F.X.5    Regentin, R.6    Horning, T.7    Tsuruta, H.8    Melis, D.J.9    Owens, A.10
  • 9
    • 34247182988 scopus 로고    scopus 로고
    • Engineering Escherichia coli for production of functionalized terpenoids using plant P450s
    • 10.1038/nchembio875, 17438551
    • Chang MC, Eachus RA, Trieu W, Ro DK, Keasling JD. Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol 2007, 3:274-277. 10.1038/nchembio875, 17438551.
    • (2007) Nat Chem Biol , vol.3 , pp. 274-277
    • Chang, M.C.1    Eachus, R.A.2    Trieu, W.3    Ro, D.K.4    Keasling, J.D.5
  • 10
    • 80052030821 scopus 로고    scopus 로고
    • Harnessing yeast subcellular compartments for the production of plant terpenoids
    • 10.1016/j.ymben.2011.05.001, 21601648
    • Farhi M, Marhevka E, Masci T, Marcos E, Eyal Y, Ovadis M, Abeliovich H, Vainstein A. Harnessing yeast subcellular compartments for the production of plant terpenoids. Metab Eng 2011, 13:474-481. 10.1016/j.ymben.2011.05.001, 21601648.
    • (2011) Metab Eng , vol.13 , pp. 474-481
    • Farhi, M.1    Marhevka, E.2    Masci, T.3    Marcos, E.4    Eyal, Y.5    Ovadis, M.6    Abeliovich, H.7    Vainstein, A.8
  • 11
    • 84885846748 scopus 로고    scopus 로고
    • Developing a yeast cell factory for the production of terpenoids
    • Kampranis SC, Makris AM. Developing a yeast cell factory for the production of terpenoids. Comput Struct Biotechnol J 2012, 3:1-7.
    • (2012) Comput Struct Biotechnol J , vol.3 , pp. 1-7
    • Kampranis, S.C.1    Makris, A.M.2
  • 12
    • 32944474480 scopus 로고    scopus 로고
    • Microbial isoprenoid production: an example of green chemistry through metabolic engineering
    • Maury J, Asadollahi MA, Moller K, Clark A, Nielsen J. Microbial isoprenoid production: an example of green chemistry through metabolic engineering. Adv Biochem Eng Biotechnol 2005, 100:19-51.
    • (2005) Adv Biochem Eng Biotechnol , vol.100 , pp. 19-51
    • Maury, J.1    Asadollahi, M.A.2    Moller, K.3    Clark, A.4    Nielsen, J.5
  • 13
    • 84871676943 scopus 로고    scopus 로고
    • Reconstruction and evaluation of the synthetic bacterial MEP Pathway in Saccharomyces cerevisiae
    • 10.1371/journal.pone.0052498, 3532213, 23285068
    • Partow S, Siewers V, Daviet L, Schalk M, Nielsen J. Reconstruction and evaluation of the synthetic bacterial MEP Pathway in Saccharomyces cerevisiae. PLoS One 2012, 7:e52498. 10.1371/journal.pone.0052498, 3532213, 23285068.
    • (2012) PLoS One , vol.7
    • Partow, S.1    Siewers, V.2    Daviet, L.3    Schalk, M.4    Nielsen, J.5
  • 15
    • 0034838359 scopus 로고    scopus 로고
    • Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol
    • 10.1016/S0968-0896(01)00072-4, 11553461
    • Huang Q, Roessner CA, Croteau R, Scott AI. Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol. Bioorg Med Chem 2001, 9:2237-2242. 10.1016/S0968-0896(01)00072-4, 11553461.
    • (2001) Bioorg Med Chem , vol.9 , pp. 2237-2242
    • Huang, Q.1    Roessner, C.A.2    Croteau, R.3    Scott, A.I.4
  • 16
    • 0035916370 scopus 로고    scopus 로고
    • Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production
    • 10.1002/1097-0290(20000220)72:4<408::AID-BIT1003>3.0.CO;2-H, 11180061
    • Kim SW, Keasling JD. Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production. Biotechnol Bioeng 2001, 72:408-415. 10.1002/1097-0290(20000220)72:4<408::AID-BIT1003>3.0.CO;2-H, 11180061.
    • (2001) Biotechnol Bioeng , vol.72 , pp. 408-415
    • Kim, S.W.1    Keasling, J.D.2
  • 17
    • 0038391517 scopus 로고    scopus 로고
    • Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
    • 10.1038/nbt833, 12778056
    • Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 2003, 21:796-802. 10.1038/nbt833, 12778056.
    • (2003) Nat Biotechnol , vol.21 , pp. 796-802
    • Martin, V.J.1    Pitera, D.J.2    Withers, S.T.3    Newman, J.D.4    Keasling, J.D.5
  • 18
    • 76849089864 scopus 로고    scopus 로고
    • Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering
    • 10.1007/s00253-009-2219-x, 2811251, 19777230
    • Morrone D, Lowry L, Determan MK, Hershey DM, Xu M, Peters RJ. Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. Appl Microbiol Biotechnol 2010, 85:1893-1906. 10.1007/s00253-009-2219-x, 2811251, 19777230.
    • (2010) Appl Microbiol Biotechnol , vol.85 , pp. 1893-1906
    • Morrone, D.1    Lowry, L.2    Determan, M.K.3    Hershey, D.M.4    Xu, M.5    Peters, R.J.6
  • 19
    • 43049089374 scopus 로고    scopus 로고
    • Carotenoid accumulation in bacteria with enhanced supply of isoprenoid precursors by upregulation of exogenous or endogenous pathways
    • 10.1016/j.jbiotec.2008.02.023, 18417238
    • Rodriguez-Villalon A, Perez-Gil J, Rodriguez-Concepcion M. Carotenoid accumulation in bacteria with enhanced supply of isoprenoid precursors by upregulation of exogenous or endogenous pathways. J Biotechnol 2008, 135:78-84. 10.1016/j.jbiotec.2008.02.023, 18417238.
    • (2008) J Biotechnol , vol.135 , pp. 78-84
    • Rodriguez-Villalon, A.1    Perez-Gil, J.2    Rodriguez-Concepcion, M.3
  • 20
    • 29544444196 scopus 로고    scopus 로고
    • Chromosomal promoter replacement of the isoprenoid pathway for enhancing carotenoid production in E. coli
    • 10.1016/j.ymben.2005.08.005, 16257556
    • Yuan LZ, Rouviere PE, Larossa RA, Suh W. Chromosomal promoter replacement of the isoprenoid pathway for enhancing carotenoid production in E. coli. Metab Eng 2006, 8:79-90. 10.1016/j.ymben.2005.08.005, 16257556.
    • (2006) Metab Eng , vol.8 , pp. 79-90
    • Yuan, L.Z.1    Rouviere, P.E.2    Larossa, R.A.3    Suh, W.4
  • 21
    • 79955009094 scopus 로고    scopus 로고
    • Novel reference genes for quantifying transcriptional responses of Escherichia coli to protein overexpression by quantitative PCR
    • 10.1186/1471-2199-12-18, 3110127, 21513543
    • Zhou K, Zhou L, Lim Q, Zou R, Stephanopoulos G, Too HP. Novel reference genes for quantifying transcriptional responses of Escherichia coli to protein overexpression by quantitative PCR. BMC Mol Biol 2011, 12:18. 10.1186/1471-2199-12-18, 3110127, 21513543.
    • (2011) BMC Mol Biol , vol.12 , pp. 18
    • Zhou, K.1    Zhou, L.2    Lim, Q.3    Zou, R.4    Stephanopoulos, G.5    Too, H.P.6
  • 22
    • 44249111668 scopus 로고    scopus 로고
    • Application of functional genomics to pathway optimization for increased isoprenoid production
    • 10.1128/AEM.02750-07, 2394933, 18344344
    • Kizer L, Pitera DJ, Pfleger BF, Keasling JD. Application of functional genomics to pathway optimization for increased isoprenoid production. Appl Environ Microbiol 2008, 74:3229-3241. 10.1128/AEM.02750-07, 2394933, 18344344.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 3229-3241
    • Kizer, L.1    Pitera, D.J.2    Pfleger, B.F.3    Keasling, J.D.4
  • 23
    • 33847309176 scopus 로고    scopus 로고
    • Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
    • 10.1016/j.ymben.2006.11.002, 17239639
    • Pitera DJ, Paddon CJ, Newman JD, Keasling JD. Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab Eng 2007, 9:193-207. 10.1016/j.ymben.2006.11.002, 17239639.
    • (2007) Metab Eng , vol.9 , pp. 193-207
    • Pitera, D.J.1    Paddon, C.J.2    Newman, J.D.3    Keasling, J.D.4
  • 25
    • 62849084758 scopus 로고    scopus 로고
    • Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli
    • 10.1016/j.jbiotec.2009.01.008, 19428716
    • Yoon SH, Lee SH, Das A, Ryu HK, Jang HJ, Kim JY, Oh DK, Keasling JD, Kim SW. Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli. J Biotechnol 2009, 140:218-226. 10.1016/j.jbiotec.2009.01.008, 19428716.
    • (2009) J Biotechnol , vol.140 , pp. 218-226
    • Yoon, S.H.1    Lee, S.H.2    Das, A.3    Ryu, H.K.4    Jang, H.J.5    Kim, J.Y.6    Oh, D.K.7    Keasling, J.D.8    Kim, S.W.9
  • 26
    • 0031962865 scopus 로고    scopus 로고
    • Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast
    • 10.1007/s002530051138, 9487712
    • Polakowski T, Stahl U, Lang C. Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast. Appl Microbiol Biotechnol 1998, 49:66-71. 10.1007/s002530051138, 9487712.
    • (1998) Appl Microbiol Biotechnol , vol.49 , pp. 66-71
    • Polakowski, T.1    Stahl, U.2    Lang, C.3
  • 27
    • 0030772492 scopus 로고    scopus 로고
    • Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme a reductase on squalene synthesis in Saccharomyces cerevisiae
    • 168639, 9292983
    • Donald KA, Hampton RY, Fritz IB. Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme a reductase on squalene synthesis in Saccharomyces cerevisiae. Appl Environ Microbiol 1997, 63:3341-3344. 168639, 9292983.
    • (1997) Appl Environ Microbiol , vol.63 , pp. 3341-3344
    • Donald, K.A.1    Hampton, R.Y.2    Fritz, I.B.3
  • 28
    • 0033615648 scopus 로고    scopus 로고
    • A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase in eukaryotes
    • 10.1074/jbc.274.44.31671, 10531376
    • Gardner RG, Hampton RY. A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase in eukaryotes. J Biol Chem 1999, 274:31671-31678. 10.1074/jbc.274.44.31671, 10531376.
    • (1999) J Biol Chem , vol.274 , pp. 31671-31678
    • Gardner, R.G.1    Hampton, R.Y.2
  • 29
    • 44449098258 scopus 로고    scopus 로고
    • Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase
    • 10.1002/bit.21766, 18175359
    • Paradise EM, Kirby J, Chan R, Keasling JD. Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. Biotechnol Bioeng 2008, 100:371-378. 10.1002/bit.21766, 18175359.
    • (2008) Biotechnol Bioeng , vol.100 , pp. 371-378
    • Paradise, E.M.1    Kirby, J.2    Chan, R.3    Keasling, J.D.4
  • 30
    • 38449112770 scopus 로고    scopus 로고
    • Production of plant sesquiterpenes in Saccharomyces cerevisiae: effect of ERG9 repression on sesquiterpene biosynthesis
    • 10.1002/bit.21581, 17705244
    • Asadollahi MA, Maury J, Moller K, Nielsen KF, Schalk M, Clark A, Nielsen J. Production of plant sesquiterpenes in Saccharomyces cerevisiae: effect of ERG9 repression on sesquiterpene biosynthesis. Biotechnol Bioeng 2008, 99:666-677. 10.1002/bit.21581, 17705244.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 666-677
    • Asadollahi, M.A.1    Maury, J.2    Moller, K.3    Nielsen, K.F.4    Schalk, M.5    Clark, A.6    Nielsen, J.7
  • 31
    • 84865545171 scopus 로고    scopus 로고
    • Combined metabolic engineering of precursor and co-factor supply to increase alpha-santalene production by Saccharomyces cerevisiae
    • 10.1186/1475-2859-11-117, 3527295, 22938570
    • Scalcinati G, Partow S, Siewers V, Schalk M, Daviet L, Nielsen J. Combined metabolic engineering of precursor and co-factor supply to increase alpha-santalene production by Saccharomyces cerevisiae. Microb Cell Fact 2012, 11:117. 10.1186/1475-2859-11-117, 3527295, 22938570.
    • (2012) Microb Cell Fact , vol.11 , pp. 117
    • Scalcinati, G.1    Partow, S.2    Siewers, V.3    Schalk, M.4    Daviet, L.5    Nielsen, J.6
  • 32
    • 74549189949 scopus 로고    scopus 로고
    • Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties
    • 10.1186/1752-0509-3-120, 2808316, 20035624
    • Melzer G, Esfandabadi ME, Franco-Lara E, Wittmann C. Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties. BMC Syst Biol 2009, 3:120. 10.1186/1752-0509-3-120, 2808316, 20035624.
    • (2009) BMC Syst Biol , vol.3 , pp. 120
    • Melzer, G.1    Esfandabadi, M.E.2    Franco-Lara, E.3    Wittmann, C.4
  • 34
    • 0034064689 scopus 로고    scopus 로고
    • A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks
    • 10.1038/73786, 10700151
    • Schuster S, Fell DA, Dandekar T. A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks. Nat Biotechnol 2000, 18:326-332. 10.1038/73786, 10700151.
    • (2000) Nat Biotechnol , vol.18 , pp. 326-332
    • Schuster, S.1    Fell, D.A.2    Dandekar, T.3
  • 35
    • 0036691976 scopus 로고    scopus 로고
    • Reaction routes in biochemical reaction systems: algebraic properties, validated calculation procedure and example from nucleotide metabolism
    • 10.1007/s002850200143, 12181603
    • Schuster S, Hilgetag C, Woods JH, Fell DA. Reaction routes in biochemical reaction systems: algebraic properties, validated calculation procedure and example from nucleotide metabolism. J Math Biol 2002, 45:153-181. 10.1007/s002850200143, 12181603.
    • (2002) J Math Biol , vol.45 , pp. 153-181
    • Schuster, S.1    Hilgetag, C.2    Woods, J.H.3    Fell, D.A.4
  • 36
    • 58149154663 scopus 로고    scopus 로고
    • Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism
    • 10.1007/s00253-008-1770-1, 2909134, 19015845
    • Trinh CT, Wlaschin A, Srienc F. Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism. Appl Microbiol Biotechnol 2009, 81:813-826. 10.1007/s00253-008-1770-1, 2909134, 19015845.
    • (2009) Appl Microbiol Biotechnol , vol.81 , pp. 813-826
    • Trinh, C.T.1    Wlaschin, A.2    Srienc, F.3
  • 37
    • 33745136489 scopus 로고    scopus 로고
    • Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum
    • 10.1016/j.ymben.2006.02.001, 16621639
    • Krömer JO, Wittmann C, Schröder H, Heinzle E. Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum. Metab Eng 2006, 8:353-369. 10.1016/j.ymben.2006.02.001, 16621639.
    • (2006) Metab Eng , vol.8 , pp. 353-369
    • Krömer, J.O.1    Wittmann, C.2    Schröder, H.3    Heinzle, E.4
  • 38
    • 0037142769 scopus 로고    scopus 로고
    • Metabolic pathway analysis of a recombinant yeast for rational strain development
    • 10.1002/bit.10305, 12115428
    • Carlson R, Fell D, Srienc F. Metabolic pathway analysis of a recombinant yeast for rational strain development. Biotechnol Bioeng 2002, 79:121-134. 10.1002/bit.10305, 12115428.
    • (2002) Biotechnol Bioeng , vol.79 , pp. 121-134
    • Carlson, R.1    Fell, D.2    Srienc, F.3
  • 39
    • 0347761259 scopus 로고    scopus 로고
    • Fundamental Escherichia coli biochemical pathways for biomass and energy production: identification of reactions
    • 10.1002/bit.10812, 14705007
    • Carlson R, Srienc F. Fundamental Escherichia coli biochemical pathways for biomass and energy production: identification of reactions. Biotechnol Bioeng 2004, 85:1-19. 10.1002/bit.10812, 14705007.
    • (2004) Biotechnol Bioeng , vol.85 , pp. 1-19
    • Carlson, R.1    Srienc, F.2
  • 40
    • 79952103372 scopus 로고    scopus 로고
    • Computing complex metabolic intervention strategies using constrained minimal cut sets
    • 10.1016/j.ymben.2010.12.004, 21147248
    • Hädicke O, Klamt S. Computing complex metabolic intervention strategies using constrained minimal cut sets. Metab Eng 2011, 13:204-213. 10.1016/j.ymben.2010.12.004, 21147248.
    • (2011) Metab Eng , vol.13 , pp. 204-213
    • Hädicke, O.1    Klamt, S.2
  • 41
    • 76749169796 scopus 로고    scopus 로고
    • Rational design and construction of an efficient E. coli for production of diapolycopendioic acid
    • 10.1016/j.ymben.2009.11.002, 2875070, 19944775
    • Unrean P, Trinh CT, Srienc F. Rational design and construction of an efficient E. coli for production of diapolycopendioic acid. Metab Eng 2010, 12:112-122. 10.1016/j.ymben.2009.11.002, 2875070, 19944775.
    • (2010) Metab Eng , vol.12 , pp. 112-122
    • Unrean, P.1    Trinh, C.T.2    Srienc, F.3
  • 42
    • 33749448704 scopus 로고    scopus 로고
    • Design, construction and performance of the most efficient biomass producing E. coli bacterium
    • 10.1016/j.ymben.2006.07.006, 16997589
    • Trinh CT, Carlson R, Wlaschin A, Srienc F. Design, construction and performance of the most efficient biomass producing E. coli bacterium. Metab Eng 2006, 8:628-638. 10.1016/j.ymben.2006.07.006, 16997589.
    • (2006) Metab Eng , vol.8 , pp. 628-638
    • Trinh, C.T.1    Carlson, R.2    Wlaschin, A.3    Srienc, F.4
  • 43
    • 45749137679 scopus 로고    scopus 로고
    • Minimal Escherichia coli cell for the most efficient production of ethanol from hexoses and pentoses
    • 10.1128/AEM.02708-07, 2446564, 18424547
    • Trinh CT, Unrean P, Srienc F. Minimal Escherichia coli cell for the most efficient production of ethanol from hexoses and pentoses. Appl Environ Microbiol 2008, 74:3634-3643. 10.1128/AEM.02708-07, 2446564, 18424547.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 3634-3643
    • Trinh, C.T.1    Unrean, P.2    Srienc, F.3
  • 44
    • 70350517579 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for efficient conversion of glycerol to ethanol
    • 10.1128/AEM.00670-09, 2772450, 19734340
    • Trinh CT, Srienc F. Metabolic engineering of Escherichia coli for efficient conversion of glycerol to ethanol. Appl Environ Microbiol 2009, 75:6696-6705. 10.1128/AEM.00670-09, 2772450, 19734340.
    • (2009) Appl Environ Microbiol , vol.75 , pp. 6696-6705
    • Trinh, C.T.1    Srienc, F.2
  • 45
    • 22844452835 scopus 로고    scopus 로고
    • Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets
    • 10.1038/nbt1083, 15821729
    • Alper H, Miyaoku K, Stephanopoulos G. Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets. Nat Biotechnol 2005, 23:612-616. 10.1038/nbt1083, 15821729.
    • (2005) Nat Biotechnol , vol.23 , pp. 612-616
    • Alper, H.1    Miyaoku, K.2    Stephanopoulos, G.3
  • 46
    • 70449592325 scopus 로고    scopus 로고
    • Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering
    • 10.1016/j.ymben.2009.07.001, 19619667
    • Asadollahi MA, Maury J, Patil KR, Schalk M, Clark A, Nielsen J. Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering. Metab Eng 2009, 11:328-334. 10.1016/j.ymben.2009.07.001, 19619667.
    • (2009) Metab Eng , vol.11 , pp. 328-334
    • Asadollahi, M.A.1    Maury, J.2    Patil, K.R.3    Schalk, M.4    Clark, A.5    Nielsen, J.6
  • 47
    • 77952265112 scopus 로고    scopus 로고
    • In silico identification of gene amplification targets for improvement of lycopene production
    • 10.1128/AEM.00115-10, 2869140, 20348305
    • Choi HS, Lee SY, Kim TY, Woo HM. In silico identification of gene amplification targets for improvement of lycopene production. Appl Environ Microbiol 2010, 76:3097-3105. 10.1128/AEM.00115-10, 2869140, 20348305.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 3097-3105
    • Choi, H.S.1    Lee, S.Y.2    Kim, T.Y.3    Woo, H.M.4
  • 48
    • 33847378479 scopus 로고    scopus 로고
    • Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids
    • 10.1016/j.ymben.2006.10.005, 17196416
    • Shiba Y, Paradise EM, Kirby J, Ro DK, Keasling JD. Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids. Metab Eng 2007, 9:160-168. 10.1016/j.ymben.2006.10.005, 17196416.
    • (2007) Metab Eng , vol.9 , pp. 160-168
    • Shiba, Y.1    Paradise, E.M.2    Kirby, J.3    Ro, D.K.4    Keasling, J.D.5
  • 49
    • 0035128694 scopus 로고    scopus 로고
    • Precursor balancing for metabolic engineering of lycopene production in Escherichia coli
    • 10.1021/bp000137t, 11170480
    • Farmer WR, Liao JC. Precursor balancing for metabolic engineering of lycopene production in Escherichia coli. Biotechnol Prog 2001, 17:57-61. 10.1021/bp000137t, 11170480.
    • (2001) Biotechnol Prog , vol.17 , pp. 57-61
    • Farmer, W.R.1    Liao, J.C.2
  • 50
    • 84875670791 scopus 로고    scopus 로고
    • Engineering central metabolic modules of Escherichia coli for improving β-carotene production
    • Zhao J, Li Q, Sun T, Zhu X, Xu H, Tang J, Zhang X, Ma Y. Engineering central metabolic modules of Escherichia coli for improving β-carotene production. Metab Eng 2013, 17:42-50.
    • (2013) Metab Eng , vol.17 , pp. 42-50
    • Zhao, J.1    Li, Q.2    Sun, T.3    Zhu, X.4    Xu, H.5    Tang, J.6    Zhang, X.7    Ma, Y.8
  • 51
    • 0032784969 scopus 로고    scopus 로고
    • A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes
    • 10.1002/(SICI)1097-0061(199907)15:10A<829::AID-YEA423>3.0.CO;2-9, 10407263
    • Navarro-Avino JP, Prasad R, Miralles VJ, Benito RM, Serrano R. A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes. Yeast 1999, 15:829-842. 10.1002/(SICI)1097-0061(199907)15:10A<829::AID-YEA423>3.0.CO;2-9, 10407263.
    • (1999) Yeast , vol.15 , pp. 829-842
    • Navarro-Avino, J.P.1    Prasad, R.2    Miralles, V.J.3    Benito, R.M.4    Serrano, R.5
  • 53
    • 84857624342 scopus 로고    scopus 로고
    • Microbial utilization of crude glycerol for the production of value-added products
    • 10.1007/s10295-011-1038-0, 21948485
    • Dobson R, Gray V, Rumbold K. Microbial utilization of crude glycerol for the production of value-added products. J Ind Microbiol Biotechnol 2012, 39:217-226. 10.1007/s10295-011-1038-0, 21948485.
    • (2012) J Ind Microbiol Biotechnol , vol.39 , pp. 217-226
    • Dobson, R.1    Gray, V.2    Rumbold, K.3
  • 54
    • 0033152146 scopus 로고    scopus 로고
    • Engineering baker's yeast: room for improvement
    • 10.1016/S0167-7799(99)01318-9, 10354561
    • Randez-Gil F, Sanz P, Prieto JA. Engineering baker's yeast: room for improvement. Trends Biotechnol 1999, 17:237-244. 10.1016/S0167-7799(99)01318-9, 10354561.
    • (1999) Trends Biotechnol , vol.17 , pp. 237-244
    • Randez-Gil, F.1    Sanz, P.2    Prieto, J.A.3
  • 55
    • 60749121157 scopus 로고    scopus 로고
    • Hemicellulose biorefineries: a review on biomass pretreatments
    • Carvalheiro F, Duarte LC, Gírio FM. Hemicellulose biorefineries: a review on biomass pretreatments. J Sci Ind Res 2008, 67:849-864.
    • (2008) J Sci Ind Res , vol.67 , pp. 849-864
    • Carvalheiro, F.1    Duarte, L.C.2    Gírio, F.M.3
  • 56
    • 0034110702 scopus 로고    scopus 로고
    • Biotechnological potential of agro-industrial residues: I: sugarcane bagasse
    • Pandey A, Soccol CR, Nigam P, Soccol VT. Biotechnological potential of agro-industrial residues: I: sugarcane bagasse. Bioresour Technol 2000, 74:69-80.
    • (2000) Bioresour Technol , vol.74 , pp. 69-80
    • Pandey, A.1    Soccol, C.R.2    Nigam, P.3    Soccol, V.T.4
  • 57
    • 57349088282 scopus 로고    scopus 로고
    • Glycerol: a promising and abundant carbon source for industrial microbiology
    • 10.1016/j.biotechadv.2008.07.006, 18775486
    • da Silva GP, Mack M, Contiero J. Glycerol: a promising and abundant carbon source for industrial microbiology. Biotechnol Adv 2009, 27:30-39. 10.1016/j.biotechadv.2008.07.006, 18775486.
    • (2009) Biotechnol Adv , vol.27 , pp. 30-39
    • da Silva, G.P.1    Mack, M.2    Contiero, J.3
  • 58
    • 33847202270 scopus 로고    scopus 로고
    • Comparison of the xylose reductase-xylitol dehydrogenase and the xylose isomerase pathways for xylose fermentation by recombinant Saccharomyces cerevisiae
    • 10.1186/1475-2859-6-5, 1797182, 17280608
    • Karhumaa K, Garcia Sanchez R, Hahn-Hagerdal B, Gorwa-Grauslund MF. Comparison of the xylose reductase-xylitol dehydrogenase and the xylose isomerase pathways for xylose fermentation by recombinant Saccharomyces cerevisiae. Microb Cell Fact 2007, 6:5. 10.1186/1475-2859-6-5, 1797182, 17280608.
    • (2007) Microb Cell Fact , vol.6 , pp. 5
    • Karhumaa, K.1    Garcia Sanchez, R.2    Hahn-Hagerdal, B.3    Gorwa-Grauslund, M.F.4
  • 59
    • 79957858524 scopus 로고    scopus 로고
    • In silico analysis and experimental improvement of taxadiene heterologous biosynthesis in Escherichia coli
    • Meng H, Wang Y, Hua Q, Zhang S, Wang X. In silico analysis and experimental improvement of taxadiene heterologous biosynthesis in Escherichia coli. Biotechnol Bioprocess Eng 2011, 16:205-215.
    • (2011) Biotechnol Bioprocess Eng , vol.16 , pp. 205-215
    • Meng, H.1    Wang, Y.2    Hua, Q.3    Zhang, S.4    Wang, X.5
  • 60
    • 78651479441 scopus 로고    scopus 로고
    • Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway
    • 10.1002/bit.22831, 20552672
    • Wang C, Yoon SH, Shah AA, Chung YR, Kim JY, Choi ES, Keasling JD, Kim SW. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. Biotechnol Bioeng 2010, 107:421-429. 10.1002/bit.22831, 20552672.
    • (2010) Biotechnol Bioeng , vol.107 , pp. 421-429
    • Wang, C.1    Yoon, S.H.2    Shah, A.A.3    Chung, Y.R.4    Kim, J.Y.5    Choi, E.S.6    Keasling, J.D.7    Kim, S.W.8
  • 61
    • 67649392816 scopus 로고    scopus 로고
    • Alkaline pH enhances farnesol production by Saccharomyces cerevisiae
    • 10.1016/j.jbiosc.2009.02.012, 19577192
    • Muramatsu M, Ohto C, Obata S, Sakuradani E, Shimizu S. Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. J Biosci Bioeng 2009, 108:52-55. 10.1016/j.jbiosc.2009.02.012, 19577192.
    • (2009) J Biosci Bioeng , vol.108 , pp. 52-55
    • Muramatsu, M.1    Ohto, C.2    Obata, S.3    Sakuradani, E.4    Shimizu, S.5
  • 62
    • 33645851015 scopus 로고    scopus 로고
    • Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae
    • 10.1007/s10529-006-0015-6, 16614895
    • Lindahl AL, Olsson ME, Mercke P, Tollbom O, Schelin J, Brodelius M, Brodelius PE. Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. Biotechnol Lett 2006, 28:571-580. 10.1007/s10529-006-0015-6, 16614895.
    • (2006) Biotechnol Lett , vol.28 , pp. 571-580
    • Lindahl, A.L.1    Olsson, M.E.2    Mercke, P.3    Tollbom, O.4    Schelin, J.5    Brodelius, M.6    Brodelius, P.E.7
  • 65
    • 0035862739 scopus 로고    scopus 로고
    • Expression of a cytoplasmic transhydrogenase in Saccharomyces cerevisiae results in formation of 2-oxoglutarate due to depletion of the NADPH pool
    • 10.1002/1097-0061(200101)18:1<19::AID-YEA650>3.0.CO;2-5, 11124698
    • Nissen TL, Anderlund M, Nielsen J, Villadsen J, Kielland-Brandt MC. Expression of a cytoplasmic transhydrogenase in Saccharomyces cerevisiae results in formation of 2-oxoglutarate due to depletion of the NADPH pool. Yeast 2001, 18:19-32. 10.1002/1097-0061(200101)18:1<19::AID-YEA650>3.0.CO;2-5, 11124698.
    • (2001) Yeast , vol.18 , pp. 19-32
    • Nissen, T.L.1    Anderlund, M.2    Nielsen, J.3    Villadsen, J.4    Kielland-Brandt, M.C.5
  • 66
    • 0242407529 scopus 로고    scopus 로고
    • Expression of Azotobacter vinelandii soluble transhydrogenase perturbs xylose reductase-mediated conversion of xylose to xylitol by recombinant Saccharomyces cerevisiae
    • Jeun Y-S, Kim M-D, Park Y-C, Lee T-H, Yoo M-S, Ryu Y-W, Seo J-H. Expression of Azotobacter vinelandii soluble transhydrogenase perturbs xylose reductase-mediated conversion of xylose to xylitol by recombinant Saccharomyces cerevisiae. J Mol Cata B: Enzym 2003, 26:251-256.
    • (2003) J Mol Cata B: Enzym , vol.26 , pp. 251-256
    • Jeun, Y.-S.1    Kim, M.-D.2    Park, Y.-C.3    Lee, T.-H.4    Yoo, M.-S.5    Ryu, Y.-W.6    Seo, J.-H.7
  • 67
    • 0032976492 scopus 로고    scopus 로고
    • Expression of the Escherichia coli pntA and pntB genes, encoding nicotinamide nucleotide transhydrogenase, in Saccharomyces cerevisiae and its effect on product formation during anaerobic glucose fermentation
    • 91345, 10347010
    • Anderlund M, Nissen TL, Nielsen J, Villadsen J, Rydstrom J, Hahn-Hagerdal B, Kielland-Brandt MC. Expression of the Escherichia coli pntA and pntB genes, encoding nicotinamide nucleotide transhydrogenase, in Saccharomyces cerevisiae and its effect on product formation during anaerobic glucose fermentation. Appl Environ Microbiol 1999, 65:2333-2340. 91345, 10347010.
    • (1999) Appl Environ Microbiol , vol.65 , pp. 2333-2340
    • Anderlund, M.1    Nissen, T.L.2    Nielsen, J.3    Villadsen, J.4    Rydstrom, J.5    Hahn-Hagerdal, B.6    Kielland-Brandt, M.C.7
  • 69
    • 0037079023 scopus 로고    scopus 로고
    • Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
    • 10.1038/nature01149, 12432395
    • Ibarra RU, Edwards JS, Palsson BO. Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature 2002, 420:186-189. 10.1038/nature01149, 12432395.
    • (2002) Nature , vol.420 , pp. 186-189
    • Ibarra, R.U.1    Edwards, J.S.2    Palsson, B.O.3
  • 70
    • 1342325419 scopus 로고    scopus 로고
    • The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli
    • Sauer U, Canonaco F, Heri S, Perrenoud A, Fischer E. The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli. J Biol Chem 2004, 279:6613-6619.
    • (2004) J Biol Chem , vol.279 , pp. 6613-6619
    • Sauer, U.1    Canonaco, F.2    Heri, S.3    Perrenoud, A.4    Fischer, E.5
  • 71
    • 25444467580 scopus 로고    scopus 로고
    • Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast
    • 10.1186/gb-2005-6-6-r49, 1175969, 15960801
    • Blank LM, Kuepfer L, Sauer U. Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast. Genome Biol 2005, 6:R49. 10.1186/gb-2005-6-6-r49, 1175969, 15960801.
    • (2005) Genome Biol , vol.6
    • Blank, L.M.1    Kuepfer, L.2    Sauer, U.3
  • 72
    • 0032544505 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH
    • 10.1074/jbc.273.38.24529, 9733747
    • Luttik MA, Overkamp KM, Kotter P, de Vries S, van Dijken JP, Pronk JT. The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH. J Biol Chem 1998, 273:24529-24534. 10.1074/jbc.273.38.24529, 9733747.
    • (1998) J Biol Chem , vol.273 , pp. 24529-24534
    • Luttik, M.A.1    Overkamp, K.M.2    Kotter, P.3    de Vries, S.4    van Dijken, J.P.5    Pronk, J.T.6
  • 73
    • 0032455440 scopus 로고    scopus 로고
    • Identification and characterization of MAE1, the Saccharomyces cerevisiae structural gene encoding mitochondrial malic enzyme
    • 107252, 9603875
    • Boles E, de Jong-Gubbels P, Pronk JT. Identification and characterization of MAE1, the Saccharomyces cerevisiae structural gene encoding mitochondrial malic enzyme. J Bacteriol 1998, 180:2875-2882. 107252, 9603875.
    • (1998) J Bacteriol , vol.180 , pp. 2875-2882
    • Boles, E.1    de Jong-Gubbels, P.2    Pronk, J.T.3
  • 74
    • 0022763351 scopus 로고
    • Deletion of the phosphoglucose isomerase structural gene makes growth and sporulation glucose dependent in Saccharomyces cerevisiae
    • 10.1007/BF00425515, 3020369
    • Aguilera A. Deletion of the phosphoglucose isomerase structural gene makes growth and sporulation glucose dependent in Saccharomyces cerevisiae. Mol Gen Genet 1986, 204:310-316. 10.1007/BF00425515, 3020369.
    • (1986) Mol Gen Genet , vol.204 , pp. 310-316
    • Aguilera, A.1
  • 75
    • 1042269472 scopus 로고    scopus 로고
    • Minimal cut sets in biochemical reaction networks
    • 10.1093/bioinformatics/btg395, 14734314
    • Klamt S, Gilles ED. Minimal cut sets in biochemical reaction networks. Bioinformatics 2004, 20:226-234. 10.1093/bioinformatics/btg395, 14734314.
    • (2004) Bioinformatics , vol.20 , pp. 226-234
    • Klamt, S.1    Gilles, E.D.2
  • 76
    • 32144453095 scopus 로고    scopus 로고
    • Generalized concept of minimal cut sets in biochemical networks
    • 10.1016/j.biosystems.2005.04.009, 16303240
    • Klamt S. Generalized concept of minimal cut sets in biochemical networks. Biosystems 2006, 83:233-247. 10.1016/j.biosystems.2005.04.009, 16303240.
    • (2006) Biosystems , vol.83 , pp. 233-247
    • Klamt, S.1
  • 77
    • 34447551397 scopus 로고    scopus 로고
    • Structural and functional analysis of cellular networks with Cell NetAnalyzer
    • 10.1186/1752-0509-1-2, 1847467, 17408509
    • Klamt S, Saez-Rodriguez J, Gilles ED. Structural and functional analysis of cellular networks with Cell NetAnalyzer. BMC Syst Biol 2007, 1:2. 10.1186/1752-0509-1-2, 1847467, 17408509.
    • (2007) BMC Syst Biol , vol.1 , pp. 2
    • Klamt, S.1    Saez-Rodriguez, J.2    Gilles, E.D.3
  • 78
    • 0037200931 scopus 로고    scopus 로고
    • A functional genomics approach using metabolomics and in silico pathway analysis
    • 10.1002/bit.10378, 12209793
    • Förster J, Gombert AK, Nielsen J. A functional genomics approach using metabolomics and in silico pathway analysis. Biotechnol Bioeng 2002, 79:703-712. 10.1002/bit.10378, 12209793.
    • (2002) Biotechnol Bioeng , vol.79 , pp. 703-712
    • Förster, J.1    Gombert, A.K.2    Nielsen, J.3
  • 79
    • 34547618131 scopus 로고    scopus 로고
    • Identification of flux regulation coefficients from elementary flux modes: a systems biology tool for analysis of metabolic networks
    • 10.1002/bit.21339, 17238207
    • Nookaew I, Meechai A, Thammarongtham C, Laoteng K, Ruanglek V, Cheevadhanarak S, Nielsen J, Bhumiratana S. Identification of flux regulation coefficients from elementary flux modes: a systems biology tool for analysis of metabolic networks. Biotechnol Bioeng 2007, 97:1535-1549. 10.1002/bit.21339, 17238207.
    • (2007) Biotechnol Bioeng , vol.97 , pp. 1535-1549
    • Nookaew, I.1    Meechai, A.2    Thammarongtham, C.3    Laoteng, K.4    Ruanglek, V.5    Cheevadhanarak, S.6    Nielsen, J.7    Bhumiratana, S.8
  • 80
    • 0025796578 scopus 로고
    • Properties of the two terminal oxidases of Escherichia coli
    • 10.1021/bi00230a019, 1850294
    • Puustinen A, Finel M, Haltia T, Gennis RB, Wikstrom M. Properties of the two terminal oxidases of Escherichia coli. Biochemistry 1991, 30:3936-3942. 10.1021/bi00230a019, 1850294.
    • (1991) Biochemistry , vol.30 , pp. 3936-3942
    • Puustinen, A.1    Finel, M.2    Haltia, T.3    Gennis, R.B.4    Wikstrom, M.5
  • 83
    • 84858983547 scopus 로고    scopus 로고
    • KEGG for integration and interpretation of large-scale molecular data sets
    • 10.1093/nar/gkr988, 3245020, 22080510
    • Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 2012, 40:D109-D114. 10.1093/nar/gkr988, 3245020, 22080510.
    • (2012) Nucleic Acids Res , vol.40
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3    Furumichi, M.4    Tanabe, M.5
  • 85
    • 52649105455 scopus 로고    scopus 로고
    • The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism
    • 10.1186/1752-0509-2-71, 2542360, 18687109
    • Nookaew I, Jewett MC, Meechai A, Thammarongtham C, Laoteng K, Cheevadhanarak S, Nielsen J, Bhumiratana S. The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism. BMC Syst Biol 2008, 2:71. 10.1186/1752-0509-2-71, 2542360, 18687109.
    • (2008) BMC Syst Biol , vol.2 , pp. 71
    • Nookaew, I.1    Jewett, M.C.2    Meechai, A.3    Thammarongtham, C.4    Laoteng, K.5    Cheevadhanarak, S.6    Nielsen, J.7    Bhumiratana, S.8
  • 86
    • 84876522835 scopus 로고    scopus 로고
    • BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA
    • 10.1093/nar/gks1049, 3531171, 23203881
    • Schomburg I, Chang A, Placzek S, Sohngen C, Rother M, Lang M, Munaretto C, Ulas S, Stelzer M, Grote A, et al. BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA. Nucleic Acids Res 2013, 41:D764-D772. 10.1093/nar/gks1049, 3531171, 23203881.
    • (2013) Nucleic Acids Res , vol.41
    • Schomburg, I.1    Chang, A.2    Placzek, S.3    Sohngen, C.4    Rother, M.5    Lang, M.6    Munaretto, C.7    Ulas, S.8    Stelzer, M.9    Grote, A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.