메뉴 건너뛰기




Volumn 20, Issue 7, 2013, Pages 880-891

Bioprocessing of plant in vitro systems for the mass production of pharmaceutically important metabolites: Paclitaxel and its derivatives

Author keywords

Anticancer agents; Metabolic engineering; Paclitaxel; Plant cell cultures; Taxane analogs; Taxus sp

Indexed keywords

3' TERT BUTYL 3' N TERT BUTYLOXYCARBONYL 4 DEACETYL 3' N DEBENZOYL 3' DEPHENYL 4 O METHOXYCARBONYLPACLITAXEL; 7 METHYLTHIOMETHYLPACLITAXEL; CREMOPHOR; DOCETAXEL; PACLITAXEL; PACLITAXEL DERIVATIVE; PACLITAXEL POLIGLUMEX; TAXANE DERIVATIVE; TESETAXEL;

EID: 84878002829     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986713805219064     Document Type: Article
Times cited : (66)

References (116)
  • 2
    • 78650254061 scopus 로고    scopus 로고
    • Production of the anticancer drug taxol in taxus baccata suspensión cultures: A review
    • Malic, S.; Cusidó, R.M.; Mirjalili, M.H.; Moyano, E.; Palazon, J.; Bonfill, M. Production of the anticancer drug taxol in Taxus baccata suspensión cultures: a review. Proc. Biochem., 2011, 46, 23-34.
    • (2011) Proc. Biochem. , vol.46 , pp. 23-34
    • Malic, S.1    Cusidó, R.M.2    Mirjalili, M.H.3    Moyano, E.4    Palazon, J.5    Bonfill, M.6
  • 3
    • 0015211527 scopus 로고
    • Plant antitumor agents vi. The isolation and structure of taxol: A novel antileukemic and antitumour agent from
    • Wani, M.C.; Taylor, H.L.; Wall, M.E. Plant antitumor agents VI. The isolation and structure of taxol: a novel antileukemic and antitumour agent from Taxus brevifolia. J. Am. Chem., 1971, 93, 2325-2327.
    • (1971) Taxus brevifolia. J. Am. Chem. , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3
  • 4
    • 34347335758 scopus 로고    scopus 로고
    • Strategies to bypass the taxol problem. Enantioselective cascade catalysis, a new approach for the efficient construction of molecular complexity
    • DOI 10.1055/s-2007-980382
    • Walji, M.A.; MacMillan, D.W.C. Strategies to bypass the taxol problem. Enantioselective cascade catalysis, a new approach for the efficient construction of molecular complexity. Synlett, 2007, 10, 1477-1489. (Pubitemid 47012845)
    • (2007) Synlett , Issue.10 , pp. 1477-1489
    • Walji, A.M.1    MacMillan, D.W.C.2
  • 5
    • 4444351323 scopus 로고    scopus 로고
    • Plant cell factories in the post-genomic era: New ways to produce designer secondary metabolites
    • Oksman-Caldentey, K.-M.; Inzé, D. Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites. Trends in Plant Sci., 2004, 433-441.
    • (2004) Trends in Plant Sci. , pp. 433-441
    • Oksman-Caldentey, K.-M.1    Inzé, D.2
  • 6
    • 33646172454 scopus 로고    scopus 로고
    • Novel formulations of taxanes: A review. Old wine in new bottle?
    • Hennenfent, K.J.; Govidan, R. Novel formulations of taxanes: a review. Old wine in new bottle? Annals of Oncol., 2006, 17, 735-749.
    • (2006) Annals of Oncol. , vol.17 , pp. 735-749
    • Hennenfent, K.J.1    Govidan, R.2
  • 7
    • 0041703019 scopus 로고    scopus 로고
    • Pharmacological effects of formulation vehicles: Implications for cancer chemotherapy
    • DOI 10.2165/00003088-200342070-00005
    • Ten Tije, A.J.; Loos, W.J.; Sparreboom, A. Pharmacological effects of formulation vehicles: implications for cancer chemotherapy. Clin. Pharmacokinet., 2003, 42, 665-685. (Pubitemid 36936530)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.7 , pp. 665-685
    • Ten Tije, A.J.1    Verweij, J.2    Loos, W.J.3    Sparreboom, A.4
  • 8
    • 0038419962 scopus 로고    scopus 로고
    • DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo
    • Shionoya, M.; Jimbo, T.; Kitagawa, M.; Sog,a T.; Tohgo, A. DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistence in vitro and in vivo. Cancer Sci., 2003, 94(5), 459-466. (Pubitemid 36790480)
    • (2003) Cancer Science , vol.94 , Issue.5 , pp. 459-466
    • Shionoya, M.1    Jimbo, T.2    Kitagawa, M.3    Soga, T.4    Tohgo, A.5
  • 11
    • 78651279520 scopus 로고    scopus 로고
    • Polymeric micelles in anticancer therapy: Targeting, imaging and triggered release
    • Oerlemans, C.; Bult, W.; Bos, M.; Storm, G.; Nijsen, J.F.W.; Hennink, W.E. Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Phar. Res., 2010, 27, 2569-2589.
    • (2010) Phar. Res. , vol.27 , pp. 2569-2589
    • Oerlemans, C.1    Bult, W.2    Bos, M.3    Storm, G.4    Nijsen, J.F.W.5    Hennink, W.E.6
  • 12
    • 31344438585 scopus 로고    scopus 로고
    • Local intracerebral administration of paclitaxel with the paclimer delivery system: Toxicity study in a canine model
    • DOI 10.1007/s11060-005-5531-z
    • Pradilla, G.; Wang, P.P.; Gabikian, P.; Li, K.; Magee, C.A.; Walter, K.A.; Brem, H. Local intracerebral administration of Px with the paclimer® delibery system: toxicity study in a canine model. J. Neurooncol., 2006, 76(2), 131-138. (Pubitemid 43135845)
    • (2006) Journal of Neuro-Oncology , vol.76 , Issue.2 , pp. 131-138
    • Pradilla, G.1    Wang, P.P.2    Gabikian, P.3    Li, K.4    Magee, C.A.5    Walter, K.A.6    Brem, H.7
  • 13
    • 0034922655 scopus 로고    scopus 로고
    • Preclinical antitumor activity of two novel taxanes
    • DOI 10.1007/s002800000241
    • Rose, W.C.; Fairchild, C.; Lee, F.Y. Preclinical antitumor activity of two novel taxanes. Cancer Chemoter. Pharmacol., 2001, 47, 97-105. (Pubitemid 32662313)
    • (2001) Cancer Chemotherapy and Pharmacology , vol.47 , Issue.2 , pp. 97-105
    • Rose, W.C.1    Fairchild, C.2    Lee, F.Y.F.3
  • 14
    • 0035479085 scopus 로고    scopus 로고
    • The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells
    • DOI 10.1016/S0360-3016(01)01658-3, PII S0360301601016583
    • Kim, J.S.; Amorino, G.P., Pyo, H. Cao, Q.; Price, J.O.; Choy, H. The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cáncer cells. Int. J. Radiat. Oncol. Biol. Phys., 2001, 51, 525-534. (Pubitemid 32884300)
    • (2001) International Journal of Radiation Oncology Biology Physics , vol.51 , Issue.2 , pp. 525-534
    • Kim, J.-S.1    Amorino, G.P.2    Pyo, H.3    Cao, Q.4    Price, J.O.5    Choy, H.6
  • 15
    • 0038419962 scopus 로고    scopus 로고
    • DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo
    • Shionoya, M.; Jimbo, T.; Kitagawa, M.; Soga, T.; Tohgo, A. DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Cancer Sci., 2003, 94, 459-466. (Pubitemid 36790480)
    • (2003) Cancer Science , vol.94 , Issue.5 , pp. 459-466
    • Shionoya, M.1    Jimbo, T.2    Kitagawa, M.3    Soga, T.4    Tohgo, A.5
  • 18
    • 84860182249 scopus 로고    scopus 로고
    • The european medicines agency review of cabazitaxel (jevtana®) for the treatment of hormone-refractory metastatic prostate cancer: Summary of the scientific assessment of the committee for medicinal products for human use
    • Pean, E.; Demolis, P.; Moreau, A.; Hemmings, R.J.; O'Connor, D.; Brown, D.; Shepard, T.; Abadie, E.; Pignatti, F. The European medicines agency review of cabazitaxel (Jevtana®) for the treatment of hormone-refractory metastatic prostate cancer: Summary of the scientific assessment of the committee for medicinal products for human use. Oncologist, 2012, 17(4), 543-549.
    • (2012) Oncologist , vol.17 , Issue.4 , pp. 543-549
    • Pean, E.1    Demolis, P.2    Moreau, A.3    Hemmings, R.J.4    O'Connor, D.5    Brown, D.6    Shepard, T.7    Abadie, E.8    Pignatti, F.9
  • 22
    • 0038216623 scopus 로고    scopus 로고
    • Taxanes: Microtubule and centrosome targets, and cell cycle dependent mechanisms of action
    • DOI 10.2174/1568009033481967
    • Abal, M.; Andreu, J.M.; Barasoain, I. Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanism of action. Curr. Cancer Drug Targets, 2003, 3, 193-203. (Pubitemid 36565761)
    • (2003) Current Cancer Drug Targets , vol.3 , Issue.3 , pp. 193-203
    • Abal, M.1    Andreu, J.M.2    Barasoain, I.3
  • 23
    • 0033214537 scopus 로고    scopus 로고
    • Structural view of microtubule dinamycs
    • Nogales E.A. Structural view of microtubule dinamycs. Cell Mol. Life Sci., 1999, 56, 133-142.
    • (1999) Cell Mol. Life Sci. , vol.56 , pp. 133-142
    • Nogales, E.A.1
  • 25
    • 0037424365 scopus 로고    scopus 로고
    • Fast kinetics of Taxol binding to microtubules: Effects of solution variables and microtubule-associated proteins
    • DOI 10.1074/jbc.M211163200
    • Diaz, J.F.; Barasoain, I.; Andreu, J.M. Fast kinetics of taxol binding to microtubules. Effects of solution variables and microtubule-Associated proteins. J. Biol. Chem., 2003, 278, 8407-8419. (Pubitemid 36800591)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8407-8419
    • Diaz, J.F.1    Barasoain, I.2    Andreu, J.M.3
  • 27
    • 65249157992 scopus 로고    scopus 로고
    • Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity
    • Freedman, H.; Huzil, J.T.; Luchko, T.; Luduena, R.F.; Tuszynski, J.A. Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity. J. Chem. Inf. Model., 2009, 49, 424-436.
    • (2009) J. Chem. Inf. Model. , vol.49 , pp. 424-436
    • Freedman, H.1    Huzil, J.T.2    Luchko, T.3    Luduena, R.F.4    Tuszynski, J.A.5
  • 28
    • 65349136654 scopus 로고    scopus 로고
    • Possible binding site for paclitaxel at microtubule pores
    • Magnani, M.; Maccari, G.; Andreu, J.M.; Díaz, J.F.; Botta, M. Possible binding site for paclitaxel at microtubule pores. FEBS J., 2009, 276, 2701-2712.
    • (2009) FEBS J , vol.276 , pp. 2701-2712
    • Magnani, M.1    Maccari, G.2    Andreu, J.M.3    Díaz, J.F.4    Botta, M.5
  • 30
    • 34548323861 scopus 로고    scopus 로고
    • Advancements in the understanding of paclitaxel metabolism in tissue culture
    • DOI 10.2174/138920107781387393
    • Vongpaseuth, K.; Roberts, S.C. Advancements in the understanding of paclitaxel metabolism in tissue cultures. Curr. Pharm. Biotechnol., 2007, 8, 219-236. (Pubitemid 47335327)
    • (2007) Current Pharmaceutical Biotechnology , vol.8 , Issue.4 , pp. 219-236
    • Vongpaseuth, K.1    Roberts, S.C.2
  • 31
    • 0032422236 scopus 로고    scopus 로고
    • Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for Taxol production
    • DOI 10.1006/abbi.1998.0926
    • Hefner, J.; Ketchum, R.E.B.; Croteau, R. Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol production. Arch. Biochem. Biophys., 1998, 360, 62-74. (Pubitemid 29010914)
    • (1998) Archives of Biochemistry and Biophysics , vol.360 , Issue.1 , pp. 62-74
    • Hefner, J.1    Ketchum, R.E.B.2    Croteau, R.3
  • 35
    • 0030198673 scopus 로고    scopus 로고
    • Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures
    • DOI 10.1021/bp9600344
    • Srinivasan, V.; Ciddi, V.; Bringi, V.; Shuler, M.L. Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures. Biotechnol. Progr., 1996, 12, 457-465. (Pubitemid 26369976)
    • (1996) Biotechnology Progress , vol.12 , Issue.4 , pp. 457-465
    • Srinivasan, V.1    Ciddi, V.2    Bringi, V.3    Shuler, M.L.4
  • 36
    • 0037327989 scopus 로고    scopus 로고
    • Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei
    • DOI 10.1042/BA20020061
    • Wang, Y.J.; Yuan, M.; Lu, M.; Wu, J.C.; Jiang, JL. Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei. Biotechnol. Appl. Bioc., 2003, 37, 39-43. (Pubitemid 36246344)
    • (2003) Biotechnology and Applied Biochemistry , vol.37 , Issue.1 , pp. 39-43
    • Wang, Y.-D.1    Yuan, Y.-J.2    Lu, M.3    Wu, J.-C.4    Jiang, J.-L.5
  • 37
    • 33846469337 scopus 로고    scopus 로고
    • Source of isopentenyl diphosphate for taxol and baccatin III biosynthesis in cell cultures of Taxus baccata
    • DOI 10.1016/j.bej.2006.10.016, PII S1369703X06003135
    • Cusidó, R.M.; Palazón, J.; Bonfill, M.; Expósito, O.; Moyano, E.; Pinol, M.T. Source of isopentenyl diphosphate for taxol and baccatin III biosynthesis in cell cultures of Taxus baccata. Biochem. Eng. J., 2007, 33, 159-167. (Pubitemid 46162263)
    • (2007) Biochemical Engineering Journal , vol.33 , Issue.2 , pp. 159-167
    • Cusido, R.M.1    Palazon, J.2    Bonfill, M.3    Exposito, O.4    Moyano, E.5    Pinol, M.T.6
  • 38
    • 0029873176 scopus 로고    scopus 로고
    • A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis
    • DOI 10.1074/jbc.271.16.9201
    • Wildung, M.R.; Croteau, R. A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the commited step of taxol biosynthesis. J. Biol. Chem., 1996, 271, 9201-9204. (Pubitemid 26137319)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.16 , pp. 9201-9204
    • Wildung, M.R.1    Croteau, R.2
  • 39
    • 0028964563 scopus 로고
    • Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in pacic yew
    • Koepp, A.E.; Hezari, M.; Zajicek, J.; Stofer-Vogel, B.; LaFever, R.E.; Lewis, N.G.; Croteau, R. Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of Taxol biosynthesis in Pacic yew. J. Biol. Chem., 1995, 270, 8686-8690.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8686-8690
    • Koepp, A.E.1    Hezari, M.2    Zajicek, J.3    Stofer-Vogel, B.4    LaFever, R.E.5    Lewis, N.G.6    Croteau, R.7
  • 40
    • 0031568221 scopus 로고    scopus 로고
    • Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures
    • DOI 10.1006/abbi.1996.9772
    • Hezari, M.; Ketchum, R.E.B.; Gibson, D.M.; Croteau, R. Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures. Arch. Biochem. Biophys., 1997, 337, 185-190. (Pubitemid 27198181)
    • (1997) Archives of Biochemistry and Biophysics , vol.337 , Issue.2 , pp. 185-190
    • Hezari, M.1    Ketchum, R.E.B.2    Gibson, D.M.3    Croteau, R.4
  • 41
    • 0030154837 scopus 로고    scopus 로고
    • Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5α-ol: The first oxygenation step in taxol biosynthesis
    • Hefner, J.; Rubenstein, S.M.; Ketchum, R.E.B.; Gibson, D.M.; Williams, R.M.; Croteau, R. Cytochrome P450-catalyzed hydroxylation of taxa-4(5), 11(12)-diene to taxa-4(20),11(12)-dien-5a-ol: the first oxygenation step in Taxol biosynthesis. Chem. Biol., 1996, 3, 479-489. (Pubitemid 126663348)
    • (1996) Chemistry and Biology , vol.3 , Issue.6 , pp. 479-489
    • Hefner, J.1    Rubenstein, S.M.2    Ketchum, R.E.B.3    Gibson, D.M.4    Williams, R.M.5    Croteau, R.6
  • 42
    • 0034652139 scopus 로고    scopus 로고
    • Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
    • DOI 10.1006/abbi.1999.1609
    • Walker, K.; Schoendorf, A.; Croteau, R. Molecular cloning of a taxa-4(20),11(12)-dien-5-ol-O-Acetyl transferase cDNA form Taxus and functional expression in Escherichia coli. Arch. Biochem. Biophys., 2000, 347, 371-380. (Pubitemid 30120275)
    • (2000) Archives of Biochemistry and Biophysics , vol.374 , Issue.2 , pp. 371-380
    • Walker, K.1    Schoendorf, A.2    Croteau, R.3
  • 43
    • 27244462261 scopus 로고    scopus 로고
    • Taxol biosynthesis: Differential transformations of taxadien-5α-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells
    • DOI 10.1006/abbi.2001.2377
    • Wheeler, L.A.; Long, R.M.; Ketchum, R.E.B.; Rithner, C.D.; Williams, R.M.; Croteau, R. Taxol biosynthesis: differential transformation of taxadien-5-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells. Arch. Biochem. Biophys., 2001, 390, 265-278. (Pubitemid 32568488)
    • (2001) Archives of Biochemistry and Biophysics , vol.390 , Issue.2 , pp. 265-278
    • Wheeler, A.L.1    Long, R.M.2    Ketchum, R.E.B.3    Rithner, C.D.4    Williams, R.M.5    Croteau, R.6
  • 45
    • 0242669969 scopus 로고    scopus 로고
    • Taxoid metabolism: Taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase
    • DOI 10.1016/S0003-9861(03)00090-0
    • Jennewein, S.; Rithner, C.D.; Williams, R.M.; Croteau R. Taxoid metabolism: taxoid 14-hydroxylase is a cytochrome P450-dependent monooxygenase. Arch. Biochem. Biophys., 2003, 413: 262-270. (Pubitemid 36506816)
    • (2003) Archives of Biochemistry and Biophysics , vol.413 , Issue.2 , pp. 262-270
    • Jennewein, S.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.4
  • 47
    • 0034610386 scopus 로고    scopus 로고
    • Taxol biosynthesis: Molecular cloning of a benzoyl coa:taxane-2-o-benzoyl transferase cdna from taxus and functional expression in escherichia coli
    • Walker, K.; Croteau, R. Taxol biosynthesis: molecular cloning of a benzoyl CoA:taxane-2-O-benzoyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A., 2000, 97, 13591-13596.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 13591-13596
    • Walker, K.1    Croteau, R.2
  • 48
    • 0034681193 scopus 로고    scopus 로고
    • Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
    • DOI 10.1073/pnas.97.2.583
    • Walker, K.; Croteau, R. Molecular cloning of a 10-deacetylbaccatin III-10-O-Acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A., 2000, 97:583-587. (Pubitemid 30070352)
    • (2000) Proceedings of the National Academy of Sciences of the United States of America , vol.97 , Issue.2 , pp. 583-587
    • Walker, K.1    Croteau, R.2
  • 49
    • 0036789932 scopus 로고    scopus 로고
    • Molecular cloning and heterologous expression of the c-13 phenylpropanoid side chain-coa acyltransferase that functions in taxol biosynthesis
    • Walker, K.; Fujisaki, S.; Long, R.; Croteau, R. Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in taxol biosynthesis. Proc. Natl. Acad. Sci. U.S.A., 2002, 99, 12715-12720.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 12715-12720
    • Walker, K.1    Fujisaki, S.2    Long, R.3    Croteau, R.4
  • 50
    • 27544457332 scopus 로고    scopus 로고
    • Preliminary assessment of the C13-side chain 2-hydroxylase involved in Taxol biosynthesis
    • DOI 10.1016/j.bbrc.2005.08.119, PII S0006291X0501853X
    • Long, R.M.; Croteau, R. Preliminary assessment of the C13-side chain 2'-hydroxylase involved in taxol biosynthesis. Biochem. Biophys. Res. Commun., 2005, 338, 410-417. (Pubitemid 41540583)
    • (2005) Biochemical and Biophysical Research Communications , vol.338 , Issue.1 , pp. 410-417
    • Long, R.M.1    Croteau, R.2
  • 51
    • 50149089756 scopus 로고    scopus 로고
    • Specificity of the nbenzoyl transferase responsible for the last step of taxol biosynthesis
    • Long, R.M.; Lagisetti, C.; Coates, R.M.; Croteau, R.B. Specificity of the Nbenzoyl transferase responsible for the last step of Taxol biosynthesis. Arch Biochem Biophys., 2008, 477, 384-389.
    • (2008) Arch Biochem Biophys. , vol.477 , pp. 384-389
    • Long, R.M.1    Lagisetti, C.2    Coates, R.M.3    Croteau, R.B.4
  • 54
    • 2642547256 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a cytochrome P450 taxoid 2α-hydroxylase involved in Taxol biosynthesis
    • DOI 10.1016/j.abb.2004.04.016, PII S0003986104002334
    • Chau, M.; Croteau, R. Molecular cloning and characterization of a cytochrome P540 taxoid 2-hydroxylase involved in taxol biosynthesis. Arch. Biochem. Biophys., 2004, 427, 48-57. (Pubitemid 38725913)
    • (2004) Archives of Biochemistry and Biophysics , vol.427 , Issue.1 , pp. 48-57
    • Chau, M.1    Croteau, R.2
  • 55
    • 2642550828 scopus 로고    scopus 로고
    • Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7β-hydroxylase
    • DOI 10.1016/j.chembiol.2004.02.025, PII S1074552104001115
    • Chau, M.; Jennewein, S.; Walker, K.; Croteau, R. Taxol biosynthesis: molecular cloning and characterization of a cytochrome P450 taxoid 7-hydroxilase. Chem. Biol., 2004, 11, 663-672. (Pubitemid 38708835)
    • (2004) Chemistry and Biology , vol.11 , Issue.5 , pp. 663-672
    • Chau, M.1    Jennewein, S.2    Walker, K.3    Croteau, R.4
  • 56
    • 11144225850 scopus 로고    scopus 로고
    • Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in taxol biosynthesis
    • DOI 10.1074/jbc.M411215200
    • Walker, K.; Klettke, K.; Akiyama, T.; Croteau, R. Cloning heterologous expression and characterization of a phenylalanine aminomutase involved in taxol biosynthesis. J. Biol. Chem., 2004, 279, 53947-53954. (Pubitemid 40053125)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.52 , pp. 53947-53954
    • Walker, K.D.1    Klettke, K.2    Akiyama, T.3    Croteau, R.4
  • 57
    • 15244353792 scopus 로고    scopus 로고
    • To stretch the boundary of secondary metabolite production in plant cell-based bioprocessing: Anthocyanin as a study
    • DOI 10.1155/S1110724304404148, PII S1110724304404148
    • Zhang, W.; Franco, C.; Curtin, C.; Conn, S. To stretch the boundary of secondary metabolite production in plant cell-based bioprocessing: anthocyanin as a case study. J. Biomed. Biotechnol., 2004, 264-271. (Pubitemid 40389466)
    • (2004) Journal of Biomedicine and Biotechnology , vol.2004 , Issue.5 , pp. 264-271
    • Zhang, W.1    Franco, C.2    Curtin, C.3    Conn, S.4
  • 58
    • 0027033799 scopus 로고
    • Cell culture of taxus as a source of the antineoplastic drug taxol and related taxanes
    • Fett-Neto, A.G.; DiCosmo, F.; Reynolds, W.F.; Sakata, K. Cell culture of Taxus as a source of the antineoplastic drug Taxol and related taxanes. Bio/Tech., 1992, 10, 1572-1575
    • (1992) Bio/Tech. , vol.10 , pp. 1572-1575
    • Fett-Neto, A.G.1    DiCosmo, F.2    Reynolds, W.F.3    Sakata, K.4
  • 59
    • 0027142357 scopus 로고
    • Taxus callus cultures: Initiation, growth optimization, characterization and taxol production
    • Wicremesinhe, E.R.M.; Arteca, R.N. Taxus callus cultures: initiation, growth optimization, characterization and taxol production. Plant Cell Tiss. Org. Cult., 1993, 35, 181-193. (Pubitemid 2020202)
    • (1993) Plant Cell, Tissue and Organ Culture , vol.35 , Issue.2 , pp. 181-193
    • Wickremesinhe, E.R.M.1    Arteca, R.N.2
  • 60
    • 0035987992 scopus 로고    scopus 로고
    • Improved paclitaxel and baccatin III production in suspension cultures of Taxus media
    • DOI 10.1021/bp0101583
    • Cusidó, R.M.; Palazón, J.; Bonfill, M.; Navia-Osorio, A.; Morales, C.; Pinol, M.T. Improved paclitaxel and baccatin III production in suspension cultures of Taxus media. Biotechnol. Prog., 2002, 18, 418-423. (Pubitemid 34623212)
    • (2002) Biotechnology Progress , vol.18 , Issue.3 , pp. 418-423
    • Cusido, R.M.1    Palazon, J.2    Bonfill, M.3    Navia-Osorio, A.4    Morales, C.5    Pinol, M.T.6
  • 61
    • 0033668960 scopus 로고    scopus 로고
    • Intermitent maltose feeding enhances paclitaxel production in suspension culture of taxus chinensis cells
    • Choi, H.K.; Kim, S.I.; Son, J.S.; Hong, S.S.; Lee, H.S.; Chung, I.S.; Lee, H.J. Intermitent maltose feeding enhances paclitaxel production in suspension culture of Taxus chinensis cells. Biotech. Lett., 2000, 22, 1793-1796.
    • (2000) Biotech. Lett. , vol.22 , pp. 1793-1796
    • Choi, H.K.1    Kim, S.I.2    Son, J.S.3    Hong, S.S.4    Lee, H.S.5    Chung, I.S.6    Lee, H.J.7
  • 62
    • 0035121651 scopus 로고    scopus 로고
    • Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding
    • DOI 10.1021/bp0001359
    • Wang, C.; Wu, J.C.; Mei, X. Enhanced taxol production and release in Taxus chinenesis cell suspension cultures with selected organic solvents and sucrose Feeding. Biotechnol. Prog., 2001, 17, 89-94. (Pubitemid 32145380)
    • (2001) Biotechnology Progress , vol.17 , Issue.1 , pp. 89-94
    • Wang, C.1    Wu, J.2    Mei, X.3
  • 63
    • 16344367973 scopus 로고    scopus 로고
    • Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata
    • DOI 10.1002/bit.20321
    • Bentebibel, S.; Moyano, E.; Palazon, J.; Cusido, R.M.; Bonfill, M.; Eibl, R., Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata. Biotechnol. Bioeng., 2005, 89, 647-655. (Pubitemid 40470352)
    • (2005) Biotechnology and Bioengineering , vol.89 , Issue.6 , pp. 647-655
    • Bentebibel, S.1    Moyano, E.2    Palazon, J.3    Cusido, R.M.4    Bonfill, M.5    Eibl, R.6    Pinol, M.T.7
  • 64
    • 0035936599 scopus 로고    scopus 로고
    • Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum
    • DOI 10.1016/S0168-1656(00)00383-7, PII S0168165600003837
    • Wu, J.; Wang, C.; Mei, X. Stimulation of taxol production and excretion in Taxus spp. cell cultures by rare earth chemical lanthanum. J. Biotechnol., 2001, 85, 67-73. (Pubitemid 32115452)
    • (2001) Journal of Biotechnology , vol.85 , Issue.1 , pp. 67-73
    • Wu, J.1    Wang, C.2    Mei, X.3
  • 65
    • 0033618872 scopus 로고    scopus 로고
    • Production of Taxol and baccatin III by a selected Taxus baccata callus line and its derived cell suspension culture
    • DOI 10.1016/S0168-9452(99)00093-X, PII S016894529900093X
    • Cusidó, R.M.; Palazon, J., Navia-Osorio, A.; Mallol, A.; Bonfill, M.; Morales, C.; Pinol, M.T. Production of Taxol® and baccatin III by a selected Taxus baccata callus line and its derived cell suspension culture. Plant Sci., 1999, 146, 101-107. (Pubitemid 29444306)
    • (1999) Plant Science , vol.146 , Issue.2 , pp. 101-107
    • Cusido, R.M.1    Palazon, J.2    Navia-Osorio, A.3    Mallol, A.4    Bonfill, M.5    Morales, C.6    Pinol, M.T.7
  • 66
    • 0036807779 scopus 로고    scopus 로고
    • Fungal elicitor-induced cell apoptosis in suspensión cultures of taxus chinenesis var. Marei for taxol production
    • Yuan, Y.J; Li, C.; Hu, Z.D.; Wu, J.C.; Zeng, A.P. Fungal elicitor-induced cell apoptosis in suspensión cultures of Taxus chinenesis var. marei for taxol production. Proc. Biochem., 2002, 38, 193-198.
    • (2002) Proc. Biochem. , vol.38 , pp. 193-198
    • Yuan Y.J Li, C.1    Hu, Z.D.2    Wu, J.C.3    Zeng, A.P.4
  • 67
    • 0037268975 scopus 로고    scopus 로고
    • Cell death unlikely contributes to Taxol production in fungal elicitor-induced cell suspension cultures of Taxus chinensis
    • DOI 10.1023/A:1021726030724
    • Lan, W.Z.; Yu, L.; Li, M.; Qin, W.M. Cell death unlike contributes to taxol production in fungal elicitor-induced cell suspensión cultures of Taxus chinensis. Biotechnol. Lett., 2003, 25, 47-49. (Pubitemid 36178424)
    • (2003) Biotechnology Letters , vol.25 , Issue.1 , pp. 47-49
    • Lan, W.Z.1    Yu, L.J.2    Li, M.Y.3    Qin, W.M.4
  • 68
    • 64649091848 scopus 로고    scopus 로고
    • Paclitaxel-produccing fungal endophyte stimulate the accumulation of taxoids in suspension cultures of taxus cuspidate
    • Li, Y.C.; Tao, W.Y. Paclitaxel-produccing fungal endophyte stimulate the accumulation of taxoids in suspension cultures of Taxus cuspidate. Sci. Hort., 2009, 121, 97-102.
    • (2009) Sci. Hort. , vol.121 , pp. 97-102
    • Li, Y.C.1    Tao, W.Y.2
  • 69
    • 0042976366 scopus 로고    scopus 로고
    • A simple method for enhancing paclitaxel release from Taxus canadensis cell suspension cultures utilizing cell wall digesting enzymes
    • DOI 10.1007/s00299-003-0575-z
    • Roberts, S.C.; Naill, M.; Gibson, D.M.; Shuler, M.L. A simple method for enhancing paclitaxel release from Taxus canadensis cell suspension cultures utilizing cell wall digesting enzymes. Plant. Cell. Rep., 2003, 21, 1217-1220. (Pubitemid 37007867)
    • (2003) Plant Cell Reports , vol.21 , Issue.12 , pp. 1217-1220
    • Roberts, S.C.1    Naill, M.2    Gibson, D.M.3    Shuler, M.L.4
  • 70
    • 0037285221 scopus 로고    scopus 로고
    • Influence of elicitors on taxane production and 3-hydroxy-3- methylglutaryl coenzyme A reductase activity in Taxus media cells
    • DOI 10.1016/S0981-9428(02)00013-X, PII S098194280200013X
    • Bonfill, M.; Palazón, J.; Cusidó, R.M.; Joly, S.; Morales, C.; Pinol, M.T. Influence of elicitors on taxane production and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Taxus media cells. Plant Physiol. Biochem., 2003, 41, 91-96. (Pubitemid 36257519)
    • (2003) Plant Physiology and Biochemistry , vol.41 , Issue.1 , pp. 91-96
    • Bonfill, M.1    Palazon, J.2    Cusido, R.M.3    Joly, S.4    Morales, C.5    Pinol, M.T.6
  • 71
    • 2542498882 scopus 로고    scopus 로고
    • Induction studies of methyl jasmonate and salicylic acid on taxane production in suspension cultures of taxus chinensis var. Mairei
    • Wang, Y.D.; Yuan, Y.J.; Wu, J.C. Induction studies of methyl jasmonate and salicylic acid on taxane production in suspension cultures of Taxus chinensis var. mairei. Biochem. Eng. J., 2004, 19, 259-265.
    • (2004) Biochem. Eng. J. , vol.19 , pp. 259-265
    • Wang, Y.D.1    Yuan, Y.J.2    Wu, J.C.3
  • 72
    • 0030060485 scopus 로고    scopus 로고
    • Methyl jasmonate induced production of taxol in suspension cultures of taxus cuspidata: Ethylene interaction and induction models
    • Mirjalili, N.; Linden, J.C. Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: ethylene interaction and induction models. Biotechnol. Progr., 1996, 12,110-118.
    • (1996) Biotechnol. Progr. , vol.12 , pp. 110-118
    • Mirjalili, N.1    Linden, J.C.2
  • 73
  • 74
    • 1542410264 scopus 로고    scopus 로고
    • Oxidative Burst, Jasmonic Acid Biosynthesis, and Taxol Production Induced by Low-Energy Ultrasound in Taxus chinensis Cell Suspension Cultures
    • DOI 10.1002/bit.10911
    • Wu, J.; Ge, X. Oxidative burst, jasmonic acid biosynthesis, and taxol production induced by low-energy ultrasound in Taxus chinensis cell suspension cultures. Biotechnol. Bioeng., 2004, 85, 714-721. (Pubitemid 38332407)
    • (2004) Biotechnology and Bioengineering , vol.85 , Issue.7 , pp. 714-721
    • Wu, J.1    Ge, X.2
  • 75
    • 3342956585 scopus 로고    scopus 로고
    • Improved cell growth and taxol production of suspension-cultured taxus chinensis var. Mairei in alternating and direct current magnetic fields
    • Shang, G.-M.; Wu, J.-Ch.; Yuan, Y.J. Improved cell growth and Taxol production of suspension-cultured Taxus chinensis var. mairei in alternating and direct current magnetic fields. Biotechnol. Lett., 2004, 26, 875-578.
    • (2004) Biotechnol. Lett. , vol.26 , pp. 875-578
    • Shang, G.-M.1    Wu, J.-Ch.2    Yuan, Y.J.3
  • 76
    • 75149158086 scopus 로고    scopus 로고
    • Responses in the morphology, physiology and biochemistry of taxus chinensis var. Mairei grown under supplementary uv-b radiation. J
    • Zu, Y.G.; Pang, H.H.; Yu, J.H.; Li, D.W.; Wei, X.X.; Gao, Y.X.; Tong, L. Responses in the morphology, physiology and biochemistry of Taxus chinensis var. mairei grown under supplementary UV-B radiation. J. Photochem. Photobiol. B., 2010, 98, 152-158.
    • (2010) Photochem. Photobiol. B. , vol.98 , pp. 152-158
    • Zu, Y.G.1    Pang, H.H.2    Yu, J.H.3    Li, D.W.4    Wei, X.X.5    Gao, Y.X.6    Tong, L.7
  • 78
  • 79
    • 17844378494 scopus 로고    scopus 로고
    • The phytotoxin coronatine and methyl jasmonate impact multiple phytohormone pathways in tomato
    • DOI 10.1111/j.1365-313X.2005.02366.x
    • Uppalapati, S.R.; Ayoubi, P.; Weng, H.; Palmer, D.A.; Mitchell, R.E.; Jones, W.; Bende, C.B. The phytotoxin coronatine and methyl jasmonate impact multiple phytohormone pathways in tomato. Plant J., 2005, 42, 201-217. (Pubitemid 40589383)
    • (2005) Plant Journal , vol.42 , Issue.2 , pp. 201-217
    • Uppalapati, S.R.1    Ayoubi, P.2    Weng, H.3    Palmer, D.A.4    Mitchell, R.E.5    Jones, W.6    Bender, C.L.7
  • 81
    • 0029737648 scopus 로고    scopus 로고
    • Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
    • Yukimune, Y.; Tabata, H.; Higashi, Y; Hara, Y. Methyl jasmonate-induced overexproduction of paclitaxel and baccatin III in Taxus cell suspensión cultures. Nat. Biotechnol., 1996, 14, 1129-1132. (Pubitemid 26299114)
    • (1996) Nature Biotechnology , vol.14 , Issue.9 , pp. 1129-1132
    • Yukimune, Y.1    Tabata, H.2    Higashi, Y.3    Hara, Y.4
  • 82
    • 0033524365 scopus 로고    scopus 로고
    • The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate
    • DOI 10.1002/(SICI)1097-0290(19990105)62:1<97::AID-BIT11>3.0.CO;2-C
    • Ketchum, R.E.B.; Gibson, D.M.; Croteau, R.B.; Shuler, M. L. The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol. Bioeng., 1999, 62, 97-105. (Pubitemid 28562000)
    • (1999) Biotechnology and Bioengineering , vol.62 , Issue.1 , pp. 97-105
    • Ketchum, R.E.B.1    Gibson, D.M.2    Croteau, R.B.3    Shuler, M.L.4
  • 83
    • 33846142212 scopus 로고    scopus 로고
    • Taxanes: Perspectives for biotechnological production
    • DOI 10.1007/s00253-006-0711-0
    • Frense, D. Taxanes: perspectives for biotechnological production. Appl. Microbiol. Biotechnol., 2007, 73, 1233-1240. (Pubitemid 46089494)
    • (2007) Applied Microbiology and Biotechnology , vol.73 , Issue.6 , pp. 1233-1240
    • Frense, D.1
  • 84
    • 77956387653 scopus 로고    scopus 로고
    • In vitro culture of taxus sp.: Strategies to increase cell growth and taxoid production
    • Sabater-Jarra, A.B.; Tudela, L.R.; López-Pérez, A.J. In vitro culture of Taxus sp.: strategies to increase cell growth and taxoid production. Phytochemistry Rev., 2010, 9, 343-356.
    • (2010) Phytochemistry Rev. , vol.9 , pp. 343-356
    • Sabater-Jarra, A.B.1    Tudela, L.R.2    López-Pérez, A.J.3
  • 85
    • 84919703033 scopus 로고    scopus 로고
    • Verpoorte, R.; Alfermann, A.W.; Johnson T.S. Eds. Springer: Dordrecht
    • Verpoorte, R. In: Applications of plant metabolic engineering, Verpoorte, R.; Alfermann, A.W.; Johnson T.S. Eds. Springer: Dordrecht, 2007.
    • (2007) Applications of plant metabolic engineering
    • Verpoorte, R.1
  • 87
    • 21244497360 scopus 로고    scopus 로고
    • An intron-free methyl jasmonate inducible geranylgeranyl diphosphate synthase gene from Taxus media and its functional identification in yeast
    • DOI 10.1007/s11008-005-0002-3
    • Liao, Z.; Gong, Y.; Kai, G.; Zuo, K.; Chen, M.; Tan, Q.; Wei, Y.; Guo, L.; Tan, F.; Sun, X.; Tang, K. An intron-free methyl jasmonate inducible geranylgeranyl diphosphate synthase gene from Taxus media and its functional identification in yeast. Mol. Biol., 2005, 39, 11-17. (Pubitemid 40941302)
    • (2005) Molecular Biology , vol.39 , Issue.1 , pp. 11-17
    • Liao, Z.1    Gong, Y.2    Kai, G.3    Zuo, K.4    Chen, M.5    Tan, Q.6    Wei, Y.7    Guo, L.8    Tan, F.9    Sun, X.10    Tang, K.11
  • 88
    • 33747787434 scopus 로고    scopus 로고
    • Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering
    • DOI 10.1016/j.ymben.2006.04.001, PII S109671760600036X
    • Nims, E.; Dubois, C.P.; Roberts, S.C.; Walker, E.L. Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering. Metab. Eng., 2006, 8, 385-394. (Pubitemid 44278723)
    • (2006) Metabolic Engineering , vol.8 , Issue.5 , pp. 385-394
    • Nims, E.1    Dubois, C.P.2    Roberts, S.C.3    Walker, E.L.4
  • 89
    • 33747149278 scopus 로고    scopus 로고
    • Responses of defense signals, biosynthetic gene transcription and taxoid biosynthesis to elicitation by a novel synthetic jasmonate in cell cultures of Taxus chinensis
    • DOI 10.1002/bit.20921
    • Hu, F.; Huang, J.; Xu, Y.; Qian, X.; Zhong, J.J. Responses of defense signals, biosynthetic gene transcription and taxoid biosynthesis to elicitation by a novel synthetic jasmonate in cell cultures of Taxus chinensis. Biotechnol. Bioeng., 2006, 94, 1064-1071. (Pubitemid 44221051)
    • (2006) Biotechnology and Bioengineering , vol.94 , Issue.6 , pp. 1064-1071
    • Hu, F.1    Huang, J.2    Xu, Y.3    Qian, X.4    Zhong, J.-J.5
  • 90
    • 2542442514 scopus 로고    scopus 로고
    • Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis
    • DOI 10.1002/bit.20068
    • Qian, Z.G.; Zhao Z.J.; Tian W.H.; Xu Y.; Zhong J.J.; Qian X. Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis. Biotechnol. Bioeng., 2004, 86, 595-599. (Pubitemid 38679778)
    • (2004) Biotechnology and Bioengineering , vol.86 , Issue.5 , pp. 595-599
    • Qian, Z.-G.1    Zhao, Z.-J.2    Tian, W.-H.3    Xu, Y.4    Zhong, J.-J.5    Qian, X.6
  • 91
    • 78650519657 scopus 로고    scopus 로고
    • An approach to the molecular mechanism of methyl jasmonate and va nadyl sulphate elicitation in taxus baccata cell cultures: The role of txs and bapt gene expression
    • Onrubia, M.; Moyano, E.; Bonfill, M.; Expósito, O.; Palazón, J.; Cusidó, R.M. An approach to the molecular mechanism of methyl jasmonate and va nadyl sulphate elicitation in Taxus baccata cell cultures: The role of txs and bapt gene expression. Biochem. Eng. J., 2010, 53, 104-111.
    • (2010) Biochem. Eng. J. , vol.53 , pp. 104-111
    • Onrubia, M.1    Moyano, E.2    Bonfill, M.3    Expósito, O.4    Palazón, J.5    Cusidó, R.M.6
  • 92
    • 0029087870 scopus 로고
    • Purification and characterization of taxa-4(5) 11(12)-diene synthase from pacific yew (taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis
    • Hezari, M.; Lewis, N.G.; Croteau, R. Purification and characterization of taxa-4(5) 11(12)-diene synthase from pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis. Arch. Biochem. Biophys., 1995, 322, 437-444.
    • (1995) Arch. Biochem. Biophys. , vol.322 , pp. 437-444
    • Hezari, M.1    Lewis, N.G.2    Croteau, R.3
  • 93
    • 79960313390 scopus 로고    scopus 로고
    • The relationship between txs, dbat, bapt and dbtnbt gene expression and taxane production during the development of taxus baccata plantlets
    • Onrubia, M.; Moyano, E.; Bonfill, M.; Palazón, J.; Goossens, A.; Cusidó, R.M. The relationship between TXS, DBAT, BAPT and DBTNBT gene expression and taxane production during the development of Taxus baccata plantlets. Plant Sci., 2011, 181, 282-287.
    • (2011) Plant Sci. , vol.181 , pp. 282-287
    • Onrubia, M.1    Moyano, E.2    Bonfill, M.3    Palazón, J.4    Goossens, A.5    Cusidó, R.M.6
  • 94
    • 77956968697 scopus 로고    scopus 로고
    • The strategies to increase taxol production by using taxus mairei cells transformed with ts and dbat genes
    • Ho, C.K.; Chang, S.H.; Lung, J.; Tsai, C.J.; Chen, K.P. The strategies to increase taxol production by using Taxus mairei cells transformed with TS and DBAT genes. Int. J. Appl. Sci. Eng., 2005, 3, 179-185.
    • (2005) Int. J. Appl. Sci. Eng. , vol.3 , pp. 179-185
    • Ho, C.K.1    Chang, S.H.2    Lung, J.3    Tsai, C.J.4    Chen, K.P.5
  • 95
    • 84857769705 scopus 로고    scopus 로고
    • Contribution of taxane biosynthetic pathway gene expression to observed variability in paclitaxel accumulation in taxus suspension cultures
    • Patil, R.A.; Kolewe, M.E.; Normanly, J.; Walker, E.L.; Roberts, S.C. Contribution of taxane biosynthetic pathway gene expression to observed variability in paclitaxel accumulation in Taxus suspension cultures. Biotechnol. J., 2012, 7, 418-427.
    • (2012) Biotechnol. J. , vol.7 , pp. 418-427
    • Patil, R.A.1    Kolewe, M.E.2    Normanly, J.3    Walker, E.L.4    Roberts, S.C.5
  • 96
    • 56249095473 scopus 로고    scopus 로고
    • Expression of dbat and dbtnbt genes involved in paclitaxel biosynthesis during the growth cycle of taxus baccata l. Callus cultures
    • Katkovcinová, Z.; Lázárová, M.; Brunáková, K.; Kosuth, J.; Cellárová, E. Expression of dbat and dbtnbt genes involved in paclitaxel biosynthesis during the growth cycle of Taxus baccata L. callus cultures. Z. Naturforsch. C., 2008, 63, 721-730.
    • (2008) Z. Naturforsch. , vol.C , Issue.63 , pp. 721-730
    • Katkovcinová, Z.1    Lázárová, M.2    Brunáková, K.3    Kosuth, J.4    Cellárová, E.5
  • 97
    • 77953973772 scopus 로고    scopus 로고
    • Expression of two genes of paclitaxel biosynthetic pathway during germination of taxus baccata zygotic embryos
    • Bruáková, K.; Kouth, J.; Katkovinová, Z.; Lázárová, M.; ellárová, E. Expression of two genes of paclitaxel biosynthetic pathway during germination of Taxus baccata zygotic embryos. Biol. Plant., 2010, 54, 515-519.
    • (2010) Biol. Plant. , vol.54 , pp. 515-519
    • Bruáková, K.1    Kouth, J.2    Katkovinová, Z.3    Lázárová, M.4    Ellárová, E.5
  • 98
    • 1842714379 scopus 로고    scopus 로고
    • Progress in plant metabolic engineering
    • DOI 10.1016/j.copbio.2004.01.009, PII S0958166904000199
    • Capell, T.; Christou, P. Progress in plant metabolic engineering. Curr. Opin Biotechnol., 2004, 15, 148-154. (Pubitemid 38469997)
    • (2004) Current Opinion in Biotechnology , vol.15 , Issue.2 , pp. 148-154
    • Capell, T.1    Christou, P.2
  • 99
  • 101
    • 79957975598 scopus 로고    scopus 로고
    • Overexpression of a 10-deacetylbaccatin iii-10-o-Acetyltransferase gene leads to increased taxol yields in cells of taxus chinensis
    • Zhang, P.; Li, S-T.; Liu, T-T.; Fu, Ch-H. ; Zhou P-P.; Zhao, Ch-F.; Yu, L-J. Overexpression of a 10-deacetylbaccatin III-10-O-Acetyltransferase gene leads to increased taxol yields in cells of Taxus chinensis. Plant Cell Tiss Organ Cult., 2011, 106, 63-70.
    • (2011) Plant Cell Tiss Organ Cult. , vol.106 , pp. 63-70
    • Zhang, P.1    Li, S.-T.2    Liu, T.-T.3    Fu, Ch.-H.4    Zhou, P.-P.5    Zhao, Ch.-F.6    Yu, L.-J.7
  • 103
    • 80051759996 scopus 로고    scopus 로고
    • Antisenseinduced suppression of taxoid 14-hydroxylase gene expression in transgenic taxus x media cells
    • Li, F-L.; Ma, X-J.; Hu, X-L.; Hoffman, A.; Dai, J-G.; Qiu, D-Y. Antisenseinduced suppression of taxoid 14-hydroxylase gene expression in transgenic Taxus x media cells. Afr. J. Biotechnol., 2011, 10, 8720-8728.
    • (2011) Afr. J. Biotechnol. , vol.10 , pp. 8720-8728
    • Li, F.-L.1    Ma, X.-J.2    Hu, X.-L.3    Hoffman, A.4    Dai, J.-G.5    Qiu, D.-Y.6
  • 104
    • 84865406854 scopus 로고    scopus 로고
    • Enhancing taxol biosynthesis by overexpressing a 9-cis-epoxycarotenoid dioxygenase gene in transgenic cell lines of taxus chinensis
    • DOI 10.1007/s11105-012-0436-4
    • Li, S-T.; Fu, Ch-H.; Zhang, M.; Ahang, Y.; Xie, S.; Yu, L-J. Enhancing taxol biosynthesis by overexpressing a 9-cis-epoxycarotenoid dioxygenase gene in transgenic cell lines of Taxus chinensis. Plant Mol. Biol. Rep., 2012, DOI 10.1007/s11105-012-0436-4
    • (2012) Plant Mol. Biol. Rep.
    • Li, S.-T.1    Fu, Ch.-H.2    Zhang, M.3    Ahang, Y.4    Xie, S.5    Yu, L.-J.6
  • 105
    • 0034647914 scopus 로고    scopus 로고
    • ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism
    • DOI 10.1126/science.289.5477.295
    • Van der Fits, L.; Memelink, J. ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. Science, 2000, 289, 295-297. (Pubitemid 30469906)
    • (2000) Science , vol.289 , Issue.5477 , pp. 295-297
    • Van Der Fits, L.1    Memelink, J.2
  • 106
    • 0035213471 scopus 로고    scopus 로고
    • ORCAnization of jasmonate-responsive gene expression in alkaloid metabolism
    • DOI 10.1016/S1360-1385(01)01924-0, PII S1360138501019240
    • Memelink, J.; Verpoorte, R.; Kijne, J.W. ORCAnisation of jasmonateresponsive gene expression in alkaloid metabolism. Trends Plant Sci., 2001, 6, 212-219. (Pubitemid 33145915)
    • (2001) Trends in Plant Science , vol.6 , Issue.5 , pp. 212-219
    • Memelink, J.1    Verpoorte, R.2    Kijne, J.W.3
  • 108
    • 67349119921 scopus 로고    scopus 로고
    • Effect of taxol feeding on taxol and related taxane production in taxus baccata suspension cultures
    • Exposito, O.; Bonfill, M.; Onrubia, O.; Jane, A.; Moyano, E.; Cusido, M. Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures. New Biotechol., 2009, 25: 252-259.
    • (2009) New Biotechol. , vol.25 , pp. 252-259
    • Exposito, O.1    Bonfill, M.2    Onrubia, O.3    Jane, A.4    Moyano, E.5    Cusido, M.6
  • 109
    • 31844438350 scopus 로고    scopus 로고
    • ABC transporters involved in the transport of plant secondary metabolites
    • DOI 10.1016/j.febslet.2005.12.009, PII S0014579305014651, ABC Transporters
    • Yazaki, K. ABC transporters involved in the transport of plant secondary metabolites. FEBS Lett., 2006, 580, 1183-1191. (Pubitemid 43185298)
    • (2006) FEBS Letters , vol.580 , Issue.4 , pp. 1183-1191
    • Yazaki, K.1
  • 110
    • 0346034533 scopus 로고    scopus 로고
    • Secretion of secondary metabolites by pdr-Type atp-binding cassette transporters in plant cell suspension cultures
    • Goosens, A.; Haäkkinen, S.T.; Laakso, I.; M.; Oksman-Caldentey, K.-M; Inzé, D. Secretion of secondary metabolites by PDR-Type ATP-binding cassette transporters in plant cell suspension cultures. Plant Physiol., 2003, 131, 1161-1164.
    • (2003) Plant Physiol. , vol.131 , pp. 1161-1164
    • Goosens, A.1    Haäkkinen, S.T.2    Laakso, I.M.3    Oksman-Caldentey, K.-M.4    Inzé, D.5
  • 112
    • 34547675748 scopus 로고    scopus 로고
    • +-antiporter active in proanthocyanidin-accumulating cells of the seed coat
    • DOI 10.1105/tpc.106.046029
    • Marinova, K.; Pourcel, L.; Werder, B.; Schwarz, M.; Barron, D.; Routaboul, J.M.; Debeaujon, I.; Klein, M. The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+-Antiporter active in proanthocyanidinaccumulating cells of the seed coat. The Plant Cell, 2007, 19, 2023-2038. (Pubitemid 47218856)
    • (2007) Plant Cell , vol.19 , Issue.6 , pp. 2023-2038
    • Marinova, K.1    Pourcel, L.2    Weder, B.3    Schwarz, M.4    Barron, D.5    Routaboul, J.-M.6    Debeaujon, I.7    Kleina, M.8
  • 113
    • 53749106827 scopus 로고    scopus 로고
    • Secretory pathways in plant immune responses
    • DOI 10.1104/pp.108.121566
    • Kwon, C.; Bednarek P.; Schulze-Lefert P. Secretory pathways in plant immune responses. Plant Physiol., 2008, 147, 1575-1583. (Pubitemid 352844204)
    • (2008) Plant Physiology , vol.147 , Issue.4 , pp. 1575-1583
    • Kwon, C.1    Bednarek, P.2    Schulze-Lefert, P.3
  • 114
    • 84877962305 scopus 로고    scopus 로고
    • Histochemical study on the development of taxol-like vesicles in callus cell of taxus cuspidata var. Nana
    • Okada, K.; Tachibana, S.; Shiraishi, M. Histochemical study on the development of taxol-like vesicles in callus cell of Taxus cuspidata var. Nana. Pak. J. Biol. Sci., 2004, 7, 542-549.
    • (2004) Pak. J. Biol. Sci. , vol.7 , pp. 542-549
    • Okada, K.1    Tachibana, S.2    Shiraishi, M.3
  • 115
    • 0034928158 scopus 로고    scopus 로고
    • Localization of paclitaxel in suspension culture of taxus chinensis
    • Choi, H.K.; Kim, S.I.; Song, J.Y. Localization of paclitaxel in suspension culture of Taxus chinensis, J. Microbiol. Biotechn., 2001, 11, 458-462.
    • (2001) J. Microbiol. Biotechn. , vol.11 , pp. 458-462
    • Choi, H.K.1    Kim, S.I.2    Song, J.Y.3
  • 116
    • 84862224451 scopus 로고    scopus 로고
    • Identification and expression analysis of methyl jasmonate responsive ests in paclitaxel producing taxus cuspidata suspension culture cells
    • Lenka, S.K.; Boutaoui, N.; Paulose, B.; Vongpaseuth, K.; Normanly, J.; Roberts, S.C.; Walker, E.L. Identification and expression analysis of methyl jasmonate responsive ESTs in paclitaxel producing Taxus cuspidata suspension culture cells. BMC Genomics, 2012, 13, 148.
    • (2012) BMC Genomics , vol.13 , pp. 148
    • Lenka, S.K.1    Boutaoui, N.2    Paulose, B.3    Vongpaseuth, K.4    Normanly, J.5    Roberts, S.C.6    Walker, E.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.