CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane

Journal of Biological Chemistry

Volumn 283, Issue 10, 2008, Pages 6067-6075

  Rontein, Denis ^a   Onillon, Sandrine ^a   Herbette, Gaëtan ^b   Lesot, Agnes ^c   Werck Reichhart, Danièle ^c   Sallaud, Christophe ^a   Tissier, Alain ^a  

^a Librophyt   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c INST DE BIOL MOLEC DES PLANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; ENCODING (SYMBOLS); ENZYMES; ETHERS; NUCLEAR MAGNETIC RESONANCE; ORGANIC COMPOUNDS; OXIDATION;

ANTI-CANCER DRUGS; CARBON RINGS; COMPLEX STRUCTURES; CYCLIC ETHERS; ETHER BRIDGES; FUNCTIONALIZED; HYDROXYLASE; METABOLIC ENGINEERING APPROACHES; NMR ANALYSES; OXYGENASES; PACLITAXEL; REACTION MECHANISMS; RECOMBINANT YEASTS; RING SYSTEMS; SEQUENCE OF EVENTS; SPECIFIC EXPRESSIONS; STRUCTURAL REARRANGEMENTS; SYNTHASE; TAXANES; TRICHOME CELLS; WILLIAMS;

GENE ENCODING;

5(12)OXA 3(11)CYCLOTAXANE; CYTOCHROME P450; CYTOCHROME P450 725A4; PACLITAXEL; TAXA 4(5),11(12)DIENE; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; 5(12) OXA 3(11) CYCLOTAXANE; 5(12)-OXA-3(11)-CYCLOTAXANE; ALKENE; ANTINEOPLASTIC AGENT; DITERPENE; ISOMERASE; TAXA 4(5),11(12) DIENE SYNTHASE; TAXA-4(5),11(12)-DIENE SYNTHASE; TAXA-4(5),11(12)DIENE; TAXOID; VEGETABLE PROTEIN;

ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; DRUG SYNTHESIS; ENZYME ISOLATION; NICOTIANA SYLVESTRIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PHYTOCHEMISTRY; PLANT CELL CULTURE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TOBACCO; ENZYMOLOGY; GENETICS; HYDROXYLATION; METABOLISM; MICROSOME; OXIDATION REDUCTION REACTION; SACCHAROMYCES CEREVISIAE; TRANSGENIC PLANT;

NICOTIANA SYLVESTRIS; TAXUS;

ALKENES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; HYDROXYLATION; ISOMERASES; MICROSOMES; OXIDATION-REDUCTION; PACLITAXEL; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; SACCHAROMYCES CEREVISIAE; TAXOIDS; TOBACCO;

EID: 44449085997     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708950200     Document Type: Article

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