Taxoid metabolism: Taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase

Archives of Biochemistry and Biophysics

Volumn 413, Issue 2, 2003, Pages 262-270

  Jennewein, Stefan ^a,c   Rithner, Christopher D ^b   Williams, Robert M ^b   Croteau, Rodney ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b Veterinary Dentistry and Oral Surgery   (United States)

^c DSM RESOLVE   (Netherlands)

Author keywords

5 Acetoxy 10 , 14 dihydroxy taxa 4(20),11(12) diene; Cytochrome P450 taxoid 14 hydroxylase; Paclitaxel; Taxol; Taxus; Yew

Indexed keywords

5ALPHA ACETOXY 10BETA HYDROXYTAXADIENE; 5ALPHA ACETOXY 10BETA,14BETA DIHYDROXYTAXADIENE; 5ALPHA,13ALPHA DIHYDROXYTAXADIENE; CYTOCHROME P450 ISOENZYME; TAXANE DERIVATIVE; TAXOID 14BETA HYDROXYLASE; TAXOID TRIOL MONOACETATE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME METABOLISM; ENZYME SUBSTRATE; ISOTOPE LABELING; MICROSOME; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST;

TAXUS;

EID: 0242669969     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(03)00090-0     Document Type: Article

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