Metabolic responses of Taxus media transformed cell cultures to the addition of methyl jasmonate

Biotechnology Progress

Volumn 26, Issue 4, 2010, Pages 1145-1153

  Exposito, Oscar ^a   Syklowska Baranek, Katarzyna ^b   Moyano, Elisabeth ^c   Onrubia, Miriam ^c   Bonfill, Mercedes ^a   Palazon, Javier ^a   Cusido, Rosa M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Agrobacterium system; Metabolic engineering; Rol genes; Taxadiene synthase; Taxol; Taxus cell cultures

Indexed keywords

AGROBACTERIUM; METABOLIC ENGINEERING; ROL GENES; TAXADIENE SYNTHASE; TAXOL; TAXUS CELL CULTURES;

CELLS; DNA; ENZYME ACTIVITY; GENE EXPRESSION; METABOLISM; OPTIMIZATION;

CELL CULTURE;

ACETIC ACID DERIVATIVE; BRIDGED COMPOUND; CYCLOPENTANE DERIVATIVE; ISOMERASE; JASMONIC ACID METHYL ESTER; OXYLIPIN; TAXA 4(5),11(12) DIENE SYNTHASE; TAXA-4(5),11(12)-DIENE SYNTHASE; TAXANE; TAXOID;

ARTICLE; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSFORMATION; GENETICS; METABOLISM; RHIZOBIUM; TAXUS;

ACETIC ACIDS; BRIDGED COMPOUNDS; CELL CULTURE TECHNIQUES; CYCLOPENTANES; GENE EXPRESSION REGULATION, PLANT; ISOMERASES; OXYLIPINS; RHIZOBIUM; TAXOIDS; TAXUS; TRANSFORMATION, GENETIC;

AGROBACTERIUM; AGROBACTERIUM RHIZOGENES; RHIZOBIUM; TAXUS; TAXUS BACCATA; TAXUS X MEDIA;

EID: 77956939198     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.424     Document Type: Article

References (46)

1. Roberts SC, Schuler ML. Strategies for bioproduct optimization in plant cell tissue cultures. In: Zaborsky O, editor. Biohydrogen. New York: Plenum Press; 1998:483-492.
2. Ramachandra SR, Ravishankarb GA. Plant cell cultures: chemical factories of secondary metabolites. Biotechnol Adv. 2002;20: 101-153.
3. Saito K, Mizukami H. Plant cell cultures as producers of secondary compounds. In: Oksman-Caldentey KM, Barz WH, editors. Plant Biotechnology and Transgenic Plants. New York: Marcel Dekker; 2002:77-109.
4. Vanisree M, Lee Ch, Lo SF, Nalawade SM, Lin Ch Y, Tsay HS. Studies on the production of some important secondary metabolites from medicinal plants by plant tissue cultures. Bot Bull Acad Sinica. 2004;45:1-22.
5. Frense D. Taxanes: perspectives for biotechnological production. Appl Microbiol Biotechnol. 2007;73:1233-1240.
6. Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Clalborne CF, Renaud J, Couladouros EA, Paulvannan K, Sorensen EJ. Total synthesis of taxol. Nature 1994;367:630-634.
7. Holton RA, Kim B, Somoza C, Liang F, Biediger RJ, Boatman PD, Shindo M, Smith, CC, Kim S, Nadizadeh H, Suzuki Y, Tao C, Vu P, Tang S, Zhang, Murthi KK, Gentile LN, Liu JH. First total synthesis of taxol. II. Completion of the C and D rings. J Am Chem Soc. 1994;116:1599-1600.
8. Holton RA, Somoza C, Kim HB, Liang F, Biediger RJ, Boatman PD, Shindo M, Smith CC, Kim S, Nadizadeh H, Suzuki Y, Tao C, Vu P, Tan, S, Zhang P, Murthi KK, Gentile LN, Liu JH. First total synthesis of taxol. I. Functionalization of the B ring. J Am Chem Soc. 1994;116:1597-1598.
9. Guenard D, Guéritte-Voegelein F, Potier P. Taxol and taxotere: discovery, chemistry and structure-activity relationships. Acc Chem Res. 1993;26:160-167.
10. Expósito O, Bonfill M, Moyano E, Onrubia M, Mirjalili H, Cusidó RM, Palazón J. Biotechnological production of taxol and related taxoids: current state and prospects. Anticancer Agents Med Chem. 2009;79:109-121.
11. Croteau R, Ketchum REB, Long RM, Kaspera R, Wildung MR. Taxol biosynthesis and molecular genetics. Phytochem Rev. 2006;5:75-97.
12. DeJong JHM, Liu Y, Bollon AP, Long RM, Jennewein S, Williams D, Croteau R. Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae. Biotechnol Bioeng. 2006; 93:212-224.
13. Nims E, Dubois CP, Roberts SC, Walker EL. Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering. Metab Eng. 2006;8:385-394.
14. Vongpaseuth K, Nims E, Amand MSt, Walker EL, Roberts SC. Development of a particle bombardment-mediated transient transformation system for Taxus spp. cells in culture. Biotechnol Progr. 2007;23:1180-1185.
15. Han KH, Fleming P, Walker K, Loper M, Chilton WS, Mocek U, Gordon MP, Floss HG. Genetic transformation of mature Taxus: an approach to genetically control the in vitro production of the anticancer drug, taxol. Plant Sci. 1994;95:187-196.
16. Furmanova M, Syklowska-Baranek K. Hairy root cultures of Taxus x media var. Hicksii Rehd. As a new source of paclitaxel and 10-deacetilbaccatin III. Biotechnol Lett. 2000;22:683-686.
17. Ho Ch-K, Chang S-H, Lung H Jr, Tsai Ch-J, Chen K-Ph. The strategies to increase taxol production by using Taxus marei cells transformed with TXS and DBAT genes. Int J Appl Sci Eng. 2005;3:179-185.
18. Ketchum REB, Wherland L, Croteau RB. Stable transformation and long-term maintenance of transgenic Taxus cell suspension cultures. Plant Cell Rep. 2007;26:1025-1033.
19. Pietrosiuk A, Syklowska-Baranek K, Wiedenfeld H, Wolinowska R, Furmanova M, Jaroszyk E. The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.) Lehm. Plant Cell Rep. 2006;25:1052-1058.
20. Besumbes O, Sauret-Güeto S, Phillips MA, Imperial S, Rodriguez- Concepción M, Boronat A. Metabolic engineering of isoprenoid biosíntesis in Arabidopsis for the production of taxadiene, the first committed precursor of taxol. Biotechnol Bioeng. 2004;88:168-175.
21. Gupta PK, Durzan DJ. Shoot multiplication from mature trees of Douglas-fir (Pseudotsuga menziesii) and Sugar pine (Pinus lambertiana). Plant Cell Rep. 1985;4:177-179.
22. Cusidó RM, Palazón J, Navia-Osorio A, Mallol A, Bonfill M, Morales C, Piñol MT. Production of taxolVR and baccatine III by a selected Taxus baccata callus line and its derived cell suspension culture. Plant Sci. 1999;146:101-107.
23. Cusidó RM, Palazón J, Bonfill M, Navia-Osorio A, Morales C, Piñol MT. Improved paclitaxel and baccatin III production in suspension cultures of Taxus x media. Biotechnol Prog. 2002; 18:418-423.
24. Widholm JM. The use of fluorecein diacetate and phenosafranine for determining viability of cultured plant cells. Stain Technol. 1972;47:189-194.
25. Hezari M, Ketchum REB, Gibson DM, Croteau R. Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures. Arch Biochem Biophys. 1997;337:185-190.
26. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein- binding. Ann Biochem Exp Med. 1976;72:248-254.
27. Hezari M, Lewis NG, Croteau R. Purification and characterization of taxa-4(5), 11(12)-diene synthase from pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis. Arch Biochem Biophys. 1995;322:437-444.
28. Expósito O, Bonfill M, Onrubia M, Jané A, Moyano E, Cusidó RM, Palazón J, Piñol MT. Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures. New Biotechnol. 2009;25:252-259.
29. Richheimer SI, Tinnermeier DM, Timmons DW. High-performance liquid chromatographic assay of taxol. Anal Chem. 1992; 64:2323-2326.
30. Qiagen. Critical Factors for Successful Real-Time PCR (Updated February 2006; cited 20 November 2008). Available at: www.qiagen.com; 2006.
31. Bonfill M, Palazón J, Cusidó RM, Joly S, Morales C, Piñol MT. Influence of elicitors on taxane production and 3-hydroxy-3- methylglutaryl coenzyme A reductase activity in Taxus media cells. Plant Physiol Biochem. 2003;41:91-96.
32. Ketchum REB, Gibson DM, Croteau RB, Shuler L. The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol Bioeng. 1999;62:97-105.
33. Bulgakov VP. Functions of rol genes in plant secondary metabolism. Biotechnol Adv. 2008;26:318-324.
34. Bulgakov VP, Tchernoded GK, Mischenko NP, Khodakovskaya MV, Glazunov VP, Zvereva, EV, Fedoreyev SA, Zhuravlev YN. Effects of salicylic acid, methyl jasmonate, etephone and cantharidin on anthraquinone production by Rubia cordifolia callus cultures transformed with rolB and rolC genes. J Biotechnol. 2002;97:213-221.
35. Wang C, Wu J, Mei X. Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding. Biotechnol Progr. 2001;17:89-94.
36. Bonfill M, Expósito O, Moyano E, Cusidó RM, Palazón J, Piñol MT. Manipulation by culture mixing and elicitation of paclitaxel and baccatin III production in Taxus baccata suspension cultures. In Vitro Cell Dev Biol-Plant. 2006;42:422-426.
37. Seki M, Ohzora C, Takeda M, Furusaki S. Taxol (Paclitaxel) production using free and immobilized cells of Taxus cuspidata. Biotechnol Bioeng. 1996;53:214-219.
38. Navia-Osorio A, Hermann G, Cusidó RM, Palazón J, Alfermann AW, Piñol MT. Taxol and baccatin III production in suspensión cultures of Taxus baccata and Taxus wallichiana in an airlift bioreactor. J Plant Physiol. 2002;159:97-102.
39. Palazón J, Cusidó RM, Roig C, Piñol MT. Effect of rol genes from Agrobacterium rhizogenes TL-DNA on nicotine production in tobacco root cultures. Plant Physiol Biochem. 1997;35: 155-162.
40. Giri A, Narasu M. Transgenic hairy roots. Recent trends and applications. Biotechnol Adv. 2000;18:1-22.
41. Sevon N, Oksman-Caldentey KM. Agrobacterium rhizogenesmediated transformation: root cultures as a source of alkaloids. Planta Med. 2002;68:859-868.
42. Hong S, Peebles C, Shanks JV, San K, Gibson S. Terpenoid indole alkaloid production by Catharanthus roseus hairy roots induced by Agrobacterium tumefaciens harbouring rol ABC genes. Biotechnol Bioeng. 2006;93:386-390.
43. Kooter JM, Matzke MA, Meyer P. Listening to the silent genes: transgene silencing, gene regulation and pathogen control. Trends Plant Sci. 1999;4:340-347.
44. Vongpaseuth K, Roberts SC. Advancements in the understanding of paclitaxel metabolism in tissue culture. Curr Pharm Biotechnol. 2007;8:219-236.
45. Dong HD, Zhong JJ. Significant improvement of taxane production in suspension cultures of Taxus chinensis by combining elicitation with sucrose feed. Biochem Eng J. 2001;8:145-150.
46. Zhang CH, Fevereiro PS, He GY, Chen Z. Enhanced paclitaxel productivity and release capacity of Taxus chinensis cell suspension cultures adapted to chitosan. Plant Sci. 2007;172:158-163.