Characterization of the Taxol binding site on the microtubule. Identification of Arg282 in β-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol

Journal of Biological Chemistry

Volumn 274, Issue 53, 1999, Pages 37990-37994

  Rao, Srinivasa ^a   He, Lifeng ^a   Chakravarty, Subrata ^b   Ojima, Iwao ^b   Orr, George A ^a   Horwitz, Susan Band ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PACLITAXEL; PACLITAXEL DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG RECEPTOR BINDING; MICROTUBULE; MOLECULAR MODEL; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ISOLATION; SEQUENCE ANALYSIS;

ANIMALS; BINDING SITES; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PACLITAXEL; PHOTOAFFINITY LABELS; TAXOIDS; TUBULIN;

EID: 0033621479     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.53.37990     Document Type: Article

References (32)

1. Rowinsky, E. K., and Donehower, R. C. (1995) N. Engl. J. Med. 332, 1004-1014
2. Manfredi, J. J., Parness, J., and Horwitz, S. B. (1982) J. Cell Biol. 94, 688-696
3. Rao, S., Horwitz, S. B., and Ringel, I. (1992) J. Natl. Cancer Inst. 84, 785-788
4. Schiff, P. B., Fant, J., and Horwitz, S. B. (1979) Nature 277, 665-667
5. Parness, J., and Horwitz, S. B. (1981) J. Cell Biol. 91, 479-487
6. Díaz, J. F., and Andreu, J. M. (1993) Biochemistry 32, 2747-2755
7. Schiff, P. B., and Horwitz, S. B. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 1561-1565
8. Jordan, M. A., Toso, R. J., Thrower, D., and Wilson, L. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9552-9556
9. Jordan, M. A., Wendell, K., Gardiner, S., Derry, W. B., Copp, H., and Wilson, L. (1996) Cancer Res. 56, 816-825
10. Rao, S., Krauss, N. E., Heerding, J. M., Swindell, C. S., Ringel, I., Orr, G. A., and Horwitz, S. B. (1994) J. Biol. Chem. 269, 3132-3134
11. Rao, S., Orr, G. A., Chaudhary, A. G., Kingston, D. G. I., and Horwitz, S. B. (1995) J. Biol. Chem. 270, 20235-20238
12. Nogales, E., Wolf, S. G., and Downing, K. H. (1998) Nature 391, 199-203
13. Wu, Q., Bounaud, P-Y., Kuduk, S. D., Yang, C-P. H., Ojima, I., Horwitz, S. B., and Orr, G. A. (1998) Biochemistry 37, 11272-11279
14. Ojima, I., Bounaud, P.-Y., and Ahern, D. G. (1999) Bioorg. Med. Chem. Lett. 9, 1189-1194
15. Shelanski, M. L., Gaskin, F., and Cantor, C. R. (1973) Proc. Natl. Acad. Sci. U. S. A. 70, 765-768
16. Gaskin, F., Cantor, C. R., and Shelanski, M. L. (1974) J. Mol. Biol. 89, 737-758
17. Luo, K., Hurley, T. R., and Sefton, B. M. (1991) Methods Enzymol. 201, 149-151
18. Gilles, A. M., Imhoff, J. M., and Keil, B. (1979) J. Biol. Chem. 254, 1462-1468
19. Guéritte-Voegelein, F., Mangatal, L., Guénard, D., Potier, P., Guilhem, J., Cesario, M., and Paacard, C. (1990) Acta Crystatlogr. C46, 781-784
20. Mastropaolo, D., Camerman, A., Luo, Y., Brayer, G. D., and Camerman, N. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6920-6924
21. Krauhs, E., Little, M., Kempf, T., Hofer-Warbinek, R., Ade, W., and Ponstingl, H. (1981)Proc. Natl. Acad. Sci. U. S. A. 78, 4156-4160
22. Sullivan, K. F., and Cleveland, D. W. (1986) Proc. Natl. Acad Sci. U. S. A. 83, 4327-4331
23. Nogales, E., Whittaker, M., Milligan, R. A., and Downing, K. H. (1999) Cell 96, 79-88
24. Dormán, G., and Prestwich, G. D. (1994) Biochemistry 33, 5661-5673
25. Kingston, D. G. I. (1995) in Taxane Anticancer Agents, Basic Science and Current Status (Georg, G. I., Chen, T. T., Ojima, I., and Vyas, D. M., eds) pp. 203-216, ACS symposium series 583, American Chemical Society, Washington, D. C.
26. Grover, S., Rimoldi, J. M., Molinero, A. A., Chaudhary, A. G., Kingston, D. G. I., and Hamel, E. (1995) Biochemistry 34, 3927-3934
27. Georg, G. I., Harriman, G. C. B., Himes, R. H., and Mejillano, M. R. (1992) Bioorg. Med. Chem. Lett. 2, 735-738
28. Amos, L. A., and Löwe, J. (1999) Chem. Biol. 6, R65-R69
29. Ojima, I., Kuduk, S. D., Chakravarty, S., Ourevitch, M., and Bégué, J.-P. (1997) J. Am. Chem. Soc. 119, 5519-5527
30. Giannakakou, P., Sackett, D. L., Kang, Y.-K., Zhan, Z., Buters, J. T. M., Fojo, T., and Poruchynsky, M. S. (1997) J. Biol. Chem. 272, 17118-17125
31. Gonzalez-Garay, M. L., Chang, L., Blade, K., Menick, D. R., and Cabral, F. (1999) J. Biol. Chem. 274, 23875-23882
32. Monzó, M., Rosell, R., Sánchez, J. J., Lee, J. S., O'Brate, A., González-Larriba, J. L., Alberola, V., Lorenzo, J. C., Núñez, L., Ro, J. Y., and Martín, C. (1999) J. Clin. Oncol. 17, 1786-1793