Nature as a remarkable chemist: A personal story of the discovery and development of Taxol

Anti-Cancer Drugs

Volumn 25, Issue 5, 2014, Pages 482-487

  Wani, Mansukh C ^a   Horwitz, Susan Band ^b  

^a RTI INTERNATIONAL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Natural products; Taxol; Tubulin microtubules

Indexed keywords

PACLITAXEL; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; BIOLOGICAL ACTIVITY; DRUG DETERMINATION; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOLID TUMOR; CHEMISTRY; DRUG DEVELOPMENT; ISOLATION AND PURIFICATION; METABOLISM; NEOPLASM; PATHOLOGY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; DRUG DISCOVERY; HUMANS; NEOPLASMS; PACLITAXEL;

EID: 84908375133     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000063     Document Type: Review

References (19)

1. Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 1971; 93:2325-2327.
2. Persinous GJ. 1990 Taxol - thirty years in the wings. Washington Insight (15 September 1990); 3, 7.
3. Wall ME, Wani MC, Cook CE, Palmer KH, McPhail HT, Sim GA. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 1966; 88:3888-3890.
4. Horwitz MS, Horwitz SB. Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin. Biochem Biophys Res Commun 1971; 45:723-727.
5. Loike JD, Horwitz SB. Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells. Biochemistry 1976; 15:5443-5448.
6. Sausville EA, Stein RW, Peisach J, Horwitz SB. Properties and products of the degradation of DNA by bleomycin and iron(II). Biochemistry 1978; 17:2746-2754.
7. Golden EB, Formenti SC, Schiff PB. Taxanes as radiosensitizers. Anti-Cancer Drugs 2014; 25:502-511.
8. Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by Taxol. Nature 1979; 277:665-667.
9. Schiff PB, Horwitz SB. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A 1980; 77:1561-1565.
10. Torres K, Horwitz SB. Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res 1998; 58:3620-3626.
11. Chen JG, Horwitz SB. Differential mitotic responses to microtubulestabilizing and -destabilizing drugs. Cancer Res 2002; 62: 1935-1938.
12. Ikui AE, Yang CP, Matsumoto T, Horwitz SB. Low concentrations of Taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy. Cell Cycle 2005; 4:1385-1388.
13. Jordan MA, Toso RJ, Thrower D, Wilson L. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations. Proc Natl Acad Sci U S A 1993; 90:9552-9556.
14. Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56:816-825.
15. Rao S, He L, Chakravarty S, Ojima I, Orr GA, Horwitz SB. Identification of Arg282 in b-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem 1999; 274:37990-37994.
16. Nogales E, Wolf SG, Downing KH. Structure of the ab tubulin dimer by electron crystallography. Nature 1998; 391:199-203.
17. Xiao H, Verdier-Pinard P, Fernandez-Fuentes N, Burd B, Angeletti R, Fiser A, et al. Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci U S A 2006; 103:10166-10173.
18. McGuire WP, Rowinsky EK, Rosenshein NB, Grumbine FC, Ettinger DS, Armstrong DK, Donehower RC. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann Intern Med 1989; 111:273-279.
19. Holmes FA, Walters RS, Theriault RL, Forman AD, Newton LK, Raber MN, et al. Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J Natl Cancer Inst 1991; 83:1797-1805.