Molecular cloning and characterization of a cytochrome P450 taxoid 2α-hydroxylase involved in Taxol biosynthesis

Archives of Biochemistry and Biophysics

Volumn 427, Issue 1, 2004, Pages 48-57

  Chau, MyDoanh ^a   Croteau, Rodney ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

2 Hydroxytaxusin; Cytochrome P450 hydroxylase; Paclitaxel; Taxoid 2 hydroxylase; Taxol biosynthesis; Taxus; Taxusin; Yew

Indexed keywords

2ALPHA HYDROLASE; ACETIC ACID DERIVATIVE; CYTOCHROME P450; HEXAOL TETRAACETATE; HYDROLASE; PACLITAXEL; PENTAOL TETRAACETATE; TAXANE DERIVATIVE; TAXOID; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ISOLATION; ENZYME SUBSTRATE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TAXUS; YEAST;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PACLITAXEL; SEQUENCE HOMOLOGY, AMINO ACID; TAXUS;

TAXUS;

EID: 2642547256     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2004.04.016     Document Type: Article

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