Heterologous expression and characterization of a 'pseudomature' form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction

Archives of Biochemistry and Biophysics

Volumn 379, Issue 1, 2000, Pages 137-146

  Williams, David C ^a   Wildung, Mark R ^a   Jin, Alan Qingwu ^b   Dalal, Dolan ^c   Oliver, John S ^c   Coates, Robert M ^b   Croteau, Rodney ^d  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c BROWN UNIVERSITY   (United States)

^d NONE

Author keywords

Paclitaxel; Taxadiene synthase; Taxol biosynthesis; Taxus; Yew

Indexed keywords

ALKADIENE; COMPLEMENTARY DNA; DITERPENE; PACLITAXEL; SYNTHETASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; REACTION ANALYSIS; SEQUENCE ANALYSIS;

ESCHERICHIA COLI; TAXUS;

EID: 0034234699     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2000.1865     Document Type: Article

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