Sphingolipids and mitochondrial function, lessons learned from yeast

Microbial Cell

Volumn 1, Issue 7, 2014, Pages 210-224

  Spincemaille, Pieter ^a   Cammue, Bruno P A ^a,b   Thevissen, Karin ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Mitochondrial function; Niemann Pick type C1; Sphingolipids; Wilson disease; Yeast

Indexed keywords

EID: 85034085252     PISSN: None     EISSN: 23112638     Source Type: Journal    
DOI: 10.15698/mic2014.07.156     Document Type: Review

References (231)

1. Hsu CC, Lee HC, Wei YH (2013). Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World journal of gastroenterology: WJG 19(47): 8880-8886.
2. Boland ML, Chourasia AH, Macleod KF (2013). Mitochondrial Dysfunction in Cancer. Frontiers in oncology 3:292.
3. Zuo L, Motherwell MS (2013). The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease. Gene 532(1): 18-23.
4. Sery O, Povova J, Misek I, Pesak L, Janout V (2013). Molecular mechanisms of neuropathological changes in Alzheimer's disease: a review. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences 51(1): 1-9.
5. Gonzalez-Cabo P, Palau F (2013). Mitochondrial pathophysiology in Friedreich's ataxia. Journal of neurochemistry 126 Suppl 1:53-64.
6. Zischka H, Lichtmannegger J (2014). Pathological mitochondrial copper overload in livers of Wilson's disease patients and related animal models. Annals of the New York Academy of Sciences. 1315(1):6-15.
7. Verbeek J, Lannoo M, Pirinen E, Ryu D, Spincemaille P, van der Elst I, Windmolders P, Thevissen K, Cammue BPA, van Pelt J, Fransis S, Van Eyken P, Ceuterick-De Groote C, Van Veldhoven PP, Bedossa P, Nevens F, Auwerx J, Cassiman D (2014). Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with nonalcoholic steatohepatitis. Gut In Press.
8. Begriche K, Igoudjil A, Pessayre D, Fromenty B (2006). Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 6(1): 1-28.
9. Serviddio G, Bellanti F, Vendemiale G, Altomare E (2011). Mitochondrial dysfunction in nonalcoholic steatohepatitis. Expert review of gastroenterology & hepatology 5(2): 233-244.
10. Nicolson GL (2007). Metabolic syndrome and mitochondrial function: molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function. Journal of cellular biochemistry 100(6): 1352-1369.
11. Stiles L, Shirihai OS (2012). Mitochondrial dynamics and morphology in beta-cells. Best practice & research Clinical endocrinology & metabolism 26(6): 725-738.
12. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N (2013). Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends in pharmacological sciences 34(4): 243-253.
13. Pessayre D, Fromenty B, Berson A, Robin MA, Letteron P, Moreau R, Mansouri A (2012). Central role of mitochondria in drug-induced liver injury. Drug metabolism reviews 44(1): 34-87.
14. Schon EA, DiMauro S, Hirano M (2012). Human mitochondrial DNA: roles of inherited and somatic mutations. Nature reviews Genetics 13(12): 878-890.
15. Schapira AH (2012). Mitochondrial diseases. Lancet 379(9828): 1825-1834.
16. Biniecka M, Fox E, Gao W, Ng CT, Veale DJ, Fearon U, O'Sullivan J (2011). Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis and rheumatism 63(8): 2172-2182.
17. Kazachkova N, Ramos A, Santos C, Lima M (2013). Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice. Aging and disease 4(6): 337-350.
18. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013). The hallmarks of aging. Cell 153(6): 1194-1217.
19. Sharma H, Singh A, Sharma C, Jain SK, Singh N (2005). Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer. Cancer cell international 5:34.
20. Wei YH, Lee HC (2002). Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Experimental biology and medicine 227(9): 671-682.
21. Birch-Machin MA, Swalwell H (2010). How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissue. Mutagenesis 25(2): 101-107.
22. Gorman S, Fox E, O'Donoghue D, Sheahan K, Hyland J, Mulcahy H, Loeb LA, O'Sullivan J (2010). Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects. Journal of molecular medicine 88(7): 701-708.
23. Cohen BH, Gold DR (2001). Mitochondrial cytopathy in adults: what we know so far. Cleveland Clinic journal of medicine 68(7): 625-626, 629-642.
24. Vernon SD, Whistler T, Cameron B, Hickie IB, Reeves WC, Lloyd A (2006). Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus. BMC infectious diseases 6:15.
25. Meyer JN, Leung MC, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, Bess AS (2013). Mitochondria as a target of environmental toxicants. Toxicological sciences: an official journal of the Society of Toxicology 134(1): 1-17.
26. Goldkorn T, Chung S, Filosto S (2013). Lung cancer and lung injury: the dual role of ceramide. Handbook of experimental pharmacology 216: 93-113.
27. Heffernan-Stroud LA, Obeid LM (2013). Sphingosine kinase 1 in cancer. Advances in cancer research 117:201-235.
28. Morad SA, Cabot MC (2013). Ceramide-orchestrated signalling in cancer cells. Nature reviews Cancer 13(1): 51-65.
29. Yuyama K, Mitsutake S, Igarashi Y (2013). Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease. Biochimica et biophysica acta. 184(5): 793-8
30. Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rubben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Haussinger D, Gulbins E, Lang F (2007). Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nature medicine 13(2): 164-170.
31. Galadari S, Rahman A, Pallichankandy S, Galadari A, Thayyullathil F (2013). Role of ceramide in diabetes mellitus: evidence and mechanisms. Lipids in health and disease 12:98.
32. Supale S, Li N, Brun T, Maechler P (2012). Mitochondrial dysfunction in pancreatic beta cells. Trends in endocrinology and metabolism: TEM 23(9): 477-487.
33. van Echten-Deckert G, Walter J (2012). Sphingolipids: critical players in Alzheimer's disease. Progress in lipid research 51(4): 378-393.
34. Vamecq J, Dessein AF, Fontaine M, Briand G, Porchet N, Latruffe N, Andreolotti P, Cherkaoui-Malki M (2012). Mitochondrial dysfunction and lipid homeostasis. Current drug metabolism 13(10): 1388-1400.
35. Chiantia S, London E (2013). Sphingolipids and membrane domains: recent advances. Handbook of experimental pharmacology 215: 33-55.
36. Spiegel S, Merrill AH, Jr. (1996). Sphingolipid metabolism and cell growth regulation. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 10(12): 1388-1397.
37. Young MM, Kester M, Wang HG (2013). Sphingolipids: regulators of crosstalk between apoptosis and autophagy. Journal of lipid research 54(1): 5-19.
38. Smith WL, Merrill AH, Jr. (2002). Sphingolipid metabolism and signaling minireview series. The Journal of biological chemistry 277(29): 25841-25842.
39. Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996). Life with 6000 genes. Science 274(5287): 546, 563-547.
40. Foury F, Roganti T, Lecrenier N, Purnelle B (1998). The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS letters 440(3): 325-331.
41. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (1981). Sequence and organization of the human mitochondrial genome. Nature 290(5806): 457-465.
42. Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AM, Elsas LJ, 2nd, Nikoskelainen EK (1988). Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 242(4884): 1427-1430.
43. Kirches E (2011). LHON: Mitochondrial Mutations and More. Current genomics 12(1): 44-54.
44. Botstein D, Chervitz SA, Cherry JM (1997). Yeast as a model organism. Science 277(5330): 1259-1260.
45. Foury F (1997). Human genetic diseases: a cross-talk between man and yeast. Gene 195(1): 1-10.
46. Bassett DE, Jr., Boguski MS, Hieter P (1996). Yeast genes and human disease. Nature 379(6566): 589-590.
47. Frohlich KU, Fussi H, Ruckenstuhl C (2007). Yeast apoptosis--from genes to pathways. Seminars in cancer biology 17(2): 112-121.
48. Rea SL, Graham BH, Nakamaru-Ogiso E, Kar A, Falk MJ (2010). Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases. Developmental disabilities research reviews 16(2): 200-218.
49. Barrientos A (2003). Yeast models of human mitochondrial diseases. IUBMB life 55(2): 83-95.
50. Foury F, Kucej M (2002). Yeast mitochondrial biogenesis: a model system for humans? Current opinion in chemical biology 6(1): 106-111.
51. Baile MG, Claypool SM (2013). The power of yeast to model diseases of the powerhouse of the cell. Frontiers in bioscience 18: 241-278.
52. Hannun YA, Luberto C, Argraves KM (2001). Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40(16): 4893-4903.
53. van der Bliek AM, Shen Q, Kawajiri S (2013). Mechanisms of mitochondrial fission and fusion. Cold Spring Harbor perspectives in biology 5(6).
54. Youle RJ, van der Bliek AM (2012). Mitochondrial fission, fusion, and stress. Science 337(6098): 1062-1065.
55. Horvath SE, Daum G (2013). Lipids of mitochondria. Progress in lipid research 52(4): 590-614.
56. Chinnery PF, Schon EA (2003). Mitochondria. Journal of neurology, neurosurgery, and psychiatry 74(9): 1188-1199.
57. Camara AK, Lesnefsky EJ, Stowe DF (2010). Potential therapeutic benefits of strategies directed to mitochondria. Antioxidants & redox signaling 13(3): 279-347.
58. Pelicano H, Martin DS, Xu RH, Huang P (2006). Glycolysis inhibition for anticancer treatment. Oncogene 25(34): 4633-4646.
59. Bayley JP, Devilee P (2012). The Warburg effect in 2012. Current opinion in oncology 24(1): 62-67.
60. Warburg O, Wind F, Negelein E (1927). The Metabolism of Tumors in the Body. The Journal of general physiology 8(6): 519-530.
61. Ring J, Sommer C, Carmona-Gutierrez D, Ruckenstuhl C, Eisenberg T, Madeo F (2012). The metabolism beyond programmed cell death in yeast. Experimental cell research 318(11): 1193-1200.
62. Ruckenstuhl C, Buttner S, Carmona-Gutierrez D, Eisenberg T, Kroemer G, Sigrist SJ, Frohlich KU, Madeo F (2009). The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer. PloS one 4(2): e4592.
63. Karlsson KA (1970). Sphingolipid long chain bases. Lipids 5(11): 878-891. PMID: 4921900.
64. Bartke N, Hannun YA (2009). Bioactive sphingolipids: metabolism and function. Journal of lipid research 50 Suppl S91-96.
65. Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q, Ramaraju H, Sullards MC, Cabot M, Merrill AH, Jr. (2006). Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochimica et biophysica acta 1758(12): 1864-1884.
66. Hannun YA, Obeid LM (2008). Principles of bioactive lipid signalling: lessons from sphingolipids. Nature reviews Molecular cell biology 9(2): 139-150.
67. Kogot-Levin A, Saada A (2014). Ceramide and the mitochondrial respiratory chain. Biochimie 100:88-94.
68. Vaena de Avalos S, Okamoto Y, Hannun YA (2004). Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. The Journal of biological chemistry 279(12): 11537-11545.
69. Barbosa AD, Graca J, Mendes V, Chaves SR, Amorim MA, Mendes MV, Moradas-Ferreira P, Corte-Real M, Costa V (2012). Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging. Mechanisms of ageing and development 133(5): 317-330.
70. Almeida T, Marques M, Mojzita D, Amorim MA, Silva RD, Almeida B, Rodrigues P, Ludovico P, Hohmann S, Moradas-Ferreira P, Corte-Real M, Costa V (2008). Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. Molecular biology of the cell 19(3): 865-876.
71. Vaena de Avalos S, Su X, Zhang M, Okamoto Y, Dowhan W, Hannun YA (2005). The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. The Journal of biological chemistry 280(8): 7170-7177.
72. Teixeira V, Medeiros, T.C., Vilaça, R., Moradas-Ferreira, P., and Costa, V. (2014). Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells. Microbial Cell 1(1): 21-36.
73. Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Corte-Real M (2012). Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PloS one 7(11): e48571.
74. Spincemaille P, Matmati N, Hannun YA, Cammue BPA, Thevissen K (2014). Sphingolipids and Mitochondrial Function in Budding Yeast. Biochimica et biophysica acta In press.
75. Bielawski J, Pierce JS, Snider J, Rembiesa B, Szulc ZM, Bielawska A (2010). Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Advances in experimental medicine and biology 688:46-59.
76. Bielawski J, Szulc ZM, Hannun YA, Bielawska A (2006). Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 39(2): 82-91.
77. Yamagata M, Obara K, Kihara A (2011). Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae. Biochemical and biophysical research communications 410(4): 786-791.
78. Huang X, Liu J, Dickson RC (2012). Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS genetics 8(2): e1002493.
79. Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM (2008). Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nature medicine 14(11): 1247-1255.
80. Tong M, Longato L, Ramirez T, Zabala V, Wands JR, de la Monte SM (2014). Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin. International journal of experimental pathology 95(1): 49-63.
81. Kurek K, Piotrowska DM, Wiesiolek-Kurek P, Lukaszuk B, Chabowski A, Gorski J, Zendzian-Piotrowska M (2013). Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease. Liver international: official journal of the International Association for the Study of the Liver.
82. Kajiwara K, Muneoka T, Watanabe Y, Karashima T, Kitagaki H, Funato K (2012). Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast. Molecular microbiology 86(5): 1246-1261.
83. Cerantola V, Guillas I, Roubaty C, Vionnet C, Uldry D, Knudsen J, Conzelmann A (2009). Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Molecular microbiology 71(6): 1523-1537.
84. Lee S, Gaspar ML, Aregullin MA, Jesch SA, Henry SA (2013). Activation of protein kinase C-mitogen-activated protein kinase signaling in response to inositol starvation triggers Sir2p-dependent telomeric silencing in yeast. The Journal of biological chemistry 288(39): 27861-27871.
85. Jenkins GM, Cowart LA, Signorelli P, Pettus BJ, Chalfant CE, Hannun YA (2002). Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. The Journal of biological chemistry 277(45): 42572-42578.
86. Shimabukuro M, Zhou YT, Levi M, Unger RH (1998). Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proceedings of the National Academy of Sciences of the United States of America 95(5): 2498-2502.
87. Rego A, Trindade D, Chaves SR, Manon S, Costa V, Sousa MJ, Corte-Real M (2013). The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids. FEMS yeast research. 14(1): 160-178.
88. Sims KJ, Spassieva SD, Voit EO, Obeid LM (2004). Yeast sphingolipid metabolism: clues and connections. Biochemistry and cell biology 82(1): 45-61.
89. Hannun YA, Obeid LM (2011). Many ceramides. The Journal of biological chemistry 286(32): 27855-27862.
90. Hanada K (2003). Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochimica et biophysica acta 1632(1-3): 16-30.
91. Kihara A, Igarashi Y (2004). FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. The Journal of biological chemistry 279(47): 49243-49250.
92. Mullen TD, Hannun YA, Obeid LM (2012). Ceramide synthases at the centre of sphingolipid metabolism and biology. The Biochemical journal 441(3): 789-802.
93. Fabrias G, Munoz-Olaya J, Cingolani F, Signorelli P, Casas J, Gagliostro V, Ghidoni R (2012). Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena. Progress in lipid research 51(2): 82-94.
94. Mao C, Obeid LM (2008). Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochimica et biophysica acta 1781(9): 424-434.
95. Sugiura M, Kono K, Liu H, Shimizugawa T, Minekura H, Spiegel S, Kohama T (2002). Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. The Journal of biological chemistry 277(26): 23294-23300.
96. Holthuis JC, Luberto C (2010). Tales and mysteries of the enigmatic sphingomyelin synthase family. Advances in experimental medicine and biology 688:72-85.
97. Ichikawa S, Hirabayashi Y (1998). Glucosylceramide synthase and glycosphingolipid synthesis. Trends in cell biology 8(5): 198-202.
98. Sprong H, Kruithof B, Leijendekker R, Slot JW, van Meer G, van der Sluijs P (1998). UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. The Journal of biological chemistry 273(40): 25880-25888.
99. Basu S, Kaufman B, Roseman S (1968). Enzymatic synthesis of ceramide-glucose and ceramide-lactose by glycosyltransferases from embryonic chicken brain. The Journal of biological chemistry 243(21): 5802-5804.
100. Slotte JP (2013). Biological functions of sphingomyelins. Progress in lipid research 52(4): 424-437.
101. Hakomori SI (2008). Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Biochimica et biophysica acta 1780(3): 325-346.
102. D'Angelo G, Capasso S, Sticco L, Russo D (2013). Glycosphingolipids: synthesis and functions. The FEBS journal 280(24): 6338-6353.
103. Hakomori S, Igarashi Y (1995). Functional role of glycosphingolipids in cell recognition and signaling. Journal of biochemistry 118(6): 1091-1103.
104. Lingwood CA (2011). Glycosphingolipid functions. Cold Spring Harbor perspectives in biology 3(7).
105. Hruska KS, LaMarca ME, Scott CR, Sidransky E (2008). Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA). Human mutation 29(5): 567-583.
106. Luzi P, Rafi MA, Wenger DA (1995). Structure and organization of the human galactocerebrosidase (GALC) gene. Genomics 26(2): 407-409.
107. Omae F, Miyazaki M, Enomoto A, Suzuki A (2004). Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2. FEBS letters 576(1-2): 63-67.
108. Omae F, Miyazaki M, Enomoto A, Suzuki M, Suzuki Y, Suzuki A (2004). DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine. The Biochemical journal 379(Pt 3): 687-695.
109. Goni FM, Alonso A (2002). Sphingomyelinases: enzymology and membrane activity. FEBS letters 531(1): 38-46.
110. Hait NC, Oskeritzian CA, Paugh SW, Milstien S, Spiegel S (2006). Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochimica et biophysica acta 1758(12): 2016-2026.
111. Bourquin F, Riezman H, Capitani G, Grutter MG (2010). Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure 18(8): 1054-1065.
112. Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003). Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. The Journal of biological chemistry 278(2): 1268-1272.
113. Van Veldhoven PP, Gijsbers S, Mannaerts GP, Vermeesch JR, Brys V (2000). Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1). Biochimica et biophysica acta 1487(2-3): 128-134.
114. Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S (2000). Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death. Proceedings of the National Academy of Sciences of the United States of America 97(14): 7859-7864.
115. Brindley DN, Xu J, Jasinska R, Waggoner DW (2000). Analysis of ceramide 1-phosphate and sphingosine-1-phosphate phosphatase activities. Methods in enzymology 311:233-244.
116. Haak D, Gable K, Beeler T, Dunn T (1997). Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. The Journal of biological chemistry 272(47): 29704-29710.
117. Schorling S, Vallee B, Barz WP, Riezman H, Oesterhelt D (2001). Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Molecular biology of the cell 12(11): 3417-3427.
118. Mao C, Xu R, Bielawska A, Szulc ZM, Obeid LM (2000). Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. The Journal of biological chemistry 275(40): 31369-31378.
119. Mao C, Xu R, Bielawska A, Obeid LM (2000). Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. The Journal of biological chemistry 275(10): 6876-6884.
120. Fischl AS, Liu Y, Browdy A, Cremesti AE (2000). Inositolphosphoryl ceramide synthase from yeast. Methods in enzymology 311:123-130.
121. Uemura S, Kihara A, Inokuchi J, Igarashi Y (2003). Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p. The Journal of biological chemistry 278(46): 45049-45055.
122. Dickson RC, Nagiec EE, Wells GB, Nagiec MM, Lester RL (1997). Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. The Journal of biological chemistry 272(47): 29620-29625.
123. Sawai H, Okamoto Y, Luberto C, Mao C, Bielawska A, Domae N, Hannun YA (2000). Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. The Journal of biological chemistry 275(50): 39793-39798.
124. Matmati N, Hannun YA (2008). Thematic review series: sphingolipids. Isc1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases. Journal of lipid research 49(5): 922-928.
125. Nagiec MM, Skrzypek M, Nagiec EE, Lester RL, Dickson RC (1998). The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. The Journal of biological chemistry 273(31): 19437-19442.
126. Mao C, Wadleigh M, Jenkins GM, Hannun YA, Obeid LM (1997). Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. The Journal of biological chemistry 272(45): 28690-28694.
127. Qie L, Nagiec MM, Baltisberger JA, Lester RL, Dickson RC (1997). Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. The Journal of biological chemistry 272(26): 16110-16117.
128. Mandala SM, Thornton R, Tu Z, Kurtz MB, Nickels J, Broach J, Menzeleev R, Spiegel S (1998). Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proceedings of the National Academy of Sciences of the United States of America 95(1): 150-155.
129. Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA (1997). The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. The Journal of biological chemistry 272(42): 26087-26090.
130. Montefusco DJ, Matmati N, Hannun YA (2014). The yeast sphingolipid signaling landscape. Chemistry and physics of lipids 177: 26-40.
131. Kluepfel D, Bagli J, Baker H, Charest MP, Kudelski A (1972). Myriocin, a new antifungal antibiotic from Myriococcum albomyces. The Journal of antibiotics 25(2): 109-115.
132. Takesako K, Kuroda H, Inoue T, Haruna F, Yoshikawa Y, Kato I, Uchida K, Hiratani T, Yamaguchi H (1993). Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic. The Journal of antibiotics 46(9): 1414-1420.
133. Gelderblom WC, Jaskiewicz K, Marasas WF, Thiel PG, Horak RM, Vleggaar R, Kriek NP (1988). Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Applied and environmental microbiology 54(7): 1806-1811.
134. Wadsworth JM, Clarke DJ, McMahon SA, Lowther JP, Beattie AE, Langridge-Smith PR, Broughton HB, Dunn TM, Naismith JH, Campopiano DJ (2013). The chemical basis of serine palmitoyltransferase inhibition by myriocin. Journal of the American Chemical Society 135(38): 14276-14285.
135. Chen JK, Lane WS, Schreiber SL (1999). The identification of myriocin-binding proteins. Chemistry & biology 6(4): 221-235.
136. Lowther J, Naismith JH, Dunn TM, Campopiano DJ (2012). Structural, mechanistic and regulatory studies of serine palmitoyltransferase. Biochemical Society transactions 40(3): 547-554.
137. Heidler SA, Radding JA (1995). The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337). Antimicrobial agents and chemotherapy 39(12): 2765-2769.
138. Stockmann-Juvala H, Savolainen K (2008). A review of the toxic effects and mechanisms of action of fumonisin B1. Human & experimental toxicology 27(11): 799-809.
139. Wu WI, McDonough VM, Nickels JT, Jr., Ko J, Fischl AS, Vales TR, Merrill AH, Jr., Carman GM (1995). Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. The Journal of biological chemistry 270(22): 13171-13178.
140. Shin DY, Matsumoto K, Iida H, Uno I, Ishikawa T (1987). Heat shock response of Saccharomyces cerevisiae mutants altered in cyclic AMP-dependent protein phosphorylation. Molecular and cellular biology 7(1): 244-250.
141. Rowley A, Johnston GC, Butler B, Werner-Washburne M, Singer RA (1993). Heat shock-mediated cell cycle blockage and G1 cyclin expression in the yeast Saccharomyces cerevisiae. Molecular and cellular biology 13(2): 1034-1041.
142. Dickson RC, Nagiec EE, Skrzypek M, Tillman P, Wells GB, Lester RL (1997). Sphingolipids are potential heat stress signals in Saccharomyces. The Journal of biological chemistry 272(48): 30196-30200.
143. De Virgilio C, Hottiger T, Dominguez J, Boller T, Wiemken A (1994). The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant. European journal of biochemistry / FEBS 219(1-2): 179-186.
144. Vuorio OE, Kalkkinen N, Londesborough J (1993). Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae. European journal of biochemistry/FEBS 216(3): 849-861.
145. Jenkins GM, Richards A, Wahl T, Mao C, Obeid L, Hannun Y (1997). Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. The Journal of biological chemistry 272(51): 32566-32572.
146. Jenkins GM, Hannun YA (2001). Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. The Journal of biological chemistry 276(11): 8574-8581.
147. Cowart LA, Okamoto Y, Lu X, Hannun YA (2006). Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. The Biochemical journal 393(Pt 3): 733-740.
148. Montefusco DJ, Chen L, Matmati N, Lu S, Newcomb B, Cooper GF, Hannun YA, Lu X (2013). Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Science signaling 6(299): rs14.
149. Dixon SJ, Stockwell BR (2014). The role of iron and reactive oxygen species in cell death. Nature chemical biology 10(1): 9-17.
150. Lee YJ, Huang X, Kropat J, Henras A, Merchant SS, Dickson RC, Chanfreau GF (2012). Sphingolipid signaling mediates iron toxicity. Cell metabolism 16(1): 90-96.
151. Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR (1999). Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Current biology: CB 9(4): 186-197.
152. Chen P, Lee KS, Levin DE (1993). A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae. Molecular & general genetics: MGG 236(2-3): 443-447.
153. Dickson RC (2008). Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast. Journal of lipid research 49(5): 909-921.
154. Dickson RC (2010). Roles for sphingolipids in Saccharomyces cerevisiae. Advances in experimental medicine and biology 688:217-231.
155. Dickson RC, Sumanasekera C, Lester RL (2006). Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. Progress in lipid research 45(6): 447-465.
156. Epstein S, Riezman H (2013). Sphingolipid signaling in yeast: potential implications for understanding disease. Front Biosci (Elite Ed) 5:97-108.
157. Kemmer D, McHardy LM, Hoon S, Reberioux D, Giaever G, Nislow C, Roskelley CD, Roberge M (2009). Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. BMC microbiology 9:9.
158. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292(5515): 288-290.
159. Swinnen E, Ghillebert R, Wilms T, Winderickx J (2013). Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation in Saccharomyces cerevisiae. FEMS yeast research 14(1): 17-32.
160. Liu J, Huang X, Withers BR, Blalock E, Liu K, Dickson RC (2013). Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. Aging cell 12(5): 833-841.
161. Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D (2004). Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Journal of cell science 117(Pt 18): 4055-4066.
162. Kimura K, Tanaka N, Nakamura N, Takano S, Ohkuma S (2007). Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in Caenorhabditis elegans. The Journal of biological chemistry 282(8): 5910-5918.
163. Menzel R, Yeo HL, Rienau S, Li S, Steinberg CE, Sturzenbaum SR (2007). Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Journal of molecular biology 370(1): 1-13.
164. Liu Y, Samuel BS, Breen PC, Ruvkun G (2014). Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508(7496): 406-410.
165. Zhang J (2013). Autophagy and Mitophagy in Cellular Damage Control. Redox biology 1(1): 19-23.
166. El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (2000). Molecular cloning and characterization of a human mitochondrial ceramidase. The Journal of biological chemistry 275(28): 21508-21513.
167. Bionda C, Portoukalian J, Schmitt D, Rodriguez-Lafrasse C, Ardail D (2004). Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria? The Biochemical journal 382(Pt 2): 527-533.
168. Yabu T, Shimuzu A, Yamashita M (2009). A novel mitochondrial sphingomyelinase in zebrafish cells. The Journal of biological chemistry 284(30): 20349-20363.
169. Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA (2010). Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. The Journal of biological chemistry 285(23): 17993-18002.
170. Itoh K, Nakamura K, Iijima M, Sesaki H (2013). Mitochondrial dynamics in neurodegeneration. Trends in cell biology 23(2): 64-71.
171. Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Hartel S, Jaimovich E, Zorzano A, Hidalgo C, Lavandero S (2008). Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovascular research 77(2): 387-397.
172. Loson OC, Song Z, Chen H, Chan DC (2013). Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Molecular biology of the cell 24(5): 659-667.
173. Ciarlo L, Manganelli V, Garofalo T, Matarrese P, Tinari A, Misasi R, Malorni W, Sorice M (2010). Association of fission proteins with mitochondrial raft-like domains. Cell death and differentiation 17(6): 1047-1058.
174. Smith ME, Tippetts TS, Brassfield ES, Tucker BJ, Ockey A, Swensen AC, Anthonymuthu TS, Washburn TD, Kane DA, Prince JT, Bikman BT (2013). Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle. The Biochemical journal 456(3): 427-439.
175. Malathi K, Higaki K, Tinkelenberg AH, Balderes DA, Almanzar-Paramio D, Wilcox LJ, Erdeniz N, Redican F, Padamsee M, Liu Y, Khan S, Alcantara F, Carstea ED, Morris JA, Sturley SL (2004). Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. The Journal of cell biology 164(4): 547-556.
176. Ferenci P (2006). Regional distribution of mutations of the ATP7B gene in patients with Wilson disease: impact on genetic testing. Human genetics 120(2): 151-159.
177. Swinnen E, Wilms T, Idkowiak-Baldys J, Smets B, De Snijder P, Accardo S, Ghillebert R, Thevissen K, Cammue B, De Vos D, Bielawski J, Hannun YA, Winderickx J (2014). The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Molecular biology of the cell 25(1): 196-211.
178. Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA (2007). Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochimica et biophysica acta 1768(11): 2849-2861.
179. Okamoto Y, Vaena De Avalos S, Hannun YA (2002). Structural requirements for selective binding of Isc1p to anionic phospholipids. The Journal of biological chemistry 277(48): 46470-46477.
180. Airola MV, Hannun YA (2013). Sphingolipid metabolism and neutral sphingomyelinases. Handbook of experimental pharmacology 215: 57-76.
181. Barbosa AD, Osorio H, Sims KJ, Almeida T, Alves M, Bielawski J, Amorim MA, Moradas-Ferreira P, Hannun YA, Costa V (2011). Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Molecular microbiology 81(2): 515-527.
182. Kitagaki H, Cowart LA, Matmati N, Montefusco D, Gandy J, de Avalos SV, Novgorodov SA, Zheng J, Obeid LM, Hannun YA (2009). Isc1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. The Journal of biological chemistry 284(16): 10818-10830.
183. Stark MJ (1996). Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 12(16): 1647-1675.
184. Hohmann S, Krantz M, Nordlander B (2007). Yeast osmoregulation. Methods in enzymology 428:29-45.
185. Bilsland E, Molin C, Swaminathan S, Ramne A, Sunnerhagen P (2004). Rck1 and Rck2 MAPK kinases and the HOG pathway are required for oxidative stress resistance. Molecular microbiology 53(6): 1743-1756.
186. Rep M, Proft M, Remize F, Tamas M, Serrano R, Thevelein JM, Hohmann S (2001). The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Molecular microbiology 40(5): 1067-1083.
187. Saito H, Posas F (2012). Response to hyperosmotic stress. Genetics 192(2): 289-318.
188. Vanier MT, Millat G (2003). Niemann-Pick disease type C. Clinical genetics 64(4): 269-281.
189. Karten B, Peake KB, Vance JE (2009). Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells. Biochimica et biophysica acta 1791(7): 659-670.
190. Loftus SK, Morris JA, Carstea ED, Gu JZ, Cummings C, Brown A, Ellison J, Ohno K, Rosenfeld MA, Tagle DA, Pentchev PG, Pavan WJ (1997). Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science 277(5323): 232-235.
191. Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF, 3rd, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, et al. (1997). Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 277(5323): 228-231.
192. Naureckiene S, Sleat DE, Lackland H, Fensom A, Vanier MT, Wattiaux R, Jadot M, Lobel P (2000). Identification of HE1 as the second gene of Niemann-Pick C disease. Science 290(5500): 2298-2301.
193. McLean KJ, Hans M, Munro AW (2012). Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes. Biochemical Society transactions 40(3): 587-593.
194. Bi X, Liao G (2010). Cholesterol in Niemann-Pick Type C disease. Sub-cellular biochemistry 51:319-335.
195. Boomkamp SD, Butters TD (2008). Glycosphingolipid disorders of the brain. Sub-cellular biochemistry 49:441-467.
196. Vazquez MC, Balboa E, Alvarez AR, Zanlungo S (2012). Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease. Oxidative medicine and cellular longevity 2012:205713.
197. Kennedy BE, LeBlanc VG, Mailman TM, Fice D, Burton I, Karakach TK, Karten B (2013). Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain. PloS one 8(12): e82685.
198. Klein A, Maldonado C, Vargas LM, Gonzalez M, Robledo F, Perez de Arce K, Munoz FJ, Hetz C, Alvarez AR, Zanlungo S (2011). Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Neurobiology of disease 41(1): 209-218.
199. Fu R, Yanjanin NM, Bianconi S, Pavan WJ, Porter FD (2010). Oxidative stress in Niemann-Pick disease, type C. Molecular genetics and metabolism 101(2-3): 214-218.
200. Yu W, Gong JS, Ko M, Garver WS, Yanagisawa K, Michikawa M (2005). Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function. The Journal of biological chemistry 280(12): 11731-11739.
201. Zervas M, Somers KL, Thrall MA, Walkley SU (2001). Critical role for glycosphingolipids in Niemann-Pick disease type C. Current biology: CB 11(16): 1283-1287.
202. Higaki K, Almanzar-Paramio D, Sturley SL (2004). Metazoan and microbial models of Niemann-Pick Type C disease. Biochimica et biophysica acta 1685(1-3): 38-47.
203. Zhang S, Ren J, Li H, Zhang Q, Armstrong JS, Munn AL, Yang H (2004). Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport. Traffic 5(12): 1017-1030.
204. Lees ND, Bard M, Kirsch DR (1999). Biochemistry and molecular biology of sterol synthesis in Saccharomyces cerevisiae. Critical reviews in biochemistry and molecular biology 34(1): 33-47.
205. Vilaca R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, Hannun YA, Sa Miranda MC, Costa V (2014). Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Molecular microbiology 91(3): 438-451.
206. Brett CL, Kallay L, Hua Z, Green R, Chyou A, Zhang Y, Graham TR, Donowitz M, Rao R (2011). Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae. PloS one 6(3): e17619.
207. Schneiter R (2007). Intracellular sterol transport in eukaryotes, a connection to mitochondrial function? Biochimie 89(2): 255-259.
208. Berger AC, Hanson PK, Wylie Nichols J, Corbett AH (2005). A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p. Traffic 6(10): 907-917.
209. Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutierrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL (2011). An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. The Journal of biological chemistry 286(27): 23842-23851.
210. Lorenz RT, Rodriguez RJ, Lewis TA, Parks LW (1986). Characteristics of sterol uptake in Saccharomyces cerevisiae. Journal of bacteriology 167(3): 981-985.
211. Lopez-Rodas G, Brosch G, Georgieva EI, Sendra R, Franco L, Loidl P (1993). Histone deacetylase. A key enzyme for the binding of regulatory proteins to chromatin. FEBS letters 317(3): 175-180.
212. El-Osta A, Wolffe AP (2000). DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease. Gene expression 9(1-2): 63-75.
213. Neubauer HA, Pitson SM (2013). Roles, regulation and inhibitors of sphingosine kinase 2. The FEBS journal 280(21): 5317-5336.
214. Glozak MA, Seto E (2007). Histone deacetylases and cancer. Oncogene 26(37): 5420-5432.
215. Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S (2009). Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325(5945): 1254-1257.
216. Maceyka M, Milstien S, Spiegel S (2013). The potential of histone deacetylase inhibitors in Niemann-Pick type C disease. The FEBS journal 280(24): 6367-6372.
217. Loudianos G, Gitlin JD (2000). Wilson's disease. Seminars in liver disease 20(3): 353-364.
218. Huster D (2010). Wilson disease. Best practice & research Clinical gastroenterology 24(5): 531-539.
219. Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW (1993). The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nature genetics 5(4): 327-337.
220. Ala A, Walker AP, Ashkan K, Dooley JS, Schilsky ML (2007). Wilson's disease. Lancet 369(9559): 397-408.
221. 2+)-ATPase subfamily. Yeast 11(3): 283-292.
222. Dancis A, Haile D, Yuan DS, Klausner RD (1994). The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. The Journal of biological chemistry 269(41): 25660-25667.
223. Lin SJ, Pufahl RA, Dancis A, O'Halloran TV, Culotta VC (1997). A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport. The Journal of biological chemistry 272(14): 9215-9220.
224. Yuan DS, Stearman R, Dancis A, Dunn T, Beeler T, Klausner RD (1995). The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proceedings of the National Academy of Sciences of the United States of America 92(7): 2632-2636.
225. Cankorur-Cetinkaya A, Eraslan S, Kirdar B (2013). Transcriptional remodelling in response to changing copper levels in the Wilson and Menkes disease model of Saccharomyces cerevisiae. Molecular bioSystems 9(11): 2889-2908.
226. Iida M, Terada K, Sambongi Y, Wakabayashi T, Miura N, Koyama K, Futai M, Sugiyama T (1998). Analysis of functional domains of Wilson disease protein (ATP7B) in Saccharomyces cerevisiae. FEBS letters 428(3): 281-285.
227. Forbes JR, Cox DW (1998). Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant? American journal of human genetics 63(6): 1663-1674.
228. Mullen TD, Obeid LM (2012). Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death. Anti-cancer agents in medicinal chemistry 12(4): 340-363.
229. De Coninck B, Carron D, Tavormina P, Willem L, Craik DJ, Vos C, Thevissen K, Mathys J, Cammue BP (2013). Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance. Journal of experimental botany 64(17): 5297-5307.
230. Spincemaille P, Chandhok G, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BP, Thevissen K (2014). The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. Biochimica et biophysica acta 1843(6): 1207-1215.
231. Park JW, Park WJ, Futerman AH (2014). Ceramide synthases as potential targets for therapeutic intervention in human diseases. Biochimica et biophysica acta 1841(5): 671-681.