메뉴 건너뛰기




Volumn 280, Issue 24, 2013, Pages 6338-6353

Glycosphingolipids: Synthesis and functions

Author keywords

glycocode; glycosphingolipids; golgi complex; sphingolipids

Indexed keywords

CARRIER PROTEIN; CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GALACTOSE; GALACTOSYLCERAMIDE; GALACTOSYLCERAMIDE SYNTHASE; GANGLIOSIDE GD2 SYNTHASE; GANGLIOSIDE GD3 SYNTHASE; GANGLIOSIDE GM3; GANGLIOSIDE GM3 SYNTHASE; GB3 SYNTHASE; GLUCOSYLCERAMIDE; GLYCOSIDASE; GLYCOSPHINGOLIPID; GLYCOSYLTRANSFERASE; LACTOSYLCERAMIDE; LACTOSYLCERAMIDE SYNTHASE; MICRORNA; MULTIDRUG RESISTANCE PROTEIN 1; N ACETYLGALACTOSAMINE; N ACETYLGLUCOSAMINE; N ACETYLNEURAMINIC ACID; N GLYCOLOYLNEURAMINIC ACID; PROTEIN FAPP2; SCATTER FACTOR RECEPTOR; SPHINGANINE; SPHINGOMYELIN; SYNTHETASE; UNCLASSIFIED DRUG;

EID: 84889660904     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12559     Document Type: Review
Times cited : (222)

References (154)
  • 1
    • 16544378946 scopus 로고    scopus 로고
    • Archaeology. The Indus script - Write or wrong?
    • Lawler A, (2004) Archaeology. The Indus script-write or wrong? Science 306, 2026-2029.
    • (2004) Science , vol.306 , pp. 2026-2029
    • Lawler, A.1
  • 3
    • 84872760819 scopus 로고    scopus 로고
    • A primer in macromolecular linguistics
    • Searls DB, (2013). A primer in macromolecular linguistics. Biopolymers 99, 203-217.
    • (2013) Biopolymers , vol.99 , pp. 203-217
    • Searls, D.B.1
  • 4
    • 0037079055 scopus 로고    scopus 로고
    • The language of genes
    • Searls DB, (2002) The language of genes. Nature 420, 211-217.
    • (2002) Nature , vol.420 , pp. 211-217
    • Searls, D.B.1
  • 5
    • 34250693209 scopus 로고    scopus 로고
    • Deciphering the glycocode: The complexity and analytical challenge of glycomics
    • Pilobello KT, &, Mahal LK, (2007) Deciphering the glycocode: the complexity and analytical challenge of glycomics. Curr Opin Chem Biol 11, 300-305.
    • (2007) Curr Opin Chem Biol , vol.11 , pp. 300-305
    • Pilobello, K.T.1    Mahal, L.K.2
  • 6
    • 84863757627 scopus 로고    scopus 로고
    • Glycomics: An overview of the complex glycocode
    • Gupta G, &, Surolia A, (2012) Glycomics: an overview of the complex glycocode. Adv Exp Med Biol 749, 1-13.
    • (2012) Adv Exp Med Biol , vol.749 , pp. 1-13
    • Gupta, G.1    Surolia, A.2
  • 7
    • 80054079107 scopus 로고    scopus 로고
    • Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics
    • Merrill AH Jr, (2011) Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev 111, 6387-6422.
    • (2011) Chem Rev , vol.111 , pp. 6387-6422
    • Merrill, Jr.A.H.1
  • 12
    • 33744519950 scopus 로고    scopus 로고
    • Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
    • Okuda T, Tokuda N, Numata S, Ito M, Ohta M, Kawamura K, Wiels J, Urano T, Tajima O, &, Furukawa K, (2006) Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J Biol Chem 281, 10230-10235.
    • (2006) J Biol Chem , vol.281 , pp. 10230-10235
    • Okuda, T.1    Tokuda, N.2    Numata, S.3    Ito, M.4    Ohta, M.5    Kawamura, K.6    Wiels, J.7    Urano, T.8    Tajima, O.9    Furukawa, K.10
  • 13
    • 40849119996 scopus 로고    scopus 로고
    • Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends
    • Hakomori SI, (2008) Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Biochim Biophys Acta 1780, 325-346.
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 325-346
    • Hakomori, S.I.1
  • 14
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Hannun YA, &, Obeid LM, (2008) Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 9, 139-150.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 16
    • 84855918312 scopus 로고    scopus 로고
    • Ceramide synthases at the centre of sphingolipid metabolism and biology
    • Mullen TD, Hannun YA, &, Obeid LM, (2012) Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J 441, 789-802.
    • (2012) Biochem J , vol.441 , pp. 789-802
    • Mullen, T.D.1    Hannun, Y.A.2    Obeid, L.M.3
  • 17
    • 0034789931 scopus 로고    scopus 로고
    • The organizing potential of sphingolipids in intracellular membrane transport
    • Holthuis JC, Pomorski T, Raggers RJ, Sprong H, &, Van Meer G, (2001) The organizing potential of sphingolipids in intracellular membrane transport. Physiol Rev 81, 1689-1723.
    • (2001) Physiol Rev , vol.81 , pp. 1689-1723
    • Holthuis, J.C.1    Pomorski, T.2    Raggers, R.J.3    Sprong, H.4    Van Meer, G.5
  • 19
    • 78049518892 scopus 로고    scopus 로고
    • An overview of sphingolipid metabolism: From synthesis to breakdown
    • Gault CR, Obeid LM, &, Hannun YA, (2010) An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol 688, 1-23.
    • (2010) Adv Exp Med Biol , vol.688 , pp. 1-23
    • Gault, C.R.1    Obeid, L.M.2    Hannun, Y.A.3
  • 20
    • 0034730746 scopus 로고    scopus 로고
    • Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells
    • Funakoshi T, Yasuda S, Fukasawa M, Nishijima M, &, Hanada K, (2000) Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells. J Biol Chem 275, 29938-29945.
    • (2000) J Biol Chem , vol.275 , pp. 29938-29945
    • Funakoshi, T.1    Yasuda, S.2    Fukasawa, M.3    Nishijima, M.4    Hanada, K.5
  • 25
    • 1542319939 scopus 로고    scopus 로고
    • Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis
    • De Rosa MF, Sillence D, Ackerley C, &, Lingwood C, (2004) Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. J Biol Chem 279, 7867-7876.
    • (2004) J Biol Chem , vol.279 , pp. 7867-7876
    • De Rosa, M.F.1    Sillence, D.2    Ackerley, C.3    Lingwood, C.4
  • 26
    • 79954988198 scopus 로고    scopus 로고
    • Cellular and molecular biology of glycosphingolipid glycosylation
    • Maccioni HJ, Quiroga R, &, Ferrari ML, (2011a) Cellular and molecular biology of glycosphingolipid glycosylation. J Neurochem 117, 589-602.
    • (2011) J Neurochem , vol.117 , pp. 589-602
    • MacCioni, H.J.1    Quiroga, R.2    Ferrari, M.L.3
  • 27
    • 77956520108 scopus 로고    scopus 로고
    • Beta4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development
    • Nishie T, Hikimochi Y, Zama K, Fukusumi Y, Ito M, Yokoyama H, Naruse C, &, Asano M, (2010) Beta4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development. Glycobiology 20, 1311-1322.
    • (2010) Glycobiology , vol.20 , pp. 1311-1322
    • Nishie, T.1    Hikimochi, Y.2    Zama, K.3    Fukusumi, Y.4    Ito, M.5    Yokoyama, H.6    Naruse, C.7    Asano, M.8
  • 30
    • 0026773370 scopus 로고
    • Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides
    • Nagata Y, Yamashiro S, Yodoi J, Lloyd KO, Shiku H, &, Furukawa K, (1992) Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides. J Biol Chem 267, 12082-12089.
    • (1992) J Biol Chem , vol.267 , pp. 12082-12089
    • Nagata, Y.1    Yamashiro, S.2    Yodoi, J.3    Lloyd, K.O.4    Shiku, H.5    Furukawa, K.6
  • 31
    • 0028172070 scopus 로고
    • Beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: Isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F
    • Hidari JK, Ichikawa S, Furukawa K, Yamasaki M, &, Hirabayashi Y, (1994) beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F. Biochem J 303, 957-965.
    • (1994) Biochem J , vol.303 , pp. 957-965
    • Hidari, J.K.1    Ichikawa, S.2    Furukawa, K.3    Yamasaki, M.4    Hirabayashi, Y.5
  • 33
    • 0034685913 scopus 로고    scopus 로고
    • Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids
    • Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, &, Ohta M, (2000) Molecular cloning of globotriaosylceramide/ CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids. J Biol Chem 275, 15152-15156.
    • (2000) J Biol Chem , vol.275 , pp. 15152-15156
    • Kojima, Y.1    Fukumoto, S.2    Furukawa, K.3    Okajima, T.4    Wiels, J.5    Yokoyama, K.6    Suzuki, Y.7    Urano, T.8    Ohta, M.9
  • 34
    • 57249105496 scopus 로고    scopus 로고
    • The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo
    • Biellmann F, Hulsmeier AJ, Zhou D, Cinelli P, &, Hennet T, (2008) The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo. BMC Dev Biol 8, 109.
    • (2008) BMC Dev Biol , vol.8 , pp. 109
    • Biellmann, F.1    Hulsmeier, A.J.2    Zhou, D.3    Cinelli, P.4    Hennet, T.5
  • 35
  • 36
    • 42249105215 scopus 로고    scopus 로고
    • The sphingolipid salvage pathway in ceramide metabolism and signaling
    • Kitatani K, Idkowiak-Baldys J, &, Hannun YA, (2008) The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal 20, 1010-1018.
    • (2008) Cell Signal , vol.20 , pp. 1010-1018
    • Kitatani, K.1    Idkowiak-Baldys, J.2    Hannun, Y.A.3
  • 38
    • 78651293534 scopus 로고    scopus 로고
    • MiRBase: Integrating microRNA annotation and deep-sequencing data
    • Kozomara A, &, Griffiths-Jones S, (2011) miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39, D152-D157.
    • (2011) Nucleic Acids Res , vol.39
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 39
    • 84856043672 scopus 로고
    • A mathematical theory of communication
    • Shannon CE, (1948) A mathematical theory of communication. Bell Sys Tech J 27, 379-423.
    • (1948) Bell Sys Tech J , vol.27 , pp. 379-423
    • Shannon, C.E.1
  • 40
    • 59149102062 scopus 로고    scopus 로고
    • Glycans: Bioactive signals decoded by lectins
    • Gabius HJ, (2008) Glycans: bioactive signals decoded by lectins. Biochem Soc Trans 36, 1491-1496.
    • (2008) Biochem Soc Trans , vol.36 , pp. 1491-1496
    • Gabius, H.J.1
  • 42
    • 80051514415 scopus 로고    scopus 로고
    • Many ceramides
    • Hannun YA, &, Obeid LM, (2011) Many ceramides. J Biol Chem 286, 27855-27862.
    • (2011) J Biol Chem , vol.286 , pp. 27855-27862
    • Hannun, Y.A.1    Obeid, L.M.2
  • 43
    • 23944483995 scopus 로고    scopus 로고
    • Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
    • Mizutani Y, Kihara A, &, Igarashi Y, (2005) Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 390, 263-271.
    • (2005) Biochem J , vol.390 , pp. 263-271
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 47
    • 78651063493 scopus 로고    scopus 로고
    • Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation
    • Liang YJ, Kuo HH, Lin CH, Chen YY, Yang BC, Cheng YY, Yu AL, Khoo KH, &, Yu J, (2010) Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation. Proc Natl Acad Sci USA 107, 22564-22569.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 22564-22569
    • Liang, Y.J.1    Kuo, H.H.2    Lin, C.H.3    Chen, Y.Y.4    Yang, B.C.5    Cheng, Y.Y.6    Yu, A.L.7    Khoo, K.H.8    Yu, J.9
  • 48
    • 81855168289 scopus 로고    scopus 로고
    • Changes in glycosphingolipid composition during differentiation of human embryonic stem cells to ectodermal or endodermal lineages
    • Liang YJ, Yang BC, Chen JM, Lin YH, Huang CL, Cheng YY, Hsu CY, Khoo KH, Shen CN, &, Yu J, (2011) Changes in glycosphingolipid composition during differentiation of human embryonic stem cells to ectodermal or endodermal lineages. Stem Cells 29, 1995-2004.
    • (2011) Stem Cells , vol.29 , pp. 1995-2004
    • Liang, Y.J.1    Yang, B.C.2    Chen, J.M.3    Lin, Y.H.4    Huang, C.L.5    Cheng, Y.Y.6    Hsu, C.Y.7    Khoo, K.H.8    Shen, C.N.9    Yu, J.10
  • 49
    • 0031441686 scopus 로고    scopus 로고
    • Regulated expression system for GD3 synthase cDNA and induction of differentiation in Neuro2a cells
    • Liu H, Kojima N, Kurosawa N, &, Tsuji S, (1997) Regulated expression system for GD3 synthase cDNA and induction of differentiation in Neuro2a cells. Glycobiology 7, 1067-1076.
    • (1997) Glycobiology , vol.7 , pp. 1067-1076
    • Liu, H.1    Kojima, N.2    Kurosawa, N.3    Tsuji, S.4
  • 50
    • 0031577763 scopus 로고    scopus 로고
    • Glycolipid sialyltransferases are enhanced during neural differentiation of mouse embryonic carcinoma cells, P19
    • Osanai T, Watanabe Y, &, Sanai Y, (1997) Glycolipid sialyltransferases are enhanced during neural differentiation of mouse embryonic carcinoma cells, P19. Biochem Biophys Res Commun 241, 327-333.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 327-333
    • Osanai, T.1    Watanabe, Y.2    Sanai, Y.3
  • 51
    • 15844393879 scopus 로고    scopus 로고
    • Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis
    • Hirschberg K, Zisling R, van Echten-Deckert G, &, Futerman AH, (1996) Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. J Biol Chem 271, 14876-14882.
    • (1996) J Biol Chem , vol.271 , pp. 14876-14882
    • Hirschberg, K.1    Zisling, R.2    Van Echten-Deckert, G.3    Futerman, A.H.4
  • 52
    • 0029088737 scopus 로고
    • Maturational regulation of globotriaosylceramide, the Shiga-like toxin 1 receptor, in cultured human gut epithelial cells
    • Jacewicz MS, Acheson DW, Mobassaleh M, Donohue-Rolfe A, Balasubramanian KA, &, Keusch GT, (1995) Maturational regulation of globotriaosylceramide, the Shiga-like toxin 1 receptor, in cultured human gut epithelial cells. J Clin Invest 96, 1328-1335.
    • (1995) J Clin Invest , vol.96 , pp. 1328-1335
    • Jacewicz, M.S.1    Acheson, D.W.2    Mobassaleh, M.3    Donohue-Rolfe, A.4    Balasubramanian, K.A.5    Keusch, G.T.6
  • 53
    • 36448995805 scopus 로고    scopus 로고
    • Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains
    • Ngamukote S, Yanagisawa M, Ariga T, Ando S, &, Yu RK, (2007) Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. J Neurochem 103, 2327-2341.
    • (2007) J Neurochem , vol.103 , pp. 2327-2341
    • Ngamukote, S.1    Yanagisawa, M.2    Ariga, T.3    Ando, S.4    Yu, R.K.5
  • 54
    • 3843114549 scopus 로고    scopus 로고
    • Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid
    • Hettmer S, McCarter R, Ladisch S, &, Kaucic K, (2004) Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid. Br J Cancer 91, 389-397.
    • (2004) Br J Cancer , vol.91 , pp. 389-397
    • Hettmer, S.1    McCarter, R.2    Ladisch, S.3    Kaucic, K.4
  • 57
    • 79957561279 scopus 로고    scopus 로고
    • Organization of the synthesis of glycolipid oligosaccharides in the Golgi complex
    • Maccioni HJ, Quiroga R, &, Spessott W, (2011b) Organization of the synthesis of glycolipid oligosaccharides in the Golgi complex. FEBS Lett 585, 1691-1698.
    • (2011) FEBS Lett , vol.585 , pp. 1691-1698
    • MacCioni, H.J.1    Quiroga, R.2    Spessott, W.3
  • 58
    • 33845961707 scopus 로고    scopus 로고
    • Modulation of GalT1 and SialT1 sub-Golgi localization by SialT2 expression reveals an organellar level of glycolipid synthesis control
    • Uliana AS, Crespo PM, Martina JA, Daniotti JL, &, Maccioni HJ, (2006) Modulation of GalT1 and SialT1 sub-Golgi localization by SialT2 expression reveals an organellar level of glycolipid synthesis control. J Biol Chem 281, 32852-32860.
    • (2006) J Biol Chem , vol.281 , pp. 32852-32860
    • Uliana, A.S.1    Crespo, P.M.2    Martina, J.A.3    Daniotti, J.L.4    MacCioni, H.J.5
  • 59
    • 0042970585 scopus 로고    scopus 로고
    • Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum
    • Sprong H, Degroote S, Nilsson T, Kawakita M, Ishida N, van der Sluijs P, &, van Meer G, (2003) Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. Mol Biol Cell 14, 3482-3493.
    • (2003) Mol Biol Cell , vol.14 , pp. 3482-3493
    • Sprong, H.1    Degroote, S.2    Nilsson, T.3    Kawakita, M.4    Ishida, N.5    Van Der Sluijs, P.6    Van Meer, G.7
  • 61
    • 0035852635 scopus 로고    scopus 로고
    • Physical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus
    • Giraudo CG, Daniotti JL, &, Maccioni HJ, (2001) Physical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus. Proc Natl Acad Sci USA 98, 1625-1630.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1625-1630
    • Giraudo, C.G.1    Daniotti, J.L.2    MacCioni, H.J.3
  • 62
    • 0141890299 scopus 로고    scopus 로고
    • Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells
    • Giraudo CG, &, Maccioni HJ, (2003) Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells. J Biol Chem 278, 40262-40271.
    • (2003) J Biol Chem , vol.278 , pp. 40262-40271
    • Giraudo, C.G.1    MacCioni, H.J.2
  • 63
    • 84870856794 scopus 로고    scopus 로고
    • RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells
    • Chia J, Goh G, Racine V, Ng S, Kumar P, &, Bard F, (2012) RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells. Mol Syst Biol 8, 629.
    • (2012) Mol Syst Biol , vol.8 , pp. 629
    • Chia, J.1    Goh, G.2    Racine, V.3    Ng, S.4    Kumar, P.5    Bard, F.6
  • 64
    • 70349466529 scopus 로고    scopus 로고
    • Population context determines cell-to-cell variability in endocytosis and virus infection
    • Snijder B, Sacher R, Ramo P, Damm EM, Liberali P, &, Pelkmans L, (2009) Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 461, 520-523.
    • (2009) Nature , vol.461 , pp. 520-523
    • Snijder, B.1    Sacher, R.2    Ramo, P.3    Damm, E.M.4    Liberali, P.5    Pelkmans, L.6
  • 72
    • 0033673678 scopus 로고    scopus 로고
    • A functional role for complex gangliosides: Motor deficits in GM2/GD2 synthase knockout mice
    • Chiavegatto S, Sun J, Nelson RJ, &, Schnaar RL, (2000) A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice. Exp Neurol 166, 227-234.
    • (2000) Exp Neurol , vol.166 , pp. 227-234
    • Chiavegatto, S.1    Sun, J.2    Nelson, R.J.3    Schnaar, R.L.4
  • 73
    • 80755189053 scopus 로고    scopus 로고
    • Mice lacking major brain gangliosides develop parkinsonism
    • Wu G, Lu ZH, Kulkarni N, Amin R, &, Ledeen RW, (2011) Mice lacking major brain gangliosides develop parkinsonism. Neurochem Res 36, 1706-1714.
    • (2011) Neurochem Res , vol.36 , pp. 1706-1714
    • Wu, G.1    Lu, Z.H.2    Kulkarni, N.3    Amin, R.4    Ledeen, R.W.5
  • 74
    • 25644442320 scopus 로고    scopus 로고
    • GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation
    • Handa Y, Ozaki N, Honda T, Furukawa K, Tomita Y, Inoue M, Okada M, &, Sugiura Y, (2005) GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation. Pain 117, 271-279.
    • (2005) Pain , vol.117 , pp. 271-279
    • Handa, Y.1    Ozaki, N.2    Honda, T.3    Furukawa, K.4    Tomita, Y.5    Inoue, M.6    Okada, M.7    Sugiura, Y.8
  • 75
    • 0037127213 scopus 로고    scopus 로고
    • B-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve
    • Okada M, Itoh Mi M, Haraguchi M, Okajima T, Inoue M, Oishi H, Matsuda Y, Iwamoto T, Kawano T, Fukumoto S, et al,. (2002) b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem 277, 1633-1636.
    • (2002) J Biol Chem , vol.277 , pp. 1633-1636
    • Okada, M.1    Itoh Mi, M.2    Haraguchi, M.3    Okajima, T.4    Inoue, M.5    Oishi, H.6    Matsuda, Y.7    Iwamoto, T.8    Kawano, T.9    Fukumoto, S.10
  • 77
    • 0037119376 scopus 로고    scopus 로고
    • Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside
    • Inoue M, Fujii Y, Furukawa K, Okada M, Okumura K, Hayakawa T, &, Sugiura Y, (2002) Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside. J Biol Chem 277, 29881-29888.
    • (2002) J Biol Chem , vol.277 , pp. 29881-29888
    • Inoue, M.1    Fujii, Y.2    Furukawa, K.3    Okada, M.4    Okumura, K.5    Hayakawa, T.6    Sugiura, Y.7
  • 78
    • 0030602822 scopus 로고    scopus 로고
    • Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability
    • Coetzee T, Fujita N, Dupree J, Shi R, Blight A, Suzuki K, &, Popko B, (1996) Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell 86, 209-219.
    • (1996) Cell , vol.86 , pp. 209-219
    • Coetzee, T.1    Fujita, N.2    Dupree, J.3    Shi, R.4    Blight, A.5    Suzuki, K.6    Popko, B.7
  • 79
    • 78349248683 scopus 로고    scopus 로고
    • Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase - A key enzyme in lacto-neolacto ganglioside synthesis
    • Kuan CT, Chang J, Mansson JE, Li J, Pegram C, Fredman P, McLendon RE, &, Bigner DD, (2010) Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase-a key enzyme in lacto-neolacto ganglioside synthesis. BMC Dev Biol 10, 114.
    • (2010) BMC Dev Biol , vol.10 , pp. 114
    • Kuan, C.T.1    Chang, J.2    Mansson, J.E.3    Li, J.4    Pegram, C.5    Fredman, P.6    McLendon, R.E.7    Bigner, D.D.8
  • 80
    • 78650682926 scopus 로고    scopus 로고
    • Sphingolipids and expression regulation of genes in cancer
    • Patwardhan GA, &, Liu YY, (2011) Sphingolipids and expression regulation of genes in cancer. Prog Lipid Res 50, 104-114.
    • (2011) Prog Lipid Res , vol.50 , pp. 104-114
    • Patwardhan, G.A.1    Liu, Y.Y.2
  • 81
    • 0036277843 scopus 로고    scopus 로고
    • Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B
    • Mirkin BL, Clark SH, &, Zhang C, (2002) Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B. Cell Prolif 35, 105-115.
    • (2002) Cell Prolif , vol.35 , pp. 105-115
    • Mirkin, B.L.1    Clark, S.H.2    Zhang, C.3
  • 83
    • 84867742532 scopus 로고    scopus 로고
    • Disialyl gangliosides enhance tumor phenotypes with differential modalities
    • Furukawa K, Hamamura K, Ohkawa Y, &, Ohmi Y, (2012) Disialyl gangliosides enhance tumor phenotypes with differential modalities. Glycoconj J 29, 579-584.
    • (2012) Glycoconj J , vol.29 , pp. 579-584
    • Furukawa, K.1    Hamamura, K.2    Ohkawa, Y.3    Ohmi, Y.4
  • 85
    • 40849103028 scopus 로고    scopus 로고
    • Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells
    • Hamamura K, Tsuji M, Ohkawa Y, Nakashima H, Miyazaki S, Urano T, Yamamoto N, Ueda M, &, Furukawa K, (2008) Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells. Biochim Biophys Acta 1780, 513-519.
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 513-519
    • Hamamura, K.1    Tsuji, M.2    Ohkawa, Y.3    Nakashima, H.4    Miyazaki, S.5    Urano, T.6    Yamamoto, N.7    Ueda, M.8    Furukawa, K.9
  • 86
    • 45849105540 scopus 로고    scopus 로고
    • Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3
    • Ohkawa Y, Miyazaki S, Miyata M, Hamamura K, &, Furukawa K, (2008) Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3. Biochem Biophys Res Commun 373, 14-19.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 14-19
    • Ohkawa, Y.1    Miyazaki, S.2    Miyata, M.3    Hamamura, K.4    Furukawa, K.5
  • 87
    • 79956309578 scopus 로고    scopus 로고
    • Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3
    • Hamamura K, Tsuji M, Hotta H, Ohkawa Y, Takahashi M, Shibuya H, Nakashima H, Yamauchi Y, Hashimoto N, Hattori H, et al,. (2011) Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. J Biol Chem 286, 18526-18537.
    • (2011) J Biol Chem , vol.286 , pp. 18526-18537
    • Hamamura, K.1    Tsuji, M.2    Hotta, H.3    Ohkawa, Y.4    Takahashi, M.5    Shibuya, H.6    Nakashima, H.7    Yamauchi, Y.8    Hashimoto, N.9    Hattori, H.10
  • 88
    • 0035872467 scopus 로고    scopus 로고
    • Ganglioside G(D2) in small cell lung cancer cell lines: Enhancement of cell proliferation and mediation of apoptosis
    • Yoshida S, Fukumoto S, Kawaguchi H, Sato S, Ueda R, &, Furukawa K, (2001) Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. Cancer Res 61, 4244-4252.
    • (2001) Cancer Res , vol.61 , pp. 4244-4252
    • Yoshida, S.1    Fukumoto, S.2    Kawaguchi, H.3    Sato, S.4    Ueda, R.5    Furukawa, K.6
  • 90
    • 0031566246 scopus 로고    scopus 로고
    • Inhibition of highly metastatic FBJ-LL cell migration by ganglioside GD1a highly expressed in poorly metastatic FBJ-S1 cells
    • Hyuga S, Yamagata S, Tai T, &, Yamagata T, (1997) Inhibition of highly metastatic FBJ-LL cell migration by ganglioside GD1a highly expressed in poorly metastatic FBJ-S1 cells. Biochem Biophys Res Commun 231, 340-343.
    • (1997) Biochem Biophys Res Commun , vol.231 , pp. 340-343
    • Hyuga, S.1    Yamagata, S.2    Tai, T.3    Yamagata, T.4
  • 91
    • 34547610743 scopus 로고    scopus 로고
    • Ganglioside GD1a negatively regulates matrix metalloproteinase-9 expression in mouse FBJ cell lines at the transcriptional level
    • Hu D, Man Z, Wang P, Tan X, Wang X, Takaku S, Hyuga S, Sato T, Yao X, Yamagata S, et al,. (2007) Ganglioside GD1a negatively regulates matrix metalloproteinase-9 expression in mouse FBJ cell lines at the transcriptional level. Connect Tissue Res 48, 198-205.
    • (2007) Connect Tissue Res , vol.48 , pp. 198-205
    • Hu, D.1    Man, Z.2    Wang, P.3    Tan, X.4    Wang, X.5    Takaku, S.6    Hyuga, S.7    Sato, T.8    Yao, X.9    Yamagata, S.10
  • 92
    • 43149112292 scopus 로고    scopus 로고
    • Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse osteosarcoma-derived FBJ cells
    • Wang L, Wang Y, Sato T, Yamagata S, &, Yamagata T, (2008) Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse osteosarcoma-derived FBJ cells. Biochem Biophys Res Commun 371, 230-235.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 230-235
    • Wang, L.1    Wang, Y.2    Sato, T.3    Yamagata, S.4    Yamagata, T.5
  • 93
    • 77954925666 scopus 로고    scopus 로고
    • Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells
    • Cao T, Zhang T, Wang L, Zhang L, Adachi T, Sato T, Yamagata S, &, Yamagata T, (2010) Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells. J Cell Biochem 110, 1165-1174.
    • (2010) J Cell Biochem , vol.110 , pp. 1165-1174
    • Cao, T.1    Zhang, T.2    Wang, L.3    Zhang, L.4    Adachi, T.5    Sato, T.6    Yamagata, S.7    Yamagata, T.8
  • 94
    • 79959905761 scopus 로고    scopus 로고
    • Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells
    • Zhang L, Wang Y, Wang L, Cao T, Hyuga S, Sato T, Wu Y, Yamagata S, &, Yamagata T, (2011) Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells. Biochim Biophys Acta 1810, 759-768.
    • (2011) Biochim Biophys Acta , vol.1810 , pp. 759-768
    • Zhang, L.1    Wang, Y.2    Wang, L.3    Cao, T.4    Hyuga, S.5    Sato, T.6    Wu, Y.7    Yamagata, S.8    Yamagata, T.9
  • 95
    • 0035501652 scopus 로고    scopus 로고
    • Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met
    • Hyuga S, Kawasaki N, Hyuga M, Ohta M, Shibayama R, Kawanishi T, Yamagata S, Yamagata T, &, Hayakawa T, (2001) Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met. Int J Cancer 94, 328-334.
    • (2001) Int J Cancer , vol.94 , pp. 328-334
    • Hyuga, S.1    Kawasaki, N.2    Hyuga, M.3    Ohta, M.4    Shibayama, R.5    Kawanishi, T.6    Yamagata, S.7    Yamagata, T.8    Hayakawa, T.9
  • 96
    • 0035896632 scopus 로고    scopus 로고
    • Carbohydrate-carbohydrate binding of ganglioside to integrin alpha(5) modulates alpha(5)beta(1) function
    • Wang X, Sun P, Al-Qamari A, Tai T, Kawashima I, &, Paller AS, (2001) Carbohydrate-carbohydrate binding of ganglioside to integrin alpha(5) modulates alpha(5)beta(1) function. J Biol Chem 276, 8436-8444.
    • (2001) J Biol Chem , vol.276 , pp. 8436-8444
    • Wang, X.1    Sun, P.2    Al-Qamari, A.3    Tai, T.4    Kawashima, I.5    Paller, A.S.6
  • 97
    • 27444438906 scopus 로고    scopus 로고
    • A specific microdomain ('glycosynapse 3′) controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9
    • Mitsuzuka K, Handa K, Satoh M, Arai Y, &, Hakomori S, (2005) A specific microdomain ('glycosynapse 3′) controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9. J Biol Chem 280, 35545-35553.
    • (2005) J Biol Chem , vol.280 , pp. 35545-35553
    • Mitsuzuka, K.1    Handa, K.2    Satoh, M.3    Arai, Y.4    Hakomori, S.5
  • 98
    • 34247184670 scopus 로고    scopus 로고
    • Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse
    • Todeschini AR, Dos Santos JN, Handa K, &, Hakomori SI, (2007) Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. J Biol Chem 282, 8123-8133.
    • (2007) J Biol Chem , vol.282 , pp. 8123-8133
    • Todeschini, A.R.1    Dos Santos, J.N.2    Handa, K.3    Hakomori, S.I.4
  • 100
    • 48349105829 scopus 로고    scopus 로고
    • Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts
    • Liu Y, Su Y, Wiznitzer M, Epifano O, &, Ladisch S, (2008) Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts. Glycobiology 18, 593-601.
    • (2008) Glycobiology , vol.18 , pp. 593-601
    • Liu, Y.1    Su, Y.2    Wiznitzer, M.3    Epifano, O.4    Ladisch, S.5
  • 101
    • 84860993482 scopus 로고    scopus 로고
    • Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor
    • Park SY, Kwak CY, Shayman JA, &, Kim JH, (2012) Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor. Biochim Biophys Acta 1820, 1141-1148.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 1141-1148
    • Park, S.Y.1    Kwak, C.Y.2    Shayman, J.A.3    Kim, J.H.4
  • 102
    • 80755163563 scopus 로고    scopus 로고
    • Regulation of epidermal growth factor receptor through interaction of ganglioside GM3 with GlcNAc of N-linked glycan of the receptor: Demonstration in ldlD cells
    • Guan F, Handa K, &, Hakomori SI, (2011) Regulation of epidermal growth factor receptor through interaction of ganglioside GM3 with GlcNAc of N-linked glycan of the receptor: demonstration in ldlD cells. Neurochem Res 36, 1645-1653.
    • (2011) Neurochem Res , vol.36 , pp. 1645-1653
    • Guan, F.1    Handa, K.2    Hakomori, S.I.3
  • 103
    • 84877711924 scopus 로고    scopus 로고
    • Ganglioside GM3 inhibits hepatoma cell motility via down-regulating activity of EGFR and PI3K/AKT signaling pathway
    • Huang X, Li Y, Zhang J, Xu Y, Tian Y, &, Ma K, (2013) Ganglioside GM3 inhibits hepatoma cell motility via down-regulating activity of EGFR and PI3K/AKT signaling pathway. J Cell Biochem 114, 1616-1624.
    • (2013) J Cell Biochem , vol.114 , pp. 1616-1624
    • Huang, X.1    Li, Y.2    Zhang, J.3    Xu, Y.4    Tian, Y.5    Ma, K.6
  • 104
    • 77950627388 scopus 로고    scopus 로고
    • Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation
    • Milani S, Sottocornola E, Zava S, Galbiati M, Berra B, &, Colombo I, (2010) Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation. Biochim Biophys Acta 1801, 617-624.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 617-624
    • Milani, S.1    Sottocornola, E.2    Zava, S.3    Galbiati, M.4    Berra, B.5    Colombo, I.6
  • 105
    • 0020336447 scopus 로고
    • GM3 ganglioside induces hamster fibroblast growth inhibition in chemically-defined medium: Ganglioside may regulate growth factor receptor function
    • Bremer EG, &, Hakomori S, (1982) GM3 ganglioside induces hamster fibroblast growth inhibition in chemically-defined medium: ganglioside may regulate growth factor receptor function. Biochem Biophys Res Commun 106, 711-718.
    • (1982) Biochem Biophys Res Commun , vol.106 , pp. 711-718
    • Bremer, E.G.1    Hakomori, S.2
  • 106
    • 4544250815 scopus 로고    scopus 로고
    • Cell growth regulation through GM3-enriched microdomain (glycosynapse) in human lung embryonal fibroblast WI38 and its oncogenic transformant VA13
    • Toledo MS, Suzuki E, Handa K, &, Hakomori S, (2004) Cell growth regulation through GM3-enriched microdomain (glycosynapse) in human lung embryonal fibroblast WI38 and its oncogenic transformant VA13. J Biol Chem 279, 34655-34664.
    • (2004) J Biol Chem , vol.279 , pp. 34655-34664
    • Toledo, M.S.1    Suzuki, E.2    Handa, K.3    Hakomori, S.4
  • 107
    • 0021186166 scopus 로고
    • Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation
    • Bremer EG, Hakomori S, Bowen-Pope DF, Raines E, &, Ross R, (1984) Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation. J Biol Chem 259, 6818-6825.
    • (1984) J Biol Chem , vol.259 , pp. 6818-6825
    • Bremer, E.G.1    Hakomori, S.2    Bowen-Pope, D.F.3    Raines, E.4    Ross, R.5
  • 108
    • 0033376512 scopus 로고    scopus 로고
    • GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells
    • Farooqui T, Kelley T, Coggeshall KM, Rampersaud AA, &, Yates AJ, (1999) GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells. Anticancer Res 19, 5007-5013.
    • (1999) Anticancer Res , vol.19 , pp. 5007-5013
    • Farooqui, T.1    Kelley, T.2    Coggeshall, K.M.3    Rampersaud, A.A.4    Yates, A.J.5
  • 110
    • 0034954598 scopus 로고    scopus 로고
    • Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells
    • Kimura M, Hidari KI, Suzuki T, Miyamoto D, &, Suzuki Y, (2001) Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells. Glycobiology 11, 335-343.
    • (2001) Glycobiology , vol.11 , pp. 335-343
    • Kimura, M.1    Hidari, K.I.2    Suzuki, T.3    Miyamoto, D.4    Suzuki, Y.5
  • 117
    • 0023025941 scopus 로고
    • Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor
    • Bremer EG, Schlessinger J, &, Hakomori S, (1986) Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J Biol Chem 261, 2434-2440.
    • (1986) J Biol Chem , vol.261 , pp. 2434-2440
    • Bremer, E.G.1    Schlessinger, J.2    Hakomori, S.3
  • 118
    • 0023761154 scopus 로고
    • Ganglioside-mediated modulation of cell growth. Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor
    • Hanai N, Nores GA, MacLeod C, Torres-Mendez CR, &, Hakomori S, (1988) Ganglioside-mediated modulation of cell growth. Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor. J Biol Chem 263, 10915-10921.
    • (1988) J Biol Chem , vol.263 , pp. 10915-10921
    • Hanai, N.1    Nores, G.A.2    MacLeod, C.3    Torres-Mendez, C.R.4    Hakomori, S.5
  • 119
    • 9244234958 scopus 로고    scopus 로고
    • Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside)
    • Miura Y, Kainuma M, Jiang H, Velasco H, Vogt PK, &, Hakomori S, (2004) Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside). Proc Natl Acad Sci USA 101, 16204-16209.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16204-16209
    • Miura, Y.1    Kainuma, M.2    Jiang, H.3    Velasco, H.4    Vogt, P.K.5    Hakomori, S.6
  • 120
    • 68249112890 scopus 로고    scopus 로고
    • Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells
    • Park SY, Yoon SJ, Freire-de-Lima L, Kim JH, &, Hakomori SI, (2009) Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells. Carbohydr Res 344, 1479-1486.
    • (2009) Carbohydr Res , vol.344 , pp. 1479-1486
    • Park, S.Y.1    Yoon, S.J.2    Freire-De-Lima, L.3    Kim, J.H.4    Hakomori, S.I.5
  • 121
    • 18144421905 scopus 로고    scopus 로고
    • Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor
    • Toledo MS, Suzuki E, Handa K, &, Hakomori S, (2005) Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor. J Biol Chem 280, 16227-16234.
    • (2005) J Biol Chem , vol.280 , pp. 16227-16234
    • Toledo, M.S.1    Suzuki, E.2    Handa, K.3    Hakomori, S.4
  • 123
    • 35448931927 scopus 로고    scopus 로고
    • Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside
    • Wang XQ, Yan Q, Sun P, Liu JW, Go L, McDaniel SM, &, Paller AS, (2007) Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside. Cancer Res 67, 9986-9995.
    • (2007) Cancer Res , vol.67 , pp. 9986-9995
    • Wang, X.Q.1    Yan, Q.2    Sun, P.3    Liu, J.W.4    Go, L.5    McDaniel, S.M.6    Paller, A.S.7
  • 124
    • 0037033052 scopus 로고    scopus 로고
    • Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor
    • Wang XQ, Sun P, &, Paller AS, (2002) Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor. J Biol Chem 277, 47028-47034.
    • (2002) J Biol Chem , vol.277 , pp. 47028-47034
    • Wang, X.Q.1    Sun, P.2    Paller, A.S.3
  • 125
    • 33749615996 scopus 로고    scopus 로고
    • Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its 'receptor'
    • Duan J, Zhang J, Zhao Y, Yang F, &, Zhang X, (2006) Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its 'receptor'. Arch Biochem Biophys 454, 155-159.
    • (2006) Arch Biochem Biophys , vol.454 , pp. 155-159
    • Duan, J.1    Zhang, J.2    Zhao, Y.3    Yang, F.4    Zhang, X.5
  • 126
    • 84866551704 scopus 로고    scopus 로고
    • Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells
    • Boscher C, Zheng YZ, Lakshminarayan R, Johannes L, Dennis JW, Foster LJ, &, Nabi IR, (2012) Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells. J Biol Chem 287, 32940-32952.
    • (2012) J Biol Chem , vol.287 , pp. 32940-32952
    • Boscher, C.1    Zheng, Y.Z.2    Lakshminarayan, R.3    Johannes, L.4    Dennis, J.W.5    Foster, L.J.6    Nabi, I.R.7
  • 127
    • 64249146003 scopus 로고    scopus 로고
    • Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: Possible role in suppressing experimental autoimmune encephalomyelitis
    • Wang J, Lu ZH, Gabius HJ, Rohowsky-Kochan C, Ledeen RW, &, Wu G, (2009) Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol 182, 4036-4045.
    • (2009) J Immunol , vol.182 , pp. 4036-4045
    • Wang, J.1    Lu, Z.H.2    Gabius, H.J.3    Rohowsky-Kochan, C.4    Ledeen, R.W.5    Wu, G.6
  • 128
    • 84867741216 scopus 로고    scopus 로고
    • Carbohydrate to carbohydrate interaction in development process and cancer progression
    • Handa K, &, Hakomori SI, (2012) Carbohydrate to carbohydrate interaction in development process and cancer progression. Glycoconj J 29, 627-637.
    • (2012) Glycoconj J , vol.29 , pp. 627-637
    • Handa, K.1    Hakomori, S.I.2
  • 129
    • 0025945830 scopus 로고
    • Cell adhesion, spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction
    • Kojima N, &, Hakomori S, (1991) Cell adhesion, spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction. J Biol Chem 266, 17552-17558.
    • (1991) J Biol Chem , vol.266 , pp. 17552-17558
    • Kojima, N.1    Hakomori, S.2
  • 130
    • 0037414924 scopus 로고    scopus 로고
    • Probing specificity in carbohydrate-carbohydrate interactions with micelles and Langmuir monolayers
    • Santacroce PV, &, Basu A, (2003) Probing specificity in carbohydrate-carbohydrate interactions with micelles and Langmuir monolayers. Angew Chem Int Ed Engl 42, 95-98.
    • (2003) Angew Chem Int Ed Engl , vol.42 , pp. 95-98
    • Santacroce, P.V.1    Basu, A.2
  • 131
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K, &, Ikonen E, (1997) Functional rafts in cell membranes. Nature 387, 569-572.
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 132
    • 40749132024 scopus 로고    scopus 로고
    • Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains
    • Regina Todeschini A, &, Hakomori SI, (2008) Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. Biochim Biophys Acta 1780, 421-433.
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 421-433
    • Regina Todeschini, A.1    Hakomori, S.I.2
  • 133
    • 0344585437 scopus 로고    scopus 로고
    • Lipid rafts: Elusive or illusive?
    • Munro S, (2003) Lipid rafts: elusive or illusive? Cell 115, 377-388.
    • (2003) Cell , vol.115 , pp. 377-388
    • Munro, S.1
  • 134
    • 77957167810 scopus 로고    scopus 로고
    • Revitalizing membrane rafts: New tools and insights
    • Simons K, &, Gerl MJ, (2010) Revitalizing membrane rafts: new tools and insights. Nat Rev Mol Cell Biol 11, 688-699.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 688-699
    • Simons, K.1    Gerl, M.J.2
  • 136
    • 84880596969 scopus 로고    scopus 로고
    • Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells
    • Toulmay A, &, Prinz WA, (2013) Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells. J Cell Biol 202, 35-44.
    • (2013) J Cell Biol , vol.202 , pp. 35-44
    • Toulmay, A.1    Prinz, W.A.2
  • 137
    • 38449083374 scopus 로고    scopus 로고
    • Lipid raft heterogeneity: An enigma
    • Mishra S, &, Joshi PG, (2007) Lipid raft heterogeneity: an enigma. J Neurochem 103 (Suppl 1), 135-142.
    • (2007) J Neurochem , vol.103 , Issue.SUPPL. 1 , pp. 135-142
    • Mishra, S.1    Joshi, P.G.2
  • 138
    • 0035082123 scopus 로고    scopus 로고
    • Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers
    • Vyas KA, Patel HV, Vyas AA, &, Schnaar RL, (2001) Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers. Biol Chem 382, 241-250.
    • (2001) Biol Chem , vol.382 , pp. 241-250
    • Vyas, K.A.1    Patel, H.V.2    Vyas, A.A.3    Schnaar, R.L.4
  • 140
    • 21244442348 scopus 로고    scopus 로고
    • Spatial and functional heterogeneity of sphingolipid-rich membrane domains
    • Kiyokawa E, Baba T, Otsuka N, Makino A, Ohno S, &, Kobayashi T, (2005) Spatial and functional heterogeneity of sphingolipid-rich membrane domains. J Biol Chem 280, 24072-24084.
    • (2005) J Biol Chem , vol.280 , pp. 24072-24084
    • Kiyokawa, E.1    Baba, T.2    Otsuka, N.3    Makino, A.4    Ohno, S.5    Kobayashi, T.6
  • 141
    • 33749503026 scopus 로고    scopus 로고
    • Analysis of detergent-resistant membranes associated with apical and basolateral GPI-anchored proteins in polarized epithelial cells
    • Tivodar S, Paladino S, Pillich R, Prinetti A, Chigorno V, van Meer G, Sonnino S, &, Zurzolo C, (2006) Analysis of detergent-resistant membranes associated with apical and basolateral GPI-anchored proteins in polarized epithelial cells. FEBS Lett 580, 5705-5712.
    • (2006) FEBS Lett , vol.580 , pp. 5705-5712
    • Tivodar, S.1    Paladino, S.2    Pillich, R.3    Prinetti, A.4    Chigorno, V.5    Van Meer, G.6    Sonnino, S.7    Zurzolo, C.8
  • 142
    • 76049121942 scopus 로고    scopus 로고
    • Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues
    • Ohmi Y, Tajima O, Ohkawa Y, Mori A, Sugiura Y, &, Furukawa K, (2009) Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proc Natl Acad Sci USA 106, 22405-22410.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 22405-22410
    • Ohmi, Y.1    Tajima, O.2    Ohkawa, Y.3    Mori, A.4    Sugiura, Y.5    Furukawa, K.6
  • 145
    • 77950612993 scopus 로고    scopus 로고
    • Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies
    • Park H, Haynes CA, Nairn AV, Kulik M, Dalton S, Moremen K, &, Merrill AH Jr, (2010) Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J Lipid Res 51, 480-489.
    • (2010) J Lipid Res , vol.51 , pp. 480-489
    • Park, H.1    Haynes, C.A.2    Nairn, A.V.3    Kulik, M.4    Dalton, S.5    Moremen, K.6    Merrill, Jr.A.H.7
  • 146
    • 0031880777 scopus 로고    scopus 로고
    • Use of BODIPY-labeled sphingolipids to study membrane traffic along the endocytic pathway
    • Pagano RE, &, Chen CS, (1998) Use of BODIPY-labeled sphingolipids to study membrane traffic along the endocytic pathway. Ann N Y Acad Sci 845, 152-160.
    • (1998) Ann N y Acad Sci , vol.845 , pp. 152-160
    • Pagano, R.E.1    Chen, C.S.2
  • 147
    • 54049110711 scopus 로고    scopus 로고
    • Use of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cells
    • Marks DL, Bittman R, &, Pagano RE, (2008) Use of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cells. Histochem Cell Biol 130, 819-832.
    • (2008) Histochem Cell Biol , vol.130 , pp. 819-832
    • Marks, D.L.1    Bittman, R.2    Pagano, R.E.3
  • 148
    • 30544433842 scopus 로고    scopus 로고
    • Glycosphingolipid structural analysis and glycosphingolipidomics
    • Levery SB, (2005) Glycosphingolipid structural analysis and glycosphingolipidomics. Methods Enzymol 405, 300-369.
    • (2005) Methods Enzymol , vol.405 , pp. 300-369
    • Levery, S.B.1
  • 149
    • 77249156030 scopus 로고    scopus 로고
    • Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: Toward in situ pharmacometabolomes
    • Sugiura Y, &, Setou M, (2010) Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes. J Neuroimmune Pharmacol 5, 31-43.
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 31-43
    • Sugiura, Y.1    Setou, M.2
  • 150
    • 0015950912 scopus 로고
    • Cholera toxin: Interaction of subunits with ganglioside GM1
    • Heyningen SV, (1974) Cholera toxin: interaction of subunits with ganglioside GM1. Science 183, 656-657.
    • (1974) Science , vol.183 , pp. 656-657
    • Heyningen, S.V.1
  • 151
    • 0022508584 scopus 로고
    • Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide
    • Jacewicz M, Clausen H, Nudelman E, Donohue-Rolfe A, &, Keusch GT, (1986) Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide. J Exp Med 163, 1391-1404.
    • (1986) J Exp Med , vol.163 , pp. 1391-1404
    • Jacewicz, M.1    Clausen, H.2    Nudelman, E.3    Donohue-Rolfe, A.4    Keusch, G.T.5
  • 154
    • 84884415245 scopus 로고    scopus 로고
    • Developmental neuroscience: Miniature human brains
    • Brustle O, (2013) Developmental neuroscience: miniature human brains. Nature 501, 319-320.
    • (2013) Nature , vol.501 , pp. 319-320
    • Brustle, O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.