Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in niemann-pick type C1-deficient murine brain

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Kennedy, Barry E ^a   LeBlanc, Veronique G ^a   Mailman, Tiffany M ^a   Fice, Debra ^a   Burton, Ian ^b   Karakach, Tobias K ^b   Karten, Barbara ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BIOGENESIS; CARBOXYLATION; CONTROLLED STUDY; DECARBOXYLATION; DNA DETERMINATION; ENERGY METABOLISM; ENZYME METABOLISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HOMEOSTASIS; METABOLOMICS; MOUSE; NEUROTRANSMISSION; NIEMANN PICK DISEASE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; UPREGULATION;

ANIMALS; ANTIOXIDANTS; BRAIN; CHOLESTEROL; GLUCOSE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NIEMANN-PICK DISEASE, TYPE C; PROTEINS; PURKINJE CELLS; PYRUVATES;

EID: 84893192165     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082685     Document Type: Article

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