Lung cancer and lung injury: The dual role of ceramide

Handbook of Experimental Pharmacology

Volumn 216, Issue , 2013, Pages 93-113

  Goldkorn, Tzipora ^a   Chung, Samuel ^a   Filosto, Simone ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ceramide; Cigarette smoke; Egfr; Lung cancer and injury; Neutral sphingomyelinase 2; Oxidative stress; Sphingolipids

Indexed keywords

CAVEOLIN 1; CERAMIDE; CERAMIDE 1 PHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR; GANGLIOSIDE GM2; HYDROGEN PEROXIDE; MICRORNA; PHOSPHOPROTEIN PHOSPHATASE 2A; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINASE 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL FATE; CELL MEMBRANE; CELL STRESS; ENZYME ACTIVATION; EXOSOME; HUMAN; INTRACELLULAR SIGNALING; LIPID ANALYSIS; LUNG CANCER; LUNG INJURY; MITOGENESIS; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SMOKING; TUMOR GROWTH; UPREGULATION; ANIMAL; DRUG EFFECT; DRUG RESISTANCE; GENETICS; LUNG; LUNG TUMOR; METABOLISM; PATHOLOGY; RESPIRATORY TRACT MUCOSA; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CERAMIDES; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG; LUNG INJURY; LUNG NEOPLASMS; MICRORNAS; ONCOGENES; OXIDATIVE STRESS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SMOKING; SPHINGOMYELIN PHOSPHODIESTERASE;

MLCS; MLOWN;

EID: 84880524731     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-7091-1511-4_5     Document Type: Article

References (90)

1. Alberg AJ, Samet JM (2003) Epidemiology of lung cancer. Chest 123:21S-49S
2. Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A et al (2008) Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 10:619-624
3. Al-Nedawi K, Meehan B, Rak J (2009) Microvesicles: messengers and mediators of tumor progression. Cell Cycle 8:2014-2018
4. Bhowmick NA, Neilson EG, Moses HL (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432:332-337
5. Caballero A, Torres-Duque CA, Jaramillo C, Bolivar F, Sanabria F, Osorio P et al (2008) Prevalence of COPD in five Colombian cities situated at low, medium, and high altitude (PREPOCOL study). Chest 133:343-349
6. Cai H, Babic I, Wei X, Huang J, Witte ON (2011) Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer Res 71:862-872
7. Ceppi P, Rapa I, Lo Iacono M, Righi L, Giorcelli J, Pautasso M et al (2012) Expression and pharmacological inhibition of thymidylate synthase and Src kinase in nonsmall cell lung cancer. Int J Cancer 130:1777-1786
8. Chan C, Goldkorn T (2000) Ceramide path in human lung cell death. Am J Respir Cell Mol Biol 22:460-468
9. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K et al (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18:997-1006
10. Chung BM, Dimri M, George M, Reddi AL, Chen G, Band V et al (2009) The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene 28:1821-1832
11. Church DF, Pryor WA (1985) Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 64:111-126
12. Clarke CJ, Guthrie JM, Hannun YA (2008) Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. Mol Pharmacol 74:1022-1032
13. Cremesti A, Paris F, Grassme H, Holler N, Tschopp J, Fuks Z et al (2001) Ceramide enables fas to cap and kill. J Biol Chem 276:23954-23961
14. D'Angelo SP, Pietanza MC, Johnson ML, Riely GJ, Miller VA, Sima CS et al (2011) Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas. J Clin Oncol 29:2066-2070
15. de Molina AR, de la Cueva A, Machado-Pinilla R, Rodriguez-Fanjul V, Del Pulgar TG, Cebrian A et al (2012) Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase alpha inhibition. Curr Cancer Drug Targets 12(6):617-24
16. de Torres JP, Bastarrika G, Wisnivesky JP, Alcaide AB, Campo A, Seijo LM et al (2007) Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. Chest 132:1932-1938
17. Devillard R, Galvani S, Thiers JC, Guenet JL, Hannun Y, Bielawski J et al (2010) Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One 5:e9826
18. Ellis AG, Doherty MM, Walker F, Weinstock J, Nerrie M, Vitali A et al (2006) Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Biochem Pharmacol 71:1422-1434
19. Esme H, Cemek M, Sezer M, Saglam H, Demir A, Melek H et al (2008) High levels of oxidative stress in patients with advanced lung cancer. Respirology 13:112-116
20. Filosto S, Fry W, Knowlton AA, Goldkorn T (2010) Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B). J Biol Chem 285:10213-10222
21. Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N et al (2011a) Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol 44:350-360
22. Filosto S, Khan E, Tognon E, Becker C, Ashfaq M, Ravid T et al (2011b) EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization. PLoS One 6:e23240
23. Filosto S, Ashfaq M, Chung S, Fry W, Goldkorn T (2012a) Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines. J Biol Chem 287:514-522
24. Filosto S, Becker CR, Goldkorn T (2012b) Cigarette smoke induces aberrant EGF receptor activation that mediates lung cancer development and resistance to tyrosine kinase inhibitors. Mol Cancer Ther 11:795-804
25. Foley TD, Petro LA, Stredny CM, Coppa TM (2007) Oxidative inhibition of protein phosphatase 2A activity: role of catalytic subunit disulfides. Neurochem Res 32:1957-1964
26. Goldkorn T, Filosto S (2010) Lung injury and cancer: mechanistic insights into ceramide and EGFR signaling under cigarette smoke. Am J Respir Cell Mol Biol 43:259-268
27. Goldkorn T, Balaban N, Shannon M, Chea V, Matsukuma K, Gilchrist D et al (1998) H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J Cell Sci 111:3209-3220
28. Goldkorn T, Ravid T, Khan EM (2005) Life and death decisions: ceramide generation and EGF receptor trafficking are modulated by oxidative stress. Antioxid Redox Signal 7:119-128
29. Gomez-Munoz A, Kong JY, Salh B, Steinbrecher UP (2004) Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res 45:99-105
30. Grassme H, Jekle A, Riehle A, Schwarz H, Berger J, Sandhoff K et al (2001) CD95 signaling via ceramide-rich membrane rafts. J Biol Chem 276:20589-20596
31. Gridelli C, Maione P, Bareschino MA, Schettino C, Sacco PC, Ambrosio R et al (2010) Erlotinib in the treatment of non-small cell lung cancer: current status and future developments. Anticancer Res 30:1301-1310
32. Gulbins E, Kolesnick R (2003) Raft ceramide in molecular medicine. Oncogene 22:7070-7077
33. Hannun YA, Obeid LM (2011) Many ceramides. J Biol Chem 286:27855-27862
34. Heering J, Weis N, Holeiter M, Neugart F, Staebler A, Fehm TN et al (2012) Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer. Cancer Res 72(11):2855-66
35. Inokuchi J, Jimbo M, Momosaki K, Shimeno H, Nagamatsu A, Radin NS (1990) Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action. Cancer Res 50:6731-6737
36. Khan E, Heidinger J, Levy M, Lisanti M, Ravid T, Goldkorn T (2006) EGF receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking. J Biol Chem 281:14486-14493
37. Khan EM, Lanir R, Danielson AR, Goldkorn T (2008) EGF receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking. FASEB J 22:910-917
38. Kim H, Chan R, Dankort DL, Zuo D, Najoukas M, Park M et al (2005) The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation. Oncogene 24:7599-7607
39. Kim LC, Song L, Haura EB (2009a) Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6:587-595
40. Kim VN, Han J, Siomi MC (2009b) Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 10:126-139
41. Kolesnick RN, Goni FM, Alonso A (2000) Compartmentalization of ceramide signaling: physical foundations and biological effects. J Cell Physiol 184:285-300
42. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T (2010) Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 285:17442-17452
43. Kuebler WM, Yang Y, Samapati R, Uhlig S (2010) Vascular barrier regulation by PAF, ceramide, caveolae, and NO - an intricate signaling network with discrepant effects in the pulmonary and systemic vasculature. Cell Physiol Biochem 26:29-40
44. Lavrentiadou SN, Chan C, Ravid T, Tsaba A, van der Vliet A, Rasooly R et al (2001) Ceramidemediated apoptosis in lung epithelial cells is regulated by GSH. Am J Respir Cell Mol Biol 25:676-684
45. Levy M, Castillo SS, Goldkorn T (2006) nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Biochem Biophys Res Commun 344:900-905
46. Levy M, Khan E, Careaga M, Goldkorn T (2009) Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death. Am J Physiol Lung Cell Mol Physiol 297:125-133
47. Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH et al (2009) Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res 15:1177-1183
48. Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y et al (2010) MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest 120:1298-1309
49. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139
50. Maceyka M, Harikumar KB, Milstien S, Spiegel S (2012) Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol 22:50-60
51. Marcotte R, Zhou L, Kim H, Roskelly CD, Muller WJ (2009) c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential. Mol Cell Biol 29:5858-5871
52. Megha, London E (2004) Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function. J Biol Chem 279:9997-10004
53. Merrill Jr. A.H. (2011) Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev 111:6387-6422
54. Minna JD, Gazdar AF, Sprang SR, Herz J (2004) Cancer. A bull's eye for targeted lung cancer therapy. Science 304:1458-1461
55. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL et al (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105:10513-10518
56. Mitra P, Maceyka M, Payne SG, Lamour N, Milstien S, Chalfant CE et al (2007) Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells. FEBS Lett 581:735-740
57. Morales A, Lee H, Goni FM, Kolesnick R, Fernandez-Checa JC (2007) Sphingolipids and cell death. Apoptosis 12:923-939
58. Mountzios G, Fouret P, Soria JC (2008) Mechanisms of disease: signal transduction in lung carcinogenesis - a comparison of smokers and never-smokers. Nat Clin Pract Oncol 5:610-618
59. Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE et al (2009) Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J 23:751-763
60. Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA et al (2011) Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res 52:68-77
61. Nikolova-Karakashian M, Karakashian A, Rutkute K (2008) Role of neutral sphingomyelinases in aging and inflammation. Subcell Biochem 49:469-486
62. Nowak D, Antczak A, Krol M, Pietras T, Shariati B, Bialasiewicz P et al (1996) Increased content of H2O2 in the expired breath of cigarette smokers. Eur Respir J 9:652-657
63. Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C et al (2001) Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem 276:24901-24910
64. Oskouian B, Saba JD (2010) Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol 688:185-205
65. Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S et al (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304:1497-1500
66. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108
67. Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Hopmans ES, Lindenberg JL et al (2010) Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci USA 107:6328-6333
68. Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP et al (2010) Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol 6:1603-1624
69. Ravid T, Sweeney C, Gee P, Carraway KRK, Goldkorn T (2002) EGF receptor activation under oxidative stress fails to promote c-Cbl mediated down regulation. J Biol Chem 12:12
70. Ravid T, Tsaba A, Gee P, Rasooly R, Medina EA, Goldkorn T (2003) Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adeno. cells. Am J Physiol Lung Cell Mol Physiol 284:L1082-1092
71. Rutkute K, Asmis RH, Nikolova-Karakashian MN (2007a) Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation. J Lipid Res 48:2443-2452
72. Rutkute K, Karakashian AA, Giltiay NV, Dobierzewska A, Nikolova-Karakashian MN (2007b) Aging in rat causes hepatic hyperresposiveness to IL-1beta which is mediated by nSMase2. Hepatology 46:1166-1176
73. Schnitzer SE, Weigert A, Zhou J, Brune B (2009) Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Mol Cancer Res 7:393-401
74. Shigematsu H, Gazdar AF (2006) Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 118:257-262
75. Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Sena-EstevesM et al (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470-1476
76. Stancevic B, Kolesnick R (2010) Ceramide-rich platforms in transmembrane signaling. FEBS Lett 584:1728-1740
77. Sznajder JI, Fraiman A, Hall JB, Sanders W, Schmidt G, Crawford G et al (1989) Increased H2O2 in the expired breath of patients with acute hypoxemic respiratory failure. Chest 96:606-612
78. Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F et al (2008) Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319:1244-1247
79. Uhlig S, Gulbins E (2008) Sphingolipids in the lungs. Am J Respir Crit Care Med 178:1100-1114
80. Watanabe S, Tanaka J, Ota T, Kondo R, Tanaka H, Kagamu H et al (2011) Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis. BMC Cancer 11:1
81. Weinstein IB (2002) Cancer. Addiction to oncogenes-The Achilles heal of cancer. Science 297:63-64
82. Williams MD, Chance B (1983) Spontaneous chemiluminescence of human breath. Spectrum, lifetime, temporal distribution, and correlation with peroxide. J Biol Chem 258:3628-3631
83. Wu BX, Clarke CJ, Hannun YA (2010) Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med 12:320-330
84. Wu JY, Wu SG, Yang CH, Chang YL, Chang YC, Hsu YC et al (2011) Comparison of gefitinib and erlotinib in advanced NSCLC and the effect of EGFR mutations. Lung Cancer 72:205-212
85. Xu X, Bittman R, Duportail G, Heissler D, Vilcheze C, London E (2001) Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide. J Biol Chem 276:33540-33546
86. Yamada T, Bando H, Takeuchi S, Kita K, Li Q, Wang W et al (2011) Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells. Cancer Sci 102:2157-2163
87. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, YiMet al (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9:189-198
88. Yang Y, Yin J, Baumgartner W, Samapati R, Solymosi EA, Reppien E et al (2010) Plateletactivating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase. Eur Respir J 36:417-427
89. Yatabe Y (2010) EGFR mutations and the terminal respiratory unit. Cancer Metastasis Rev 29:23-36
90. Zhang Y, Li X, Becker KA, Gulbins E (2009) Ceramide-enriched membrane domains-structure and function. Biochim Biophys Acta 1788:178-183