The warburg effect suppresses oxidative stress induced apoptosis yeast model for cancer

PLoS ONE

Volumn 4, Issue 2, 2009, Pages

  Ruckenstuhl, Christoph ^a   Büttner, Sabrina ^a   Carmona Gutierrez, Didac ^a   Eisenberg, Tobias ^a   Kroemer, Guido ^b,c,d   Sigrist, Stephan J ^e,f   Fröhlich, Kai Uwe ^a   Madeo, Frank ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b Institut Gustave Roussy   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE;

APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL DEATH; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GLYCOLYSIS; IATROGENIC DISEASE; NONHUMAN; ORGANISM COLONY; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SCAVENGING SYSTEM;

SACCHAROMYCES CEREVISIAE;

EID: 84887212425     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004592     Document Type: Article

References (34)

1. Warburg O (1956) On respiratory impairment in cancer cells. Science 124: 269-270.
2. Kondoh H (2008) Cellular life span and the Warburg effect. Exp Cell Res 314: 1923-1928.
3. Pedersen PL (1978) Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res 22: 190-274.
4. Gambhir SS (2002) Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2: 683-693.
5. Gordan JD, Thompson CB, Simon MC (2007) HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 12: 108-113.
6. Pedersen PL (2007) Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J Bioenerg Biomembr 39: 211-222.
7. Denko NC (2008) Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer.
8. Garber K (2006) Energy deregulation: licensing tumors to grow. Science 312: 1158-1159.
9. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20.
10. Gogvadze V, Orrenius S, Zhivotovsky B (2008) Mitochondria in cancer cells: what is so special about them? Trends Cell Biol 18: 165-173.
11. Kaelin WG Jr (2008) The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 8: 865-873.
12. Warburg O (1956) On the origin of cancer cells. Science 123: 309-314.
13. Madeo F, Frohlich E, Frohlich KU (1997) A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol 139: 729-734.
14. Madeo F, Frohlich E, Ligr M, Grey M, Sigrist SJ, et al. (1999) Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol 145: 757-767.
15. Eisenberg T, Buttner S, Kroemer G, Madeo F (2007) The mitochondrial pathway in yeast apoptosis. Apoptosis 12: 1011-1023.
16. Pereira C, Silva RD, Saraiva L, Johansson B, Sousa MJ, et al. (2008) Mitochondria-dependent apoptosis in yeast. Biochim Biophys Acta 1783: 1286-1302.
17. Ludovico P, Rodrigues F, Almeida A, Silva MT, Barrientos A, et al. (2002) Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol Biol Cell 13: 2598-2606.
18. Manon S, Chaudhuri B, Guerin M (1997) Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-xL. FEBS Lett 415: 29-32.
19. Wissing S, Ludovico P, Herker E, Buttner S, Engelhardt SM, et al. (2004) An AIF orthologue regulates apoptosis in yeast. J Cell Biol 166: 969-974.
20. Pozniakovsky AI, Knorre DA, Markova OV, Hyman AA, Skulachev VP, et al. (2005) Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast. J Cell Biol 168: 257-269.
21. Fannjiang Y, Cheng WC, Lee SJ, Qi B, Pevsner J, et al. (2004) Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev 18: 2785-2797.
22. Kroemer G (1997) Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution. Cell Death Differ 4: 443-456.
23. Haussmann P, Zimmermann FK (1976) The role of mitochondria in carbon catabolite repression in yeast. Mol Gen Genet 148: 205-211.
24. Sesaki H, Southard SM, Yaffe MP, Jensen RE (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14: 2342-2356.
25. Hell K, Herrmann JM, Pratje E, Neupert W, Stuart RA (1998) Oxa1p, an essential component of the N-tail protein export machinery in mitochondria. Proc Natl Acad Sci U S A 95: 2250-2255.
26. Jia L, Dienhart M, Schramp M, McCauley M, Hell K, et al. (2003) Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1. Embo J 22: 6438-6447.
27. Meunier JR, Choder M (1999) Saccharomyces cerevisiae colony growth and ageing: biphasic growth accompanied by changes in gene expression. Yeast 15: 1159-1169.
28. Kroemer G, Pouyssegur J (2008) Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13: 472-482.
29. Schulz TJ, Thierbach R, Voigt A, Drewes G, Mietzner B, et al. (2006) Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited. J Biol Chem 281: 977-981.
30. Vaughn AE, Deshmukh M (2008) Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol 10: 1477-1483.
31. Cardenas-Navia LI, Mace D, Richardson RA, Wilson DF, Shan S, et al. (2008) The pervasive presence of fluctuating oxygenation in tumors. Cancer Res 68: 5812-5819.
32. Hammond EM, Giaccia AJ (2004) The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. DNA Repair (Amst) 3: 1117-1122.
33. Buttner S, Bitto A, Ring J, Augsten M, Zabrocki P, et al. (2008) Functional mitochondria are required for alpha-synuclein toxicity in aging yeast. J Biol Chem 283: 7554-7560.
34. Buttner S, Eisenberg T, Carmona-Gutierrez D, Ruli D, Knauer H, et al. (2007) Endonuclease G regulates budding yeast life and death. Mol Cell 25: 233-246.