Sphingolipid signaling in yeast: Potential implications for understanding disease

Frontiers in Bioscience - Elite

Volumn 5 E, Issue 1, 2013, Pages 97-108

  Epstein, Sharon ^a   Riezman, Howard ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Ceramide; Diseases; Model organism; Review; Signalling; Sphingolipids; Yeast

Indexed keywords

CERAMIDE; DIHYDROCERAMIDE; SPHINGOLIPID; UNCLASSIFIED DRUG; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ARTICLE; CELL WALL; G1 PHASE CELL CYCLE CHECKPOINT; HEAT SHOCK; METABOLISM; NONHUMAN; OSMOTIC STRESS; PH; YEAST; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CYCLE CHECKPOINT; HEAT SHOCK RESPONSE; OSMOTIC PRESSURE; PHYSIOLOGY; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ANIMALIA; SACCHAROMYCES CEREVISIAE; SPHINGOIDEA;

CELL CYCLE CHECKPOINTS; HEAT-SHOCK RESPONSE; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; OSMOTIC PRESSURE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; TOR SERINE-THREONINE KINASES;

MLCS; MLOWN;

EID: 84877779452     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e599     Document Type: Article

References (103)

1. Hannun, Y. A. and L. M. Obeid: The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem, 277, 25847-50 (2002) (Pubitemid 34967060)
2. Obeid, L. M., Y. Okamoto and C. Mao: Yeast sphingolipids: metabolism and biology. Biochim Biophys Acta, 1585, 163-71 (2002) (Pubitemid 36092081)
3. Hannich, J. T., K. Umebayashi and H. Riezman: Distribution and functions of sterols and sphingolipids. Cold Spring Harbor perspectives in biology, 3, (2011)
4. Ternes, P., T. Wobbe, M. Schwarz, S. Albrecht, K. Feussner, I. Riezman, J. M. Cregg, E. Heinz, H. Riezman, I. Feussner and D. Warnecke: Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris. J Biol Chem, 286, 11401-14 (2011)
5. Munn, A. L. and H. Riezman: Endocytosis is required for the growth of vacuolar H (+)-ATPase-defective yeast: identification of six new END genes. The Journal of cell biology, 127, 373-86 (1994) (Pubitemid 24313727)
6. Barz, W. P. and P. Walter: Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol- anchored proteins. Mol Biol Cell, 10, 1043-59 (1999) (Pubitemid 29193730)
7. Guillas, I., P. A. Kirchman, R. Chuard, M. Pfefferli, J. C. Jiang, S. M. Jazwinski and A. Conzelmann: C26-CoAdependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. Embo J, 20, 2655-65 (2001) (Pubitemid 32938550)
8. Schorling, S., B. Vallee, W. P. Barz, H. Riezman and D. Oesterhelt: Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell, 12, 3417-27 (2001) (Pubitemid 33108475)
9. D'Mello N, P., A. M. Childress, D. S. Franklin, S. P. Kale, C. Pinswasdi and S. M. Jazwinski: Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J Biol Chem, 269, 15451-9 (1994) (Pubitemid 24202126)
10. Jiang, J. C., P. A. Kirchman, M. Zagulski, J. Hunt and S. M. Jazwinski: Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res, 8, 1259-72 (1998) (Pubitemid 29039098)
11. Vallee, B. and H. Riezman: Lip1p: a novel subunit of acyl-CoA ceramide synthase. Embo J, 24, 730-41 (2005) (Pubitemid 40396103)
12. Mizutani, Y., A. Kihara and Y. Igarashi: LASS3 (longevity assurance homologue 3) is a mainly testisspecific (dihydro) ceramide synthase with relatively broad substrate specificity. Biochem J, 398, 531-8 (2006) (Pubitemid 44453398)
13. Lahiri, S. and A. H. Futerman: LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem, 280, 33735-8 (2005) (Pubitemid 41443091)
14. Laviad, E. L., L. Albee, I. Pankova-Kholmyansky, S. Epstein, H. Park, A. H. Merrill, Jr. and A. H. Futerman: Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem, 283, 5677-84 (2008)
15. Mizutani, Y., A. Kihara and Y. Igarashi: Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J, 390, 263-71 (2005) (Pubitemid 41192252)
16. Riebeling, C., J. C. Allegood, E. Wang, A. H. Merrill, Jr. and A. H. Futerman: Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem, 278, 43452-9 (2003) (Pubitemid 37345968)
17. Venkataraman, K., C. Riebeling, J. Bodennec, H. Riezman, J. C. Allegood, M. C. Sullards, A. H. Merrill, Jr. and A. H. Futerman: Upstream of growth and differentiation factor 1(uog1), a mammalian homolog of the yeast longevity assurance gene 1(LAG1), regulates Nstearoylsphinganine (C18-(dihydro) ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. J Biol Chem, 277, 35642-9 (2002)
18. Guillas, I., J. C. Jiang, C. Vionnet, C. Roubaty, D. Uldry, R. Chuard, J. Wang, S. M. Jazwinski and A. Conzelmann: Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem, 278, 37083-91 (2003) (Pubitemid 37175222)
19. Haak, D., K. Gable, T. Beeler and T. Dunn: Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. J Biol Chem, 272, 29704-10 (1997) (Pubitemid 27508064)
20. Sawai, H., Y. Okamoto, C. Luberto, C. Mao, A. Bielawska, N. Domae and Y. A. Hannun: Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem, 275, 39793-8 (2000) (Pubitemid 32059011)
21. Hashida-Okado, T., A. Ogawa, M. Endo, R. Yasumoto, K. Takesako and I. Kato: AUR1, a novel gene conferring aureobasidin resistance on Saccharomyces cerevisiae: a study of defective morphologies in Aur1p-depleted cells. Mol Gen Genet, 251, 236-44 (1996)
22. Tani, M. and O. Kuge: Defect of synthesis of very longchain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae. J Biochem, 148, 565-71 (2010)
23. Cerantola, V., I. Guillas, C. Roubaty, C. Vionnet, D. Uldry, J. Knudsen and A. Conzelmann: Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol, 71, 1523-37 (2009)
24. Sato, K., Y. Noda and K. Yoda: Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol Biol Cell, 20, 4444-57 (2009)
25. Uemura, S., A. Kihara, J. Inokuchi and Y. Igarashi: Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p. J Biol Chem, 278, 45049-55 (2003) (Pubitemid 37432636)
26. Beeler, T. J., D. Fu, J. Rivera, E. Monaghan, K. Gable and T. M. Dunn: SUR1 (CSG1/BCL21), a gene necessary for growth of Saccharomyces cerevisiae in the presence of high Ca2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide. Mol Gen Genet, 255, 570-9 (1997)
27. Dickson, R. C., E. E. Nagiec, G. B. Wells, M. M. Nagiec and R. L. Lester: Synthesis of mannose-(inositol-P) 2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem, 272, 29620-5 (1997)
28. Patton, J. L., B. Srinivasan, R. C. Dickson and R. L. Lester: Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. J Bacteriol, 174, 7180-4 (1992)
29. Nagiec, M. M., M. Skrzypek, E. E. Nagiec, R. L. Lester and R. C. Dickson: The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J Biol Chem, 273, 19437-42 (1998) (Pubitemid 28366992)
30. Kim, S., H. Fyrst and J. Saba: Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics, 156, 1519-29 (2000) (Pubitemid 32001222)
31. Skrzypek, M. S., M. M. Nagiec, R. L. Lester and R. C. Dickson: Analysis of phosphorylated sphingolipid longchain bases reveals potential roles in heat stress and growth control in Saccharomyces. J Bacteriol, 181, 1134-40 (1999) (Pubitemid 29119550)
32. Friant, S., K. D. Meier and H. Riezman: Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein induction. Embo J, 22, 3783-91 (2003) (Pubitemid 36975707)
33. Meier, K. D., O. Deloche, K. Kajiwara, K. Funato and H. Riezman: Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae. Mol Biol Cell, 17, 1164-75 (2006) (Pubitemid 43376538)
34. Gottlieb, D., W. Heideman and J. D. Saba: The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. Mol Cell Biol Res Commun, 1, 66-71 (1999) (Pubitemid 129532295)
35. Breslow, D. K., S. R. Collins, B. Bodenmiller, R. Aebersold, K. Simons, A. Shevchenko, C. S. Ejsing and J. S. Weissman: Orm family proteins mediate sphingolipid homeostasis. Nature, 463, 1048-53 (2010)
36. Han, S., M. A. Lone, R. Schneiter and A. Chang: Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control. Proc Natl Acad Sci U S A, 107, 5851-6 (2010)
37. Moffatt, M. F., M. Kabesch, L. Liang, A. L. Dixon, D. Strachan, S. Heath, M. Depner, A. von Berg, A. Bufe, E. Rietschel, A. Heinzmann, B. Simma, T. Frischer, S. A. Willis-Owen, K. C. Wong, T. Illig, C. Vogelberg, S. K. Weiland, E. von Mutius, G. R. Abecasis, M. Farrall, I. G. Gut, G. M. Lathrop and W. O. Cookson: Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 448, 470-3 (2007) (Pubitemid 47123521)
38. Zanolari, B., S. Friant, K. Funato, C. Sutterlin, B. J. Stevenson and H. Riezman: Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. Embo J, 19, 2824-33 (2000) (Pubitemid 30386755)
39. Friant, S., R. Lombardi, T. Schmelzle, M. N. Hall and H. Riezman: Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. Embo J, 20, 6783-92 (2001) (Pubitemid 33134208)
40. Birchwood, C. J., J. D. Saba, R. C. Dickson and K. W. Cunningham: Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. J Biol Chem, 276, 11712-8 (2001)
41. Lee, Y. J., S. Wang, S. R. Slone, T. A. Yacoubian and S. N. Witt: Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. PLoS One, 6, e15946
42. Welsch, C. A., S. Hagiwara, J. F. Goetschy and N. R. Movva: Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem, 278, 26976-82 (2003) (Pubitemid 36876851)
43. Cohen, J. A., F. Barkhof, G. Comi, H. P. Hartung, B. O. Khatri, X. Montalban, J. Pelletier, R. Capra, P. Gallo, G. Izquierdo, K. Tiel-Wilck, A. de Vera, J. Jin, T. Stites, S. Wu, S. Aradhye and L. Kappos: Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med, 362, 402-15 (2010)
44. Hla, T. and V. Brinkmann: Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology, 76, S3-8 (2011)
45. Lim, K. G., F. Tonelli, Z. Li, X. Lu, R. Bittman, S. Pyne and N. J. Pyne: FTY720 Analogues as Sphingosine Kinase 1 Inhibitors: Enzyme inhibition kinetcs, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. J Biol Chem, 286, 18633-40 (2011)
46. Welsch, C. A., L. W. Roth, J. F. Goetschy and N. R. Movva: Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. J Biol Chem, 279, 36720-31 (2004) (Pubitemid 39129019)
47. Bandhuvula, P., Y. Y. Tam, B. Oskouian and J. D. Saba: The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J Biol Chem, 280, 33697-700 (2005) (Pubitemid 41443086)
48. Mukhopadhyay, D., K. S. Howell, H. Riezman and G. Capitani: Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro. J Biol Chem, 283, 20159-69 (2008)
49. Bourquin, F., H. Riezman, G. Capitani and M. G. Grutter: Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure, 18, 1054-65 (2010)
50. Alvarez, S. E., K. B. Harikumar, N. C. Hait, J. Allegood, G. M. Strub, E. Y. Kim, M. Maceyka, H. Jiang, C. Luo, T. Kordula, S. Milstien and S. Spiegel: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature, 465, 1084-8 (2010)
51. Hait, N. C., J. Allegood, M. Maceyka, G. M. Strub, K. B. Harikumar, S. K. Singh, C. Luo, R. Marmorstein, T. Kordula, S. Milstien and S. Spiegel: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science, 325, 1254-7 (2009)
52. Aronova, S., K. Wedaman, P. A. Aronov, K. Fontes, K. Ramos, B. D. Hammock and T. Powers: Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab, 7, 148-58 (2008) (Pubitemid 351168557)
53. Mousley, C. J., K. Tyeryar, K. E. Ile, G. Schaaf, R. L. Brost, C. Boone, X. Guan, M. R. Wenk and V. A. Bankaitis: Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast. Mol Biol Cell, 19, 4785-803 (2008)
54. Nickels, J. T. and J. R. Broach: A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev, 10, 382-94 (1996)
55. Wells, G. B., R. C. Dickson and R. L. Lester: Heatinduced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J Biol Chem, 273, 7235-43 (1998) (Pubitemid 28152740)
56. Fishbein, J. D., R. T. Dobrowsky, A. Bielawska, S. Garrett and Y. A. Hannun: Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem, 268, 9255-61 (1993) (Pubitemid 23145968)
57. Kunz, J., R. Henriquez, U. Schneider, M. Deuter-Reinhard, N. R. Movva and M. N. Hall: Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell, 73, 585-96 (1993) (Pubitemid 23143356)
58. Loewith, R., E. Jacinto, S. Wullschleger, A. Lorberg, J. L. Crespo, D. Bonenfant, W. Oppliger, P. Jenoe and M. N. Hall: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell, 10, 457-68 (2002) (Pubitemid 35284167)
59. De Virgilio, C. and R. Loewith: The TOR signalling network from yeast to man. Int J Biochem Cell Biol, 38, 1476-81 (2006) (Pubitemid 43729300)
60. Laplante, M. and D. M. Sabatini: An emerging role of mTOR in lipid biosynthesis. Curr Biol, 19, R1046-52 (2009)
61. Wullschleger, S., R. Loewith and M. N. Hall: TOR signaling in growth and metabolism. Cell, 124, 471-84 (2006) (Pubitemid 43199434)
62. Mulet, J. M., D. E. Martin, R. Loewith and M. N. Hall: Mutual antagonism of target of rapamycin and calcineurin signaling. J Biol Chem, 281, 33000-7 (2006) (Pubitemid 46043258)
63. Bultynck, G., V. L. Heath, A. P. Majeed, J. M. Galan, R. Haguenauer-Tsapis and M. S. Cyert: Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease. Mol Cell Biol, 26, 4729-45 (2006) (Pubitemid 43877588)
64. Tabuchi, M., A. Audhya, A. B. Parsons, C. Boone and S. D. Emr: The phosphatidylinositol 4, 5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol, 26, 5861-75 (2006) (Pubitemid 44134340)
65. Audhya, A., R. Loewith, A. B. Parsons, L. Gao, M. Tabuchi, H. Zhou, C. Boone, M. N. Hall and S. D. Emr: Genome-wide lethality screen identifies new PI4, 5P2 effectors that regulate the actin cytoskeleton. EMBO J, 23, 3747-57 (2004) (Pubitemid 39389706)
66. Fadri, M., A. Daquinag, S. Wang, T. Xue and J. Kunz: The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4, 5-bisphosphate and TORC2. Mol Biol Cell, 16, 1883-900 (2005) (Pubitemid 40471957)
67. Wiederkehr, A., K. D. Meier and H. Riezman: Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast, 18, 759-73 (2001) (Pubitemid 32590973)
68. Avaro, S., N. Belgareh-Touze, C. Sibella-Arguelles, C. Volland and R. Haguenauer-Tsapis: Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants. Yeast, 19, 351-71 (2002) (Pubitemid 34211064)
69. Reggiori, F., E. Canivenc-Gansel and A. Conzelmann: Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. EMBO J, 16, 3506-18 (1997) (Pubitemid 27250046)
70. Horvath, A., C. Sutterlin, U. Manning-Krieg, N. R. Movva and H. Riezman: Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast. EMBO J, 13, 3687-95 (1994) (Pubitemid 24275014)
71. Watanabe, R., G. A. Castillon, A. Meury and H. Riezman: The presence of an ER exit signal determines the protein sorting upon ER exit in yeast. Biochem J, 414, 237-45 (2008)
72. Fujita, M. and Y. Jigami: Lipid remodeling of GPIanchored proteins and its function. Biochim Biophys Acta, 1780, 410-20 (2008) (Pubitemid 351381242)
73. Castillon, G. A., R. Watanabe, M. Taylor, T. M. Schwabe and H. Riezman: Concentration of GPI-anchored proteins upon ER exit in yeast. Traffic, 10, 186-200 (2009)
74. Rivier, A. S., G. A. Castillon, L. Michon, M. Fukasawa, M. Romanova-Michaelides, N. Jaensch, K. Hanada and R. Watanabe: Exit of GPI-anchored proteins from the ER differs in yeast and mammalian cells. Traffic, 11, 1017-33 (2010)
75. Fujita, M., Y. Maeda, M. Ra, Y. Yamaguchi, R. Taguchi and T. Kinoshita: GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. Cell, 139, 352-65 (2009)
76. Bessler, M., P. J. Mason, P. Hillmen, T. Miyata, N. Yamada, J. Takeda, L. Luzzatto and T. Kinoshita: Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene. EMBO J, 13, 110-7 (1994)
77. Herrero, A. B., A. M. Astudillo, M. A. Balboa, C. Cuevas, J. Balsinde and S. Moreno: Levels of SCS7/FA2Hmediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734. Cancer Res, 68, 9779-87 (2008)
78. Matmati, N., H. Kitagaki, D. Montefusco, B. K. Mohanty and Y. A. Hannun: Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M. J Biol Chem, 284, 8241-6 (2009)
79. Almeida, T., M. Marques, D. Mojzita, M. A. Amorim, R. D. Silva, B. Almeida, P. Rodrigues, P. Ludovico, S. Hohmann, P. Moradas-Ferreira, M. Corte-Real and V. Costa: Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. Mol Biol Cell, 19, 865-76 (2008) (Pubitemid 351481804)
80. Betz, C., D. Zajonc, M. Moll and E. Schweizer: ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. Eur J Biochem, 269, 4033-9 (2002) (Pubitemid 34994898)
81. Watanabe, R., K. Funato, K. Venkataraman, A. H. Futerman and H. Riezman: Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. J Biol Chem, 277, 49538-44 (2002) (Pubitemid 36014392)
82. de Nobel, H. and P. N. Lipke: Is there a role for GPIs in yeast cell-wall assembly? Trends Cell Biol, 4, 42-5 (1994) (Pubitemid 24052969)
83. Lauwers, E., G. Grossmann and B. Andre: Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination. Mol Biol Cell, 18, 3068-80 (2007) (Pubitemid 47235312)
84. Baxter, B. K., L. DiDone, D. Ogu, S. Schor and D. J. Krysan: Identification, in vitro activity and mode of action of phosphoinositide- dependent-1 kinase inhibitors as antifungal molecules. ACS Chem Biol, 6, 502-10 (2011)
85. Kajiwara, K., R. Watanabe, H. Pichler, K. Ihara, S. Murakami, H. Riezman and K. Funato: Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Mol Biol Cell, 19, 2069-82 (2008)
86. Swain, E., J. Stukey, V. McDonough, M. Germann, Y. Liu, S. L. Sturley and J. T. Nickels, Jr.: Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem, 277, 36152-60 (2002)
87. Tinkelenberg, A. H., Y. Liu, F. Alcantara, S. Khan, Z. Guo, M. Bard and S. L. Sturley: Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem, 275, 40667-70 (2000) (Pubitemid 32054882)
88. Lisman, Q., D. Urli-Stam and J. C. Holthuis: HOR7, a multicopy suppressor of the Ca2+-induced growth defect in sphingolipid mannosyltransferase-deficient yeast. J Biol Chem, 279, 36390-6 (2004) (Pubitemid 39128977)
89. Cerbon, J., A. Falcon, C. Hernandez-Luna and D. Segura-Cobos: Inositol phosphoceramide synthase is a regulator of intracellular levels of diacylglycerol and ceramide during the G1 to S transition in Saccharomyces cerevisiae. Biochem J, 388, 169-76 (2005) (Pubitemid 40732944)
90. Zink, S., C. Mehlgarten, H. K. Kitamoto, J. Nagase, D. Jablonowski, R. C. Dickson, M. J. Stark and R. Schaffrath: Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin. Eukaryot Cell, 4, 879-89 (2005) (Pubitemid 40697752)
91. Brice, S. E., C. W. Alford and L. A. Cowart: Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae. J Biol Chem, 284, 7588-96 (2009)
92. Guan, X. L., C. M. Souza, H. Pichler, G. Dewhurst, O. Schaad, K. Kajiwara, H. Wakabayashi, T. Ivanova, G. A. Castillon, M. Piccolis, F. Abe, R. Loewith, K. Funato, M. R. Wenk and H. Riezman: Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell, 20, 2083-95 (2009)
93. Wanke, V., E. Cameroni, A. Uotila, M. Piccolis, J. Urban, R. Loewith and C. De Virgilio: Caffeine extends yeast lifespan by targeting TORC1. Mol Microbiol, 69, 277-85 (2008) (Pubitemid 351832771)
94. Gelperin, D., L. Horton, A. DeChant, J. Hensold and S. K. Lemmon: Loss of ypk1 function causes rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast. Genetics, 161, 1453-64 (2002) (Pubitemid 35014748)
95. Dickson, R. C.: Roles for sphingolipids in Saccharomyces cerevisiae. Adv Exp Med Biol, 688, 217-31 (2010)
96. Alvarez-Vasquez, F., K. J. Sims, L. A. Cowart, Y. Okamoto, E. O. Voit and Y. A. Hannun: Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature, 433, 425-30 (2005) (Pubitemid 40203323)
97. Nookaew, I., M. C. Jewett, A. Meechai, C. Thammarongtham, K. Laoteng, S. Cheevadhanarak, J. Nielsen and S. Bhumiratana: The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism. BMC Syst Biol, 2, 71 (2008)
98. Dobson, P. D., K. Smallbone, D. Jameson, E. Simeonidis, K. Lanthaler, P. Pir, C. Lu, N. Swainston, W. B. Dunn, P. Fisher, D. Hull, M. Brown, O. Oshota, N. J. Stanford, D. B. Kell, R. D. King, S. G. Oliver, R. D. Stevens and P. Mendes: Further developments towards a genome-scale metabolic model of yeast. BMC Syst Biol, 4, 145 (2010)
99. Kemmer, D., L. M. McHardy, S. Hoon, D. Reberioux, G. Giaever, C. Nislow, C. D. Roskelley and M. Roberge: Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. BMC Microbiol, 9, 9 (2009)
100. Cowart, L. A., M. Shotwell, M. L. Worley, A. J. Richards, D. J. Montefusco, Y. A. Hannun and X. Lu: Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol, 6, 349 (2010)
101. Baetz, K., L. McHardy, K. Gable, T. Tarling, D. Reberioux, J. Bryan, R. J. Andersen, T. Dunn, P. Hieter and M. Roberge: Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action. Proc Natl Acad Sci U S A, 101, 4525-30 (2004) (Pubitemid 38437444)
102. Ericson, E., M. Gebbia, L. E. Heisler, J. Wildenhain, M. Tyers, G. Giaever and C. Nislow: Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS Genet, 4, e1000151 (2008)
103. Heinisch, J. J.: Baker's yeast as a tool for the development of antifungal kinase inhibitors-targeting protein kinase C and the cell integrity pathway. Biochim Biophys Acta, 1754, 171-82 (2005) (Pubitemid 41799604)