Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons

Neurobiology of Disease

Volumn 41, Issue 1, 2011, Pages 209-218

  Klein, Andres ^a   Maldonado, Carola ^a   Vargas, Lina M ^b   Gonzalez, Marcela ^a   Robledo, Fermín ^a   Perez de Arce, Karen ^b   Muñoz, Francisco J ^c   Hetz, Claudio ^d,e   Alvarez, Alejandra R ^b   Zanlungo, Silvana ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d UNIVERSITY OF CHILE   (Chile)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Apoptosis; C Abl p73; Neurodegeneration; Niemann Pick type C; Oxidative stress

Indexed keywords

3 NITROTYROSINE; ABELSON KINASE; ACETYLCYSTEINE; IMATINIB; PROTEIN P73;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EMBRYO; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL; NIEMANN PICK DISEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOWN-REGULATION; MICE; MICE, INBRED BALB C; NEURONS; NIEMANN-PICK DISEASE, TYPE C; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-ABL; RATS; RATS, SPRAGUE-DAWLEY; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 78349306067     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.09.008     Document Type: Article

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