메뉴 건너뛰기




Volumn 18, Issue 8, 2010, Pages 1054-1065

Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism

Author keywords

Cellbio; Proteins

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LYASE; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; UNCLASSIFIED DRUG;

EID: 77955508596     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2010.05.011     Document Type: Article
Times cited : (68)

References (63)
  • 3
    • 37249006747 scopus 로고    scopus 로고
    • A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity
    • Bandhuvula P., Fyrst H., Saba J.D. A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity. J. Lipid Res. 2007, 48:2769-2778.
    • (2007) J. Lipid Res. , vol.48 , pp. 2769-2778
    • Bandhuvula, P.1    Fyrst, H.2    Saba, J.D.3
  • 4
    • 34247617182 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren
    • Bandhuvula P., Saba J.D. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. Trends Mol. Med. 2007, 13:210-217.
    • (2007) Trends Mol. Med. , vol.13 , pp. 210-217
    • Bandhuvula, P.1    Saba, J.D.2
  • 5
    • 60349119099 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate
    • Bandhuvula P., Li Z., Bittman R., Saba J.D. Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. Biochem. Biophys. Res. Commun. 2009, 380:366-370.
    • (2009) Biochem. Biophys. Res. Commun. , vol.380 , pp. 366-370
    • Bandhuvula, P.1    Li, Z.2    Bittman, R.3    Saba, J.D.4
  • 6
    • 65549171632 scopus 로고    scopus 로고
    • Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity
    • Bedia C., Camacho L., Casas J., Abad J.L., Delgado A., Van Veldhoven P.P., Fabriàs G. Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. ChemBioChem 2009, 10:820-822.
    • (2009) ChemBioChem , vol.10 , pp. 820-822
    • Bedia, C.1    Camacho, L.2    Casas, J.3    Abad, J.L.4    Delgado, A.5    Van Veldhoven, P.P.6    Fabriàs, G.7
  • 7
    • 77955489182 scopus 로고    scopus 로고
    • Questioning the Sphinx: structural and functional studies of sphingosine-1-phosphate lyase. PhD thesis, Department of Biochemistry, University of Zurich, Zurich, Switzerland.
    • Bourquin, F. (2010). Questioning the Sphinx: structural and functional studies of sphingosine-1-phosphate lyase. PhD thesis, Department of Biochemistry, University of Zurich, Zurich, Switzerland.
    • (2010)
    • Bourquin, F.1
  • 9
    • 0041465717 scopus 로고    scopus 로고
    • Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase
    • Capitani G., De Biase D., Aurizi C., Gut H., Bossa F., Grutter M.G. Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase. EMBO J. 2003, 22:4027-4037.
    • (2003) EMBO J. , vol.22 , pp. 4027-4037
    • Capitani, G.1    De Biase, D.2    Aurizi, C.3    Gut, H.4    Bossa, F.5    Grutter, M.G.6
  • 12
    • 1242341176 scopus 로고    scopus 로고
    • Phosphate group binding "cup" of PLP-dependent and non-PLP-dependent enzymes: leitmotif and variations
    • Denesyuk A.I., Denessiouk K.A., Korpela T., Johnson M.S. Phosphate group binding "cup" of PLP-dependent and non-PLP-dependent enzymes: leitmotif and variations. Biochim. Biophys. Acta 2003, 1647:234-238.
    • (2003) Biochim. Biophys. Acta , vol.1647 , pp. 234-238
    • Denesyuk, A.I.1    Denessiouk, K.A.2    Korpela, T.3    Johnson, M.S.4
  • 13
    • 0013902457 scopus 로고
    • Conformation and reaction specificity in pyridoxal phosphate enzymes
    • Dunathan H.C. Conformation and reaction specificity in pyridoxal phosphate enzymes. Proc. Natl. Acad. Sci. USA 1966, 55:712-716.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.55 , pp. 712-716
    • Dunathan, H.C.1
  • 14
    • 2542449977 scopus 로고    scopus 로고
    • A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana
    • Dunn T.M., Lynch D.V., Michaelson L.V., Napier J.A. A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Ann. Bot. 2004, 93:483-497.
    • (2004) Ann. Bot. , vol.93 , pp. 483-497
    • Dunn, T.M.1    Lynch, D.V.2    Michaelson, L.V.3    Napier, J.A.4
  • 15
    • 3943113663 scopus 로고    scopus 로고
    • Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations
    • Eliot A.C., Kirsch J.F. Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations. Annu. Rev. Biochem. 2004, 73:383-415.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 383-415
    • Eliot, A.C.1    Kirsch, J.F.2
  • 18
    • 11144355672 scopus 로고    scopus 로고
    • Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes
    • Forrest M., Sun S.Y., Hajdu R., Bergstrom J., Card D., Doherty G., Hale J., Keohane C., Meyers C., Milligan J., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J. Pharmacol. Exp. Ther. 2004, 309:758-768.
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 758-768
    • Forrest, M.1    Sun, S.Y.2    Hajdu, R.3    Bergstrom, J.4    Card, D.5    Doherty, G.6    Hale, J.7    Keohane, C.8    Meyers, C.9    Milligan, J.10
  • 19
    • 50049122673 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight
    • Fyrst H., Saba J.D. Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. Biochim. Biophys. Acta 2008, 1781:448-458.
    • (2008) Biochim. Biophys. Acta , vol.1781 , pp. 448-458
    • Fyrst, H.1    Saba, J.D.2
  • 20
    • 70349588812 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments
    • García-Pacios M., Collado M.I., Busto J.V., Sot J., Alonso A., Arrondo J.L., Goñi F.M. Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments. Biophys. J. 2009, 97:1398-1407.
    • (2009) Biophys. J. , vol.97 , pp. 1398-1407
    • García-Pacios, M.1    Collado, M.I.2    Busto, J.V.3    Sot, J.4    Alonso, A.5    Arrondo, J.L.6    Goñi, F.M.7
  • 22
    • 33745752814 scopus 로고    scopus 로고
    • Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB
    • Gut H., Pennacchietti E., John R.A., Bossa F., Capitani G., De Biase D., Grutter M.G. Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB. EMBO J. 2006, 25:2643-2651.
    • (2006) EMBO J. , vol.25 , pp. 2643-2651
    • Gut, H.1    Pennacchietti, E.2    John, R.A.3    Bossa, F.4    Capitani, G.5    De Biase, D.6    Grutter, M.G.7
  • 26
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: lessons from sphingolipids
    • Hannun Y.A., Obeid L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 2008, 9:139-150.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 29
    • 7444239039 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol
    • Ikeda M., Kihara A., Igarashi Y. Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol. Biochem. Biophys. Res. Commun. 2004, 325:338-343.
    • (2004) Biochem. Biophys. Res. Commun. , vol.325 , pp. 338-343
    • Ikeda, M.1    Kihara, A.2    Igarashi, Y.3
  • 30
    • 70350047142 scopus 로고    scopus 로고
    • Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum
    • Ikushiro H., Islam M.M., Okamoto A., Hoseki J., Murakawa T., Fujii S., Miyahara I., Hayashi H. Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum. J. Biochem. 2009, 146:549-562.
    • (2009) J. Biochem. , vol.146 , pp. 549-562
    • Ikushiro, H.1    Islam, M.M.2    Okamoto, A.3    Hoseki, J.4    Murakawa, T.5    Fujii, S.6    Miyahara, I.7    Hayashi, H.8
  • 31
    • 0027879008 scopus 로고
    • Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
    • Kabsch W. Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J. Appl. Crystallogr. 1993, 26:795-800.
    • (1993) J. Appl. Crystallogr. , vol.26 , pp. 795-800
    • Kabsch, W.1
  • 32
    • 69149089682 scopus 로고    scopus 로고
    • Lyase to live by: sphingosine phosphate lyase as a therapeutic target
    • Kumar A., Saba J.D. Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin. Ther. Targets 2009, 13:1013-1025.
    • (2009) Expert Opin. Ther. Targets , vol.13 , pp. 1013-1025
    • Kumar, A.1    Saba, J.D.2
  • 33
    • 0027169515 scopus 로고
    • Main-chain bond lengths and bond angles in protein structures
    • Laskowski R.A., Moss D.S., Thornton J.M. Main-chain bond lengths and bond angles in protein structures. J. Mol. Biol. 1993, 231:1049-1067.
    • (1993) J. Mol. Biol. , vol.231 , pp. 1049-1067
    • Laskowski, R.A.1    Moss, D.S.2    Thornton, J.M.3
  • 34
    • 33846426122 scopus 로고    scopus 로고
    • Solving structures of protein complexes by molecular replacement with Phaser
    • McCoy A.J. Solving structures of protein complexes by molecular replacement with Phaser. Acta Crystallogr. D Biol. Crystallogr. 2007, 63:32-41.
    • (2007) Acta Crystallogr. D Biol. Crystallogr. , vol.63 , pp. 32-41
    • McCoy, A.J.1
  • 35
    • 0037591003 scopus 로고    scopus 로고
    • Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans
    • Mendel J., Heinecke K., Fyrst H., Saba J.D. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. J. Biol. Chem. 2003, 278:22341-22349.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22341-22349
    • Mendel, J.1    Heinecke, K.2    Fyrst, H.3    Saba, J.D.4
  • 36
    • 50649095750 scopus 로고    scopus 로고
    • Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro
    • Mukhopadhyay D., Howell K.S., Riezman H., Capitani G. Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro. J. Biol. Chem. 2008, 283:20159-20169.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20159-20169
    • Mukhopadhyay, D.1    Howell, K.S.2    Riezman, H.3    Capitani, G.4
  • 37
    • 56449128295 scopus 로고    scopus 로고
    • Degradation of sphingoid long-chain base 1-phosphates (LCB-1Ps): functional characterization and expression of AtDPL1 encoding LCB-1P lyase involved in the dehydration stress response in Arabidopsis
    • Nishikawa M., Hosokawa K., Ishiguro M., Minamioka H., Tamura K., Hara-Nishimura I., Takahashi Y., Shimazaki K., Imai H. Degradation of sphingoid long-chain base 1-phosphates (LCB-1Ps): functional characterization and expression of AtDPL1 encoding LCB-1P lyase involved in the dehydration stress response in Arabidopsis. Plant Cell Physiol. 2008, 49:1758-1763.
    • (2008) Plant Cell Physiol. , vol.49 , pp. 1758-1763
    • Nishikawa, M.1    Hosokawa, K.2    Ishiguro, M.3    Minamioka, H.4    Tamura, K.5    Hara-Nishimura, I.6    Takahashi, Y.7    Shimazaki, K.8    Imai, H.9
  • 38
    • 34548388014 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis
    • Oskeritzian C.A., Milstien S., Spiegel S. Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacol. Ther. 2007, 115:390-399.
    • (2007) Pharmacol. Ther. , vol.115 , pp. 390-399
    • Oskeritzian, C.A.1    Milstien, S.2    Spiegel, S.3
  • 39
    • 3242656984 scopus 로고    scopus 로고
    • Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate
    • Oskouian B., Saba J.D. Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. Semin. Cell Dev. Biol. 2004, 15:529-540.
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 529-540
    • Oskouian, B.1    Saba, J.D.2
  • 41
    • 74549135806 scopus 로고    scopus 로고
    • Plant sphingolipids: decoding the enigma of the Sphinx
    • Pata M.O., Hannun Y.A., Ng C.K. Plant sphingolipids: decoding the enigma of the Sphinx. New Phytol. 2009, 185:611-630.
    • (2009) New Phytol. , vol.185 , pp. 611-630
    • Pata, M.O.1    Hannun, Y.A.2    Ng, C.K.3
  • 42
    • 67650567356 scopus 로고    scopus 로고
    • The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics
    • Raman M.C., Johnson K.A., Yard B.A., Lowther J., Carter L.G., Naismith J.H., Campopiano D.J. The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics. J. Biol. Chem. 2009, 284:17328-17339.
    • (2009) J. Biol. Chem. , vol.284 , pp. 17328-17339
    • Raman, M.C.1    Johnson, K.A.2    Yard, B.A.3    Lowther, J.4    Carter, L.G.5    Naismith, J.H.6    Campopiano, D.J.7
  • 43
    • 52949108813 scopus 로고    scopus 로고
    • The alliance of sphingosine-1-phosphate and its receptors in immunity
    • Rivera J., Proia R.L., Olivera A. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat. Rev. Immunol. 2008, 8:753-763.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 753-763
    • Rivera, J.1    Proia, R.L.2    Olivera, A.3
  • 44
    • 1842455323 scopus 로고    scopus 로고
    • Point-counterpoint of sphingosine 1-phosphate metabolism
    • Saba J.D., Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ. Res. 2004, 94:724-734.
    • (2004) Circ. Res. , vol.94 , pp. 724-734
    • Saba, J.D.1    Hla, T.2
  • 45
    • 0030671394 scopus 로고    scopus 로고
    • The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase
    • Saba J.D., Nara F., Bielawska A., Garrett S., Hannun Y.A. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J. Biol. Chem. 1997, 272:26087-26090.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26087-26090
    • Saba, J.D.1    Nara, F.2    Bielawska, A.3    Garrett, S.4    Hannun, Y.A.5
  • 46
    • 0029361476 scopus 로고
    • Comparative protein modeling by satisfaction of spatial restraints
    • Sali A. Comparative protein modeling by satisfaction of spatial restraints. Mol. Med. Today 1995, 1:270-277.
    • (1995) Mol. Med. Today , vol.1 , pp. 270-277
    • Sali, A.1
  • 47
  • 48
    • 36248956701 scopus 로고    scopus 로고
    • Finding a way out: lymphocyte egress from lymphoid organs
    • Schwab S.R., Cyster J.G. Finding a way out: lymphocyte egress from lymphoid organs. Nat. Immunol. 2007, 8:1295-1301.
    • (2007) Nat. Immunol. , vol.8 , pp. 1295-1301
    • Schwab, S.R.1    Cyster, J.G.2
  • 49
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab S.R., Pereira J.P., Matloubian M., Xu Y., Huang Y., Cyster J.G. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005, 309:1735-1739.
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1    Pereira, J.P.2    Matloubian, M.3    Xu, Y.4    Huang, Y.5    Cyster, J.G.6
  • 50
    • 67650106540 scopus 로고    scopus 로고
    • Multifunctional role of his159in the catalytic reaction of serine palmitoyltransferase
    • Shiraiwa Y., Ikushiro H., Hayashi H. Multifunctional role of his159in the catalytic reaction of serine palmitoyltransferase. J. Biol. Chem. 2009, 284:15487-15495.
    • (2009) J. Biol. Chem. , vol.284 , pp. 15487-15495
    • Shiraiwa, Y.1    Ikushiro, H.2    Hayashi, H.3
  • 51
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: an enigmatic signalling lipid
    • Spiegel S., Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 2003, 4:397-407.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 52
    • 0014365904 scopus 로고
    • Metabolism of sphingosine bases. IX. Degradation in vitro of dihydrospingosine and dihydrospingosine phosphate to palmitaldehyde and ethanolamine phosphate
    • Stoffel W., Sticht G., LeKim D. Metabolism of sphingosine bases. IX. Degradation in vitro of dihydrospingosine and dihydrospingosine phosphate to palmitaldehyde and ethanolamine phosphate. Hoppe Seylers Z. Physiol. Chem. 1968, 349:1745-1748.
    • (1968) Hoppe Seylers Z. Physiol. Chem. , vol.349 , pp. 1745-1748
    • Stoffel, W.1    Sticht, G.2    LeKim, D.3
  • 53
    • 46949104885 scopus 로고    scopus 로고
    • "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
    • Takabe K., Paugh S.W., Milstien S., Spiegel S. "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol. Rev. 2008, 60:181-195.
    • (2008) Pharmacol. Rev. , vol.60 , pp. 181-195
    • Takabe, K.1    Paugh, S.W.2    Milstien, S.3    Spiegel, S.4
  • 54
    • 9744235147 scopus 로고    scopus 로고
    • Reaction specificity in pyridoxal phosphate enzymes
    • Toney M.D. Reaction specificity in pyridoxal phosphate enzymes. Arch. Biochem. Biophys. 2005, 433:279-287.
    • (2005) Arch. Biochem. Biophys. , vol.433 , pp. 279-287
    • Toney, M.D.1
  • 57
    • 0025743953 scopus 로고
    • Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver
    • Van Veldhoven P.P., Mannaerts G.P. Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. J. Biol. Chem. 1991, 266:12502-12507.
    • (1991) J. Biol. Chem. , vol.266 , pp. 12502-12507
    • Van Veldhoven, P.P.1    Mannaerts, G.P.2
  • 59
    • 0034721549 scopus 로고    scopus 로고
    • Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)
    • Van Veldhoven P.P., Gijsbers S., Mannaerts G.P., Vermeesch J.R., Brys V. Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1). Biochim. Biophys. Acta 2000, 1487:128-134.
    • (2000) Biochim. Biophys. Acta , vol.1487 , pp. 128-134
    • Van Veldhoven, P.P.1    Gijsbers, S.2    Mannaerts, G.P.3    Vermeesch, J.R.4    Brys, V.5
  • 61
    • 34250195015 scopus 로고    scopus 로고
    • The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis
    • Yard B.A., et al. The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. J. Mol. Biol. 2007, 370:870-886.
    • (2007) J. Mol. Biol. , vol.370 , pp. 870-886
    • Yard, B.A.1
  • 62
    • 0032567648 scopus 로고    scopus 로고
    • Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast
    • Zhou J., Saba J.D. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem. Biophys. Res. Commun. 1998, 242:502-507.
    • (1998) Biochem. Biophys. Res. Commun. , vol.242 , pp. 502-507
    • Zhou, J.1    Saba, J.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.