Yeast as a model organism

Science

Volumn 277, Issue 5330, 1997, Pages 1259-1260

  Botstein, David ^a   Chervitz, Steven A ^a   Cherry, J Michael ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; COLON CANCER; DNA SEQUENCE; EUKARYOTIC CELL; GENE MUTATION; GENOME; HUMAN; MAMMAL; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SEQUENCE TAGGED SITE; YEAST;

ANIMALS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA HELICASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENES, FUNGAL; HUMANS; MAMMALS; MUTS HOMOLOG 2 PROTEIN; PROTO-ONCOGENE PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; WERNER SYNDROME;

EID: 0030768919     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5330.1259     Document Type: Review

References (14)

1. Saccharomyces Genome Database (SGD) at http://genome-www.stanford.edu/Saccharomyces/; Yeast Genome from MIPS (Martinsried Institute for Protein Sequences) at http:// speedy.mips.biochem.mpg.de/mips/yeast/; Yeast Protein Database (YPD) at http:// www.proteome.com/YPDhome.html; A. Goffeau et al., Science 274, 546 (1996).
2. Saccharomyces Genome Database (SGD) at http://genome-www.stanford.edu/Saccharomyces/; Yeast Genome from MIPS (Martinsried Institute for Protein Sequences) at http:// speedy.mips.biochem.mpg.de/mips/yeast/; Yeast Protein Database (YPD) at http:// www.proteome.com/YPDhome.html; A. Goffeau et al., Science 274, 546 (1996).
3. Saccharomyces Genome Database (SGD) at http://genome-www.stanford.edu/Saccharomyces/; Yeast Genome from MIPS (Martinsried Institute for Protein Sequences) at http:// speedy.mips.biochem.mpg.de/mips/yeast/; Yeast Protein Database (YPD) at http:// www.proteome.com/YPDhome.html; A. Goffeau et al., Science 274, 546 (1996).
4. Saccharomyces Genome Database (SGD) at http://genome-www.stanford.edu/Saccharomyces/; Yeast Genome from MIPS (Martinsried Institute for Protein Sequences) at http:// speedy.mips.biochem.mpg.de/mips/yeast/; Yeast Protein Database (YPD) at http:// www.proteome.com/YPDhome.html; A. Goffeau et al., Science 274, 546 (1996).
5. D. Botstein and G. R. Fink, Science. 240, 1439 (1988).
6. T. Kataoka et al., Cell 40, 19 (1985).
7. BLASTP analysis were done between all yeast ORF translations and all unique protein sequences in the human, mouse, rat, cow, and sheep sequences in GenBank as of 22 July 1997. We used the BLOSUM62 substitution matrix and low-complexity filters seg and xnu. "Unknown function" means that the ORF had no entry in either the Gene_Product or Description fields within its SGD Locus page as of 30 July 1997. For all ORFs, 3783 (60.8%) have unknown function by this definition. BLASTP, version 2.0a, W. Gish, unpublished data; S. F. Altschul, W. Gish, W. Miller, E. W. Myers, D. J. Lipman, J. Mol. Biol. 215, 403 (1990).
8. BLASTP analysis were done between all yeast ORF translations and all unique protein sequences in the human, mouse, rat, cow, and sheep sequences in GenBank as of 22 July 1997. We used the BLOSUM62 substitution matrix and low-complexity filters seg and xnu. "Unknown function" means that the ORF had no entry in either the Gene_Product or Description fields within its SGD Locus page as of 30 July 1997. For all ORFs, 3783 (60.8%) have unknown function by this definition. BLASTP, version 2.0a, W. Gish, unpublished data; S. F. Altschul, W. Gish, W. Miller, E. W. Myers, D. J. Lipman, J. Mol. Biol. 215, 403 (1990).
9. For details, see http://genome-www.stanford.edu/ Saccharomyces/mammal/.
10. These data are in XREFdb from the National Center for Biotechnology Information at http:// www.ncbi.nlm.nih.gov/Bassett/cerevisiae/ index.html.
11. These data are in XREFdb at http:// www.ncbi.nlm.nih.gov/Bassett/Yeast/ PosiClonSceNew.html.
12. M. Strand, T. A. Prolla, R. M. Liskay, T. D. Petes, Nature 365, 274 (1993).
13. D. A. Sinclair, K. Mills, L. Guarente, Science 277, 1313 (1997).
14. The Saccharomyces Genome Database is supported by an NIH research resources grant (HG 01315).