Sphingolipid signaling mediates iron toxicity

Cell Metabolism

Volumn 16, Issue 1, 2012, Pages 90-96

  Lee, Yueh Jung ^a   Huang, Xinhe ^b   Kropat, Janette ^a   Henras, Anthony ^a,c   Merchant, Sabeeha S ^a   Dickson, Robert C ^b   Chanfreau, Guillaume F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; IRON; PROTEIN KINASE; PROTEIN ORM2P; PROTEIN PKH1P; PROTEIN YPK1P; SPHINGOLIPID; THERMOZYMOCIDIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; IRON OVERLOAD; LIPOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ANTIFUNGAL AGENTS; FATTY ACIDS, MONOUNSATURATED; GENE KNOCKOUT TECHNIQUES; GLYCOGEN SYNTHASE KINASE 3; IRON; MADS DOMAIN PROTEINS; MICROBIAL VIABILITY; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; TRANSCRIPTION FACTORS;

EID: 84863522393     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2012.06.004     Document Type: Article

References (38)

1. D.K. Breslow, and J.S. Weissman Membranes in balance: mechanisms of sphingolipid homeostasis Mol. Cell 40 2010 267 279
2. D.K. Breslow, S.R. Collins, B. Bodenmiller, R. Aebersold, K. Simons, A. Shevchenko, C.S. Ejsing, and J.S. Weissman Orm family proteins mediate sphingolipid homeostasis Nature 463 2010 1048 1053
3. O.S. Chen, and J. Kaplan CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation J. Biol. Chem. 275 2000 7626 7632
4. O.S. Chen, S. Hemenway, and J. Kaplan Genetic analysis of iron citrate toxicity in yeast: implications for mammalian iron homeostasis Proc. Natl. Acad. Sci. USA 99 2002 16922 16927
5. M. Colombini Ceramide channels and their role in mitochondria-mediated apoptosis Biochim. Biophys. Acta 1797 2010 1239 1244
6. L.A. Cowart, and L.M. Obeid Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function Biochim. Biophys. Acta 1771 2007 421 431
7. J.S. Cox, and P. Walter A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response Cell 87 1996 391 404
8. E. de Nadal, L. Casadomé, and F. Posas Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase Mol. Cell. Biol. 23 2003 229 237
9. A.K. deHart, J.D. Schnell, D.A. Allen, and L. Hicke The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast J. Cell Biol. 156 2002 241 248
10. R.C. Dickson Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast J. Lipid Res. 49 2008 909 921
11. R.C. Dickson, C. Sumanasekera, and R.L. Lester Functions and metabolism of sphingolipids in Saccharomyces cerevisiae Prog. Lipid Res. 45 2006 447 465
12. B. Fahrenkrog, U. Sauder, and U. Aebi The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis J. Cell Sci. 117 2004 115 126
13. G.C. Finnigan, M. Ryan, and T.H. Stevens A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae Genetics 187 2011 771 783
14. S. Friant, R. Lombardi, T. Schmelzle, M.N. Hall, and H. Riezman Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast EMBO J. 20 2001 6783 6792
15. A. Gardarin, S. Chédin, G. Lagniel, J.C. Aude, E. Godat, P. Catty, and J. Labarre Endoplasmic reticulum is a major target of cadmium toxicity in yeast Mol. Microbiol. 76 2010 1034 1048
16. S. Han, M.A. Lone, R. Schneiter, and A. Chang Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control Proc. Natl. Acad. Sci. USA 107 2010 5851 5856
17. M.W. Hentze, M.U. Muckenthaler, and N.C. Andrews Balancing acts: molecular control of mammalian iron metabolism Cell 117 2004 285 297
18. X. Huang, J. Liu, and R.C. Dickson Down-regulating sphingolipid synthesis increases yeast lifespan PLoS Genet. 8 2012 e1002493
19. J. Kropat, A. Hong-Hermesdorf, D. Casero, P. Ent, M. Castruita, M. Pellegrini, S.S. Merchant, and D. Malasarn A revised mineral nutrient supplement increases biomass and growth rate in Chlamydomonas reinhardtii Plant J. 66 2011 770 780
20. A. Lee, A.K. Henras, and G. Chanfreau Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae Mol. Cell 19 2005 39 51
21. R.L. Lester, and R.C. Dickson High-performance liquid chromatography analysis of molecular species of sphingolipid-related long chain bases and long chain base phosphates in Saccharomyces cerevisiae after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate Anal. Biochem. 298 2001 283 292
22. L. Li, O.S. Chen, D. McVey Ward, and J. Kaplan CCC1 is a transporter that mediates vacuolar iron storage in yeast J. Biol. Chem. 276 2001 29515 29519
23. Q. Liang, and B. Zhou Copper and manganese induce yeast apoptosis via different pathways Mol. Biol. Cell 18 2007 4741 4749
24. H. Lin, L. Li, X. Jia, D.M. Ward, and J. Kaplan Genetic and biochemical analysis of high iron toxicity in yeast: iron toxicity is due to the accumulation of cytosolic iron and occurs under both aerobic and anaerobic conditions J. Biol. Chem. 286 2011 3851 3862
25. K. Liu, X. Zhang, C. Sumanasekera, R.L. Lester, and R.C. Dickson Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae Biochem. Soc. Trans. 33 2005 1170 1173
26. F. Madeo, E. Herker, C. Maldener, S. Wissing, S. Lächelt, M. Herlan, M. Fehr, K. Lauber, S.J. Sigrist, S. Wesselborg, and K.U. Fröhlich A caspase-related protease regulates apoptosis in yeast Mol. Cell 9 2002 911 917
27. C.C. Philpott Iron uptake in fungi: a system for every source Biochim. Biophys. Acta 1763 2006 636 645
28. C.C. Philpott, J. Rashford, Y. Yamaguchi-Iwai, T.A. Rouault, A. Dancis, and R.D. Klausner Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast EMBO J. 17 1998 5026 5036
29. F.M. Roelants, P.D. Torrance, N. Bezman, and J. Thorner Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity Mol. Biol. Cell 13 2002 3005 3028
30. F.M. Roelants, A.G. Baltz, A.E. Trott, S. Fereres, and J. Thorner A protein kinase network regulates the function of aminophospholipid flippases Proc. Natl. Acad. Sci. USA 107 2010 34 39
31. F.M. Roelants, D.K. Breslow, A. Muir, J.S. Weissman, and J. Thorner Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae Proc. Natl. Acad. Sci. USA 108 2011 19222 19227
32. M. Shakoury-Elizeh, O. Protchenko, A. Berger, J. Cox, K. Gable, T.M. Dunn, W.A. Prinz, M. Bard, and C.C. Philpott Metabolic response to iron deficiency in Saccharomyces cerevisiae J. Biol. Chem. 285 2010 14823 14833
33. Y. Sun, Y. Miao, Y. Yamane, C. Zhang, K.M. Shokat, H. Takematsu, Y. Kozutsumi, and D.G. Drubin Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways Mol. Biol. Cell 23 2012 2388 2398
34. D. Touati Iron and oxidative stress in bacteria Arch. Biochem. Biophys. 373 2000 1 6
35. J.S. Valentine, D.L. Wertz, T.J. Lyons, L.L. Liou, J.J. Goto, and E.B. Gralla The dark side of dioxygen biochemistry Curr. Opin. Chem. Biol. 2 1998 253 262
36. M. Valko, H. Morris, and M.T. Cronin Metals, toxicity and oxidative stress Curr. Med. Chem. 12 2005 1161 1208
37. A. Van Ho, D.M. Ward, and J. Kaplan Transition metal transport in yeast Annu. Rev. Microbiol. 56 2002 237 261
38. N.Y. Villa, B.R. Kupchak, I. Garitaonandia, J.L. Smith, E. Alonso, C. Alford, L.A. Cowart, Y.A. Hannun, and T.J. Lyons Sphingolipids function as downstream effectors of a fungal PAQR Mol. Pharmacol. 75 2009 866 875