-
1
-
-
0022481133
-
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
-
Sen, R.; Baltimore, D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986, 46, 705-716
-
(1986)
Cell
, vol.46
, pp. 705-716
-
-
Sen, R.1
Baltimore, D.2
-
2
-
-
77957570183
-
Inhibiting NF-κB activation by small molecules as a therapeutic strategy
-
Gupta, S.C.; Sundaram, C.; Reuter, S.; Aggarwal, B.B. Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim. Biophys. Acta 2010, 1799, 775-787
-
(2010)
Biochim. Biophys. Acta
, vol.1799
, pp. 775-787
-
-
Gupta, S.C.1
Sundaram, C.2
Reuter, S.3
Aggarwal, B.B.4
-
3
-
-
85066057489
-
Roles of NF-κB in Cancer and inflammatory diseases and their therapeutic approaches
-
Park, M.H.; Hong, J.T. Roles of NF-κB in Cancer and inflammatory diseases and their therapeutic approaches. Cells 2016, 5, 15
-
(2016)
Cells
, vol.5
, pp. 15
-
-
Park, M.H.1
Hong, J.T.2
-
4
-
-
77954460424
-
A structural guide to proteins of the NF-κB signaling module
-
Huxford, T.; Ghosh, G. A structural guide to proteins of the NF-κB signaling module. Cold Spring Harb. Perspect. Biol. 2009, 1, a000075
-
(2009)
Cold Spring Harb. Perspect. Biol
, vol.1
-
-
Huxford, T.1
Ghosh, G.2
-
5
-
-
84880869807
-
The complexity of NF-κB signaling in inflammation and cancer
-
Hoesel, B.; Schmid, J.A. The complexity of NF-κB signaling in inflammation and cancer. Mol. Cancer 2013, 12, 86
-
(2013)
Mol. Cancer
, vol.12
, pp. 86
-
-
Hoesel, B.1
Schmid, J.A.2
-
6
-
-
84923683740
-
Tale of two transcription factors: NF-κB and HIF crosstalk
-
Bandarra, D.; Rocha, S. Tale of two transcription factors: NF-κB and HIF crosstalk. OA Mol. Cell Biol. 2013, 1, 6
-
(2013)
OA Mol. Cell Biol
, vol.1
, pp. 6
-
-
Bandarra, D.1
Rocha, S.2
-
7
-
-
84858735072
-
The noncanonical NF-κB pathway
-
Sun, S.C. The noncanonical NF-κB pathway. Immunol. Rev. 2012, 246, 125-140
-
(2012)
Immunol. Rev
, vol.246
, pp. 125-140
-
-
Sun, S.C.1
-
8
-
-
80051987703
-
Crosstalk in NF-κB signaling pathways
-
Oeckinghaus, A.; Hayden, M.S.; Ghosh, S. Crosstalk in NF-κB signaling pathways. Nat. Immunol. 2011, 12, 695-708
-
(2011)
Nat. Immunol
, vol.12
, pp. 695-708
-
-
Oeckinghaus, A.1
Hayden, M.S.2
Ghosh, S.3
-
9
-
-
33750466230
-
Introduction to NF-κB: Players, pathways, perspectives
-
Gilmore, T.D. Introduction to NF-κB: Players, pathways, perspectives. Oncogene 2006, 25, 6680-6684
-
(2006)
Oncogene
, vol.25
, pp. 6680-6684
-
-
Gilmore, T.D.1
-
10
-
-
77957252647
-
The IKK complex, a central regulator of NF-κB activation
-
Israel, A. The IKK complex, a central regulator of NF-κB activation. Cold Spring Harb. Perspect. Biol. 2010, 2, a000158
-
(2010)
Cold Spring Harb. Perspect. Biol
, vol.2
-
-
Israel, A.1
-
11
-
-
84923673640
-
The role of hypoxia in inflammatory disease (review)
-
Biddlestone, J.; Bandarra, D.; Rocha, S. The role of hypoxia in inflammatory disease (review). Int. J. Mol. Med. 2015, 35, 859-869
-
(2015)
Int. J. Mol. Med
, vol.35
, pp. 859-869
-
-
Biddlestone, J.1
Bandarra, D.2
Rocha, S.3
-
12
-
-
84960402826
-
NF-κB and HIF crosstalk in immune responses
-
D'Ignazio, L.; Bandarra, D.; Rocha, S. NF-κB and HIF crosstalk in immune responses. FEBS J. 2016, 283, 413-424
-
(2016)
FEBS J
, vol.283
, pp. 413-424
-
-
D'Ignazio, L.1
Bandarra, D.2
Rocha, S.3
-
13
-
-
79952284127
-
Weinberg, Hallmarks of cancer: The next generation
-
Hanahan, D.; Robert, A. Weinberg, Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Robert, A.2
-
14
-
-
84940523524
-
NF-κB, an active player in human cancers
-
Xia, Y.; Shen, S.; Verma, I.M. NF-κB, an active player in human cancers. Cancer Immunol. Res. 2014, 2, 823-830
-
(2014)
Cancer Immunol. Res
, vol.2
, pp. 823-830
-
-
Xia, Y.1
Shen, S.2
Verma, I.M.3
-
15
-
-
0036546501
-
NF-κB in cancer: From innocent bystander to major culprit
-
Karin, M.; Cao, Y.; Greten, F.R.; Li, Z.W. NF-κB in cancer: From innocent bystander to major culprit. Nat. Rev. Cancer 2002, 2, 301-310
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
16
-
-
0032588186
-
NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
-
Guttridge, D.C.; Albanese, C.; Reuther, J.Y.; Pestell, R.G.; Baldwin, A.S., Jr. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 1999, 19, 5785-5799
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 5785-5799
-
-
Guttridge, D.C.1
Albanese, C.2
Reuther, J.Y.3
Pestell, R.G.4
Baldwin, A.S.5
-
17
-
-
0029849620
-
Cancer cell cycles
-
Sherr, C.J. Cancer cell cycles. Science 1996, 274, 1672-1677
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
18
-
-
0033596121
-
Activators and target genes of Rel/NF-κB transcription factors
-
Pahl, H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 1999, 18, 6853-6866
-
(1999)
Oncogene
, vol.18
, pp. 6853-6866
-
-
Pahl, H.L.1
-
19
-
-
1842526076
-
Active repression of antiapoptotic gene expression by RelA(p65) NF-κ B
-
Campbell, J.K.; Rocha, S.; Perkins, N.D. Active repression of antiapoptotic gene expression by RelA(p65) NF-κ B. Mol. Cell 2004, 13, 853-865
-
(2004)
Mol. Cell
, vol.13
, pp. 853-865
-
-
Campbell, J.K.1
Rocha, S.2
Perkins, N.D.3
-
20
-
-
0036009115
-
NF-κB at the crossroads of life and death
-
Karin, M.; Lin, A. NF-κB at the crossroads of life and death. Nat. Immunol. 2002, 3, 221-227
-
(2002)
Nat. Immunol
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
21
-
-
0032954928
-
Transcriptional cross talk between NF-κB and p53
-
Webster, G.A.; Perkins, N.D. Transcriptional cross talk between NF-κB and p53. Mol. Cell. Biol. 1999, 19, 3485-3495
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 3485-3495
-
-
Webster, G.A.1
Perkins, N.D.2
-
22
-
-
0027097806
-
Interleukin-8 as amacrophage-derivedmediator of angiogenesis
-
Koch, A.E.; Polverini, P.J.; Kunkel, S.L.; Harlow, L.A.; DiPietro, L.A.; Elner, V.M.; Elner, S.G.; Strieter, R.M. Interleukin-8 as amacrophage-derivedmediator of angiogenesis. Science 1992, 258, 1798-1801
-
(1992)
Science
, vol.258
, pp. 1798-1801
-
-
Koch, A.E.1
Polverini, P.J.2
Kunkel, S.L.3
Harlow, L.A.4
DiPietro, L.A.5
Elner, V.M.6
Elner, S.G.7
Strieter, R.M.8
-
23
-
-
0034306969
-
Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
-
Huang, S.; Robinson, J.B.; Deguzman, A.; Bucana, C.D.; Fidler, I.J. Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res. 2000, 60, 5334-5339
-
(2000)
Cancer Res
, vol.60
, pp. 5334-5339
-
-
Huang, S.1
Robinson, J.B.2
Deguzman, A.3
Bucana, C.D.4
Fidler, I.J.5
-
24
-
-
85010764998
-
Colorectal Carcinoma: A general overview and future perspectives in colorectal cancer
-
Marmol, I.; Sanchez-de-Diego, C.; Pradilla Dieste, A.; Cerrada, E.; Rodriguez Yoldi, M.J. Colorectal Carcinoma: A general overview and future perspectives in colorectal cancer. Int. J. Mol. Sci. 2017, 18
-
(2017)
Int. J. Mol. Sci
, pp. 18
-
-
Marmol, I.1
Sanchez-de-Diego, C.2
Pradilla Dieste, A.3
Cerrada, E.4
Rodriguez Yoldi, M.J.5
-
25
-
-
84922485491
-
HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals
-
Bandarra, D.; Biddlestone, J.; Mudie, S.; Muller, H.A.; Rocha, S. HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals. Dis. Models Mech. 2015, 8, 169-181
-
(2015)
Dis. Models Mech
, vol.8
, pp. 169-181
-
-
Bandarra, D.1
Biddlestone, J.2
Mudie, S.3
Muller, H.A.4
Rocha, S.5
-
26
-
-
84862487817
-
Targeted genes and interacting proteins of hypoxia inducible factor-1
-
Liu, W.; Shen, S.M.; Zhao, X.Y.; Chen, G.Q. Targeted genes and interacting proteins of hypoxia inducible factor-1. Int. J. Biochem. Mol. Biol. 2012, 3, 165-178
-
(2012)
Int. J. Biochem. Mol. Biol
, vol.3
, pp. 165-178
-
-
Liu, W.1
Shen, S.M.2
Zhao, X.Y.3
Chen, G.Q.4
-
27
-
-
0032508674
-
Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-κB
-
Bond, M.; Fabunmi, R.P.; Baker, A.H.; Newby, A.C. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-κB. FEBS Lett. 1998, 435, 29-34
-
(1998)
FEBS Lett
, vol.435
, pp. 29-34
-
-
Bond, M.1
Fabunmi, R.P.2
Baker, A.H.3
Newby, A.C.4
-
28
-
-
77955544352
-
Correlation of NF-κB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma
-
Yan, M.; Xu, Q.; Zhang, P.; Zhou, X.J.; Zhang, Z.Y.; Chen, W.T. Correlation of NF-κB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma. BMC Cancer 2010, 10, 437
-
(2010)
BMC Cancer
, vol.10
, pp. 437
-
-
Yan, M.1
Xu, Q.2
Zhang, P.3
Zhou, X.J.4
Zhang, Z.Y.5
Chen, W.T.6
-
29
-
-
4344612243
-
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
-
Huber, M.A.; Azoitei, N.; Baumann, B.; Grunert, S.; Sommer, A.; Pehamberger, H.; Kraut, N.; Beug, H.; Wirth, T. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Investig. 2004, 114, 569-581
-
(2004)
J. Clin. Investig
, vol.114
, pp. 569-581
-
-
Huber, M.A.1
Azoitei, N.2
Baumann, B.3
Grunert, S.4
Sommer, A.5
Pehamberger, H.6
Kraut, N.7
Beug, H.8
Wirth, T.9
-
30
-
-
78149432308
-
Immune regulation of cancer
-
Disis, M.L. Immune regulation of cancer. J. Clin. Oncol. 2010, 28, 4531-4538
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 4531-4538
-
-
Disis, M.L.1
-
31
-
-
33846839443
-
Deletion of NEMO/IKK in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
-
Luedde, T.; Beraza, N.; Kotsikoris, V.; van Loo, G.; Nenci, A.; de Vos, R.; Roskams, T.; Trautwein, C.; Pasparakis, M. Deletion of NEMO/IKK in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007, 11, 119-132
-
(2007)
Cancer Cell
, vol.11
, pp. 119-132
-
-
Luedde, T.1
Beraza, N.2
Kotsikoris, V.3
van Loo, G.4
Nenci, A.5
de Vos, R.6
Roskams, T.7
Trautwein, C.8
Pasparakis, M.9
-
32
-
-
0033565763
-
Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-κB signaling
-
Van Hogerlinden, M.; Rozell, B.L.; Ahrlund-Richter, L.; Toftgard, R. Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-κB signaling. Cancer Res. 1999, 59, 3299-3303
-
(1999)
Cancer Res
, vol.59
, pp. 3299-3303
-
-
Van Hogerlinden, M.1
Rozell, B.L.2
Ahrlund-Richter, L.3
Toftgard, R.4
-
33
-
-
33645999706
-
NF-κB and IKK as therapeutic targets in cancer
-
Kim, H.J.; Hawke, N.; Baldwin, A.S. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ. 2006, 13, 738-747
-
(2006)
Cell Death Differ
, vol.13
, pp. 738-747
-
-
Kim, H.J.1
Hawke, N.2
Baldwin, A.S.3
-
34
-
-
66649127621
-
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
-
Compagno, M.; Lim, W.K.; Grunn, A.; Nandula, S.V.; Brahmachary, M.; Shen, Q.; Bertoni, F.; Ponzoni, M.; Scandurra, M.; Califano, A.; et al. Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma. Nature 2009, 459, 717-721
-
(2009)
Nature
, vol.459
, pp. 717-721
-
-
Compagno, M.1
Lim, W.K.2
Grunn, A.3
Nandula, S.V.4
Brahmachary, M.5
Shen, Q.6
Bertoni, F.7
Ponzoni, M.8
Scandurra, M.9
Califano, A.10
-
35
-
-
84896717297
-
B-cell lymphoma mutations: Improving diagnostics and enabling targeted therapies
-
Vaque, J.P.; Martinez, N.; Batlle-Lopez, A.; Perez, C.; Montes-Moreno, S.; Sanchez-Beato, M.; Piris, M.A. B-cell lymphoma mutations: Improving diagnostics and enabling targeted therapies. Haematologica 2014, 99, 222-231
-
(2014)
Haematologica
, vol.99
, pp. 222-231
-
-
Vaque, J.P.1
Martinez, N.2
Batlle-Lopez, A.3
Perez, C.4
Montes-Moreno, S.5
Sanchez-Beato, M.6
Piris, M.A.7
-
36
-
-
33947586159
-
Aberrant NF-κB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications
-
Jost, P.J.; Ruland, J. Aberrant NF-κB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications. Blood 2007, 109, 2700-2707
-
(2007)
Blood
, vol.109
, pp. 2700-2707
-
-
Jost, P.J.1
Ruland, J.2
-
37
-
-
84862818029
-
Somatic mutations in the notch, NF-κB, PIK3CA, and Hedgehog pathways in human breast cancers
-
Jiao, X.; Wood, L.D.; Lindman, M.; Jones, S.; Buckhaults, P.; Polyak, K.; Sukumar, S.; Carter, H.; Kim, D.; Karchin, R.; et al. Somatic mutations in the notch, NF-κB, PIK3CA, and Hedgehog pathways in human breast cancers. Genes Chromosom. Cancer 2012, 51, 480-489
-
(2012)
Genes Chromosom. Cancer
, vol.51
, pp. 480-489
-
-
Jiao, X.1
Wood, L.D.2
Lindman, M.3
Jones, S.4
Buckhaults, P.5
Polyak, K.6
Sukumar, S.7
Carter, H.8
Kim, D.9
Karchin, R.10
-
38
-
-
85008430551
-
High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer
-
Bennett, L.; Quinn, J.; McCall, P.; Mallon, E.A.; Horgan, P.G.; McMillan, D.C.; Paul, A.; Edwards, J. High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer. Int. J. Cancer 2017, 140, 1633-1644
-
(2017)
Int. J. Cancer
, vol.140
, pp. 1633-1644
-
-
Bennett, L.1
Quinn, J.2
McCall, P.3
Mallon, E.A.4
Horgan, P.G.5
McMillan, D.C.6
Paul, A.7
Edwards, J.8
-
39
-
-
65249141108
-
Constitutive NF-κB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth
-
Sakamoto, K.; Maeda, S.; Hikiba, Y.; Nakagawa, H.; Hayakawa, Y.; Shibata, W.; Yanai, A.; Ogura, K.; Omata, M. Constitutive NF-κB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin. Cancer Res. 2009, 15, 2248-2258
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 2248-2258
-
-
Sakamoto, K.1
Maeda, S.2
Hikiba, Y.3
Nakagawa, H.4
Hayakawa, Y.5
Shibata, W.6
Yanai, A.7
Ogura, K.8
Omata, M.9
-
40
-
-
4043088499
-
IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten, F.R.; Eckmann, L.; Greten, T.F.; Park, J.M.; Li, Z.W.; Egan, L.J.; Kagnoff, M.F.; Karin, M. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004, 118, 285-296
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
Eckmann, L.2
Greten, T.F.3
Park, J.M.4
Li, Z.W.5
Egan, L.J.6
Kagnoff, M.F.7
Karin, M.8
-
41
-
-
79955068704
-
NF-κB in lung cancer, a carcinogenesis mediator and a prevention and therapy target
-
Chen, W.; Li, Z.; Bai, L.; Lin, Y. NF-κB in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front. Biosci. 2011, 16, 1172-1185
-
(2011)
Front. Biosci
, vol.16
, pp. 1172-1185
-
-
Chen, W.1
Li, Z.2
Bai, L.3
Lin, Y.4
-
42
-
-
79751492851
-
NF-κB in the liver-Linking injury, fibrosis and hepatocellular carcinoma
-
Luedde, T.; Schwabe, R.F. NF-κB in the liver-Linking injury, fibrosis and hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 2011, 8, 108-118
-
(2011)
Nat. Rev. Gastroenterol. Hepatol
, vol.8
, pp. 108-118
-
-
Luedde, T.1
Schwabe, R.F.2
-
43
-
-
33644841576
-
NF-κB activation in melanoma
-
Ueda, Y.; Richmond, A. NF-κB activation in melanoma. Pigment Cell Res. 2006, 19, 112-124
-
(2006)
Pigment Cell Res
, vol.19
, pp. 112-124
-
-
Ueda, Y.1
Richmond, A.2
-
45
-
-
85014634179
-
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
-
Muz, B.; de la Puente, P.; Azab, F.; Azab, A.K. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia 2015, 3, 83-92
-
(2015)
Hypoxia
, vol.3
, pp. 83-92
-
-
Muz, B.1
de la Puente, P.2
Azab, F.3
Azab, A.K.4
-
47
-
-
34547153223
-
Gene regulation under low oxygen: Holding your breath for transcription
-
Rocha, S. Gene regulation under low oxygen: Holding your breath for transcription. Trends Biochem. Sci. 2007, 32, 389-397
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 389-397
-
-
Rocha, S.1
-
48
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
-
Talks, K.L.; Turley, H.; Gatter, K.C.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.; Harris, A.L. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 2000, 157, 411-421
-
(2000)
Am. J. Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
Harris, A.L.7
-
49
-
-
84994101177
-
Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)
-
Yang, S.L.; Wu, C.; Xiong, Z.F.; Fang, X. Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review). Mol. Med. Rep. 2015, 12, 2411-2416
-
(2015)
Mol. Med. Rep
, vol.12
, pp. 2411-2416
-
-
Yang, S.L.1
Wu, C.2
Xiong, Z.F.3
Fang, X.4
-
50
-
-
49649108032
-
Regulation of gene expression by hypoxia
-
Kenneth, N.S.; Rocha, S. Regulation of gene expression by hypoxia. Biochem. J. 2008, 414, 19-29
-
(2008)
Biochem. J
, vol.414
, pp. 19-29
-
-
Kenneth, N.S.1
Rocha, S.2
-
51
-
-
84655161946
-
HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression
-
Keith, B.; Johnson, R.S.; Simon, M.C. HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2011, 12, 9-22
-
(2011)
Nat. Rev. Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
52
-
-
84897042356
-
Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia
-
Zhang, P.; Yao, Q.; Lu, L.; Li, Y.; Chen, P.J.; Duan, C. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 2014, 6, 1110-1121
-
(2014)
Cell Rep
, vol.6
, pp. 1110-1121
-
-
Zhang, P.1
Yao, Q.2
Lu, L.3
Li, Y.4
Chen, P.J.5
Duan, C.6
-
53
-
-
84906939724
-
Cell cycle progression in response to oxygen levels
-
Ortmann, B.; Druker, J.; Rocha, S. Cell cycle progression in response to oxygen levels. Cell. Mol. Life Sci. 2014, 71, 3569-3582
-
(2014)
Cell. Mol. Life Sci
, vol.71
, pp. 3569-3582
-
-
Ortmann, B.1
Druker, J.2
Rocha, S.3
-
55
-
-
84920856112
-
Hypoxia-inducible factor 1 and breast cancer metastasis
-
Liu, Z.J.; Semenza, G.L.; Zhang, H.F. Hypoxia-inducible factor 1 and breast cancer metastasis. J. Zhejiang Univ. Sci. B 2015, 16, 32-43
-
(2015)
J. Zhejiang Univ. Sci. B
, vol.16
, pp. 32-43
-
-
Liu, Z.J.1
Semenza, G.L.2
Zhang, H.F.3
-
56
-
-
0029004775
-
Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation
-
Takeuchi, T.; Yamazaki, Y.; Katoh-Fukui, Y.; Tsuchiya, R.; Kondo, S.; Motoyama, J.; Higashinakagawa, T. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 1995, 9, 1211-1222
-
(1995)
Genes Dev
, vol.9
, pp. 1211-1222
-
-
Takeuchi, T.1
Yamazaki, Y.2
Katoh-Fukui, Y.3
Tsuchiya, R.4
Kondo, S.5
Motoyama, J.6
Higashinakagawa, T.7
-
57
-
-
84907347748
-
Chromatin and oxygen sensing in the context of JmjC histone demethylases
-
Shmakova, A.; Batie, M.; Druker, J.; Rocha, S. Chromatin and oxygen sensing in the context of JmjC histone demethylases. Biochem. J. 2014, 462, 385-395
-
(2014)
Biochem. J
, vol.462
, pp. 385-395
-
-
Shmakova, A.1
Batie, M.2
Druker, J.3
Rocha, S.4
-
58
-
-
0037449811
-
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 α
-
Elkins, J.M.; Hewitson, K.S.; McNeill, L.A.; Seibel, J.F.; Schlemminger, I.; Pugh, C.W.; Ratcliffe, P.J.; Schofield, C.J. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 α. J. Biol. Chem. 2003, 278, 1802-1806
-
(2003)
J. Biol. Chem
, vol.278
, pp. 1802-1806
-
-
Elkins, J.M.1
Hewitson, K.S.2
McNeill, L.A.3
Seibel, J.F.4
Schlemminger, I.5
Pugh, C.W.6
Ratcliffe, P.J.7
Schofield, C.J.8
-
59
-
-
17644392469
-
Methylation: Lost in hydroxylation
-
Trewick, S.C.; McLaughlin, P.J.; Allshire, R.C. Methylation: Lost in hydroxylation? EMBO Rep. 2005, 6, 315-320
-
(2005)
EMBO Rep
, vol.6
, pp. 315-320
-
-
Trewick, S.C.1
McLaughlin, P.J.2
Allshire, R.C.3
-
60
-
-
84871433719
-
Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase
-
Sanchez-Fernandez, E.M.; Tarhonskaya, H.; Al-Qahtani, K.; Hopkinson, R.J.; McCullagh, J.S.; Schofield, C.J.; Flashman, E. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. Biochem. J. 2013, 449, 491-496
-
(2013)
Biochem. J
, vol.449
, pp. 491-496
-
-
Sanchez-Fernandez, E.M.1
Tarhonskaya, H.2
Al-Qahtani, K.3
Hopkinson, R.J.4
McCullagh, J.S.5
Schofield, C.J.6
Flashman, E.7
-
61
-
-
85018461057
-
The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations
-
Hancock, R.L.; Masson, N.; Dunne, K.; Flashman, E.; Kawamura, A. The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations. ACS Chem. Biol. 2017, 12, 1011
-
(2017)
ACS Chem. Biol
, vol.12
, pp. 1011
-
-
Hancock, R.L.1
Masson, N.2
Dunne, K.3
Flashman, E.4
Kawamura, A.5
-
62
-
-
40649114443
-
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
-
Johnson, A.B.; Denko, N.; Barton, M.C. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat. Res. 2008, 640, 174-179
-
(2008)
Mutat. Res
, vol.640
, pp. 174-179
-
-
Johnson, A.B.1
Denko, N.2
Barton, M.C.3
-
63
-
-
77952795537
-
Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
-
Zhou, X.; Sun, H.; Chen, H.; Zavadil, J.; Kluz, T.; Arita, A.; Costa, M. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res. 2010, 70, 4214-4221
-
(2010)
Cancer Res
, vol.70
, pp. 4214-4221
-
-
Zhou, X.1
Sun, H.2
Chen, H.3
Zavadil, J.4
Kluz, T.5
Arita, A.6
Costa, M.7
-
64
-
-
78651086487
-
Hypoxia causes epigenetic gene regulation in macrophages by attenuating jumonji histone demethylase activity
-
Tausendschon, M.; Dehne, N.; Brune, B. Hypoxia causes epigenetic gene regulation in macrophages by attenuating jumonji histone demethylase activity. Cytokine 2011, 53, 256-262
-
(2011)
Cytokine
, vol.53
, pp. 256-262
-
-
Tausendschon, M.1
Dehne, N.2
Brune, B.3
-
65
-
-
84992346873
-
Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
-
Prickaerts, P.; Adriaens, M.E.; Beucken, T.V.; Koch, E.; Dubois, L.; Dahlmans, V.E.; Gits, C.; Evelo, C.T.; Chan-Seng-Yue, M.;Wouters, B.G.; et al. Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3. Epigenet. Chromatin 2016, 9, 46
-
(2016)
Epigenet. Chromatin
, vol.9
, pp. 46
-
-
Prickaerts, P.1
Adriaens, M.E.2
Beucken, T.V.3
Koch, E.4
Dubois, L.5
Dahlmans, V.E.6
Gits, C.7
Evelo, C.T.8
Chan-Seng-Yue, M.9
Wouters, B.G.10
-
66
-
-
61349088682
-
The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF
-
Beyer, S.; Kristensen, M.M.; Jensen, K.S.; Johansen, J.V.; Staller, P. The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J. Biol. Chem. 2008, 283, 36542-36552
-
(2008)
J. Biol. Chem
, vol.283
, pp. 36542-36552
-
-
Beyer, S.1
Kristensen, M.M.2
Jensen, K.S.3
Johansen, J.V.4
Staller, P.5
-
67
-
-
58949097017
-
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
-
Pollard, P.J.; Loenarz, C.; Mole, D.R.; McDonough, M.A.; Gleadle, J.M.; Schofield, C.J.; Ratcliffe, P.J. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α. Biochem. J. 2008, 416, 387-394
-
(2008)
Biochem. J
, vol.416
, pp. 387-394
-
-
Pollard, P.J.1
Loenarz, C.2
Mole, D.R.3
McDonough, M.A.4
Gleadle, J.M.5
Schofield, C.J.6
Ratcliffe, P.J.7
-
68
-
-
45449110185
-
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
-
Wellmann, S.; Bettkober, M.; Zelmer, A.; Seeger, K.; Faigle, M.; Eltzschig, H.K.; Buhrer, C. Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem. Biophys. Res. Commun. 2008, 372, 892-897
-
(2008)
Biochem. Biophys. Res. Commun
, vol.372
, pp. 892-897
-
-
Wellmann, S.1
Bettkober, M.2
Zelmer, A.3
Seeger, K.4
Faigle, M.5
Eltzschig, H.K.6
Buhrer, C.7
-
69
-
-
73549088729
-
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 α enhances hypoxic gene expression and tumor growth
-
Krieg, A.J.; Rankin, E.B.; Chan, D.; Razorenova, O.; Fernandez, S.; Giaccia, A.J. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 α enhances hypoxic gene expression and tumor growth. Mol. Cell Biol. 2010, 30, 344-353
-
(2010)
Mol. Cell Biol
, vol.30
, pp. 344-353
-
-
Krieg, A.J.1
Rankin, E.B.2
Chan, D.3
Razorenova, O.4
Fernandez, S.5
Giaccia, A.J.6
-
70
-
-
84901424976
-
HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions
-
Lee, H.Y.; Choi, K.; Oh, H.; Park, Y.K.; Park, H. HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions. Mol. Cells 2014, 37, 43-50
-
(2014)
Mol. Cells
, vol.37
, pp. 43-50
-
-
Lee, H.Y.1
Choi, K.2
Oh, H.3
Park, Y.K.4
Park, H.5
-
71
-
-
85033567883
-
KDM2 Family Members are Regulated by HIF-1 in Hypoxia
-
Batie, M.; Druker, J.; D'Ignazio, L.; Rocha, S. KDM2 Family Members are Regulated by HIF-1 in Hypoxia. Cells 2017, 6, 8
-
(2017)
Cells
, vol.6
, pp. 8
-
-
Batie, M.1
Druker, J.2
D'Ignazio, L.3
Rocha, S.4
-
72
-
-
85117872385
-
Hypoxia Induced NF-κB
-
D'Ignazio, L.; Rocha, S. Hypoxia Induced NF-κB. Cells 2016, 5, 10
-
(2016)
Cells
, vol.5
, pp. 10
-
-
D'Ignazio, L.1
Rocha, S.2
-
73
-
-
84935878792
-
The impact of hypoxia on bacterial infection
-
Schaffer, K.; Taylor, C.T. The impact of hypoxia on bacterial infection. FEBS J. 2015, 282, 2260-2266
-
(2015)
FEBS J
, vol.282
, pp. 2260-2266
-
-
Schaffer, K.1
Taylor, C.T.2
-
74
-
-
84907646163
-
Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing
-
Scott, C.; Bonner, J.; Min, D.; Boughton, P.; Stokes, R.; Cha, K.M.; Walters, S.N.; Maslowski, K.; Sierro, F.; Grey, S.T.; et al. Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing. Am. J. Physiol. Cell Physiol. 2014, 307, C349-C357
-
(2014)
Am. J. Physiol. Cell Physiol
, vol.307
, pp. C349-C357
-
-
Scott, C.1
Bonner, J.2
Min, D.3
Boughton, P.4
Stokes, R.5
Cha, K.M.6
Walters, S.N.7
Maslowski, K.8
Sierro, F.9
Grey, S.T.10
-
75
-
-
84893091765
-
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
-
Thompson, A.A.; Elks, P.M.; Marriott, H.M.; Eamsamarng, S.; Higgins, K.R.; Lewis, A.; Williams, L.; Parmar, S.; Shaw, G.; McGrath, E.E.; et al. Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood 2014, 123, 366-376
-
(2014)
Blood
, vol.123
, pp. 366-376
-
-
Thompson, A.A.1
Elks, P.M.2
Marriott, H.M.3
Eamsamarng, S.4
Higgins, K.R.5
Lewis, A.6
Williams, L.7
Parmar, S.8
Shaw, G.9
McGrath, E.E.10
-
76
-
-
84897977203
-
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
-
Pawlus, M.R.;Wang, L.; Hu, C.J. STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2014, 33, 1670-1679
-
(2014)
Oncogene
, vol.33
, pp. 1670-1679
-
-
Pawlus, M.R.1
Wang, L.2
Hu, C.J.3
-
77
-
-
45349097483
-
Regulation of hypoxia-inducible factor-1α by NF-κB
-
Van Uden, P.; Kenneth, N.S.; Rocha, S. Regulation of hypoxia-inducible factor-1α by NF-κB. Biochem. J. 2008, 412, 477-484
-
(2008)
Biochem. J
, vol.412
, pp. 477-484
-
-
Van Uden, P.1
Kenneth, N.S.2
Rocha, S.3
-
78
-
-
79851471726
-
Evolutionary conserved regulation of HIF-1beta by NF-κB
-
van Uden, P.; Kenneth, N.S.;Webster, R.; Muller, H.A.; Mudie, S.; Rocha, S. Evolutionary conserved regulation of HIF-1beta by NF-κB. PLoS Genet. 2011, 7, e1001285
-
(2011)
PLoS Genet
, vol.7
-
-
van Uden, P.1
Kenneth, N.S.2
Webster, R.3
Muller, H.A.4
Mudie, S.5
Rocha, S.6
-
79
-
-
58149380071
-
The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-κB-dependent transcription
-
Wright, C.W.; Duckett, C.S. The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-κB-dependent transcription. Science 2009, 323, 251-255
-
(2009)
Science
, vol.323
, pp. 251-255
-
-
Wright, C.W.1
Duckett, C.S.2
-
80
-
-
17144420466
-
Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator
-
Bracken, C.P.; Whitelaw, M.L.; Peet, D.J. Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator. J. Biol. Chem. 2005, 280, 14240-14251
-
(2005)
J. Biol. Chem
, vol.280
, pp. 14240-14251
-
-
Bracken, C.P.1
Whitelaw, M.L.2
Peet, D.J.3
-
81
-
-
84955657303
-
HIF-1 at the crossroads of hypoxia, inflammation, and cancer
-
Balamurugan, K. HIF-1 at the crossroads of hypoxia, inflammation, and cancer. Int. J. Cancer 2016, 138, 1058-1066
-
(2016)
Int. J. Cancer
, vol.138
, pp. 1058-1066
-
-
Balamurugan, K.1
-
82
-
-
84905833585
-
Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis
-
Kim, E.R.; Chang, D.K. Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis. World J. Gastroenterol. 2014, 20, 9872-9881
-
(2014)
World J. Gastroenterol
, vol.20
, pp. 9872-9881
-
-
Kim, E.R.1
Chang, D.K.2
-
83
-
-
85013883423
-
Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils
-
Triner, D.; Xue, X.; Schwartz, A.J.; Jung, I.; Colacino, J.A.; Shah, Y.M. Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils. Mol. Cell. Biol. 2017, 37, e00481-16
-
(2017)
Mol. Cell. Biol
, vol.37
-
-
Triner, D.1
Xue, X.2
Schwartz, A.J.3
Jung, I.4
Colacino, J.A.5
Shah, Y.M.6
-
84
-
-
84991728255
-
Hypoxia-inducible factors: A central link between inflammation and cancer
-
Triner, D.; Shah, Y.M. Hypoxia-inducible factors: A central link between inflammation and cancer. J. Clin. Investig. 2016, 126, 3689-3698
-
(2016)
J. Clin. Investig
, vol.126
, pp. 3689-3698
-
-
Triner, D.1
Shah, Y.M.2
-
85
-
-
33749518516
-
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
-
Cockman, M.E.; Lancaster, D.E.; Stolze, I.P.; Hewitson, K.S.; McDonough, M.A.; Coleman, M.L.; Coles, C.H.; Yu, X.; Hay, R.T.; Ley, S.C.; et al. Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc. Natl. Acad. Sci. USA 2006, 103, 14767-14772
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14767-14772
-
-
Cockman, M.E.1
Lancaster, D.E.2
Stolze, I.P.3
Hewitson, K.S.4
McDonough, M.A.5
Coleman, M.L.6
Coles, C.H.7
Yu, X.8
Hay, R.T.9
Ley, S.C.10
-
86
-
-
84887501809
-
Regulation of IL-1beta-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways
-
Scholz, C.C.; Cavadas, M.A.; Tambuwala, M.M.;Hams, E.; Rodriguez, J.; von Kriegsheim, A.; Cotter, P.; Bruning, U.; Fallon, P.G.; Cheong, A.; et al. Regulation of IL-1beta-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc. Natl. Acad. Sci. USA 2013, 110, 18490-18495
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 18490-18495
-
-
Scholz, C.C.1
Cavadas, M.A.2
Tambuwala, M.M.3
Hams, E.4
Rodriguez, J.5
von Kriegsheim, A.6
Cotter, P.7
Bruning, U.8
Fallon, P.G.9
Cheong, A.10
-
87
-
-
84956807073
-
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
-
Scholz, C.C.; Rodriguez, J.; Pickel, C.; Burr, S.; Fabrizio, J.A.; Nolan, K.A.; Spielmann, P.; Cavadas, M.A.; Crifo, B.; Halligan, D.N.; et al. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. PLoS Biol. 2016, 14, e1002347
-
(2016)
PLoS Biol
, vol.14
-
-
Scholz, C.C.1
Rodriguez, J.2
Pickel, C.3
Burr, S.4
Fabrizio, J.A.5
Nolan, K.A.6
Spielmann, P.7
Cavadas, M.A.8
Crifo, B.9
Halligan, D.N.10
-
88
-
-
78649655806
-
Consequences of IκB α hydroxylation by the factor inhibiting HIF (FIH)
-
Devries, I.L.; Hampton-Smith, R.J.; Mulvihill, M.M.; Alverdi, V.; Peet, D.J.; Komives, E.A. Consequences of IκB α hydroxylation by the factor inhibiting HIF (FIH). FEBS Lett. 2010, 584, 4725-4730
-
(2010)
FEBS Lett
, vol.584
, pp. 4725-4730
-
-
Devries, I.L.1
Hampton-Smith, R.J.2
Mulvihill, M.M.3
Alverdi, V.4
Peet, D.J.5
Komives, E.A.6
-
89
-
-
70350373671
-
The role of NF-κB in hypoxia-induced gene expression
-
Taylor, C.T.; Cummins, E.P. The role of NF-κB in hypoxia-induced gene expression. Ann. N. Y. Acad. Sci. 2009, 1177, 178-184
-
(2009)
Ann. N. Y. Acad. Sci
, vol.1177
, pp. 178-184
-
-
Taylor, C.T.1
Cummins, E.P.2
-
90
-
-
79952672743
-
Further insights into the mechanism of hypoxia-induced NFκB
-
Melvin, A.; Mudie, S.; Rocha, S. Further insights into the mechanism of hypoxia-induced NFκB. Cell Cycle 2011, 10, 879-882
-
(2011)
Cell Cycle
, vol.10
, pp. 879-882
-
-
Melvin, A.1
Mudie, S.2
Rocha, S.3
-
91
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
-
Cummins, E.P.; Berra, E.; Comerford, K.M.; Ginouves, A.; Fitzgerald, K.T.; Seeballuck, F.; Godson, C.; Nielsen, J.E.; Moynagh, P.; Pouyssegur, J.; et al. Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity. Proc. Natl. Acad. Sci. USA 2006, 103, 18154-18159
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 18154-18159
-
-
Cummins, E.P.1
Berra, E.2
Comerford, K.M.3
Ginouves, A.4
Fitzgerald, K.T.5
Seeballuck, F.6
Godson, C.7
Nielsen, J.E.8
Moynagh, P.9
Pouyssegur, J.10
-
92
-
-
84904735527
-
Over-expression of prolyl hydroxylase-1 blocks NF-κB-mediated cyclin D1 expression and proliferation in lung carcinoma cells
-
Xie, X.; Xiao, H.; Ding, F.; Zhong, H.; Zhu, J.; Ma, N.; Mei, J. Over-expression of prolyl hydroxylase-1 blocks NF-κB-mediated cyclin D1 expression and proliferation in lung carcinoma cells. Cancer Genet. 2014, 207, 188-194
-
(2014)
Cancer Genet
, vol.207
, pp. 188-194
-
-
Xie, X.1
Xiao, H.2
Ding, F.3
Zhong, H.4
Zhu, J.5
Ma, N.6
Mei, J.7
-
93
-
-
77950565914
-
Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway
-
Fu, J.; Taubman, M.B. Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway. J. Biol. Chem. 2010, 285, 8927-8935
-
(2010)
J. Biol. Chem
, vol.285
, pp. 8927-8935
-
-
Fu, J.1
Taubman, M.B.2
-
94
-
-
84880658083
-
EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase gamma ubiquitination
-
Fu, J.; Taubman, M.B. EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase gamma ubiquitination. Mol. Cell. Biol. 2013, 33, 3050-3061
-
(2013)
Mol. Cell. Biol
, vol.33
, pp. 3050-3061
-
-
Fu, J.1
Taubman, M.B.2
-
95
-
-
80455122752
-
Macrophage skewing by PHD2 haplodeficiency prevents ischaemia by inducing arteriogenesis
-
Takeda, Y.; Costa, S.; Delamarre, E.; Roncal, C.; Leite de Oliveira, R.; Squadrito, M.L.; Finisguerra, V.; Deschoemaeker, S.; Bruyere, F.;Wenes, M.; et al. Macrophage skewing by PHD2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature 2011, 479, 122-126
-
(2011)
Nature
, vol.479
, pp. 122-126
-
-
Takeda, Y.1
Costa, S.2
Delamarre, E.3
Roncal, C.4
Leite de Oliveira, R.5
Squadrito, M.L.6
Finisguerra, V.7
Deschoemaeker, S.8
Bruyere, F.9
Wenes, M.10
-
96
-
-
84903769379
-
Prolyl hydroxylation by EGLN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
-
Zheng, X.; Zhai, B.; Koivunen, P.; Shin, S.J.; Lu, G.; Liu, J.; Geisen, C.; Chakraborty, A.A.; Moslehi, J.J.; Smalley, D.M.; et al. Prolyl hydroxylation by EGLN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev. 2014, 28, 1429-1444
-
(2014)
Genes Dev
, vol.28
, pp. 1429-1444
-
-
Zheng, X.1
Zhai, B.2
Koivunen, P.3
Shin, S.J.4
Lu, G.5
Liu, J.6
Geisen, C.7
Chakraborty, A.A.8
Moslehi, J.J.9
Smalley, D.M.10
-
97
-
-
84924873099
-
Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus
-
Li, J.; Yuan, W.; Jiang, S.; Ye, W.; Yang, H.; Shapiro, I.M.; Risbud, M.V. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. J. Biol. Chem. 2015, 290, 7195-7207
-
(2015)
J. Biol. Chem
, vol.290
, pp. 7195-7207
-
-
Li, J.1
Yuan, W.2
Jiang, S.3
Ye, W.4
Yang, H.5
Shapiro, I.M.6
Risbud, M.V.7
-
98
-
-
76249100563
-
Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65
-
Lu, T.; Jackson, M.W.; Wang, B.; Yang, M.; Chance, M.R.; Miyagi, M.; Gudkov, A.V.; Stark, G.R. Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc. Natl. Acad. Sci. USA 2010, 107, 46-51
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 46-51
-
-
Lu, T.1
Jackson, M.W.2
Wang, B.3
Yang, M.4
Chance, M.R.5
Miyagi, M.6
Gudkov, A.V.7
Stark, G.R.8
-
99
-
-
84882370181
-
Role of lysine methylation of NF-κB in differential gene regulation
-
Lu, T.; Yang, M.; Huang, D.B.;Wei, H.; Ozer, G.H.; Ghosh, G.; Stark, G.R. Role of lysine methylation of NF-κB in differential gene regulation. Proc. Natl. Acad. Sci. USA 2013, 110, 13510-13515
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 13510-13515
-
-
Lu, T.1
Yang, M.2
Huang, D.B.3
Wei, H.4
Ozer, G.H.5
Ghosh, G.6
Stark, G.R.7
-
100
-
-
73149099403
-
Regulation of NF-κB activity through lysine monomethylation of p65
-
Ea, C.K.; Baltimore, D. Regulation of NF-κB activity through lysine monomethylation of p65. Proc. Natl. Acad. Sci. USA 2009, 106, 18972-18977
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18972-18977
-
-
Ea, C.K.1
Baltimore, D.2
-
101
-
-
67349285384
-
Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunit
-
Yang, X.D.; Huang, B.; Li, M.; Lamb, A.; Kelleher, N.L.; Chen, L.F. Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J. 2009, 28, 1055-1066
-
(2009)
EMBO J
, vol.28
, pp. 1055-1066
-
-
Yang, X.D.1
Huang, B.2
Li, M.3
Lamb, A.4
Kelleher, N.L.5
Chen, L.F.6
-
102
-
-
78650308842
-
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling
-
Levy, D.; Kuo, A.J.; Chang, Y.; Schaefer, U.; Kitson, C.; Cheung, P.; Espejo, A.; Zee, B.M.; Liu, C.L.; Tangsombatvisit, S.; et al. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat. Immunol. 2011, 12, 29-36
-
(2011)
Nat. Immunol
, vol.12
, pp. 29-36
-
-
Levy, D.1
Kuo, A.J.2
Chang, Y.3
Schaefer, U.4
Kitson, C.5
Cheung, P.6
Espejo, A.7
Zee, B.M.8
Liu, C.L.9
Tangsombatvisit, S.10
-
103
-
-
79958797383
-
F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway
-
Ge, R.; Wang, Z.; Zeng, Q.; Xu, X.; Olumi, A.F. F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway. Cell Death Differ. 2011, 18, 1184-1195
-
(2011)
Cell Death Differ
, vol.18
, pp. 1184-1195
-
-
Ge, R.1
Wang, Z.2
Zeng, Q.3
Xu, X.4
Olumi, A.F.5
-
104
-
-
70350754328
-
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
-
De Santa, F.; Narang, V.; Yap, Z.H.; Tusi, B.K.; Burgold, T.; Austenaa, L.; Bucci, G.; Caganova, M.; Notarbartolo, S.; Casola, S.; et al. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J. 2009, 28, 3341-3352
-
(2009)
EMBO J
, vol.28
, pp. 3341-3352
-
-
De Santa, F.1
Narang, V.2
Yap, Z.H.3
Tusi, B.K.4
Burgold, T.5
Austenaa, L.6
Bucci, G.7
Caganova, M.8
Notarbartolo, S.9
Casola, S.10
-
105
-
-
84988939763
-
JMJD8 is a positive regulator of TNF-induced NF-κB signaling
-
Yeo, K.S.; Tan, M.C.; Wong, W.Y.; Loh, S.W.; Lam, Y.L.; Tan, C.L.; Lim, Y.Y.; Ea, C.K. JMJD8 is a positive regulator of TNF-induced NF-κB signaling. Sci. Rep. 2016, 6, 34125
-
(2016)
Sci. Rep
, vol.6
, pp. 34125
-
-
Yeo, K.S.1
Tan, M.C.2
Wong, W.Y.3
Loh, S.W.4
Lam, Y.L.5
Tan, C.L.6
Lim, Y.Y.7
Ea, C.K.8
-
106
-
-
0028268629
-
Hypoxia causes the activation of nuclear factor κ B through the phosphorylation of IκB α on tyrosine residues
-
Koong, A.C.; Chen, E.Y.; Giaccia, A.J. Hypoxia causes the activation of nuclear factor κ B through the phosphorylation of IκB α on tyrosine residues. Cancer Res. 1994, 54, 1425-1430
-
(1994)
Cancer Res
, vol.54
, pp. 1425-1430
-
-
Koong, A.C.1
Chen, E.Y.2
Giaccia, A.J.3
-
107
-
-
78049364235
-
Mechanism of hypoxia-induced NF-κB
-
Culver, C.; Sundqvist, A.; Mudie, S.; Melvin, A.; Xirodimas, D.; Rocha, S. Mechanism of hypoxia-induced NF-κB. Mol. Cell Biol. 2010, 30, 4901-4921
-
(2010)
Mol. Cell Biol
, vol.30
, pp. 4901-4921
-
-
Culver, C.1
Sundqvist, A.2
Mudie, S.3
Melvin, A.4
Xirodimas, D.5
Rocha, S.6
-
108
-
-
79251549807
-
An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia
-
Fitzpatrick, S.F.; Tambuwala, M.M.; Bruning, U.; Schaible, B.; Scholz, C.C.; Byrne, A.; O'Connor, A.; Gallagher, W.M.; Lenihan, C.R.; Garvey, J.F.; et al. An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia. J. Immunol. 2011, 186, 1091-1096
-
(2011)
J. Immunol
, vol.186
, pp. 1091-1096
-
-
Fitzpatrick, S.F.1
Tambuwala, M.M.2
Bruning, U.3
Schaible, B.4
Scholz, C.C.5
Byrne, A.6
O'Connor, A.7
Gallagher, W.M.8
Lenihan, C.R.9
Garvey, J.F.10
-
109
-
-
84906831786
-
Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster
-
Bandarra, D.; Biddlestone, J.; Mudie, S.; Muller, H.A.; Rocha, S. Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster. Biosci. Rep. 2014, 34
-
(2014)
Biosci. Rep
, pp. 34
-
-
Bandarra, D.1
Biddlestone, J.2
Mudie, S.3
Muller, H.A.4
Rocha, S.5
-
110
-
-
67649403609
-
Adenosine signaling mediates SUMO-1 modification of IκBα during hypoxia and reoxygenation
-
Liu, Q.; Li, J.; Khoury, J.; Colgan, S.P.; Ibla, J.C. Adenosine signaling mediates SUMO-1 modification of IκBα during hypoxia and reoxygenation. J. Biol. Chem. 2009, 284, 13686-13695
-
(2009)
J. Biol. Chem
, vol.284
, pp. 13686-13695
-
-
Liu, Q.1
Li, J.2
Khoury, J.3
Colgan, S.P.4
Ibla, J.C.5
-
111
-
-
84871443133
-
Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity
-
Aillet, F.; Lopitz-Otsoa, F.; Egana, I.; Hjerpe, R.; Fraser, P.; Hay, R.T.; Rodriguez, M.S.; Lang, V. Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity. PLoS ONE 2012, 7, e51672
-
(2012)
PLoS ONE
, vol.7
-
-
Aillet, F.1
Lopitz-Otsoa, F.2
Egana, I.3
Hjerpe, R.4
Fraser, P.5
Hay, R.T.6
Rodriguez, M.S.7
Lang, V.8
-
112
-
-
84881519604
-
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer
-
Mulero, M.C.; Ferres-Marco, D.; Islam, A.; Margalef, P.; Pecoraro, M.; Toll, A.; Drechsel, N.; Charneco, C.; Davis, S.; Bellora, N.; et al. Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell 2013, 24, 151-166
-
(2013)
Cancer Cell
, vol.24
, pp. 151-166
-
-
Mulero, M.C.1
Ferres-Marco, D.2
Islam, A.3
Margalef, P.4
Pecoraro, M.5
Toll, A.6
Drechsel, N.7
Charneco, C.8
Davis, S.9
Bellora, N.10
-
113
-
-
84962150091
-
Global patterns and trends in colorectal cancer incidence and mortality
-
Arnold, M.; Sierra, M.S.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2017, 66, 683-691
-
(2017)
Gut
, vol.66
, pp. 683-691
-
-
Arnold, M.1
Sierra, M.S.2
Laversanne, M.3
Soerjomataram, I.4
Jemal, A.5
Bray, F.6
-
114
-
-
70350764831
-
NF-κB signaling pathway, inflammation and colorectal cancer
-
Wang, S.; Liu, Z.; Wang, L.; Zhang, X. NF-κB signaling pathway, inflammation and colorectal cancer. Cell. Mol. Immunol. 2009, 6, 327-334
-
(2009)
Cell. Mol. Immunol
, vol.6
, pp. 327-334
-
-
Wang, S.1
Liu, Z.2
Wang, L.3
Zhang, X.4
-
115
-
-
33846091089
-
Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer
-
Fernandez-Majada, V.; Aguilera, C.; Villanueva, A.; Vilardell, F.; Robert-Moreno, A.; Aytes, A.; Real, F.X.; Capella, G.; Mayo, M.W.; Espinosa, L.; et al. Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer. Proc. Natl. Acad. Sci. USA 2007, 104, 276-281
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 276-281
-
-
Fernandez-Majada, V.1
Aguilera, C.2
Villanueva, A.3
Vilardell, F.4
Robert-Moreno, A.5
Aytes, A.6
Real, F.X.7
Capella, G.8
Mayo, M.W.9
Espinosa, L.10
-
116
-
-
58149478525
-
HIF-1α and HIF-2α have divergent roles in colon cancer
-
Imamura, T.; Kikuchi, H.; Herraiz, M.T.; Park, D.Y.; Mizukami, Y.; Mino-Kenduson, M.; Lynch, M.P.; Rueda, B.R.; Benita, Y.; Xavier, R.J.; et al. HIF-1α and HIF-2α have divergent roles in colon cancer. Int. J. Cancer 2009, 124, 763-771
-
(2009)
Int. J. Cancer
, vol.124
, pp. 763-771
-
-
Imamura, T.1
Kikuchi, H.2
Herraiz, M.T.3
Park, D.Y.4
Mizukami, Y.5
Mino-Kenduson, M.6
Lynch, M.P.7
Rueda, B.R.8
Benita, Y.9
Xavier, R.J.10
-
117
-
-
0037374289
-
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
-
Krishnamachary, B.; Berg-Dixon, S.; Kelly, B.; Agani, F.; Feldser, D.; Ferreira, G.; Iyer, N.; LaRusch, J.; Pak, B.; Taghavi, P.; et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 2003, 63, 1138-1143
-
(2003)
Cancer Res
, vol.63
, pp. 1138-1143
-
-
Krishnamachary, B.1
Berg-Dixon, S.2
Kelly, B.3
Agani, F.4
Feldser, D.5
Ferreira, G.6
Iyer, N.7
LaRusch, J.8
Pak, B.9
Taghavi, P.10
-
118
-
-
2442625634
-
Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours
-
Jubb, A.M.; Pham, T.Q.; Hanby, A.M.; Frantz, G.D.; Peale, F.V.; Wu, T.D.; Koeppen, H.W.; Hillan, K.J. Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours. J. Clin. Pathol. 2004, 57, 504-512
-
(2004)
J. Clin. Pathol
, vol.57
, pp. 504-512
-
-
Jubb, A.M.1
Pham, T.Q.2
Hanby, A.M.3
Frantz, G.D.4
Peale, F.V.5
Wu, T.D.6
Koeppen, H.W.7
Hillan, K.J.8
-
119
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda, R.; Hirota, K.; Fan, F.; Jung, Y.D.; Ellis, L.M.; Semenza, G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 2002, 277, 38205-38211
-
(2002)
J. Biol. Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
120
-
-
32944477859
-
Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts
-
Dang, D.T.; Chen, F.; Gardner, L.B.; Cummins, J.M.; Rago, C.; Bunz, F.; Kantsevoy, S.V.; Dang, L.H. Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts. Cancer Res. 2006, 66, 1684-1936
-
(2006)
Cancer Res
, vol.66
, pp. 1684-1936
-
-
Dang, D.T.1
Chen, F.2
Gardner, L.B.3
Cummins, J.M.4
Rago, C.5
Bunz, F.6
Kantsevoy, S.V.7
Dang, L.H.8
-
121
-
-
33646864077
-
Interplay between VHL/HIF1α and Wnt/β-catenin pathways during colorectal tumorigenesis
-
Giles, R.H.; Lolkema, M.P.; Snijckers, C.M.; Belderbos, M.; van der Groep, P.; Mans, D.A.; van Beest, M.; van Noort, M.; Goldschmeding, R.; van Diest, P.J.; et al. Interplay between VHL/HIF1α and Wnt/β-catenin pathways during colorectal tumorigenesis. Oncogene 2006, 25, 3065-3070
-
(2006)
Oncogene
, vol.25
, pp. 3065-3070
-
-
Giles, R.H.1
Lolkema, M.P.2
Snijckers, C.M.3
Belderbos, M.4
van der Groep, P.5
Mans, D.A.6
van Beest, M.7
van Noort, M.8
Goldschmeding, R.9
van Diest, P.J.10
-
122
-
-
84905980742
-
Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer
-
Rawluszko-Wieczorek, A.A.; Horbacka, K.; Krokowicz, P.; Misztal, M.; Jagodzinski, P.P. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. Mol. Cancer Res. 2014, 12, 1112-1127
-
(2014)
Mol. Cancer Res
, vol.12
, pp. 1112-1127
-
-
Rawluszko-Wieczorek, A.A.1
Horbacka, K.2
Krokowicz, P.3
Misztal, M.4
Jagodzinski, P.P.5
-
123
-
-
84901997518
-
Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer
-
Shay, J.E.; Imtiyaz, H.Z.; Sivanand, S.; Durham, A.C.; Skuli, N.; Hsu, S.; Mucaj, V.; Eisinger-Mathason, T.S.; Krock, B.L.; Giannoukos, D.N.; et al. Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer. Carcinogenesis 2014, 35, 1067-1077
-
(2014)
Carcinogenesis
, vol.35
, pp. 1067-1077
-
-
Shay, J.E.1
Imtiyaz, H.Z.2
Sivanand, S.3
Durham, A.C.4
Skuli, N.5
Hsu, S.6
Mucaj, V.7
Eisinger-Mathason, T.S.8
Krock, B.L.9
Giannoukos, D.N.10
-
124
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon, E.R.; Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 1990, 61, 759-767
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
125
-
-
41549117418
-
Cell regulation by the Apc protein Apc as master regulator of epithelia
-
McCartney, B.M.; Nathke, I.S. Cell regulation by the Apc protein Apc as master regulator of epithelia. Curr. Opin. Cell Biol. 2008, 20, 186-193
-
(2008)
Curr. Opin. Cell Biol
, vol.20
, pp. 186-193
-
-
McCartney, B.M.1
Nathke, I.S.2
-
126
-
-
0034644526
-
Linking colorectal cancer to Wnt signaling
-
Bienz, M.; Clevers, H. Linking colorectal cancer to Wnt signaling. Cell 2000, 103, 311-320
-
(2000)
Cell
, vol.103
, pp. 311-320
-
-
Bienz, M.1
Clevers, H.2
-
127
-
-
78149316509
-
Adenomatous polyposis coli and hypoxia-inducible factor-1α have an antagonistic connection
-
Newton, I.P.; Kenneth, N.S.; Appleton, P.L.;Nathke, I.; Rocha, S.Adenomatous polyposis coli and hypoxia-inducible factor-1α have an antagonistic connection.Mol. Biol. Cell 2010, 21, 3630-3638
-
(2010)
Mol. Biol Cell
, vol.21
, pp. 3630-3638
-
-
Newton, I.P.1
Kenneth, N.S.2
Appleton, P.L.3
Nathke, I.4
Rocha, S.5
-
128
-
-
79956015465
-
Antagonistic crosstalk between APC and HIF-1α
-
Nathke, I.; Rocha, S. Antagonistic crosstalk between APC and HIF-1α. Cell Cycle 2011, 10, 1545-1547
-
(2011)
Cell Cycle
, vol.10
, pp. 1545-1547
-
-
Nathke, I.1
Rocha, S.2
-
129
-
-
84937579754
-
Kdm2α/β Lysine demethylases regulate canonical wnt signaling by modulating the stability of nuclear β-catenin
-
Lu, L.; Gao, Y.; Zhang, Z.; Cao, Q.; Zhang, X.; Zou, J.; Cao, Y. Kdm2α/β Lysine demethylases regulate canonical wnt signaling by modulating the stability of nuclear β-catenin. Dev. Cell 2015, 33, 660-674
-
(2015)
Dev. Cell
, vol.33
, pp. 660-674
-
-
Lu, L.1
Gao, Y.2
Zhang, Z.3
Cao, Q.4
Zhang, X.5
Zou, J.6
Cao, Y.7
-
130
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang, H.; Gao, P.; Fukuda, R.; Kumar, G.; Krishnamachary, B.; Zeller, K.I.; Dang, C.V.; Semenza, G.L. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007, 11, 407-420
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
Dang, C.V.7
Semenza, G.L.8
-
131
-
-
31144478127
-
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis
-
Corn, P.G.; Ricci, M.S.; Scata, K.A.; Arsham, A.M.; Simon, M.C.; Dicker, D.T.; El-Deiry, W.S. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol. Ther. 2005, 4, 1285-1294
-
(2005)
Cancer Biol. Ther
, vol.4
, pp. 1285-1294
-
-
Corn, P.G.1
Ricci, M.S.2
Scata, K.A.3
Arsham, A.M.4
Simon, M.C.5
Dicker, D.T.6
El-Deiry, W.S.7
-
132
-
-
34547580590
-
HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
-
Gordan, J.D.; Thompson, C.B.; Simon, M.C. HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007, 12, 108-113
-
(2007)
Cancer Cell
, vol.12
, pp. 108-113
-
-
Gordan, J.D.1
Thompson, C.B.2
Simon, M.C.3
-
133
-
-
3142631736
-
HIF-1α induces cell cycle arrest by functionally counteracting Myc
-
Koshiji, M.; Kageyama, Y.; Pete, E.A.; Horikawa, I.; Barrett, J.C.; Huang, L.E. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J. 2004, 23, 1949-1956
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
134
-
-
77953597349
-
A therapeutic role for targeting c-Myc/HIF-1-dependent signaling pathways
-
Podar, K.; Anderson, K.C. A therapeutic role for targeting c-Myc/HIF-1-dependent signaling pathways. Cell. Cycle 2010, 9, 1722-1728
-
(2010)
Cell. Cycle
, vol.9
, pp. 1722-1728
-
-
Podar, K.1
Anderson, K.C.2
-
135
-
-
0025302552
-
Interaction of an NF-κB-like factor with a site upstream of the c-myc promoter
-
Duyao, M.P.; Buckler, A.J.; Sonenshein, G.E. Interaction of an NF-κB-like factor with a site upstream of the c-myc promoter. Proc. Natl. Acad. Sci. USA 1990, 87, 4727-4731
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 4727-4731
-
-
Duyao, M.P.1
Buckler, A.J.2
Sonenshein, G.E.3
-
136
-
-
34047156190
-
HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
Gordan, J.D.; Bertout, J.A.; Hu, C.J.; Diehl, J.A.; Simon, M.C. HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007, 11, 335-347
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
137
-
-
84872680968
-
Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer
-
Fan, X.J.; Wan, X.B.; Yang, Z.L.; Fu, X.H.; Huang, Y.; Chen, D.K.; Song, S.X.; Liu, Q.; Xiao, H.Y.; Wang, L.; et al. Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer. Hum. Pathol. 2013, 44, 173-180
-
(2013)
Hum. Pathol
, vol.44
, pp. 173-180
-
-
Fan, X.J.1
Wan, X.B.2
Yang, Z.L.3
Fu, X.H.4
Huang, Y.5
Chen, D.K.6
Song, S.X.7
Liu, Q.8
Xiao, H.Y.9
Wang, L.10
-
138
-
-
33845724527
-
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
-
Evans, A.J.; Russell, R.C.; Roche, O.; Burry, T.N.; Fish, J.E.; Chow, V.W.; Kim, W.Y.; Saravanan, A.; Maynard, M.A.; Gervais, M.L.; et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol. Cell. Biol. 2007, 27, 157-169
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 157-169
-
-
Evans, A.J.1
Russell, R.C.2
Roche, O.3
Burry, T.N.4
Fish, J.E.5
Chow, V.W.6
Kim, W.Y.7
Saravanan, A.8
Maynard, M.A.9
Gervais, M.L.10
-
139
-
-
40249113328
-
Direct regulation of TWIST by HIF-1α promotes metastasis
-
Yang, M.H.;Wu, M.Z.; Chiou, S.H.; Chen, P.M.; Chang, S.Y.; Liu, C.J.; Teng, S.C.;Wu, K.J. Direct regulation of TWIST by HIF-1α promotes metastasis. Nat. Cell Biol. 2008, 10, 295-305
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 295-305
-
-
Yang, M.H.1
Wu, M.Z.2
Chiou, S.H.3
Chen, P.M.4
Chang, S.Y.5
Liu, C.J.6
Teng, S.C.7
Wu, K.J.8
-
140
-
-
40449114805
-
The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α
-
Gort, E.H.; van Haaften, G.; Verlaan, I.; Groot, A.J.; Plasterk, R.H.; Shvarts, A.; Suijkerbuijk, K.P.; van Laar, T.; van der Wall, E.; Raman, V.; et al. The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α. Oncogene 2008, 27, 1501-1510
-
(2008)
Oncogene
, vol.27
, pp. 1501-1510
-
-
Gort, E.H.1
van Haaften, G.2
Verlaan, I.3
Groot, A.J.4
Plasterk, R.H.5
Shvarts, A.6
Suijkerbuijk, K.P.7
van Laar, T.8
van der Wall, E.9
Raman, V.10
-
141
-
-
76949084622
-
TNF-α/ NF-κB/Snail pathway in cancer cell migration and invasion
-
Wu, Y.; Zhou, B.P. TNF-α/ NF-κB/Snail pathway in cancer cell migration and invasion. Br. J. Cancer 2010, 102, 639-644
-
(2010)
Br. J. Cancer
, vol.102
, pp. 639-644
-
-
Wu, Y.1
Zhou, B.P.2
-
142
-
-
84872370561
-
Loss of p53 in enterocytes generates an inflammatorymicroenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
-
Schwitalla, S.; Ziegler, P.K.; Horst, D.; Becker, V.; Kerle, I.; Begus-Nahrmann, Y.; Lechel, A.; Rudolph, K.L.; Langer, R.; Slotta-Huspenina, J.; et al. Loss of p53 in enterocytes generates an inflammatorymicroenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell 2013, 23, 93-106
-
(2013)
Cancer Cell
, vol.23
, pp. 93-106
-
-
Schwitalla, S.1
Ziegler, P.K.2
Horst, D.3
Becker, V.4
Kerle, I.5
Begus-Nahrmann, Y.6
Lechel, A.7
Rudolph, K.L.8
Langer, R.9
Slotta-Huspenina, J.10
-
143
-
-
84856213846
-
The diverse and complex roles of NF-κB subunits in cancer
-
Perkins, N.D. The diverse and complex roles of NF-κB subunits in cancer. Nat. Rev. Cancer 2012, 12, 121-132
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 121-132
-
-
Perkins, N.D.1
-
144
-
-
77956692764
-
Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: In vivo identification from hypoxic tumor cells
-
Uemura, M.; Yamamoto, H.; Takemasa, I.; Mimori, K.; Hemmi, H.; Mizushima, T.; Ikeda, M.; Sekimoto, M.; Matsuura, N.; Doki, Y.; et al. Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: In vivo identification from hypoxic tumor cells. Clin. Cancer Res. 2010, 16, 4636-4646
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 4636-4646
-
-
Uemura, M.1
Yamamoto, H.2
Takemasa, I.3
Mimori, K.4
Hemmi, H.5
Mizushima, T.6
Ikeda, M.7
Sekimoto, M.8
Matsuura, N.9
Doki, Y.10
-
145
-
-
81255147963
-
KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells
-
Pereira, F.; Barbachano, A.; Silva, J.; Bonilla, F.; Campbell, M.J.; Munoz, A.; Larriba, M.J. KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. Hum. Mol. Genet. 2011, 20, 4655-4665
-
(2011)
Hum. Mol. Genet
, vol.20
, pp. 4655-4665
-
-
Pereira, F.1
Barbachano, A.2
Silva, J.3
Bonilla, F.4
Campbell, M.J.5
Munoz, A.6
Larriba, M.J.7
-
146
-
-
75149150805
-
Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKβ independent of hydroxylase activity
-
Xue, J.; Li, X.; Jiao, S.;Wei, Y.;Wu, G.; Fang, J. Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKβ independent of hydroxylase activity. Gastroenterology 2010, 138, 606-615
-
(2010)
Gastroenterology
, vol.138
, pp. 606-615
-
-
Xue, J.1
Li, X.2
Jiao, S.3
Wei, Y.4
Wu, G.5
Fang, J.6
-
147
-
-
84942826593
-
PHD1 regulates p53-mediated colorectal cancer chemoresistance
-
Deschoemaeker, S.; Di Conza, G.; Lilla, S.; Martin-Perez, R.; Mennerich, D.; Boon, L.; Hendrikx, S.; Maddocks, O.D.; Marx, C.; Radhakrishnan, P.; et al. PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Mol. Med. 2015, 7, 1350-1365
-
(2015)
EMBO Mol. Med
, vol.7
, pp. 1350-1365
-
-
Deschoemaeker, S.1
Di Conza, G.2
Lilla, S.3
Martin-Perez, R.4
Mennerich, D.5
Boon, L.6
Hendrikx, S.7
Maddocks, O.D.8
Marx, C.9
Radhakrishnan, P.10
-
148
-
-
3042716638
-
NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis
-
Biswas, D.K.; Shi, Q.; Baily, S.; Strickland, I.; Ghosh, S.; Pardee, A.B.; Iglehart, J.D. NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc. Natl. Acad. Sci. USA 2004, 101, 10137-10142
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10137-10142
-
-
Biswas, D.K.1
Shi, Q.2
Baily, S.3
Strickland, I.4
Ghosh, S.5
Pardee, A.B.6
Iglehart, J.D.7
-
149
-
-
33846828787
-
NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2
-
Chua, H.L.; Bhat-Nakshatri, P.; Clare, S.E.; Morimiya, A.; Badve, S.; Nakshatri, H. NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2. Oncogene 2007, 26, 711-724
-
(2007)
Oncogene
, vol.26
, pp. 711-724
-
-
Chua, H.L.1
Bhat-Nakshatri, P.2
Clare, S.E.3
Morimiya, A.4
Badve, S.5
Nakshatri, H.6
-
150
-
-
0034682527
-
Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells
-
Biswas, D.K.; Cruz, A.P.; Gansberger, E.; Pardee, A.B. Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc. Natl. Acad. Sci. USA 2000, 97, 8542-8547
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8542-8547
-
-
Biswas, D.K.1
Cruz, A.P.2
Gansberger, E.3
Pardee, A.B.4
-
151
-
-
84945206872
-
Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα
-
Sethi, G.; Ahn, K.S.; Chaturvedi, M.M.; Aggarwal, B.B. Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα. Oncogene 2015, 34, 5407
-
(2015)
Oncogene
, vol.34
, pp. 5407
-
-
Sethi, G.1
Ahn, K.S.2
Chaturvedi, M.M.3
Aggarwal, B.B.4
-
152
-
-
79953046542
-
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR
-
Bivona, T.G.; Hieronymus, H.; Parker, J.; Chang, K.; Taron, M.; Rosell, R.; Moonsamy, P.; Dahlman, K.; Miller, V.A.; Costa, C.; et al. FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR. Nature 2011, 471, 523-526
-
(2011)
Nature
, vol.471
, pp. 523-526
-
-
Bivona, T.G.1
Hieronymus, H.2
Parker, J.3
Chang, K.4
Taron, M.5
Rosell, R.6
Moonsamy, P.7
Dahlman, K.8
Miller, V.A.9
Costa, C.10
-
153
-
-
84887314092
-
Role of hypoxia-inducible factors in breast cancer metastasis
-
Gilkes, D.M.; Semenza, G.L. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncol. 2013, 9, 1623-1636
-
(2013)
Future Oncol
, vol.9
, pp. 1623-1636
-
-
Gilkes, D.M.1
Semenza, G.L.2
-
154
-
-
84865149277
-
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
-
Wong, C.C.; Zhang, H.; Gilkes, D.M.; Chen, J.; Wei, H.; Chaturvedi, P.; Hubbi, M.E.; Semenza, G.L. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J. Mol. Med. 2012, 90, 803-815
-
(2012)
J. Mol. Med
, vol.90
, pp. 803-815
-
-
Wong, C.C.1
Zhang, H.2
Gilkes, D.M.3
Chen, J.4
Wei, H.5
Chaturvedi, P.6
Hubbi, M.E.7
Semenza, G.L.8
-
155
-
-
60549092506
-
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
-
Lee, K.; Qian, D.Z.; Rey, S.; Wei, H.; Liu, J.O.; Semenza, G.L. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. USA 2009, 106, 2353-2358
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2353-2358
-
-
Lee, K.1
Qian, D.Z.2
Rey, S.3
Wei, H.4
Liu, J.O.5
Semenza, G.L.6
-
156
-
-
79960989122
-
Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors
-
Kummar, S.; Raffeld, M.; Juwara, L.; Horneffer, Y.; Strassberger, A.; Allen, D.; Steinberg, S.M.; Rapisarda, A.; Spencer, S.D.; Figg, W.D.; et al. Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors. Clin. Cancer Res. 2011, 17, 5123-5131
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 5123-5131
-
-
Kummar, S.1
Raffeld, M.2
Juwara, L.3
Horneffer, Y.4
Strassberger, A.5
Allen, D.6
Steinberg, S.M.7
Rapisarda, A.8
Spencer, S.D.9
Figg, W.D.10
-
157
-
-
0036493984
-
Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer
-
Leek, R.D.; Talks, K.L.; Pezzella, F.; Turley, H.; Campo, L.; Brown, N.S.; Bicknell, R.; Taylor, M.; Gatter, K.C.; Harris, A.L. Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer. Cancer Res. 2002, 62, 1326-1329
-
(2002)
Cancer Res
, vol.62
, pp. 1326-1329
-
-
Leek, R.D.1
Talks, K.L.2
Pezzella, F.3
Turley, H.4
Campo, L.5
Brown, N.S.6
Bicknell, R.7
Taylor, M.8
Gatter, K.C.9
Harris, A.L.10
-
158
-
-
33645144603
-
Hypoxia-inducible factor-2 α (HIF-2 α) induces angiogenesis in breast carcinomas
-
Giatromanolaki, A.; Sivridis, E.; Fiska, A.; Koukourakis, M.I. Hypoxia-inducible factor-2 α (HIF-2 α) induces angiogenesis in breast carcinomas. Appl. Immunohistochem. Mol. Morphol. 2006, 14, 78-82
-
(2006)
Appl. Immunohistochem. Mol. Morphol
, vol.14
, pp. 78-82
-
-
Giatromanolaki, A.1
Sivridis, E.2
Fiska, A.3
Koukourakis, M.I.4
-
159
-
-
84879424156
-
Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients
-
De Boniface, J.; Mao, Y.; Schmidt-Mende, J.; Kiessling, R.; Poschke, I. Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients. Oncoimmunology 2012, 1, 1305-1312
-
(2012)
Oncoimmunology
, vol.1
, pp. 1305-1312
-
-
De Boniface, J.1
Mao, Y.2
Schmidt-Mende, J.3
Kiessling, R.4
Poschke, I.5
-
160
-
-
82455199298
-
Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor
-
Pryor, J.G.; Brown-Kipphut, B.A.; Iqbal, A.; Scott, G.A. Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor. Am. J. Dermatopathol. 2011, 33, 780-785
-
(2011)
Am. J. Dermatopathol
, vol.33
, pp. 780-785
-
-
Pryor, J.G.1
Brown-Kipphut, B.A.2
Iqbal, A.3
Scott, G.A.4
-
161
-
-
0034282790
-
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines
-
Yang, Z.Q.; Imoto, I.; Fukuda, Y.; Pimkhaokham, A.; Shimada, Y.; Imamura, M.; Sugano, S.; Nakamura, Y.; Inazawa, J. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res. 2000, 60, 4735-4739
-
(2000)
Cancer Res
, vol.60
, pp. 4735-4739
-
-
Yang, Z.Q.1
Imoto, I.2
Fukuda, Y.3
Pimkhaokham, A.4
Shimada, Y.5
Imamura, M.6
Sugano, S.7
Nakamura, Y.8
Inazawa, J.9
-
162
-
-
84855168980
-
Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer
-
Patani, N.; Jiang, W.G.; Newbold, R.F.;Mokbel, K. Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer. Anticancer Res. 2011, 31, 4115-4125
-
(2011)
Anticancer Res
, vol.31
, pp. 4115-4125
-
-
Patani, N.1
Jiang, W.G.2
Newbold, R.F.3
Mokbel, K.4
-
163
-
-
79956291600
-
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
-
Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; et al. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc. Natl. Acad. Sci. USA 2011, 108, 7541-7546
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 7541-7546
-
-
Shi, L.1
Sun, L.2
Li, Q.3
Liang, J.4
Yu, W.5
Yi, X.6
Yang, X.7
Li, Y.8
Han, X.9
Zhang, Y.10
-
164
-
-
0037145309
-
PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: A new cancer/testis antigen?
-
Barrett, A.; Madsen, B.; Copier, J.; Lu, P.J.; Cooper, L.; Scibetta, A.G.; Burchell, J.; Taylor-Papadimitriou, J. PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: A new cancer/testis antigen? Int. J. Cancer 2002, 101, 581-588
-
(2002)
Int. J. Cancer
, vol.101
, pp. 581-588
-
-
Barrett, A.1
Madsen, B.2
Copier, J.3
Lu, P.J.4
Cooper, L.5
Scibetta, A.G.6
Burchell, J.7
Taylor-Papadimitriou, J.8
-
165
-
-
77949468885
-
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway
-
Hayami, S.; Yoshimatsu, M.; Veerakumarasivam, A.; Unoki, M.; Iwai, Y.; Tsunoda, T.; Field, H.I.; Kelly, J.D.; Neal, D.E.; Yamaue, H.; et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol. Cancer 2010, 9, 59
-
(2010)
Mol. Cancer
, vol.9
, pp. 59
-
-
Hayami, S.1
Yoshimatsu, M.2
Veerakumarasivam, A.3
Unoki, M.4
Iwai, Y.5
Tsunoda, T.6
Field, H.I.7
Kelly, J.D.8
Neal, D.E.9
Yamaue, H.10
-
166
-
-
33947244845
-
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
-
Yamane, K.; Tateishi, K.; Klose, R.J.; Fang, J.; Fabrizio, L.A.; Erdjument-Bromage, H.; Taylor-Papadimitriou, J.; Tempst, P.; Zhang, Y. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol. Cell 2007, 25, 801-812
-
(2007)
Mol. Cell
, vol.25
, pp. 801-812
-
-
Yamane, K.1
Tateishi, K.2
Klose, R.J.3
Fang, J.4
Fabrizio, L.A.5
Erdjument-Bromage, H.6
Taylor-Papadimitriou, J.7
Tempst, P.8
Zhang, Y.9
-
167
-
-
84959116049
-
Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448
-
Bamodu, O.A.; Huang, W.C.; Lee, W.H.;Wu, A.;Wang, L.S.; Hsiao, M.; Yeh, C.T.; Chao, T.Y. Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. BMC Cancer 2016, 16, 160
-
(2016)
BMC Cancer
, vol.16
, pp. 160
-
-
Bamodu, O.A.1
Huang, W.C.2
Lee, W.H.3
Wu, A.4
Wang, L.S.5
Hsiao, M.6
Yeh, C.T.7
Chao, T.Y.8
-
168
-
-
84947127960
-
JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression
-
Shen, X.; Zhuang, Z.; Zhang, Y.; Chen, Z.; Shen, L.; Pu, W.; Chen, L.; Xu, Z. JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression. Tumour Biol. 2015, 36, 7133-7142
-
(2015)
Tumour Biol
, vol.36
, pp. 7133-7142
-
-
Shen, X.1
Zhuang, Z.2
Zhang, Y.3
Chen, Z.4
Shen, L.5
Pu, W.6
Chen, L.7
Xu, Z.8
-
169
-
-
70449109147
-
Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
-
Meylan, E.; Dooley, A.L.; Feldser, D.M.; Shen, L.; Turk, E.; Ouyang, C.; Jacks, T. Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma. Nature 2009, 462, 104-107
-
(2009)
Nature
, vol.462
, pp. 104-107
-
-
Meylan, E.1
Dooley, A.L.2
Feldser, D.M.3
Shen, L.4
Turk, E.5
Ouyang, C.6
Jacks, T.7
-
170
-
-
84934966421
-
Advances in the development of histone lysine demethylase inhibitors
-
Maes, T.; Carceller, E.; Salas, J.; Ortega, A.; Buesa, C. Advances in the development of histone lysine demethylase inhibitors. Curr. Opin. Pharmacol. 2015, 23, 52-60
-
(2015)
Curr. Opin. Pharmacol
, vol.23
, pp. 52-60
-
-
Maes, T.1
Carceller, E.2
Salas, J.3
Ortega, A.4
Buesa, C.5
-
171
-
-
84945176281
-
Epigenetic regulation by histone demethylases in hypoxia
-
Hancock, R.L.; Dunne, K.; Walport, L.J.; Flashman, E.; Kawamura, A. Epigenetic regulation by histone demethylases in hypoxia. Epigenomics 2015, 7, 791-811
-
(2015)
Epigenomics
, vol.7
, pp. 791-811
-
-
Hancock, R.L.1
Dunne, K.2
Walport, L.J.3
Flashman, E.4
Kawamura, A.5
-
172
-
-
84937774684
-
Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer
-
Liu, H.; Liu, L.; Holowatyj, A.; Jiang, Y.; Yang, Z.Q. Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. Mol. Carcinog. 2016, 55, 977-990
-
(2016)
Mol. Carcinog
, vol.55
, pp. 977-990
-
-
Liu, H.1
Liu, L.2
Holowatyj, A.3
Jiang, Y.4
Yang, Z.Q.5
-
173
-
-
84890060286
-
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling
-
Wagner, K.W.; Alam, H.; Dhar, S.S.; Giri, U.; Li, N.; Wei, Y.; Giri, D.; Cascone, T.; Kim, J.H.; Ye, Y.; et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J. Clin. Investig. 2013, 123, 5231-5246
-
(2013)
J. Clin. Investig
, vol.123
, pp. 5231-5246
-
-
Wagner, K.W.1
Alam, H.2
Dhar, S.S.3
Giri, U.4
Li, N.5
Wei, Y.6
Giri, D.7
Cascone, T.8
Kim, J.H.9
Ye, Y.10
-
174
-
-
70350507985
-
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase
-
Zhang, Q.; Gu, J.; Li, L.; Liu, J.; Luo, B.; Cheung, H.W.; Boehm, J.S.; Ni, M.; Geisen, C.; Root, D.E.; et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell 2009, 16, 413-424
-
(2009)
Cancer Cell
, vol.16
, pp. 413-424
-
-
Zhang, Q.1
Gu, J.2
Li, L.3
Liu, J.4
Luo, B.5
Cheung, H.W.6
Boehm, J.S.7
Ni, M.8
Geisen, C.9
Root, D.E.10
-
175
-
-
84973304712
-
Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia
-
Oh, E.T.; Kim, C.W.; Kim, S.J.; Lee, J.S.; Hong, S.S.; Park, H.J. Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia. Sci. Rep. 2016, 6, 27382
-
(2016)
Sci. Rep
, vol.6
, pp. 27382
-
-
Oh, E.T.1
Kim, C.W.2
Kim, S.J.3
Lee, J.S.4
Hong, S.S.5
Park, H.J.6
-
176
-
-
84860351589
-
Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients
-
Peurala, E.; Koivunen, P.; Bloigu, R.; Haapasaari, K.M.; Jukkola-Vuorinen, A. Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients. Breast Cancer Res. Treat. 2012, 133, 179-188
-
(2012)
Breast Cancer Res. Treat
, vol.133
, pp. 179-188
-
-
Peurala, E.1
Koivunen, P.2
Bloigu, R.3
Haapasaari, K.M.4
Jukkola-Vuorinen, A.5
-
177
-
-
84879790190
-
The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with BCL-2 in non-small cell lung cancer
-
Chen, S.; Zhang, J.; Li, X.; Luo, X.; Fang, J.; Chen, H. The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with BCL-2 in non-small cell lung cancer. Mol. Cell. Biochem. 2011, 358, 257-263
-
(2011)
Mol. Cell. Biochem
, vol.358
, pp. 257-263
-
-
Chen, S.1
Zhang, J.2
Li, X.3
Luo, X.4
Fang, J.5
Chen, H.6
-
178
-
-
80051934217
-
Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival
-
Andersen, S.; Donnem, T.; Stenvold, H.; Al-Saad, S.; Al-Shibli, K.; Busund, L.T.; Bremnes, R.M. Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival. PLoS ONE 2011, 6, e23847
-
(2011)
PLoS ONE
, vol.6
-
-
Andersen, S.1
Donnem, T.2
Stenvold, H.3
Al-Saad, S.4
Al-Shibli, K.5
Busund, L.T.6
Bremnes, R.M.7
-
179
-
-
84994592337
-
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
-
Frost, J.; Galdeano, C.; Soares, P.; Gadd, M.S.; Grzes, K.M.; Ellis, L.; Epemolu, O.; Shimamura, S.; Bantscheff, M.; Grandi, P.; et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat. Commun. 2016, 7, 13312
-
(2016)
Nat. Commun
, vol.7
, pp. 13312
-
-
Frost, J.1
Galdeano, C.2
Soares, P.3
Gadd, M.S.4
Grzes, K.M.5
Ellis, L.6
Epemolu, O.7
Shimamura, S.8
Bantscheff, M.9
Grandi, P.10
-
180
-
-
84937513949
-
Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses
-
Curtis, V.F.; Ehrentraut, S.F.; Campbell, E.L.; Glover, L.E.; Bayless, A.; Kelly, C.J.; Kominsky, D.J.; Colgan, S.P. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB J. 2015, 29, 208-215
-
(2015)
FASEB J
, vol.29
, pp. 208-215
-
-
Curtis, V.F.1
Ehrentraut, S.F.2
Campbell, E.L.3
Glover, L.E.4
Bayless, A.5
Kelly, C.J.6
Kominsky, D.J.7
Colgan, S.P.8
-
181
-
-
84983546693
-
Targeting hypoxia in inflammatory bowel disease
-
Colgan, S.P. Targeting hypoxia in inflammatory bowel disease. J. Investig. Med. 2016, 64, 364-368
-
(2016)
J. Investig. Med
, vol.64
, pp. 364-368
-
-
Colgan, S.P.1
-
182
-
-
84876569908
-
Modulators of HIF1α and NFkB in cancer treatment: Is it a rational approach for controlling malignant progression?
-
Tafani, M.; Pucci, B.; Russo, A.; Schito, L.; Pellegrini, L.; Perrone, G.A.; Villanova, L.; Salvatori, L.; Ravenna, L.; Petrangeli, E.; et al. Modulators of HIF1α and NFkB in cancer treatment: Is it a rational approach for controlling malignant progression? Front. Pharmacol. 2013, 4, 13
-
(2013)
Front. Pharmacol
, vol.4
, pp. 13
-
-
Tafani, M.1
Pucci, B.2
Russo, A.3
Schito, L.4
Pellegrini, L.5
Perrone, G.A.6
Villanova, L.7
Salvatori, L.8
Ravenna, L.9
Petrangeli, E.10
-
183
-
-
84867335615
-
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
-
Okumura, C.Y.; Hollands, A.; Tran, D.N.; Olson, J.; Dahesh, S.; von Kockritz-Blickwede, M.; Thienphrapa, W.; Corle, C.; Jeung, S.N.; Kotsakis, A.; et al. A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J. Mol. Med. 2012, 90, 1079-1089
-
(2012)
J. Mol. Med
, vol.90
, pp. 1079-1089
-
-
Okumura, C.Y.1
Hollands, A.2
Tran, D.N.3
Olson, J.4
Dahesh, S.5
von Kockritz-Blickwede, M.6
Thienphrapa, W.7
Corle, C.8
Jeung, S.N.9
Kotsakis, A.10
-
184
-
-
84994626953
-
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
-
Cho, H.; Du, X.; Rizzi, J.P.; Liberzon, E.; Chakraborty, A.A.; Gao, W.; Carvo, I.; Signoretti, S.; Bruick, R.K.; Josey, J.A.; et al. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature 2016, 539, 107-111
-
(2016)
Nature
, vol.539
, pp. 107-111
-
-
Cho, H.1
Du, X.2
Rizzi, J.P.3
Liberzon, E.4
Chakraborty, A.A.5
Gao, W.6
Carvo, I.7
Signoretti, S.8
Bruick, R.K.9
Josey, J.A.10
-
185
-
-
84988983212
-
A small-molecule antagonist of HIF2α is efficacious in preclinical models of renal cell carcinoma
-
Wallace, E.M.; Rizzi, J.P.; Han, G.; Wehn, P.M.; Cao, Z.; Du, X.; Cheng, T.; Czerwinski, R.M.; Dixon, D.D.; Goggin, B.S.; et al. A small-molecule antagonist of HIF2α is efficacious in preclinical models of renal cell carcinoma. Cancer Res. 2016, 76, 5491-5500
-
(2016)
Cancer Res
, vol.76
, pp. 5491-5500
-
-
Wallace, E.M.1
Rizzi, J.P.2
Han, G.3
Wehn, P.M.4
Cao, Z.5
Du, X.6
Cheng, T.7
Czerwinski, R.M.8
Dixon, D.D.9
Goggin, B.S.10
-
186
-
-
84994669316
-
Targeting renal cell carcinoma with a HIF-2 antagonist
-
Chen, W.; Hill, H.; Christie, A.; Kim, M.S.; Holloman, E.; Pavia-Jimenez, A.; Homayoun, F.; Ma, Y.; Patel, N.; Yell, P.; et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature 2016, 539, 112-117
-
(2016)
Nature
, vol.539
, pp. 112-117
-
-
Chen, W.1
Hill, H.2
Christie, A.3
Kim, M.S.4
Holloman, E.5
Pavia-Jimenez, A.6
Homayoun, F.7
Ma, Y.8
Patel, N.9
Yell, P.10
-
187
-
-
84959516180
-
Aspirin and colorectal cancer: The promise of precision chemoprevention
-
Drew, D.A.; Cao, Y.; Chan, A.T. Aspirin and colorectal cancer: The promise of precision chemoprevention. Nat. Rev. Cancer 2016, 16, 173-186
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 173-186
-
-
Drew, D.A.1
Cao, Y.2
Chan, A.T.3
-
188
-
-
85006256356
-
Blocking NF-κB is essential for the immunotherapeutic effect of recombinant IL18 in pancreatic cancer
-
Guo, X.; Zheng, L.; Jiang, J.; Zhao, Y.; Wang, X.; Shen, M.; Zhu, F.; Tian, R.; Shi, C.; Xu, M.; et al. Blocking NF-κB is essential for the immunotherapeutic effect of recombinant IL18 in pancreatic cancer. Clin. Cancer Res. 2016, 22, 5939-5950
-
(2016)
Clin. Cancer Res
, vol.22
, pp. 5939-5950
-
-
Guo, X.1
Zheng, L.2
Jiang, J.3
Zhao, Y.4
Wang, X.5
Shen, M.6
Zhu, F.7
Tian, R.8
Shi, C.9
Xu, M.10
-
189
-
-
85016724516
-
Cancer immunotherapies targeting the PD-1 signaling pathway
-
Iwai, Y.; Hamanishi, J.; Chamoto, K.; Honjo, T. Cancer immunotherapies targeting the PD-1 signaling pathway. J. Biomed. Sci. 2017, 24, 26
-
(2017)
J. Biomed. Sci
, vol.24
, pp. 26
-
-
Iwai, Y.1
Hamanishi, J.2
Chamoto, K.3
Honjo, T.4
-
190
-
-
84899753178
-
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
-
Noman, M.Z.; Desantis, G.; Janji, B.; Hasmim, M.; Karray, S.; Dessen, P.; Bronte, V.; Chouaib, S. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J. Exp. Med. 2014, 211, 781-790
-
(2014)
J. Exp. Med
, vol.211
, pp. 781-790
-
-
Noman, M.Z.1
Desantis, G.2
Janji, B.3
Hasmim, M.4
Karray, S.5
Dessen, P.6
Bronte, V.7
Chouaib, S.8
-
191
-
-
23844527189
-
Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor κB activity
-
An, J.; Rettig, M.B. Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor κB activity. Mol. Cell. Biol. 2005, 25, 7546-7556
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 7546-7556
-
-
An, J.1
Rettig, M.B.2
-
192
-
-
85021848426
-
VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1
-
Labrousse-Arias, D.; Martinez-Alonso, E.; Corral-Escariz, M.; Bienes-Martinez, R.; Berridy, J.; Serrano-Oviedo, L.; Conde, E.; Garcia-Bermejo, M.L.; Gimenez-Bachs, J.M.; Salinas-Sanchez, A.S.; et al. VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1. J. Cell. Biol. 2017, 216, 835-847
-
(2017)
J. Cell. Biol
, vol.216
, pp. 835-847
-
-
Labrousse-Arias, D.1
Martinez-Alonso, E.2
Corral-Escariz, M.3
Bienes-Martinez, R.4
Berridy, J.5
Serrano-Oviedo, L.6
Conde, E.7
Garcia-Bermejo, M.L.8
Gimenez-Bachs, J.M.9
Salinas-Sanchez, A.S.10
-
193
-
-
84989908979
-
pVHL mediates K63-linked ubiquitination of IKKβ, leading to IKKβ inactivation
-
Wang, Y.; Zhao, W.; Gao, Q.; Fan, L.; Qin, Y.; Zhou, H.; Li, M.; Fang, J. pVHL mediates K63-linked ubiquitination of IKKβ, leading to IKKβ inactivation. Cancer Lett. 2016, 383, 1-8
-
(2016)
Cancer Lett
, vol.383
, pp. 1-8
-
-
Wang, Y.1
Zhao, W.2
Gao, Q.3
Fan, L.4
Qin, Y.5
Zhou, H.6
Li, M.7
Fang, J.8
|