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Volumn 5, Issue 2, 2017, Pages

Hypoxia and inflammation in cancer, focus on HIF and NF-κB

Author keywords

Cancer; Factor Inhibiting HIF (FIH); Hypoxia; Inflammation; NF B; Prolyl Hydroxylases (PHDs); Transforming Growth Factor Activated Kinase 1 (TAK1); B Kinase (IKK)

Indexed keywords


EID: 85029882313     PISSN: None     EISSN: 22279059     Source Type: Journal    
DOI: 10.3390/biomedicines5020021     Document Type: Review
Times cited : (163)

References (193)
  • 1
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • Sen, R.; Baltimore, D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986, 46, 705-716
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 2
    • 77957570183 scopus 로고    scopus 로고
    • Inhibiting NF-κB activation by small molecules as a therapeutic strategy
    • Gupta, S.C.; Sundaram, C.; Reuter, S.; Aggarwal, B.B. Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim. Biophys. Acta 2010, 1799, 775-787
    • (2010) Biochim. Biophys. Acta , vol.1799 , pp. 775-787
    • Gupta, S.C.1    Sundaram, C.2    Reuter, S.3    Aggarwal, B.B.4
  • 3
    • 85066057489 scopus 로고    scopus 로고
    • Roles of NF-κB in Cancer and inflammatory diseases and their therapeutic approaches
    • Park, M.H.; Hong, J.T. Roles of NF-κB in Cancer and inflammatory diseases and their therapeutic approaches. Cells 2016, 5, 15
    • (2016) Cells , vol.5 , pp. 15
    • Park, M.H.1    Hong, J.T.2
  • 4
    • 77954460424 scopus 로고    scopus 로고
    • A structural guide to proteins of the NF-κB signaling module
    • Huxford, T.; Ghosh, G. A structural guide to proteins of the NF-κB signaling module. Cold Spring Harb. Perspect. Biol. 2009, 1, a000075
    • (2009) Cold Spring Harb. Perspect. Biol , vol.1
    • Huxford, T.1    Ghosh, G.2
  • 5
    • 84880869807 scopus 로고    scopus 로고
    • The complexity of NF-κB signaling in inflammation and cancer
    • Hoesel, B.; Schmid, J.A. The complexity of NF-κB signaling in inflammation and cancer. Mol. Cancer 2013, 12, 86
    • (2013) Mol. Cancer , vol.12 , pp. 86
    • Hoesel, B.1    Schmid, J.A.2
  • 6
    • 84923683740 scopus 로고    scopus 로고
    • Tale of two transcription factors: NF-κB and HIF crosstalk
    • Bandarra, D.; Rocha, S. Tale of two transcription factors: NF-κB and HIF crosstalk. OA Mol. Cell Biol. 2013, 1, 6
    • (2013) OA Mol. Cell Biol , vol.1 , pp. 6
    • Bandarra, D.1    Rocha, S.2
  • 7
    • 84858735072 scopus 로고    scopus 로고
    • The noncanonical NF-κB pathway
    • Sun, S.C. The noncanonical NF-κB pathway. Immunol. Rev. 2012, 246, 125-140
    • (2012) Immunol. Rev , vol.246 , pp. 125-140
    • Sun, S.C.1
  • 8
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-κB signaling pathways
    • Oeckinghaus, A.; Hayden, M.S.; Ghosh, S. Crosstalk in NF-κB signaling pathways. Nat. Immunol. 2011, 12, 695-708
    • (2011) Nat. Immunol , vol.12 , pp. 695-708
    • Oeckinghaus, A.1    Hayden, M.S.2    Ghosh, S.3
  • 9
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-κB: Players, pathways, perspectives
    • Gilmore, T.D. Introduction to NF-κB: Players, pathways, perspectives. Oncogene 2006, 25, 6680-6684
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 10
    • 77957252647 scopus 로고    scopus 로고
    • The IKK complex, a central regulator of NF-κB activation
    • Israel, A. The IKK complex, a central regulator of NF-κB activation. Cold Spring Harb. Perspect. Biol. 2010, 2, a000158
    • (2010) Cold Spring Harb. Perspect. Biol , vol.2
    • Israel, A.1
  • 11
    • 84923673640 scopus 로고    scopus 로고
    • The role of hypoxia in inflammatory disease (review)
    • Biddlestone, J.; Bandarra, D.; Rocha, S. The role of hypoxia in inflammatory disease (review). Int. J. Mol. Med. 2015, 35, 859-869
    • (2015) Int. J. Mol. Med , vol.35 , pp. 859-869
    • Biddlestone, J.1    Bandarra, D.2    Rocha, S.3
  • 12
    • 84960402826 scopus 로고    scopus 로고
    • NF-κB and HIF crosstalk in immune responses
    • D'Ignazio, L.; Bandarra, D.; Rocha, S. NF-κB and HIF crosstalk in immune responses. FEBS J. 2016, 283, 413-424
    • (2016) FEBS J , vol.283 , pp. 413-424
    • D'Ignazio, L.1    Bandarra, D.2    Rocha, S.3
  • 13
    • 79952284127 scopus 로고    scopus 로고
    • Weinberg, Hallmarks of cancer: The next generation
    • Hanahan, D.; Robert, A. Weinberg, Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Robert, A.2
  • 14
    • 84940523524 scopus 로고    scopus 로고
    • NF-κB, an active player in human cancers
    • Xia, Y.; Shen, S.; Verma, I.M. NF-κB, an active player in human cancers. Cancer Immunol. Res. 2014, 2, 823-830
    • (2014) Cancer Immunol. Res , vol.2 , pp. 823-830
    • Xia, Y.1    Shen, S.2    Verma, I.M.3
  • 15
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From innocent bystander to major culprit
    • Karin, M.; Cao, Y.; Greten, F.R.; Li, Z.W. NF-κB in cancer: From innocent bystander to major culprit. Nat. Rev. Cancer 2002, 2, 301-310
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 16
    • 0032588186 scopus 로고    scopus 로고
    • NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge, D.C.; Albanese, C.; Reuther, J.Y.; Pestell, R.G.; Baldwin, A.S., Jr. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 1999, 19, 5785-5799
    • (1999) Mol. Cell. Biol , vol.19 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin, A.S.5
  • 17
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C.J. Cancer cell cycles. Science 1996, 274, 1672-1677
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 18
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-κB transcription factors
    • Pahl, H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 1999, 18, 6853-6866
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 19
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-κ B
    • Campbell, J.K.; Rocha, S.; Perkins, N.D. Active repression of antiapoptotic gene expression by RelA(p65) NF-κ B. Mol. Cell 2004, 13, 853-865
    • (2004) Mol. Cell , vol.13 , pp. 853-865
    • Campbell, J.K.1    Rocha, S.2    Perkins, N.D.3
  • 20
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin, M.; Lin, A. NF-κB at the crossroads of life and death. Nat. Immunol. 2002, 3, 221-227
    • (2002) Nat. Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 21
    • 0032954928 scopus 로고    scopus 로고
    • Transcriptional cross talk between NF-κB and p53
    • Webster, G.A.; Perkins, N.D. Transcriptional cross talk between NF-κB and p53. Mol. Cell. Biol. 1999, 19, 3485-3495
    • (1999) Mol. Cell. Biol , vol.19 , pp. 3485-3495
    • Webster, G.A.1    Perkins, N.D.2
  • 23
    • 0034306969 scopus 로고    scopus 로고
    • Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
    • Huang, S.; Robinson, J.B.; Deguzman, A.; Bucana, C.D.; Fidler, I.J. Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res. 2000, 60, 5334-5339
    • (2000) Cancer Res , vol.60 , pp. 5334-5339
    • Huang, S.1    Robinson, J.B.2    Deguzman, A.3    Bucana, C.D.4    Fidler, I.J.5
  • 25
    • 84922485491 scopus 로고    scopus 로고
    • HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals
    • Bandarra, D.; Biddlestone, J.; Mudie, S.; Muller, H.A.; Rocha, S. HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals. Dis. Models Mech. 2015, 8, 169-181
    • (2015) Dis. Models Mech , vol.8 , pp. 169-181
    • Bandarra, D.1    Biddlestone, J.2    Mudie, S.3    Muller, H.A.4    Rocha, S.5
  • 26
    • 84862487817 scopus 로고    scopus 로고
    • Targeted genes and interacting proteins of hypoxia inducible factor-1
    • Liu, W.; Shen, S.M.; Zhao, X.Y.; Chen, G.Q. Targeted genes and interacting proteins of hypoxia inducible factor-1. Int. J. Biochem. Mol. Biol. 2012, 3, 165-178
    • (2012) Int. J. Biochem. Mol. Biol , vol.3 , pp. 165-178
    • Liu, W.1    Shen, S.M.2    Zhao, X.Y.3    Chen, G.Q.4
  • 27
    • 0032508674 scopus 로고    scopus 로고
    • Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-κB
    • Bond, M.; Fabunmi, R.P.; Baker, A.H.; Newby, A.C. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-κB. FEBS Lett. 1998, 435, 29-34
    • (1998) FEBS Lett , vol.435 , pp. 29-34
    • Bond, M.1    Fabunmi, R.P.2    Baker, A.H.3    Newby, A.C.4
  • 28
    • 77955544352 scopus 로고    scopus 로고
    • Correlation of NF-κB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma
    • Yan, M.; Xu, Q.; Zhang, P.; Zhou, X.J.; Zhang, Z.Y.; Chen, W.T. Correlation of NF-κB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma. BMC Cancer 2010, 10, 437
    • (2010) BMC Cancer , vol.10 , pp. 437
    • Yan, M.1    Xu, Q.2    Zhang, P.3    Zhou, X.J.4    Zhang, Z.Y.5    Chen, W.T.6
  • 30
    • 78149432308 scopus 로고    scopus 로고
    • Immune regulation of cancer
    • Disis, M.L. Immune regulation of cancer. J. Clin. Oncol. 2010, 28, 4531-4538
    • (2010) J. Clin. Oncol , vol.28 , pp. 4531-4538
    • Disis, M.L.1
  • 32
    • 0033565763 scopus 로고    scopus 로고
    • Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-κB signaling
    • Van Hogerlinden, M.; Rozell, B.L.; Ahrlund-Richter, L.; Toftgard, R. Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-κB signaling. Cancer Res. 1999, 59, 3299-3303
    • (1999) Cancer Res , vol.59 , pp. 3299-3303
    • Van Hogerlinden, M.1    Rozell, B.L.2    Ahrlund-Richter, L.3    Toftgard, R.4
  • 33
    • 33645999706 scopus 로고    scopus 로고
    • NF-κB and IKK as therapeutic targets in cancer
    • Kim, H.J.; Hawke, N.; Baldwin, A.S. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ. 2006, 13, 738-747
    • (2006) Cell Death Differ , vol.13 , pp. 738-747
    • Kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 36
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-κB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications
    • Jost, P.J.; Ruland, J. Aberrant NF-κB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications. Blood 2007, 109, 2700-2707
    • (2007) Blood , vol.109 , pp. 2700-2707
    • Jost, P.J.1    Ruland, J.2
  • 38
    • 85008430551 scopus 로고    scopus 로고
    • High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer
    • Bennett, L.; Quinn, J.; McCall, P.; Mallon, E.A.; Horgan, P.G.; McMillan, D.C.; Paul, A.; Edwards, J. High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer. Int. J. Cancer 2017, 140, 1633-1644
    • (2017) Int. J. Cancer , vol.140 , pp. 1633-1644
    • Bennett, L.1    Quinn, J.2    McCall, P.3    Mallon, E.A.4    Horgan, P.G.5    McMillan, D.C.6    Paul, A.7    Edwards, J.8
  • 40
  • 41
    • 79955068704 scopus 로고    scopus 로고
    • NF-κB in lung cancer, a carcinogenesis mediator and a prevention and therapy target
    • Chen, W.; Li, Z.; Bai, L.; Lin, Y. NF-κB in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front. Biosci. 2011, 16, 1172-1185
    • (2011) Front. Biosci , vol.16 , pp. 1172-1185
    • Chen, W.1    Li, Z.2    Bai, L.3    Lin, Y.4
  • 42
    • 79751492851 scopus 로고    scopus 로고
    • NF-κB in the liver-Linking injury, fibrosis and hepatocellular carcinoma
    • Luedde, T.; Schwabe, R.F. NF-κB in the liver-Linking injury, fibrosis and hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 2011, 8, 108-118
    • (2011) Nat. Rev. Gastroenterol. Hepatol , vol.8 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 43
    • 33644841576 scopus 로고    scopus 로고
    • NF-κB activation in melanoma
    • Ueda, Y.; Richmond, A. NF-κB activation in melanoma. Pigment Cell Res. 2006, 19, 112-124
    • (2006) Pigment Cell Res , vol.19 , pp. 112-124
    • Ueda, Y.1    Richmond, A.2
  • 45
    • 85014634179 scopus 로고    scopus 로고
    • The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
    • Muz, B.; de la Puente, P.; Azab, F.; Azab, A.K. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia 2015, 3, 83-92
    • (2015) Hypoxia , vol.3 , pp. 83-92
    • Muz, B.1    de la Puente, P.2    Azab, F.3    Azab, A.K.4
  • 47
    • 34547153223 scopus 로고    scopus 로고
    • Gene regulation under low oxygen: Holding your breath for transcription
    • Rocha, S. Gene regulation under low oxygen: Holding your breath for transcription. Trends Biochem. Sci. 2007, 32, 389-397
    • (2007) Trends Biochem. Sci , vol.32 , pp. 389-397
    • Rocha, S.1
  • 48
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks, K.L.; Turley, H.; Gatter, K.C.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.; Harris, A.L. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 2000, 157, 411-421
    • (2000) Am. J. Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 49
    • 84994101177 scopus 로고    scopus 로고
    • Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)
    • Yang, S.L.; Wu, C.; Xiong, Z.F.; Fang, X. Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review). Mol. Med. Rep. 2015, 12, 2411-2416
    • (2015) Mol. Med. Rep , vol.12 , pp. 2411-2416
    • Yang, S.L.1    Wu, C.2    Xiong, Z.F.3    Fang, X.4
  • 50
    • 49649108032 scopus 로고    scopus 로고
    • Regulation of gene expression by hypoxia
    • Kenneth, N.S.; Rocha, S. Regulation of gene expression by hypoxia. Biochem. J. 2008, 414, 19-29
    • (2008) Biochem. J , vol.414 , pp. 19-29
    • Kenneth, N.S.1    Rocha, S.2
  • 51
    • 84655161946 scopus 로고    scopus 로고
    • HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression
    • Keith, B.; Johnson, R.S.; Simon, M.C. HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2011, 12, 9-22
    • (2011) Nat. Rev. Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 52
    • 84897042356 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia
    • Zhang, P.; Yao, Q.; Lu, L.; Li, Y.; Chen, P.J.; Duan, C. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 2014, 6, 1110-1121
    • (2014) Cell Rep , vol.6 , pp. 1110-1121
    • Zhang, P.1    Yao, Q.2    Lu, L.3    Li, Y.4    Chen, P.J.5    Duan, C.6
  • 53
    • 84906939724 scopus 로고    scopus 로고
    • Cell cycle progression in response to oxygen levels
    • Ortmann, B.; Druker, J.; Rocha, S. Cell cycle progression in response to oxygen levels. Cell. Mol. Life Sci. 2014, 71, 3569-3582
    • (2014) Cell. Mol. Life Sci , vol.71 , pp. 3569-3582
    • Ortmann, B.1    Druker, J.2    Rocha, S.3
  • 55
    • 84920856112 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and breast cancer metastasis
    • Liu, Z.J.; Semenza, G.L.; Zhang, H.F. Hypoxia-inducible factor 1 and breast cancer metastasis. J. Zhejiang Univ. Sci. B 2015, 16, 32-43
    • (2015) J. Zhejiang Univ. Sci. B , vol.16 , pp. 32-43
    • Liu, Z.J.1    Semenza, G.L.2    Zhang, H.F.3
  • 57
    • 84907347748 scopus 로고    scopus 로고
    • Chromatin and oxygen sensing in the context of JmjC histone demethylases
    • Shmakova, A.; Batie, M.; Druker, J.; Rocha, S. Chromatin and oxygen sensing in the context of JmjC histone demethylases. Biochem. J. 2014, 462, 385-395
    • (2014) Biochem. J , vol.462 , pp. 385-395
    • Shmakova, A.1    Batie, M.2    Druker, J.3    Rocha, S.4
  • 61
    • 85018461057 scopus 로고    scopus 로고
    • The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations
    • Hancock, R.L.; Masson, N.; Dunne, K.; Flashman, E.; Kawamura, A. The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations. ACS Chem. Biol. 2017, 12, 1011
    • (2017) ACS Chem. Biol , vol.12 , pp. 1011
    • Hancock, R.L.1    Masson, N.2    Dunne, K.3    Flashman, E.4    Kawamura, A.5
  • 62
    • 40649114443 scopus 로고    scopus 로고
    • Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
    • Johnson, A.B.; Denko, N.; Barton, M.C. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat. Res. 2008, 640, 174-179
    • (2008) Mutat. Res , vol.640 , pp. 174-179
    • Johnson, A.B.1    Denko, N.2    Barton, M.C.3
  • 63
    • 77952795537 scopus 로고    scopus 로고
    • Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
    • Zhou, X.; Sun, H.; Chen, H.; Zavadil, J.; Kluz, T.; Arita, A.; Costa, M. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res. 2010, 70, 4214-4221
    • (2010) Cancer Res , vol.70 , pp. 4214-4221
    • Zhou, X.1    Sun, H.2    Chen, H.3    Zavadil, J.4    Kluz, T.5    Arita, A.6    Costa, M.7
  • 64
    • 78651086487 scopus 로고    scopus 로고
    • Hypoxia causes epigenetic gene regulation in macrophages by attenuating jumonji histone demethylase activity
    • Tausendschon, M.; Dehne, N.; Brune, B. Hypoxia causes epigenetic gene regulation in macrophages by attenuating jumonji histone demethylase activity. Cytokine 2011, 53, 256-262
    • (2011) Cytokine , vol.53 , pp. 256-262
    • Tausendschon, M.1    Dehne, N.2    Brune, B.3
  • 66
    • 61349088682 scopus 로고    scopus 로고
    • The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF
    • Beyer, S.; Kristensen, M.M.; Jensen, K.S.; Johansen, J.V.; Staller, P. The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J. Biol. Chem. 2008, 283, 36542-36552
    • (2008) J. Biol. Chem , vol.283 , pp. 36542-36552
    • Beyer, S.1    Kristensen, M.M.2    Jensen, K.S.3    Johansen, J.V.4    Staller, P.5
  • 69
    • 73549088729 scopus 로고    scopus 로고
    • Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 α enhances hypoxic gene expression and tumor growth
    • Krieg, A.J.; Rankin, E.B.; Chan, D.; Razorenova, O.; Fernandez, S.; Giaccia, A.J. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 α enhances hypoxic gene expression and tumor growth. Mol. Cell Biol. 2010, 30, 344-353
    • (2010) Mol. Cell Biol , vol.30 , pp. 344-353
    • Krieg, A.J.1    Rankin, E.B.2    Chan, D.3    Razorenova, O.4    Fernandez, S.5    Giaccia, A.J.6
  • 70
    • 84901424976 scopus 로고    scopus 로고
    • HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions
    • Lee, H.Y.; Choi, K.; Oh, H.; Park, Y.K.; Park, H. HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions. Mol. Cells 2014, 37, 43-50
    • (2014) Mol. Cells , vol.37 , pp. 43-50
    • Lee, H.Y.1    Choi, K.2    Oh, H.3    Park, Y.K.4    Park, H.5
  • 71
    • 85033567883 scopus 로고    scopus 로고
    • KDM2 Family Members are Regulated by HIF-1 in Hypoxia
    • Batie, M.; Druker, J.; D'Ignazio, L.; Rocha, S. KDM2 Family Members are Regulated by HIF-1 in Hypoxia. Cells 2017, 6, 8
    • (2017) Cells , vol.6 , pp. 8
    • Batie, M.1    Druker, J.2    D'Ignazio, L.3    Rocha, S.4
  • 72
    • 85117872385 scopus 로고    scopus 로고
    • Hypoxia Induced NF-κB
    • D'Ignazio, L.; Rocha, S. Hypoxia Induced NF-κB. Cells 2016, 5, 10
    • (2016) Cells , vol.5 , pp. 10
    • D'Ignazio, L.1    Rocha, S.2
  • 73
    • 84935878792 scopus 로고    scopus 로고
    • The impact of hypoxia on bacterial infection
    • Schaffer, K.; Taylor, C.T. The impact of hypoxia on bacterial infection. FEBS J. 2015, 282, 2260-2266
    • (2015) FEBS J , vol.282 , pp. 2260-2266
    • Schaffer, K.1    Taylor, C.T.2
  • 76
    • 84897977203 scopus 로고    scopus 로고
    • STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
    • Pawlus, M.R.;Wang, L.; Hu, C.J. STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2014, 33, 1670-1679
    • (2014) Oncogene , vol.33 , pp. 1670-1679
    • Pawlus, M.R.1    Wang, L.2    Hu, C.J.3
  • 77
    • 45349097483 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1α by NF-κB
    • Van Uden, P.; Kenneth, N.S.; Rocha, S. Regulation of hypoxia-inducible factor-1α by NF-κB. Biochem. J. 2008, 412, 477-484
    • (2008) Biochem. J , vol.412 , pp. 477-484
    • Van Uden, P.1    Kenneth, N.S.2    Rocha, S.3
  • 79
    • 58149380071 scopus 로고    scopus 로고
    • The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-κB-dependent transcription
    • Wright, C.W.; Duckett, C.S. The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-κB-dependent transcription. Science 2009, 323, 251-255
    • (2009) Science , vol.323 , pp. 251-255
    • Wright, C.W.1    Duckett, C.S.2
  • 80
    • 17144420466 scopus 로고    scopus 로고
    • Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator
    • Bracken, C.P.; Whitelaw, M.L.; Peet, D.J. Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator. J. Biol. Chem. 2005, 280, 14240-14251
    • (2005) J. Biol. Chem , vol.280 , pp. 14240-14251
    • Bracken, C.P.1    Whitelaw, M.L.2    Peet, D.J.3
  • 81
    • 84955657303 scopus 로고    scopus 로고
    • HIF-1 at the crossroads of hypoxia, inflammation, and cancer
    • Balamurugan, K. HIF-1 at the crossroads of hypoxia, inflammation, and cancer. Int. J. Cancer 2016, 138, 1058-1066
    • (2016) Int. J. Cancer , vol.138 , pp. 1058-1066
    • Balamurugan, K.1
  • 82
    • 84905833585 scopus 로고    scopus 로고
    • Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis
    • Kim, E.R.; Chang, D.K. Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis. World J. Gastroenterol. 2014, 20, 9872-9881
    • (2014) World J. Gastroenterol , vol.20 , pp. 9872-9881
    • Kim, E.R.1    Chang, D.K.2
  • 83
    • 85013883423 scopus 로고    scopus 로고
    • Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils
    • Triner, D.; Xue, X.; Schwartz, A.J.; Jung, I.; Colacino, J.A.; Shah, Y.M. Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils. Mol. Cell. Biol. 2017, 37, e00481-16
    • (2017) Mol. Cell. Biol , vol.37
    • Triner, D.1    Xue, X.2    Schwartz, A.J.3    Jung, I.4    Colacino, J.A.5    Shah, Y.M.6
  • 84
    • 84991728255 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: A central link between inflammation and cancer
    • Triner, D.; Shah, Y.M. Hypoxia-inducible factors: A central link between inflammation and cancer. J. Clin. Investig. 2016, 126, 3689-3698
    • (2016) J. Clin. Investig , vol.126 , pp. 3689-3698
    • Triner, D.1    Shah, Y.M.2
  • 85
  • 89
    • 70350373671 scopus 로고    scopus 로고
    • The role of NF-κB in hypoxia-induced gene expression
    • Taylor, C.T.; Cummins, E.P. The role of NF-κB in hypoxia-induced gene expression. Ann. N. Y. Acad. Sci. 2009, 1177, 178-184
    • (2009) Ann. N. Y. Acad. Sci , vol.1177 , pp. 178-184
    • Taylor, C.T.1    Cummins, E.P.2
  • 90
    • 79952672743 scopus 로고    scopus 로고
    • Further insights into the mechanism of hypoxia-induced NFκB
    • Melvin, A.; Mudie, S.; Rocha, S. Further insights into the mechanism of hypoxia-induced NFκB. Cell Cycle 2011, 10, 879-882
    • (2011) Cell Cycle , vol.10 , pp. 879-882
    • Melvin, A.1    Mudie, S.2    Rocha, S.3
  • 92
    • 84904735527 scopus 로고    scopus 로고
    • Over-expression of prolyl hydroxylase-1 blocks NF-κB-mediated cyclin D1 expression and proliferation in lung carcinoma cells
    • Xie, X.; Xiao, H.; Ding, F.; Zhong, H.; Zhu, J.; Ma, N.; Mei, J. Over-expression of prolyl hydroxylase-1 blocks NF-κB-mediated cyclin D1 expression and proliferation in lung carcinoma cells. Cancer Genet. 2014, 207, 188-194
    • (2014) Cancer Genet , vol.207 , pp. 188-194
    • Xie, X.1    Xiao, H.2    Ding, F.3    Zhong, H.4    Zhu, J.5    Ma, N.6    Mei, J.7
  • 93
    • 77950565914 scopus 로고    scopus 로고
    • Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway
    • Fu, J.; Taubman, M.B. Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway. J. Biol. Chem. 2010, 285, 8927-8935
    • (2010) J. Biol. Chem , vol.285 , pp. 8927-8935
    • Fu, J.1    Taubman, M.B.2
  • 94
    • 84880658083 scopus 로고    scopus 로고
    • EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase gamma ubiquitination
    • Fu, J.; Taubman, M.B. EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase gamma ubiquitination. Mol. Cell. Biol. 2013, 33, 3050-3061
    • (2013) Mol. Cell. Biol , vol.33 , pp. 3050-3061
    • Fu, J.1    Taubman, M.B.2
  • 97
    • 84924873099 scopus 로고    scopus 로고
    • Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus
    • Li, J.; Yuan, W.; Jiang, S.; Ye, W.; Yang, H.; Shapiro, I.M.; Risbud, M.V. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. J. Biol. Chem. 2015, 290, 7195-7207
    • (2015) J. Biol. Chem , vol.290 , pp. 7195-7207
    • Li, J.1    Yuan, W.2    Jiang, S.3    Ye, W.4    Yang, H.5    Shapiro, I.M.6    Risbud, M.V.7
  • 100
    • 73149099403 scopus 로고    scopus 로고
    • Regulation of NF-κB activity through lysine monomethylation of p65
    • Ea, C.K.; Baltimore, D. Regulation of NF-κB activity through lysine monomethylation of p65. Proc. Natl. Acad. Sci. USA 2009, 106, 18972-18977
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 18972-18977
    • Ea, C.K.1    Baltimore, D.2
  • 101
    • 67349285384 scopus 로고    scopus 로고
    • Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunit
    • Yang, X.D.; Huang, B.; Li, M.; Lamb, A.; Kelleher, N.L.; Chen, L.F. Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J. 2009, 28, 1055-1066
    • (2009) EMBO J , vol.28 , pp. 1055-1066
    • Yang, X.D.1    Huang, B.2    Li, M.3    Lamb, A.4    Kelleher, N.L.5    Chen, L.F.6
  • 102
    • 78650308842 scopus 로고    scopus 로고
    • Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling
    • Levy, D.; Kuo, A.J.; Chang, Y.; Schaefer, U.; Kitson, C.; Cheung, P.; Espejo, A.; Zee, B.M.; Liu, C.L.; Tangsombatvisit, S.; et al. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat. Immunol. 2011, 12, 29-36
    • (2011) Nat. Immunol , vol.12 , pp. 29-36
    • Levy, D.1    Kuo, A.J.2    Chang, Y.3    Schaefer, U.4    Kitson, C.5    Cheung, P.6    Espejo, A.7    Zee, B.M.8    Liu, C.L.9    Tangsombatvisit, S.10
  • 103
    • 79958797383 scopus 로고    scopus 로고
    • F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway
    • Ge, R.; Wang, Z.; Zeng, Q.; Xu, X.; Olumi, A.F. F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway. Cell Death Differ. 2011, 18, 1184-1195
    • (2011) Cell Death Differ , vol.18 , pp. 1184-1195
    • Ge, R.1    Wang, Z.2    Zeng, Q.3    Xu, X.4    Olumi, A.F.5
  • 106
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor κ B through the phosphorylation of IκB α on tyrosine residues
    • Koong, A.C.; Chen, E.Y.; Giaccia, A.J. Hypoxia causes the activation of nuclear factor κ B through the phosphorylation of IκB α on tyrosine residues. Cancer Res. 1994, 54, 1425-1430
    • (1994) Cancer Res , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 109
    • 84906831786 scopus 로고    scopus 로고
    • Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster
    • Bandarra, D.; Biddlestone, J.; Mudie, S.; Muller, H.A.; Rocha, S. Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster. Biosci. Rep. 2014, 34
    • (2014) Biosci. Rep , pp. 34
    • Bandarra, D.1    Biddlestone, J.2    Mudie, S.3    Muller, H.A.4    Rocha, S.5
  • 110
    • 67649403609 scopus 로고    scopus 로고
    • Adenosine signaling mediates SUMO-1 modification of IκBα during hypoxia and reoxygenation
    • Liu, Q.; Li, J.; Khoury, J.; Colgan, S.P.; Ibla, J.C. Adenosine signaling mediates SUMO-1 modification of IκBα during hypoxia and reoxygenation. J. Biol. Chem. 2009, 284, 13686-13695
    • (2009) J. Biol. Chem , vol.284 , pp. 13686-13695
    • Liu, Q.1    Li, J.2    Khoury, J.3    Colgan, S.P.4    Ibla, J.C.5
  • 113
    • 84962150091 scopus 로고    scopus 로고
    • Global patterns and trends in colorectal cancer incidence and mortality
    • Arnold, M.; Sierra, M.S.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2017, 66, 683-691
    • (2017) Gut , vol.66 , pp. 683-691
    • Arnold, M.1    Sierra, M.S.2    Laversanne, M.3    Soerjomataram, I.4    Jemal, A.5    Bray, F.6
  • 114
    • 70350764831 scopus 로고    scopus 로고
    • NF-κB signaling pathway, inflammation and colorectal cancer
    • Wang, S.; Liu, Z.; Wang, L.; Zhang, X. NF-κB signaling pathway, inflammation and colorectal cancer. Cell. Mol. Immunol. 2009, 6, 327-334
    • (2009) Cell. Mol. Immunol , vol.6 , pp. 327-334
    • Wang, S.1    Liu, Z.2    Wang, L.3    Zhang, X.4
  • 118
    • 2442625634 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours
    • Jubb, A.M.; Pham, T.Q.; Hanby, A.M.; Frantz, G.D.; Peale, F.V.; Wu, T.D.; Koeppen, H.W.; Hillan, K.J. Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours. J. Clin. Pathol. 2004, 57, 504-512
    • (2004) J. Clin. Pathol , vol.57 , pp. 504-512
    • Jubb, A.M.1    Pham, T.Q.2    Hanby, A.M.3    Frantz, G.D.4    Peale, F.V.5    Wu, T.D.6    Koeppen, H.W.7    Hillan, K.J.8
  • 119
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda, R.; Hirota, K.; Fan, F.; Jung, Y.D.; Ellis, L.M.; Semenza, G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 2002, 277, 38205-38211
    • (2002) J. Biol. Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 120
    • 32944477859 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts
    • Dang, D.T.; Chen, F.; Gardner, L.B.; Cummins, J.M.; Rago, C.; Bunz, F.; Kantsevoy, S.V.; Dang, L.H. Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts. Cancer Res. 2006, 66, 1684-1936
    • (2006) Cancer Res , vol.66 , pp. 1684-1936
    • Dang, D.T.1    Chen, F.2    Gardner, L.B.3    Cummins, J.M.4    Rago, C.5    Bunz, F.6    Kantsevoy, S.V.7    Dang, L.H.8
  • 122
    • 84905980742 scopus 로고    scopus 로고
    • Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer
    • Rawluszko-Wieczorek, A.A.; Horbacka, K.; Krokowicz, P.; Misztal, M.; Jagodzinski, P.P. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. Mol. Cancer Res. 2014, 12, 1112-1127
    • (2014) Mol. Cancer Res , vol.12 , pp. 1112-1127
    • Rawluszko-Wieczorek, A.A.1    Horbacka, K.2    Krokowicz, P.3    Misztal, M.4    Jagodzinski, P.P.5
  • 124
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R.; Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 1990, 61, 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 125
    • 41549117418 scopus 로고    scopus 로고
    • Cell regulation by the Apc protein Apc as master regulator of epithelia
    • McCartney, B.M.; Nathke, I.S. Cell regulation by the Apc protein Apc as master regulator of epithelia. Curr. Opin. Cell Biol. 2008, 20, 186-193
    • (2008) Curr. Opin. Cell Biol , vol.20 , pp. 186-193
    • McCartney, B.M.1    Nathke, I.S.2
  • 126
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • Bienz, M.; Clevers, H. Linking colorectal cancer to Wnt signaling. Cell 2000, 103, 311-320
    • (2000) Cell , vol.103 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 127
    • 78149316509 scopus 로고    scopus 로고
    • Adenomatous polyposis coli and hypoxia-inducible factor-1α have an antagonistic connection
    • Newton, I.P.; Kenneth, N.S.; Appleton, P.L.;Nathke, I.; Rocha, S.Adenomatous polyposis coli and hypoxia-inducible factor-1α have an antagonistic connection.Mol. Biol. Cell 2010, 21, 3630-3638
    • (2010) Mol. Biol Cell , vol.21 , pp. 3630-3638
    • Newton, I.P.1    Kenneth, N.S.2    Appleton, P.L.3    Nathke, I.4    Rocha, S.5
  • 128
    • 79956015465 scopus 로고    scopus 로고
    • Antagonistic crosstalk between APC and HIF-1α
    • Nathke, I.; Rocha, S. Antagonistic crosstalk between APC and HIF-1α. Cell Cycle 2011, 10, 1545-1547
    • (2011) Cell Cycle , vol.10 , pp. 1545-1547
    • Nathke, I.1    Rocha, S.2
  • 129
    • 84937579754 scopus 로고    scopus 로고
    • Kdm2α/β Lysine demethylases regulate canonical wnt signaling by modulating the stability of nuclear β-catenin
    • Lu, L.; Gao, Y.; Zhang, Z.; Cao, Q.; Zhang, X.; Zou, J.; Cao, Y. Kdm2α/β Lysine demethylases regulate canonical wnt signaling by modulating the stability of nuclear β-catenin. Dev. Cell 2015, 33, 660-674
    • (2015) Dev. Cell , vol.33 , pp. 660-674
    • Lu, L.1    Gao, Y.2    Zhang, Z.3    Cao, Q.4    Zhang, X.5    Zou, J.6    Cao, Y.7
  • 130
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • Zhang, H.; Gao, P.; Fukuda, R.; Kumar, G.; Krishnamachary, B.; Zeller, K.I.; Dang, C.V.; Semenza, G.L. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007, 11, 407-420
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6    Dang, C.V.7    Semenza, G.L.8
  • 131
  • 132
    • 34547580590 scopus 로고    scopus 로고
    • HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
    • Gordan, J.D.; Thompson, C.B.; Simon, M.C. HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007, 12, 108-113
    • (2007) Cancer Cell , vol.12 , pp. 108-113
    • Gordan, J.D.1    Thompson, C.B.2    Simon, M.C.3
  • 134
    • 77953597349 scopus 로고    scopus 로고
    • A therapeutic role for targeting c-Myc/HIF-1-dependent signaling pathways
    • Podar, K.; Anderson, K.C. A therapeutic role for targeting c-Myc/HIF-1-dependent signaling pathways. Cell. Cycle 2010, 9, 1722-1728
    • (2010) Cell. Cycle , vol.9 , pp. 1722-1728
    • Podar, K.1    Anderson, K.C.2
  • 135
    • 0025302552 scopus 로고
    • Interaction of an NF-κB-like factor with a site upstream of the c-myc promoter
    • Duyao, M.P.; Buckler, A.J.; Sonenshein, G.E. Interaction of an NF-κB-like factor with a site upstream of the c-myc promoter. Proc. Natl. Acad. Sci. USA 1990, 87, 4727-4731
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4727-4731
    • Duyao, M.P.1    Buckler, A.J.2    Sonenshein, G.E.3
  • 136
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan, J.D.; Bertout, J.A.; Hu, C.J.; Diehl, J.A.; Simon, M.C. HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007, 11, 335-347
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5
  • 137
    • 84872680968 scopus 로고    scopus 로고
    • Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer
    • Fan, X.J.; Wan, X.B.; Yang, Z.L.; Fu, X.H.; Huang, Y.; Chen, D.K.; Song, S.X.; Liu, Q.; Xiao, H.Y.; Wang, L.; et al. Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer. Hum. Pathol. 2013, 44, 173-180
    • (2013) Hum. Pathol , vol.44 , pp. 173-180
    • Fan, X.J.1    Wan, X.B.2    Yang, Z.L.3    Fu, X.H.4    Huang, Y.5    Chen, D.K.6    Song, S.X.7    Liu, Q.8    Xiao, H.Y.9    Wang, L.10
  • 141
    • 76949084622 scopus 로고    scopus 로고
    • TNF-α/ NF-κB/Snail pathway in cancer cell migration and invasion
    • Wu, Y.; Zhou, B.P. TNF-α/ NF-κB/Snail pathway in cancer cell migration and invasion. Br. J. Cancer 2010, 102, 639-644
    • (2010) Br. J. Cancer , vol.102 , pp. 639-644
    • Wu, Y.1    Zhou, B.P.2
  • 143
    • 84856213846 scopus 로고    scopus 로고
    • The diverse and complex roles of NF-κB subunits in cancer
    • Perkins, N.D. The diverse and complex roles of NF-κB subunits in cancer. Nat. Rev. Cancer 2012, 12, 121-132
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 121-132
    • Perkins, N.D.1
  • 145
    • 81255147963 scopus 로고    scopus 로고
    • KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells
    • Pereira, F.; Barbachano, A.; Silva, J.; Bonilla, F.; Campbell, M.J.; Munoz, A.; Larriba, M.J. KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. Hum. Mol. Genet. 2011, 20, 4655-4665
    • (2011) Hum. Mol. Genet , vol.20 , pp. 4655-4665
    • Pereira, F.1    Barbachano, A.2    Silva, J.3    Bonilla, F.4    Campbell, M.J.5    Munoz, A.6    Larriba, M.J.7
  • 146
    • 75149150805 scopus 로고    scopus 로고
    • Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKβ independent of hydroxylase activity
    • Xue, J.; Li, X.; Jiao, S.;Wei, Y.;Wu, G.; Fang, J. Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKβ independent of hydroxylase activity. Gastroenterology 2010, 138, 606-615
    • (2010) Gastroenterology , vol.138 , pp. 606-615
    • Xue, J.1    Li, X.2    Jiao, S.3    Wei, Y.4    Wu, G.5    Fang, J.6
  • 149
    • 33846828787 scopus 로고    scopus 로고
    • NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2
    • Chua, H.L.; Bhat-Nakshatri, P.; Clare, S.E.; Morimiya, A.; Badve, S.; Nakshatri, H. NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2. Oncogene 2007, 26, 711-724
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 150
    • 0034682527 scopus 로고    scopus 로고
    • Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells
    • Biswas, D.K.; Cruz, A.P.; Gansberger, E.; Pardee, A.B. Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc. Natl. Acad. Sci. USA 2000, 97, 8542-8547
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8542-8547
    • Biswas, D.K.1    Cruz, A.P.2    Gansberger, E.3    Pardee, A.B.4
  • 151
    • 84945206872 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα
    • Sethi, G.; Ahn, K.S.; Chaturvedi, M.M.; Aggarwal, B.B. Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα. Oncogene 2015, 34, 5407
    • (2015) Oncogene , vol.34 , pp. 5407
    • Sethi, G.1    Ahn, K.S.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 153
    • 84887314092 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factors in breast cancer metastasis
    • Gilkes, D.M.; Semenza, G.L. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncol. 2013, 9, 1623-1636
    • (2013) Future Oncol , vol.9 , pp. 1623-1636
    • Gilkes, D.M.1    Semenza, G.L.2
  • 154
    • 84865149277 scopus 로고    scopus 로고
    • Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
    • Wong, C.C.; Zhang, H.; Gilkes, D.M.; Chen, J.; Wei, H.; Chaturvedi, P.; Hubbi, M.E.; Semenza, G.L. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J. Mol. Med. 2012, 90, 803-815
    • (2012) J. Mol. Med , vol.90 , pp. 803-815
    • Wong, C.C.1    Zhang, H.2    Gilkes, D.M.3    Chen, J.4    Wei, H.5    Chaturvedi, P.6    Hubbi, M.E.7    Semenza, G.L.8
  • 155
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee, K.; Qian, D.Z.; Rey, S.; Wei, H.; Liu, J.O.; Semenza, G.L. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. USA 2009, 106, 2353-2358
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 2353-2358
    • Lee, K.1    Qian, D.Z.2    Rey, S.3    Wei, H.4    Liu, J.O.5    Semenza, G.L.6
  • 157
    • 0036493984 scopus 로고    scopus 로고
    • Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer
    • Leek, R.D.; Talks, K.L.; Pezzella, F.; Turley, H.; Campo, L.; Brown, N.S.; Bicknell, R.; Taylor, M.; Gatter, K.C.; Harris, A.L. Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer. Cancer Res. 2002, 62, 1326-1329
    • (2002) Cancer Res , vol.62 , pp. 1326-1329
    • Leek, R.D.1    Talks, K.L.2    Pezzella, F.3    Turley, H.4    Campo, L.5    Brown, N.S.6    Bicknell, R.7    Taylor, M.8    Gatter, K.C.9    Harris, A.L.10
  • 159
    • 84879424156 scopus 로고    scopus 로고
    • Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients
    • De Boniface, J.; Mao, Y.; Schmidt-Mende, J.; Kiessling, R.; Poschke, I. Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients. Oncoimmunology 2012, 1, 1305-1312
    • (2012) Oncoimmunology , vol.1 , pp. 1305-1312
    • De Boniface, J.1    Mao, Y.2    Schmidt-Mende, J.3    Kiessling, R.4    Poschke, I.5
  • 160
    • 82455199298 scopus 로고    scopus 로고
    • Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor
    • Pryor, J.G.; Brown-Kipphut, B.A.; Iqbal, A.; Scott, G.A. Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor. Am. J. Dermatopathol. 2011, 33, 780-785
    • (2011) Am. J. Dermatopathol , vol.33 , pp. 780-785
    • Pryor, J.G.1    Brown-Kipphut, B.A.2    Iqbal, A.3    Scott, G.A.4
  • 161
    • 0034282790 scopus 로고    scopus 로고
    • Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines
    • Yang, Z.Q.; Imoto, I.; Fukuda, Y.; Pimkhaokham, A.; Shimada, Y.; Imamura, M.; Sugano, S.; Nakamura, Y.; Inazawa, J. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res. 2000, 60, 4735-4739
    • (2000) Cancer Res , vol.60 , pp. 4735-4739
    • Yang, Z.Q.1    Imoto, I.2    Fukuda, Y.3    Pimkhaokham, A.4    Shimada, Y.5    Imamura, M.6    Sugano, S.7    Nakamura, Y.8    Inazawa, J.9
  • 162
    • 84855168980 scopus 로고    scopus 로고
    • Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer
    • Patani, N.; Jiang, W.G.; Newbold, R.F.;Mokbel, K. Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer. Anticancer Res. 2011, 31, 4115-4125
    • (2011) Anticancer Res , vol.31 , pp. 4115-4125
    • Patani, N.1    Jiang, W.G.2    Newbold, R.F.3    Mokbel, K.4
  • 163
    • 79956291600 scopus 로고    scopus 로고
    • Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
    • Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; et al. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc. Natl. Acad. Sci. USA 2011, 108, 7541-7546
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 7541-7546
    • Shi, L.1    Sun, L.2    Li, Q.3    Liang, J.4    Yu, W.5    Yi, X.6    Yang, X.7    Li, Y.8    Han, X.9    Zhang, Y.10
  • 164
    • 0037145309 scopus 로고    scopus 로고
    • PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: A new cancer/testis antigen?
    • Barrett, A.; Madsen, B.; Copier, J.; Lu, P.J.; Cooper, L.; Scibetta, A.G.; Burchell, J.; Taylor-Papadimitriou, J. PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: A new cancer/testis antigen? Int. J. Cancer 2002, 101, 581-588
    • (2002) Int. J. Cancer , vol.101 , pp. 581-588
    • Barrett, A.1    Madsen, B.2    Copier, J.3    Lu, P.J.4    Cooper, L.5    Scibetta, A.G.6    Burchell, J.7    Taylor-Papadimitriou, J.8
  • 165
    • 77949468885 scopus 로고    scopus 로고
    • Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway
    • Hayami, S.; Yoshimatsu, M.; Veerakumarasivam, A.; Unoki, M.; Iwai, Y.; Tsunoda, T.; Field, H.I.; Kelly, J.D.; Neal, D.E.; Yamaue, H.; et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol. Cancer 2010, 9, 59
    • (2010) Mol. Cancer , vol.9 , pp. 59
    • Hayami, S.1    Yoshimatsu, M.2    Veerakumarasivam, A.3    Unoki, M.4    Iwai, Y.5    Tsunoda, T.6    Field, H.I.7    Kelly, J.D.8    Neal, D.E.9    Yamaue, H.10
  • 167
    • 84959116049 scopus 로고    scopus 로고
    • Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448
    • Bamodu, O.A.; Huang, W.C.; Lee, W.H.;Wu, A.;Wang, L.S.; Hsiao, M.; Yeh, C.T.; Chao, T.Y. Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. BMC Cancer 2016, 16, 160
    • (2016) BMC Cancer , vol.16 , pp. 160
    • Bamodu, O.A.1    Huang, W.C.2    Lee, W.H.3    Wu, A.4    Wang, L.S.5    Hsiao, M.6    Yeh, C.T.7    Chao, T.Y.8
  • 168
    • 84947127960 scopus 로고    scopus 로고
    • JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression
    • Shen, X.; Zhuang, Z.; Zhang, Y.; Chen, Z.; Shen, L.; Pu, W.; Chen, L.; Xu, Z. JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression. Tumour Biol. 2015, 36, 7133-7142
    • (2015) Tumour Biol , vol.36 , pp. 7133-7142
    • Shen, X.1    Zhuang, Z.2    Zhang, Y.3    Chen, Z.4    Shen, L.5    Pu, W.6    Chen, L.7    Xu, Z.8
  • 169
    • 70449109147 scopus 로고    scopus 로고
    • Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
    • Meylan, E.; Dooley, A.L.; Feldser, D.M.; Shen, L.; Turk, E.; Ouyang, C.; Jacks, T. Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma. Nature 2009, 462, 104-107
    • (2009) Nature , vol.462 , pp. 104-107
    • Meylan, E.1    Dooley, A.L.2    Feldser, D.M.3    Shen, L.4    Turk, E.5    Ouyang, C.6    Jacks, T.7
  • 170
  • 172
    • 84937774684 scopus 로고    scopus 로고
    • Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer
    • Liu, H.; Liu, L.; Holowatyj, A.; Jiang, Y.; Yang, Z.Q. Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. Mol. Carcinog. 2016, 55, 977-990
    • (2016) Mol. Carcinog , vol.55 , pp. 977-990
    • Liu, H.1    Liu, L.2    Holowatyj, A.3    Jiang, Y.4    Yang, Z.Q.5
  • 175
    • 84973304712 scopus 로고    scopus 로고
    • Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia
    • Oh, E.T.; Kim, C.W.; Kim, S.J.; Lee, J.S.; Hong, S.S.; Park, H.J. Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia. Sci. Rep. 2016, 6, 27382
    • (2016) Sci. Rep , vol.6 , pp. 27382
    • Oh, E.T.1    Kim, C.W.2    Kim, S.J.3    Lee, J.S.4    Hong, S.S.5    Park, H.J.6
  • 176
    • 84860351589 scopus 로고    scopus 로고
    • Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients
    • Peurala, E.; Koivunen, P.; Bloigu, R.; Haapasaari, K.M.; Jukkola-Vuorinen, A. Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients. Breast Cancer Res. Treat. 2012, 133, 179-188
    • (2012) Breast Cancer Res. Treat , vol.133 , pp. 179-188
    • Peurala, E.1    Koivunen, P.2    Bloigu, R.3    Haapasaari, K.M.4    Jukkola-Vuorinen, A.5
  • 177
    • 84879790190 scopus 로고    scopus 로고
    • The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with BCL-2 in non-small cell lung cancer
    • Chen, S.; Zhang, J.; Li, X.; Luo, X.; Fang, J.; Chen, H. The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with BCL-2 in non-small cell lung cancer. Mol. Cell. Biochem. 2011, 358, 257-263
    • (2011) Mol. Cell. Biochem , vol.358 , pp. 257-263
    • Chen, S.1    Zhang, J.2    Li, X.3    Luo, X.4    Fang, J.5    Chen, H.6
  • 178
    • 80051934217 scopus 로고    scopus 로고
    • Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival
    • Andersen, S.; Donnem, T.; Stenvold, H.; Al-Saad, S.; Al-Shibli, K.; Busund, L.T.; Bremnes, R.M. Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival. PLoS ONE 2011, 6, e23847
    • (2011) PLoS ONE , vol.6
    • Andersen, S.1    Donnem, T.2    Stenvold, H.3    Al-Saad, S.4    Al-Shibli, K.5    Busund, L.T.6    Bremnes, R.M.7
  • 181
    • 84983546693 scopus 로고    scopus 로고
    • Targeting hypoxia in inflammatory bowel disease
    • Colgan, S.P. Targeting hypoxia in inflammatory bowel disease. J. Investig. Med. 2016, 64, 364-368
    • (2016) J. Investig. Med , vol.64 , pp. 364-368
    • Colgan, S.P.1
  • 187
    • 84959516180 scopus 로고    scopus 로고
    • Aspirin and colorectal cancer: The promise of precision chemoprevention
    • Drew, D.A.; Cao, Y.; Chan, A.T. Aspirin and colorectal cancer: The promise of precision chemoprevention. Nat. Rev. Cancer 2016, 16, 173-186
    • (2016) Nat. Rev. Cancer , vol.16 , pp. 173-186
    • Drew, D.A.1    Cao, Y.2    Chan, A.T.3
  • 188
    • 85006256356 scopus 로고    scopus 로고
    • Blocking NF-κB is essential for the immunotherapeutic effect of recombinant IL18 in pancreatic cancer
    • Guo, X.; Zheng, L.; Jiang, J.; Zhao, Y.; Wang, X.; Shen, M.; Zhu, F.; Tian, R.; Shi, C.; Xu, M.; et al. Blocking NF-κB is essential for the immunotherapeutic effect of recombinant IL18 in pancreatic cancer. Clin. Cancer Res. 2016, 22, 5939-5950
    • (2016) Clin. Cancer Res , vol.22 , pp. 5939-5950
    • Guo, X.1    Zheng, L.2    Jiang, J.3    Zhao, Y.4    Wang, X.5    Shen, M.6    Zhu, F.7    Tian, R.8    Shi, C.9    Xu, M.10
  • 189
    • 85016724516 scopus 로고    scopus 로고
    • Cancer immunotherapies targeting the PD-1 signaling pathway
    • Iwai, Y.; Hamanishi, J.; Chamoto, K.; Honjo, T. Cancer immunotherapies targeting the PD-1 signaling pathway. J. Biomed. Sci. 2017, 24, 26
    • (2017) J. Biomed. Sci , vol.24 , pp. 26
    • Iwai, Y.1    Hamanishi, J.2    Chamoto, K.3    Honjo, T.4
  • 190
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman, M.Z.; Desantis, G.; Janji, B.; Hasmim, M.; Karray, S.; Dessen, P.; Bronte, V.; Chouaib, S. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J. Exp. Med. 2014, 211, 781-790
    • (2014) J. Exp. Med , vol.211 , pp. 781-790
    • Noman, M.Z.1    Desantis, G.2    Janji, B.3    Hasmim, M.4    Karray, S.5    Dessen, P.6    Bronte, V.7    Chouaib, S.8
  • 191
    • 23844527189 scopus 로고    scopus 로고
    • Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor κB activity
    • An, J.; Rettig, M.B. Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor κB activity. Mol. Cell. Biol. 2005, 25, 7546-7556
    • (2005) Mol. Cell. Biol , vol.25 , pp. 7546-7556
    • An, J.1    Rettig, M.B.2
  • 193
    • 84989908979 scopus 로고    scopus 로고
    • pVHL mediates K63-linked ubiquitination of IKKβ, leading to IKKβ inactivation
    • Wang, Y.; Zhao, W.; Gao, Q.; Fan, L.; Qin, Y.; Zhou, H.; Li, M.; Fang, J. pVHL mediates K63-linked ubiquitination of IKKβ, leading to IKKβ inactivation. Cancer Lett. 2016, 383, 1-8
    • (2016) Cancer Lett , vol.383 , pp. 1-8
    • Wang, Y.1    Zhao, W.2    Gao, Q.3    Fan, L.4    Qin, Y.5    Zhou, H.6    Li, M.7    Fang, J.8


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