A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection

Journal of Molecular Medicine

Volumn 90, Issue 9, 2012, Pages 1079-1089

  Okumura, Cheryl Y M ^a   Hollands, Andrew ^a   Tran, Dan N ^a   Olson, Joshua ^a   Dahesh, Samira ^a   Von Köckritz Blickwede, Maren ^a   Thienphrapa, Wdee ^a   Corle, Courtney ^b   Jeung, Seung Nam ^b   Kotsakis, Anna ^d   Shalwitz, Robert A ^d   Johnson, Randall S ^b   Nizet, Victor ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Aerpio Therapeutics Inc   (United States)

Author keywords

Antibiotic resistant bacteria; Bacterial infection; Hypoxia inducible factor 1 (HIF 1); Innate immunity; Staphylococcus aureus

Indexed keywords

AKB 4924; ANTIINFECTIVE AGENT; HYPOXIA INDUCIBLE FACTOR 1; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; INNATE IMMUNITY; KERATINOCYTE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; PHAGOCYTE; PSEUDOMONAS AERUGINOSA; SKIN ABSCESS;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; IMMUNITY, INNATE; KERATINOCYTES; MICE; PHAGOCYTES; PIPERAZINES; PYRIDONES; SKIN; SKIN DISEASES, BACTERIAL; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84867335615     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0882-3     Document Type: Article

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