메뉴 건너뛰기




Volumn 126, Issue 10, 2016, Pages 3689-3698

Hypoxia-inducible factors: A central link between inflammation and cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; REACTIVE OXYGEN METABOLITE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HYPOXIA INDUCIBLE FACTOR 1;

EID: 84991728255     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI84430     Document Type: Review
Times cited : (148)

References (144)
  • 1
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014-1022.
    • (2013) Nat Immunol , vol.14 , Issue.10 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 2
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 2012;148(3):399-408.
    • (2012) Cell , vol.148 , Issue.3 , pp. 399-408
    • Semenza, G.L.1
  • 3
    • 0037315337 scopus 로고    scopus 로고
    • Widespread hypoxiainducible expression of HIF-2alpha in distinct cell populations of different organs
    • Wiesener MS, et al. Widespread hypoxiainducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J. 2003;17(2):271-273.
    • (2003) FASEB J , vol.17 , Issue.2 , pp. 271-273
    • Wiesener, M.S.1
  • 4
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxiainducible factor 1
    • Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxiainducible factor 1. Biochem Biophys Res Commun. 1996;225(2):485-488.
    • (1996) Biochem Biophys Res Commun , vol.225 , Issue.2 , pp. 485-488
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 5
    • 0031733828 scopus 로고    scopus 로고
    • Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
    • Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr. 1998;7(3):205-213.
    • (1998) Gene Expr , vol.7 , Issue.3 , pp. 205-213
    • Gu, Y.Z.1    Moran, S.M.2    Hogenesch, J.B.3    Wartman, L.4    Bradfield, C.A.5
  • 6
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • Rius J, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008;453(7196):807-811.
    • (2008) Nature , vol.453 , Issue.7196 , pp. 807-811
    • Rius, J.1
  • 7
    • 85027948564 scopus 로고    scopus 로고
    • Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1α upon LPS activation in the presence of ample oxygen
    • Siegert I, et al. ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1α upon LPS activation in the presence of ample oxygen. Cell Rep. 2015;13(10):2048-2055.
    • (2015) Cell Rep , vol.13 , Issue.10 , pp. 2048-2055
    • Siegert, I.1
  • 8
    • 15944397647 scopus 로고    scopus 로고
    • Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha
    • Haddad JJ, Harb HL. Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha. Int Immunopharmacol. 2005;5(3):461-483.
    • (2005) Int Immunopharmacol , vol.5 , Issue.3 , pp. 461-483
    • Haddad, J.J.1    Harb, H.L.2
  • 9
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1β through HIF-1α
    • Tannahill GM, et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature. 2013;496(7444):238-242.
    • (2013) Nature , vol.496 , Issue.7444 , pp. 238-242
    • Tannahill, G.M.1
  • 10
    • 77649177217 scopus 로고    scopus 로고
    • Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
    • Takeda N, et al. Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis. Genes Dev. 2010;24(5):491-501.
    • (2010) Genes Dev , vol.24 , Issue.5 , pp. 491-501
    • Takeda, N.1
  • 11
    • 0033181324 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
    • Hellwig-Bürgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood. 1999;94(5):1561-1567.
    • (1999) Blood , vol.94 , Issue.5 , pp. 1561-1567
    • Hellwig-Bürgel, T.1    Rutkowski, K.2    Metzen, E.3    Fandrey, J.4    Jelkmann, W.5
  • 12
    • 0035860375 scopus 로고    scopus 로고
    • A non-hypoxic, ROSsensitive pathway mediates TNF-alphadependent regulation of HIF-1alpha
    • Haddad JJ, Land SC. A non-hypoxic, ROSsensitive pathway mediates TNF-alphadependent regulation of HIF-1alpha. FEBS Lett. 2001;505(2):269-274.
    • (2001) FEBS Lett , vol.505 , Issue.2 , pp. 269-274
    • Haddad, J.J.1    Land, S.C.2
  • 14
    • 84957439277 scopus 로고    scopus 로고
    • TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions
    • Martínez-Reyes I, et al. TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions. Mol Cell. 2016;61(2):199-209.
    • (2016) Mol Cell , vol.61 , Issue.2 , pp. 199-209
    • Martínez-Reyes, I.1
  • 15
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci. 2012;33(4):207-214.
    • (2012) Trends Pharmacol Sci , vol.33 , Issue.4 , pp. 207-214
    • Semenza, G.L.1
  • 16
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000;157(2):411-421.
    • (2000) Am J Pathol , vol.157 , Issue.2 , pp. 411-421
    • Talks, K.L.1
  • 17
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003;23(24):9361-9374.
    • (2003) Mol Cell Biol , vol.23 , Issue.24 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 18
    • 84655161946 scopus 로고    scopus 로고
    • HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression
    • Keith B, Johnson RS, Simon MC. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer. 2012;12(1):9-22.
    • (2012) Nat Rev Cancer , vol.12 , Issue.1 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 19
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • Raval RR, et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol. 2005;25(13):5675-5686.
    • (2005) Mol Cell Biol , vol.25 , Issue.13 , pp. 5675-5686
    • Raval, R.R.1
  • 20
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007;11(4):335-347.
    • (2007) Cancer Cell , vol.11 , Issue.4 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5
  • 21
    • 84908141221 scopus 로고    scopus 로고
    • HIF transcription factors, inflammation, and immunity
    • Palazon A, Goldrath AW, Nizet V, Johnson RS. HIF transcription factors, inflammation, and immunity. Immunity. 2014;41(4):518-528.
    • (2014) Immunity , vol.41 , Issue.4 , pp. 518-528
    • Palazon, A.1    Goldrath, A.W.2    Nizet, V.3    Johnson, R.S.4
  • 22
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12(4):252-264.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 23
    • 84962223267 scopus 로고    scopus 로고
    • Helicobacter pylori in gastric carcinogenesis
    • Ahn HJ, Lee DS. Helicobacter pylori in gastric carcinogenesis. World J Gastrointest Oncol. 2015;7(12):455-465.
    • (2015) World J Gastrointest Oncol , vol.7 , Issue.12 , pp. 455-465
    • Ahn, H.J.1    Lee, D.S.2
  • 24
    • 0033305110 scopus 로고    scopus 로고
    • Hepatitis C-related hepatocellular carcinoma: Prevalence around the world, factors interacting, and role of genotypes
    • Mitra AK. Hepatitis C-related hepatocellular carcinoma: prevalence around the world, factors interacting, and role of genotypes. Epidemiol Rev. 1999;21(2):180-187.
    • (1999) Epidemiol Rev , vol.21 , Issue.2 , pp. 180-187
    • Mitra, A.K.1
  • 25
    • 0141651527 scopus 로고    scopus 로고
    • Review article: The incidence and prevalence of colorectal cancer in inflammatory bowel disease
    • Munkholm P. Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease. Aliment Pharmacol Ther. 2003;18 Suppl 2:1-5.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 1-5
    • Munkholm, P.1
  • 26
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon ER. Molecular genetics of colorectal cancer. Annu Rev Pathol. 2011;6:479-507.
    • (2011) Annu Rev Pathol , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 27
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61(5):759-767.
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 28
    • 84905833585 scopus 로고    scopus 로고
    • Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis
    • Kim ER, Chang DK. Colorectal cancer in inflammatory bowel disease: the risk, pathogenesis, prevention and diagnosis. World J Gastroenterol. 2014;20(29):9872-9881.
    • (2014) World J Gastroenterol , vol.20 , Issue.29 , pp. 9872-9881
    • Kim, E.R.1    Chang, D.K.2
  • 29
    • 84962921222 scopus 로고    scopus 로고
    • Whole-exome sequencing analyses of inflammatory bowel diseaseassociated colorectal cancers
    • Robles AI, et al. Whole-exome sequencing analyses of inflammatory bowel diseaseassociated colorectal cancers. Gastroenterology. 2016;150(4):931-943.
    • (2016) Gastroenterology , vol.150 , Issue.4 , pp. 931-943
    • Robles, A.I.1
  • 30
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883-899.
    • (2010) Cell , vol.140 , Issue.6 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 31
    • 84872600554 scopus 로고    scopus 로고
    • Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stemcell-like properties
    • Schwitalla S, et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stemcell-like properties. Cell. 2013;152(1-2):25-38.
    • (2013) Cell , vol.152 , Issue.1-2 , pp. 25-38
    • Schwitalla, S.1
  • 32
    • 7944223098 scopus 로고    scopus 로고
    • Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
    • Sparmann A, Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell. 2004;6(5):447-458.
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 447-458
    • Sparmann, A.1    Bar-Sagi, D.2
  • 33
    • 84868613705 scopus 로고    scopus 로고
    • Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
    • Grivennikov SI, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;491(7423):254-258.
    • (2012) Nature , vol.491 , Issue.7423 , pp. 254-258
    • Grivennikov, S.I.1
  • 34
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313(5795):1960-1964.
    • (2006) Science , vol.313 , Issue.5795 , pp. 1960-1964
    • Galon, J.1
  • 35
    • 84938984463 scopus 로고    scopus 로고
    • The prognostic landscape of genes and infiltrating immune cells across human cancers
    • Gentles AJ, et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med. 2015;21(8):938-945.
    • (2015) Nat Med , vol.21 , Issue.8 , pp. 938-945
    • Gentles, A.J.1
  • 36
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato E, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 2005;102(51):18538-18543.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.51 , pp. 18538-18543
    • Sato, E.1
  • 37
    • 29144514645 scopus 로고    scopus 로고
    • Effector memory T cells, early metastasis, and survival in colorectal cancer
    • Pagès F, et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med. 2005;353(25):2654-2666.
    • (2005) N Engl J Med , vol.353 , Issue.25 , pp. 2654-2666
    • Pagès, F.1
  • 38
    • 34347396593 scopus 로고    scopus 로고
    • Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis
    • Shaykhiev R, Bals R. Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis. J Leukoc Biol. 2007;82(1):1-15.
    • (2007) J Leukoc Biol , vol.82 , Issue.1 , pp. 1-15
    • Shaykhiev, R.1    Bals, R.2
  • 39
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol. 2008;8(6):411-420.
    • (2008) Nat Rev Immunol , vol.8 , Issue.6 , pp. 411-420
    • Artis, D.1
  • 40
    • 84937519151 scopus 로고    scopus 로고
    • CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function
    • Chun E, et al. CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function. Cell Rep. 2015;12(2):244-257.
    • (2015) Cell Rep , vol.12 , Issue.2 , pp. 244-257
    • Chun, E.1
  • 41
    • 84922689090 scopus 로고    scopus 로고
    • PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer
    • Bonavita E, et al. PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell. 2015;160(4):700-714.
    • (2015) Cell , vol.160 , Issue.4 , pp. 700-714
    • Bonavita, E.1
  • 42
    • 84925701525 scopus 로고    scopus 로고
    • Stromal contribution to the colorectal cancer transcriptome
    • Isella C, et al. Stromal contribution to the colorectal cancer transcriptome. Nat Genet. 2015;47(4):312-319.
    • (2015) Nat Genet , vol.47 , Issue.4 , pp. 312-319
    • Isella, C.1
  • 43
    • 77955982276 scopus 로고    scopus 로고
    • HIF-2alpha deletion promotes Kras-driven lung tumor development
    • Mazumdar J, et al. HIF-2alpha deletion promotes Kras-driven lung tumor development. Proc Natl Acad Sci U S A. 2010;107(32):14182-14187.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.32 , pp. 14182-14187
    • Mazumdar, J.1
  • 45
    • 84881471477 scopus 로고    scopus 로고
    • PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis
    • Criscimanna A, et al. PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis. Cancer Res. 2013;73(15):4781-4790.
    • (2013) Cancer Res , vol.73 , Issue.15 , pp. 4781-4790
    • Criscimanna, A.1
  • 46
    • 84960123964 scopus 로고    scopus 로고
    • Hif1a deletion reveals pro-neoplastic function of B cells in pancreatic neoplasia
    • Lee KE, et al. Hif1a deletion reveals pro-neoplastic function of B cells in pancreatic neoplasia. Cancer Discov. 2016;6(3):256-269.
    • (2016) Cancer Discov , vol.6 , Issue.3 , pp. 256-269
    • Lee, K.E.1
  • 47
    • 84860520642 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis
    • Xue X, et al. Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res. 2012;72(9):2285-2293.
    • (2012) Cancer Res , vol.72 , Issue.9 , pp. 2285-2293
    • Xue, X.1
  • 48
    • 84884390272 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice
    • Xue X, et al. Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology. 2013;145(4):831-841.
    • (2013) Gastroenterology , vol.145 , Issue.4 , pp. 831-841
    • Xue, X.1
  • 49
    • 38849171267 scopus 로고    scopus 로고
    • Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    • Popivanova BK, et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest. 2008;118(2):560-570.
    • (2008) J Clin Invest , vol.118 , Issue.2 , pp. 560-570
    • Popivanova, B.K.1
  • 50
    • 84868629269 scopus 로고    scopus 로고
    • TNF signaling drives myeloidderived suppressor cell accumulation
    • Zhao X, et al. TNF signaling drives myeloidderived suppressor cell accumulation. J Clin Invest. 2012;122(11):4094-4104.
    • (2012) J Clin Invest , vol.122 , Issue.11 , pp. 4094-4104
    • Zhao, X.1
  • 52
    • 22144439081 scopus 로고    scopus 로고
    • Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
    • Knutson KL, Disis ML. Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Cancer Immunol Immunother. 2005;54(8):721-728.
    • (2005) Cancer Immunol Immunother , vol.54 , Issue.8 , pp. 721-728
    • Knutson, K.L.1    Disis, M.L.2
  • 53
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235-238.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1
  • 54
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • Dang EV, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell. 2011;146(5):772-784.
    • (2011) Cell , vol.146 , Issue.5 , pp. 772-784
    • Dang, E.V.1
  • 55
    • 47649122633 scopus 로고    scopus 로고
    • Tumor-specific Th17-polarized cells eradicate large established melanoma
    • Muranski P, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112(2):362-373.
    • (2008) Blood , vol.112 , Issue.2 , pp. 362-373
    • Muranski, P.1
  • 56
    • 78650359166 scopus 로고    scopus 로고
    • IL-17 enhances tumor development in carcinogen-induced skin cancer
    • Wang L, Yi T, Zhang W, Pardoll DM, Yu H. IL-17 enhances tumor development in carcinogen-induced skin cancer. Cancer Res. 2010;70(24):10112-10120.
    • (2010) Cancer Res , vol.70 , Issue.24 , pp. 10112-10120
    • Wang, L.1    Yi, T.2    Zhang, W.3    Pardoll, D.M.4    Yu, H.5
  • 57
    • 84898777944 scopus 로고    scopus 로고
    • T helper 17 cells play a critical pathogenic role in lung cancer
    • Chang SH, et al. T helper 17 cells play a critical pathogenic role in lung cancer. Proc Natl Acad Sci U S A. 2014;111(15):5664-5669.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.15 , pp. 5664-5669
    • Chang, S.H.1
  • 58
    • 84883681998 scopus 로고    scopus 로고
    • Natural and induced T regulatory cells in cancer
    • Adeegbe DO, Nishikawa H. Natural and induced T regulatory cells in cancer. Front Immunol. 2013;4:190.
    • (2013) Front Immunol , vol.4 , pp. 190
    • Adeegbe, D.O.1    Nishikawa, H.2
  • 59
    • 78649557780 scopus 로고    scopus 로고
    • Efficient Treg depletion induces T-cell infiltration and rejection of large tumors
    • Li X, Kostareli E, Suffner J, Garbi N, Hämmerling GJ. Efficient Treg depletion induces T-cell infiltration and rejection of large tumors. Eur J Immunol. 2010;40(12):3325-3335.
    • (2010) Eur J Immunol , vol.40 , Issue.12 , pp. 3325-3335
    • Li, X.1    Kostareli, E.2    Suffner, J.3    Garbi, N.4    Hämmerling, G.J.5
  • 60
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    • Klages K, et al. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res. 2010;70(20):7788-7799.
    • (2010) Cancer Res , vol.70 , Issue.20 , pp. 7788-7799
    • Klages, K.1
  • 62
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene A, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature. 2011;475(7355):226-230.
    • (2011) Nature , vol.475 , Issue.7355 , pp. 226-230
    • Facciabene, A.1
  • 63
    • 79960975784 scopus 로고    scopus 로고
    • Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression
    • Li Q, et al. Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression. Clin Cancer Res. 2011;17(15):4987-4995.
    • (2011) Clin Cancer Res , vol.17 , Issue.15 , pp. 4987-4995
    • Li, Q.1
  • 64
    • 55249103660 scopus 로고    scopus 로고
    • B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models
    • Kim S, et al. B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models. J Immunother. 2008;31(5):446-457.
    • (2008) J Immunother , vol.31 , Issue.5 , pp. 446-457
    • Kim, S.1
  • 65
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9(3):162-174.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 66
    • 80053421470 scopus 로고    scopus 로고
    • Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
    • Lu T, et al. Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. J Clin Invest. 2011;121(10):4015-4029.
    • (2011) J Clin Invest , vol.121 , Issue.10 , pp. 4015-4029
    • Lu, T.1
  • 67
    • 41149148269 scopus 로고    scopus 로고
    • Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives
    • Rodríguez PC, Ochoa AC. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol Rev. 2008;222:180-191.
    • (2008) Immunol Rev , vol.222 , pp. 180-191
    • Rodríguez, P.C.1    Ochoa, A.C.2
  • 68
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    • Nagaraj S, et al. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med. 2007;13(7): 828-835.
    • (2007) Nat Med , vol.13 , Issue.7 , pp. 828-835
    • Nagaraj, S.1
  • 69
    • 84887512876 scopus 로고    scopus 로고
    • CXCR2-expressing myeloidderived suppressor cells are essential to promote colitis-associated tumorigenesis
    • Katoh H, Wang D, Daikoku T, Sun H, Dey SK, Dubois RN. CXCR2-expressing myeloidderived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell. 2013;24(5):631-644.
    • (2013) Cancer Cell , vol.24 , Issue.5 , pp. 631-644
    • Katoh, H.1    Wang, D.2    Daikoku, T.3    Sun, H.4    Dey, S.K.5    Dubois, R.N.6
  • 70
    • 84865130953 scopus 로고    scopus 로고
    • Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche
    • Sceneay J, et al. Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche. Cancer Res. 2012;72(16):3906-3911.
    • (2012) Cancer Res , vol.72 , Issue.16 , pp. 3906-3911
    • Sceneay, J.1
  • 71
    • 84900413193 scopus 로고    scopus 로고
    • HIF-α/MIF and NF-κB/IL-6 axes contribute to the recruitment of CD11b+Gr-1+ myeloid cells in hypoxic microenvironment of HNSCC
    • Zhu G, et al. HIF-α/MIF and NF-κB/IL-6 axes contribute to the recruitment of CD11b+Gr-1+ myeloid cells in hypoxic microenvironment of HNSCC. Neoplasia. 2014;16(2):168-179.
    • (2014) Neoplasia , vol.16 , Issue.2 , pp. 168-179
    • Zhu, G.1
  • 72
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122(3):787-795.
    • (2012) J Clin Invest , vol.122 , Issue.3 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 73
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin EY, et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 2006;66(23):11238-11246.
    • (2006) Cancer Res , vol.66 , Issue.23 , pp. 11238-11246
    • Lin, E.Y.1
  • 74
    • 84913580379 scopus 로고    scopus 로고
    • Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
    • Wan S, et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology. 2014;147(6):1393-1404.
    • (2014) Gastroenterology , vol.147 , Issue.6 , pp. 1393-1404
    • Wan, S.1
  • 75
    • 23244451640 scopus 로고    scopus 로고
    • Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK
    • Hagemann T, et al. Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol. 2005;175(2):1197-1205.
    • (2005) J Immunol , vol.175 , Issue.2 , pp. 1197-1205
    • Hagemann, T.1
  • 76
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    • Gocheva V, et al. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 2010;24(3):241-255.
    • (2010) Genes Dev , vol.24 , Issue.3 , pp. 241-255
    • Gocheva, V.1
  • 78
    • 84918775146 scopus 로고    scopus 로고
    • "of mice and men": Arginine metabolism in macrophages
    • Thomas AC, Mattila JT. "Of mice and men": arginine metabolism in macrophages. Front Immunol. 2014;5:479.
    • (2014) Front Immunol , vol.5 , pp. 479
    • Thomas, A.C.1    Mattila, J.T.2
  • 79
    • 4143130091 scopus 로고    scopus 로고
    • Arginase i production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    • Rodriguez PC, et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 2004;64(16):5839-5849.
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5839-5849
    • Rodriguez, P.C.1
  • 80
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
    • Lewis C, Murdoch C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol. 2005;167(3):627-635.
    • (2005) Am J Pathol , vol.167 , Issue.3 , pp. 627-635
    • Lewis, C.1    Murdoch, C.2
  • 81
    • 84906280651 scopus 로고    scopus 로고
    • Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin
    • Tripathi C, et al. Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin. Oncotarget. 2014;5(14):5350-5368.
    • (2014) Oncotarget , vol.5 , Issue.14 , pp. 5350-5368
    • Tripathi, C.1
  • 82
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008;13(3):206-220.
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 206-220
    • Du, R.1
  • 83
    • 10744219598 scopus 로고    scopus 로고
    • Regulation of the chemokine receptor CXCR4 by hypoxia
    • Schioppa T, et al. Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med. 2003;198(9):1391-1402.
    • (2003) J Exp Med , vol.198 , Issue.9 , pp. 1391-1402
    • Schioppa, T.1
  • 84
    • 84907223092 scopus 로고    scopus 로고
    • Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
    • Colegio OR, et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 2014;513(7519):559-563.
    • (2014) Nature , vol.513 , Issue.7519 , pp. 559-563
    • Colegio, O.R.1
  • 85
    • 84891930215 scopus 로고    scopus 로고
    • Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
    • Casazza A, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell. 2013;24(6):695-709.
    • (2013) Cancer Cell , vol.24 , Issue.6 , pp. 695-709
    • Casazza, A.1
  • 86
    • 84892447705 scopus 로고    scopus 로고
    • Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation
    • Campbell EL, et al. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014;40(1):66-77.
    • (2014) Immunity , vol.40 , Issue.1 , pp. 66-77
    • Campbell, E.L.1
  • 87
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta "n1" versus "n2" TAN
    • Fridlender ZG, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell. 2009;16(3):183-194.
    • (2009) Cancer Cell , vol.16 , Issue.3 , pp. 183-194
    • Fridlender, Z.G.1
  • 89
    • 84926473508 scopus 로고    scopus 로고
    • IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
    • Coffelt SB, et al. IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature. 2015;522(7556):345-348.
    • (2015) Nature , vol.522 , Issue.7556 , pp. 345-348
    • Coffelt, S.B.1
  • 90
    • 84934973340 scopus 로고    scopus 로고
    • MET is required for the recruitment of anti-tumoural neutrophils
    • Finisguerra V, et al. MET is required for the recruitment of anti-tumoural neutrophils. Nature. 2015;522(7556):349-353.
    • (2015) Nature , vol.522 , Issue.7556 , pp. 349-353
    • Finisguerra, V.1
  • 91
    • 84959216787 scopus 로고    scopus 로고
    • Neutrophils oppose uterine epithelial carcinogenesis via debridement of hypoxic tumor cells
    • Blaisdell A, et al. Neutrophils oppose uterine epithelial carcinogenesis via debridement of hypoxic tumor cells. Cancer Cell. 2015;28(6):785-799.
    • (2015) Cancer Cell , vol.28 , Issue.6 , pp. 785-799
    • Blaisdell, A.1
  • 93
    • 0036007293 scopus 로고    scopus 로고
    • Expression of HIF-1alpha by human macrophages: Implications for the use of macrophages in hypoxia-regulated cancer gene therapy
    • Burke B, et al. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol. 2002;196(2):204-212.
    • (2002) J Pathol , vol.196 , Issue.2 , pp. 204-212
    • Burke, B.1
  • 94
    • 0036493984 scopus 로고    scopus 로고
    • Relation of hypoxia-inducible factor-2α (HIF-2α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer
    • Leek RD, et al. Relation of hypoxia-inducible factor-2α (HIF-2α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer. Cancer Res. 2002;62(5):1326-1329.
    • (2002) Cancer Res , vol.62 , Issue.5 , pp. 1326-1329
    • Leek, R.D.1
  • 95
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
    • Imtiyaz HZ, et al. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest. 2010;120(8):2699-2714.
    • (2010) J Clin Invest , vol.120 , Issue.8 , pp. 2699-2714
    • Imtiyaz, H.Z.1
  • 96
    • 77957350018 scopus 로고    scopus 로고
    • Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
    • Doedens AL, et al. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010;70(19):7465-7475.
    • (2010) Cancer Res , vol.70 , Issue.19 , pp. 7465-7475
    • Doedens, A.L.1
  • 98
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. 2010;207(11):2439-2453.
    • (2010) J Exp Med , vol.207 , Issue.11 , pp. 2439-2453
    • Corzo, C.A.1
  • 99
    • 84942943894 scopus 로고    scopus 로고
    • Tumor-promoting effects of myeloid-derived suppressor cells are potentiated by hypoxia-induced expression of miR-210
    • Noman MZ, et al. Tumor-promoting effects of myeloid-derived suppressor cells are potentiated by hypoxia-induced expression of miR-210. Cancer Res. 2015;75(18):3771-3787.
    • (2015) Cancer Res , vol.75 , Issue.18 , pp. 3771-3787
    • Noman, M.Z.1
  • 100
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman MZ, et al. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med. 2014;211(5):781-790.
    • (2014) J Exp Med , vol.211 , Issue.5 , pp. 781-790
    • Noman, M.Z.1
  • 101
    • 19944432390 scopus 로고    scopus 로고
    • Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NFkappaB activity
    • Walmsley SR, et al. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NFkappaB activity. J Exp Med. 2005;201(1):105-115.
    • (2005) J Exp Med , vol.201 , Issue.1 , pp. 105-115
    • Walmsley, S.R.1
  • 102
    • 84893091765 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
    • Thompson AA, et al. Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014;123(3):366-376.
    • (2014) Blood , vol.123 , Issue.3 , pp. 366-376
    • Thompson, A.A.1
  • 103
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer. 2012;12(4):265-277.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 104
    • 44449117540 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharideinduced dendritic cell activation and function
    • Jantsch J, et al. Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharideinduced dendritic cell activation and function. J Immunol. 2008;180(7):4697-4705.
    • (2008) J Immunol , vol.180 , Issue.7 , pp. 4697-4705
    • Jantsch, J.1
  • 105
    • 57149108317 scopus 로고    scopus 로고
    • The 2008 Dolph Adams award and the state of the journal of leukocyte biology
    • Oppenheim JJ, Rosenberg HF. The 2008 Dolph Adams award and the state of the journal of leukocyte biology. J Leukoc Biol. 2008;84(6):1361-1362.
    • (2008) J Leukoc Biol. , vol.84 , Issue.6 , pp. 1361-1362
    • Oppenheim, J.J.1    Rosenberg, H.F.2
  • 106
    • 68249153389 scopus 로고    scopus 로고
    • Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cellderived osteopontin
    • Yang M, et al. Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cellderived osteopontin. Immunology. 2009; 128(1 Suppl):e237-e249.
    • (2009) Immunology , vol.128 , Issue.1 , pp. e237-e249
    • Yang, M.1
  • 107
    • 55749095015 scopus 로고    scopus 로고
    • Divergent effects of hypoxia on dendritic cell functions
    • Mancino A, et al. Divergent effects of hypoxia on dendritic cell functions. Blood. 2008;112(9):3723-3734.
    • (2008) Blood , vol.112 , Issue.9 , pp. 3723-3734
    • Mancino, A.1
  • 108
    • 84878292368 scopus 로고    scopus 로고
    • Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-β1 in gastric cancer
    • Deng B, et al. Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-β1 in gastric cancer. PLoS ONE. 2013;8(5):e63777.
    • (2013) PLoS ONE , vol.8 , Issue.5 , pp. e63777
    • Deng, B.1
  • 109
    • 84856101841 scopus 로고    scopus 로고
    • Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch
    • Wang C, Lee JH, Kim CH. Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch. PLoS ONE. 2012;7(1):e30793.
    • (2012) PLoS ONE , vol.7 , Issue.1 , pp. e30793
    • Wang, C.1    Lee, J.H.2    Kim, C.H.3
  • 110
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey ET, et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012;109(41):E2784-E2793.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.41 , pp. E2784-E2793
    • Clambey, E.T.1
  • 111
    • 55249095393 scopus 로고    scopus 로고
    • Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha
    • Ben-Shoshan J, Maysel-Auslender S, Mor A, Keren G, George J. Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol. 2008;38(9):2412-2418.
    • (2008) Eur J Immunol , vol.38 , Issue.9 , pp. 2412-2418
    • Ben-Shoshan, J.1    Maysel-Auslender, S.2    Mor, A.3    Keren, G.4    George, J.5
  • 112
    • 33749512970 scopus 로고    scopus 로고
    • Cutting edge: Hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
    • Lukashev D, et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol. 2006;177(8):4962-4965.
    • (2006) J Immunol , vol.177 , Issue.8 , pp. 4962-4965
    • Lukashev, D.1
  • 113
    • 84886672916 scopus 로고    scopus 로고
    • Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen
    • Doedens AL, et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol. 2013;14(11):1173-1182.
    • (2013) Nat Immunol , vol.14 , Issue.11 , pp. 1173-1182
    • Doedens, A.L.1
  • 114
    • 84866335513 scopus 로고    scopus 로고
    • The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
    • Palazón A, et al. The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy. Cancer Discov. 2012;2(7):608-623.
    • (2012) Cancer Discov , vol.2 , Issue.7 , pp. 608-623
    • Palazón, A.1
  • 115
    • 84862909156 scopus 로고    scopus 로고
    • Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success
    • Branco-Price C, et al. Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success. Cancer Cell. 2012;21(1):52-65.
    • (2012) Cancer Cell , vol.21 , Issue.1 , pp. 52-65
    • Branco-Price, C.1
  • 116
    • 0037080021 scopus 로고    scopus 로고
    • Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
    • Mazzoni A, et al. Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism. J Immunol. 2002;168(2):689-695.
    • (2002) J Immunol , vol.168 , Issue.2 , pp. 689-695
    • Mazzoni, A.1
  • 117
    • 0033485941 scopus 로고    scopus 로고
    • Augmentation of an antitumor CTL response in vivo by inhibition of suppressor macrophage nitric oxide
    • Medot-Pirenne M, Heilman MJ, Saxena M, McDermott PE, Mills CD. Augmentation of an antitumor CTL response in vivo by inhibition of suppressor macrophage nitric oxide. J Immunol. 1999;163(11):5877-5882.
    • (1999) J Immunol , vol.163 , Issue.11 , pp. 5877-5882
    • Medot-Pirenne, M.1    Heilman, M.J.2    Saxena, M.3    McDermott, P.E.4    Mills, C.D.5
  • 118
    • 33846006154 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    • Sato K, et al. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood. 2007;109(1):228-234.
    • (2007) Blood , vol.109 , Issue.1 , pp. 228-234
    • Sato, K.1
  • 119
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006;6(5):392-401.
    • (2006) Nat Rev Cancer , vol.6 , Issue.5 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 120
    • 13544255506 scopus 로고    scopus 로고
    • PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    • Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, Kuliopulos A. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell. 2005;120(3):303-313.
    • (2005) Cell , vol.120 , Issue.3 , pp. 303-313
    • Boire, A.1    Covic, L.2    Agarwal, A.3    Jacques, S.4    Sherifi, S.5    Kuliopulos, A.6
  • 121
    • 0027960791 scopus 로고
    • Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression
    • Hlatky L, Tsionou C, Hahnfeldt P, Coleman CN. Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression. Cancer Res. 1994;54(23):6083-6086.
    • (1994) Cancer Res , vol.54 , Issue.23 , pp. 6083-6086
    • Hlatky, L.1    Tsionou, C.2    Hahnfeldt, P.3    Coleman, C.N.4
  • 122
    • 84863606091 scopus 로고    scopus 로고
    • Loss of fibroblast HIF-1α accelerates tumorigenesis
    • Kim JW, et al. Loss of fibroblast HIF-1α accelerates tumorigenesis. Cancer Res. 2012;72(13):3187-3195.
    • (2012) Cancer Res , vol.72 , Issue.13 , pp. 3187-3195
    • Kim, J.W.1
  • 123
    • 84964240053 scopus 로고    scopus 로고
    • Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
    • McGranahan N, Swanton C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell. 2015;27(1):15-26.
    • (2015) Cancer Cell , vol.27 , Issue.1 , pp. 15-26
    • McGranahan, N.1    Swanton, C.2
  • 124
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010;467(7319):1114-1117.
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1114-1117
    • Yachida, S.1
  • 125
    • 84944731630 scopus 로고    scopus 로고
    • 18F-fluoromisonidazole PET reveals spatial and temporal heterogeneity of hypoxia in mouse models of human non-small-cell lung cancer
    • Cui YL, Wang X, Li XF. 18F-fluoromisonidazole PET reveals spatial and temporal heterogeneity of hypoxia in mouse models of human non-small-cell lung cancer. Future Oncol. 2015;11(20):2841-2849.
    • (2015) Future Oncol , vol.11 , Issue.20 , pp. 2841-2849
    • Cui, Y.L.1    Wang, X.2    Li, X.F.3
  • 126
    • 84949254795 scopus 로고    scopus 로고
    • Micro regional heterogeneity of 64Cu-ATSM and 18F-FDG uptake in canine soft tissue sarcomas: Relation to cell proliferation, hypoxia and glycolysis
    • Zornhagen KW, et al. Micro regional heterogeneity of 64Cu-ATSM and 18F-FDG uptake in canine soft tissue sarcomas: relation to cell proliferation, hypoxia and glycolysis. PLoS ONE. 2015;10(10):e0141379.
    • (2015) PLoS ONE , vol.10 , Issue.10 , pp. e0141379
    • Zornhagen, K.W.1
  • 127
    • 84955375766 scopus 로고    scopus 로고
    • A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level
    • Erapaneedi R, Belousov VV, Schäfers M, Kiefer F. A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. EMBO J. 2016;35(1):102-113.
    • (2016) EMBO J , vol.35 , Issue.1 , pp. 102-113
    • Erapaneedi, R.1    Belousov, V.V.2    Schäfers, M.3    Kiefer, F.4
  • 128
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • Movahedi K, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 2010;70(14):5728-5739.
    • (2010) Cancer Res , vol.70 , Issue.14 , pp. 5728-5739
    • Movahedi, K.1
  • 129
    • 84892747845 scopus 로고    scopus 로고
    • Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population
    • Laoui D, et al. Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res. 2014;74(1):24-30.
    • (2014) Cancer Res , vol.74 , Issue.1 , pp. 24-30
    • Laoui, D.1
  • 130
    • 84890449252 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: Tricking the body into mounting orchestrated survival and repair responses
    • Rabinowitz MH. Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. J Med Chem. 2013;56(23):9369-9402.
    • (2013) J Med Chem , vol.56 , Issue.23 , pp. 9369-9402
    • Rabinowitz, M.H.1
  • 132
    • 37349118314 scopus 로고    scopus 로고
    • The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
    • Cummins EP, et al. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology. 2008;134(1):156-165.
    • (2008) Gastroenterology , vol.134 , Issue.1 , pp. 156-165
    • Cummins, E.P.1
  • 133
    • 84884537503 scopus 로고    scopus 로고
    • HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium
    • Eckle T, et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013;11(9):e1001665.
    • (2013) PLoS Biol , vol.11 , Issue.9 , pp. e1001665
    • Eckle, T.1
  • 134
    • 84886073769 scopus 로고    scopus 로고
    • Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis
    • Keely S, et al. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 2014;7(1):114-123.
    • (2014) Mucosal Immunol , vol.7 , Issue.1 , pp. 114-123
    • Keely, S.1
  • 135
    • 10744231706 scopus 로고    scopus 로고
    • 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
    • Mabjeesh NJ, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3(4):363-375.
    • (2003) Cancer Cell , vol.3 , Issue.4 , pp. 363-375
    • Mabjeesh, N.J.1
  • 136
    • 58149374576 scopus 로고    scopus 로고
    • Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    • Zhang H, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A. 2008;105(50):19579-19586.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.50 , pp. 19579-19586
    • Zhang, H.1
  • 137
    • 19644376976 scopus 로고    scopus 로고
    • Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
    • Beppu K, Nakamura K, Linehan WM, Rapisarda A, Thiele CJ. Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res. 2005;65(11):4775-4781.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4775-4781
    • Beppu, K.1    Nakamura, K.2    Linehan, W.M.3    Rapisarda, A.4    Thiele, C.J.5
  • 138
    • 63149114714 scopus 로고    scopus 로고
    • Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis
    • Pencreach E, et al. Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis. Clin Cancer Res. 2009;15(4):1297-1307.
    • (2009) Clin Cancer Res , vol.15 , Issue.4 , pp. 1297-1307
    • Pencreach, E.1
  • 139
    • 57849147670 scopus 로고    scopus 로고
    • Small-molecule inhibitors of HIF-2a translation link its 5′UTR ironresponsive element to oxygen sensing
    • Zimmer M, et al. Small-molecule inhibitors of HIF-2a translation link its 5′UTR ironresponsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.
    • (2008) Mol Cell , vol.32 , Issue.6 , pp. 838-848
    • Zimmer, M.1
  • 141
    • 84875443909 scopus 로고    scopus 로고
    • Allosteric inhibition of hypoxia inducible factor-2 with small molecules
    • Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9(4):271-276.
    • (2013) Nat Chem Biol , vol.9 , Issue.4 , pp. 271-276
    • Scheuermann, T.H.1
  • 142
    • 84939789669 scopus 로고    scopus 로고
    • Structural integration in hypoxia-inducible factors
    • Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature. 2015;524(7565):303-308.
    • (2015) Nature , vol.524 , Issue.7565 , pp. 303-308
    • Wu, D.1    Potluri, N.2    Lu, J.3    Kim, Y.4    Rastinejad, F.5
  • 143
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 144
    • 73949112134 scopus 로고    scopus 로고
    • Differentiation stage-specific requirement in hypoxia-inducible factor-1alpharegulated glycolytic pathway during murine B cell development in bone marrow
    • Kojima H, et al. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpharegulated glycolytic pathway during murine B cell development in bone marrow. J Immunol. 2010;184(1):154-163.
    • (2010) J Immunol , vol.184 , Issue.1 , pp. 154-163
    • Kojima, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.