FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

PLoS Biology

Volumn 14, Issue 1, 2016, Pages

  Scholz, Carsten C ^a,b   Rodriguez, Javier ^a   Pickel, Christina ^b   Burr, Stephen ^c   Fabrizio, Jacqueline Alba ^d   Nolan, Karen A ^b   Spielmann, Patrick ^b   Cavadas, Miguel A S ^a   Crifo, Bianca ^a   Halligan, Doug N ^a   Nathan, James A ^c   Peet, Daniel J ^d   Wenger, Roland H ^b   Von Kriegsheim, Alex ^a   Cummins, Eoin P ^a   Taylor, Cormac T ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEUBIQUITINASE; FACTOR INHIBITING HYPOXIA INDUCIBLE FACTOR; OVARIAN TUMOR DOMAIN CONTAINING UBIQUITIN ALDEHYDE BINDING PROTEIN 1; OXYGENASE; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; HIF1AN PROTEIN, HUMAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MIXED FUNCTION OXIDASE; OTUBAIN 1 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ARTICLE; CELL ENERGY; CELL METABOLISM; CELL STRESS; CONTROLLED STUDY; EMBRYO; FIH GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; IN VITRO STUDY; METABOLIC REGULATION; OTUB1 GENE; OXYGEN SENSING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS; ENERGY METABOLISM; GENETICS; HEK293 CELL LINE; METABOLISM; PROTEIN STABILITY;

AMP-ACTIVATED PROTEIN KINASES; CYSTEINE ENDOPEPTIDASES; ENERGY METABOLISM; HEK293 CELLS; HUMANS; HYDROXYLATION; MIXED FUNCTION OXYGENASES; MUTAGENESIS, SITE-DIRECTED; PROTEIN STABILITY; REPRESSOR PROTEINS;

EID: 84956807073     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002347     Document Type: Article

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