Relation of hypoxia-inducible factor-2α (HIF-2α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer

Cancer Research

Volumn 62, Issue 5, 2002, Pages 1326-1329

  Leek, Russell D ^a   Talks, Kate L ^a   Pezzella, Francesco ^a   Turley, Helen ^a   Campo, Leticia ^a   Brown, Nicholas S ^a   Bicknell, Roy ^a   Taylor, Marian ^b   Gatter, Kevin C ^a   Harris, Adrian L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGEN; THYMIDINE PHOSPHORYLASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ANGIOGENESIS; ARTICLE; BREAST CANCER; DENSITY; HUMAN; HUMAN TISSUE; HYPOXIA; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR VASCULARIZATION; UNITED KINGDOM;

ADULT; AGED; AGED, 80 AND OVER; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BREAST NEOPLASMS; FEMALE; HUMANS; MACROPHAGES; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; OXIDATIVE STRESS; THYMIDINE PHOSPHORYLASE; TRANS-ACTIVATORS;

EID: 0036493984     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. The role of macrophages in tumour angiogenesis
2. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast-carcinoma
3. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
4. Tumor hypoxia in pelvic recurrences of cervical cancer
5. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 α
6. Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1alpha
7. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
8. Association of tumor-necrosis-factor-α and its receptors with thymidine phosphorylase expression in invasive breast-carcinoma
9. Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors
10. Expression of the angiogenic factors vascular endothelial-cell growth-factor, acidic and basic fibroblast growth-factor, tumor-growth factor-β-1, platelet-derived endothelial-cell growth-factor, placenta growth-factor, and pleiotrophin in human primary breast-cancer and its relation to angiogenesis
11. Constitutive activation of hypoxiainducible genes related to overexpression of hypoxia-inducible factor-1α in clear cell renal carcinomas
12. Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
13. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
14. PR39, a peptide regulator of angiogenesis
15. Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
16. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
17. Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - A potential mechanism
18. The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo
19. Suppression of tumor growth through disruption of hypoxia-inducible transcription
20. The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors