Kdm2a promotes lung tumorigenesis by epigenetically enhancing erk1/2 signaling

Journal of Clinical Investigation

Volumn 123, Issue 12, 2013, Pages 5231-5246

  Wagner, Klaus W ^a,b   Alam, Hunain ^a   Dhar, Shilpa S ^a   Giri, Uma ^c   Li, Na ^a   Wei, Yongkun ^a   Giri, Dipak ^d   Cascone, Tina ^c   Kim, Jae Hwan ^a   Ye, Yuanqing ^a   Multani, Asha S ^c   Chan, Chia Hsin ^a   Erez, Baruch ^c   Saigal, Babita ^c   Chung, Jimyung ^e   Lin, Hui Kuan ^a,f   Wu, Xifeng ^a   Hung, Mien Chie ^a,f,g   Heymach, John V ^c   Lee, Min Gyu ^a,c  

^a Department of Molecular and Cellular Oncology ^*  (United States)

^b Division of Cancer Medicine   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d INTEGRATED LABORATORY SYSTEMS   (United States)

^e Yonsei University   (South Korea)

^f UNIVERSITY OF TEXAS   (United States)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; DUAL SPECIFICITY PHOSPHATASE 3; GPR157 PROTEIN; HISTONE DEMETHYLASE; HISTONE H3; HISTONE H3 LYSINE 36 DEMETHYLASE KDM2A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN; TIMM17 PROTEIN; TMEM65 PROTEIN; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER PATIENT; CANCER PROGNOSIS; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; ENZYME MECHANISM; EPIGENETIC REPRESSION; EPIGENETICS; GENE; GENE LOCUS; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HISTONE METHYLATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KDM2A GENE; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIVISION; CELL LINE, TUMOR; DUAL SPECIFICITY PHOSPHATASE 3; EPIGENESIS, GENETIC; F-BOX PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGRAFTS; HISTONES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; LUNG NEOPLASMS; MALE; MAP KINASE SIGNALING SYSTEM; METHYLATION; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA INTERFERENCE; RNA, MESSENGER; RNA, NEOPLASM;

EID: 84890060286     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI68642     Document Type: Article

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