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Volumn 16, Issue 3, 2016, Pages 173-186

Aspirin and colorectal cancer: The promise of precision chemoprevention

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Indexed keywords

ACETYLSALICYLIC ACID;

EID: 84959516180     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc.2016.4     Document Type: Review
Times cited : (374)

References (165)
  • 2
    • 84855556537 scopus 로고    scopus 로고
    • Aspirin in the chemoprevention of colorectal neoplasia: An overview
    • Chan, A. T., et al. Aspirin in the chemoprevention of colorectal neoplasia: an overview. Cancer Prev. Res. (Phila.) 5, 164-178 (2012
    • (2012) Cancer Prev. Res. (Phila , vol.5 , pp. 164-178
    • Chan, A.T.1
  • 3
    • 84925537586 scopus 로고    scopus 로고
    • Prophylactic use of aspirin: Systematic review of harms and approaches to mitigation in the general population
    • Thorat, M. A., & Cuzick, J. Prophylactic use of aspirin: systematic review of harms and approaches to mitigation in the general population. Eur. J. Epidemiol. 30, 5-18 (2015
    • (2015) Eur. J. Epidemiol , vol.30 , pp. 5-18
    • Thorat, M.A.1    Cuzick, J.2
  • 4
    • 33947541519 scopus 로고    scopus 로고
    • U.S. Preventive Services Task Force. Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: U. S. Preventive Services Task Force recommendation statement
    • U.S. Preventive Services Task Force. Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: U. S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 146, 361-364 (2007
    • (2007) Ann. Intern. Med , vol.146 , pp. 361-364
  • 8
    • 65349152488 scopus 로고    scopus 로고
    • Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: An international consensus statement
    • Cuzick, J., et al. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol. 10, 501-507 (2009
    • (2009) Lancet Oncol , vol.10 , pp. 501-507
    • Cuzick, J.1
  • 9
    • 34248157118 scopus 로고    scopus 로고
    • Effect of aspirin on long-Term risk of colorectal cancer: Consistent evidence from randomised and observational studies
    • Flossmann, E., et al. Effect of aspirin on long-Term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 369, 1603-1613 (2007
    • (2007) Lancet , vol.369 , pp. 1603-1613
    • Flossmann, E.1
  • 10
    • 84863412124 scopus 로고    scopus 로고
    • Short-Term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials
    • Rothwell, P. M., et al. Short-Term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet 379, 1602-1612 (2012
    • (2012) Lancet , vol.379 , pp. 1602-1612
    • Rothwell, P.M.1
  • 12
    • 84929390853 scopus 로고    scopus 로고
    • Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants
    • Nan, H., et al. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. JAMA 313, 1133-1142 (2015
    • (2015) JAMA , vol.313 , pp. 1133-1142
    • Nan, H.1
  • 13
    • 84940481188 scopus 로고    scopus 로고
    • Low-dose aspirin or nonsteroidal anti-inflammatory drug use and colorectal cancer risk: A population-based, case-control study
    • Friis, S., Riis, A. H., Erichsen, R., Baron, J. A., & Sorensen, H. T. Low-dose aspirin or nonsteroidal anti-inflammatory drug use and colorectal cancer risk: a population-based, case-control study. Ann. Intern. Med. 163, 347-355 (2015
    • (2015) Ann. Intern. Med , vol.163 , pp. 347-355
    • Friis, S.1    Riis, A.H.2    Erichsen, R.3    Baron, J.A.4    Sorensen, H.T.5
  • 14
    • 78650215449 scopus 로고    scopus 로고
    • Long-Term effect of aspirin on colorectal cancer incidence and mortality: 20 year follow up of five randomised trials
    • Rothwell, P. M., et al. Long-Term effect of aspirin on colorectal cancer incidence and mortality: 20 year follow up of five randomised trials. Lancet 376, 1741-1750 (2010
    • (2010) Lancet , vol.376 , pp. 1741-1750
    • Rothwell, P.M.1
  • 15
    • 2442493541 scopus 로고    scopus 로고
    • Aspirin use and colorectal cancer: Post-Trial follow up data from the Physicians' Health Study
    • Sturmer, T., et al. Aspirin use and colorectal cancer: post-Trial follow up data from the Physicians' Health Study. Ann. Intern. Med. 128, 713-720 (1998
    • (1998) Ann. Intern. Med , vol.128 , pp. 713-720
    • Sturmer, T.1
  • 16
    • 21444450527 scopus 로고    scopus 로고
    • Low-dose aspirin in the primary prevention of cancer: The Women's Health Study: A randomized controlled trial
    • Cook, N. R., et al. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 294, 47-55 (2005
    • (2005) JAMA , vol.294 , pp. 47-55
    • Cook, N.R.1
  • 17
    • 57749107623 scopus 로고    scopus 로고
    • Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome
    • Burn, J., et al. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N. Engl. J. Med. 359, 2567-2578 (2008
    • (2008) N. Engl. J. Med , vol.359 , pp. 2567-2578
    • Burn, J.1
  • 18
    • 84880278340 scopus 로고    scopus 로고
    • Alternate-day low-dose aspirin and cancer risk: Long-Term observational follow up of a randomized trial
    • Cook, N. R., Lee, I. M., Zhang, S. M., Moorthy, M. V., & Buring, J. E. Alternate-day, low-dose aspirin and cancer risk: long-Term observational follow up of a randomized trial. Ann. Intern. Med. 159, 77-85 (2013
    • (2013) Ann. Intern. Med , vol.159 , pp. 77-85
    • Cook, N.R.1    Lee, I.M.2    Zhang, S.M.3    Moorthy, M.V.4    Buring, J.E.5
  • 19
    • 83955161674 scopus 로고    scopus 로고
    • Long-Term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomized controlled trial
    • Burn, J., et al. Long-Term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomized controlled trial. Lancet 378, 2081-2087 (2011
    • (2011) Lancet , vol.378 , pp. 2081-2087
    • Burn, J.1
  • 20
    • 0034827025 scopus 로고    scopus 로고
    • The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas
    • Cunningham, J. M., et al. The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am. J. Hum. Genet. 69, 780-790 (2001
    • (2001) Am. J. Hum. Genet , vol.69 , pp. 780-790
    • Cunningham, J.M.1
  • 21
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon, E. R. Molecular genetics of colorectal cancer. Annu. Rev. Pathol. 6, 479-507 (2011
    • (2011) Annu. Rev. Pathol , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 22
    • 0025964302 scopus 로고
    • Natural history of adenomas
    • Eide, T. J. Natural history of adenomas. World J. Surg. 15, 3-6 (1991
    • (1991) World J. Surg , vol.15 , pp. 3-6
    • Eide, T.J.1
  • 23
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E. R., & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 24
    • 0021678754 scopus 로고
    • The evolution of colorectal carcinoma
    • Morson, B. C. The evolution of colorectal carcinoma. Clin. Radiol. 35, 425-431 (1984
    • (1984) Clin. Radiol , vol.35 , pp. 425-431
    • Morson, B.C.1
  • 25
  • 26
    • 0037421985 scopus 로고    scopus 로고
    • A randomized trial of aspirin to prevent colorectal adenomas
    • Baron, J. A., et al. A randomized trial of aspirin to prevent colorectal adenomas. N. Engl. J. Med. 348, 891-899 (2003
    • (2003) N. Engl. J. Med , vol.348 , pp. 891-899
    • Baron, J.A.1
  • 27
    • 0037421984 scopus 로고    scopus 로고
    • A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
    • Sandler, R. S., et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N. Engl. J. Med. 348, 883-890 (2003
    • (2003) N. Engl. J. Med , vol.348 , pp. 883-890
    • Sandler, R.S.1
  • 28
    • 37349129228 scopus 로고    scopus 로고
    • Aspirin and folic acid for the prevention of recurrent colorectal adenomas
    • Logan, R. F., et al. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 134, 29-38 (2008
    • (2008) Gastroenterology , vol.134 , pp. 29-38
    • Logan, R.F.1
  • 29
    • 0042031492 scopus 로고    scopus 로고
    • Daily soluble aspirin and prevention of colorectal adenoma recurrence: One-year results of the APACC trial
    • Benamouzig, R., et al. Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology 125, 328-336 (2003
    • (2003) Gastroenterology , vol.125 , pp. 328-336
    • Benamouzig, R.1
  • 30
    • 84893158245 scopus 로고    scopus 로고
    • The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: A randomised trial
    • Ishikawa, H., et al. The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. Gut 63, 1755-1759 (2014
    • (2014) Gut , vol.63 , pp. 1755-1759
    • Ishikawa, H.1
  • 31
    • 84953359651 scopus 로고    scopus 로고
    • Colorectal polyp prevention by daily aspirin use is abrogated among active smokers
    • Drew, D. A., et al. Colorectal polyp prevention by daily aspirin use is abrogated among active smokers. Cancer Causes Control 27, 93-103 (2015
    • (2015) Cancer Causes Control , vol.27 , pp. 93-103
    • Drew, D.A.1
  • 32
    • 84952683194 scopus 로고    scopus 로고
    • Aspirin calcitriol, and calcium do not prevent adenoma recurrence in a randomized controlled trial
    • Pommergaard, H. C., Burcharth, J., Rosenberg, J., & Raskov, H. Aspirin, calcitriol, and calcium do not prevent adenoma recurrence in a randomized controlled trial. Gastroenterology 150, 114-122 (2015
    • (2015) Gastroenterology , vol.150 , pp. 114-122
    • Pommergaard, H.C.1    Burcharth, J.2    Rosenberg, J.3    Raskov, H.4
  • 33
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00501059 (2015
    • (2015) ClinicalTrials.gov
  • 34
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00565708 (2015
    • (2015) ClinicalTrials.gov
  • 35
  • 36
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02394769 (2015
    • (2015) US National Library of Medicine
  • 40
    • 80052026195 scopus 로고    scopus 로고
    • Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-Analysis
    • Lanas, A., Wu, P., Medin, J., & Mills, E. J. Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-Analysis. Clin. Gastroenterol. Hepatol. 9, 762-768 (2011
    • (2011) Clin. Gastroenterol. Hepatol , vol.9 , pp. 762-768
    • Lanas, A.1    Wu, P.2    Medin, J.3    Mills, E.J.4
  • 41
    • 18144373789 scopus 로고    scopus 로고
    • Analysis of risk of bleeding complications after different doses of aspirin in 192, 036 patients enrolled in 31 randomized controlled trials
    • Serebruany, V. L., et al. Analysis of risk of bleeding complications after different doses of aspirin in 192, 036 patients enrolled in 31 randomized controlled trials. Am. J. Cardiol. 95, 1218-1222 (2005
    • (2005) Am. J. Cardiol , vol.95 , pp. 1218-1222
    • Serebruany, V.L.1
  • 42
    • 0034638656 scopus 로고    scopus 로고
    • Risk of gastrointestinal haemorrhage with long term use of aspirin: Meta-Analysis
    • Derry, S., & Loke, Y. K. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-Analysis. BMJ 321, 1183-1187 (2000
    • (2000) BMJ , vol.321 , pp. 1183-1187
    • Derry, S.1    Loke, Y.K.2
  • 43
    • 33746448278 scopus 로고    scopus 로고
    • Systematic review and meta-Analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials
    • McQuaid, K. R., & Laine, L. Systematic review and meta-Analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. Am. J. Med. 119, 624-638 (2006
    • (2006) Am. J. Med , vol.119 , pp. 624-638
    • McQuaid, K.R.1    Laine, L.2
  • 44
    • 0026072561 scopus 로고
    • The Dutch TIA Trial Study Group. A comparison of two doses of aspirin (30 mg versus 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke
    • The Dutch TIA Trial Study Group. A comparison of two doses of aspirin (30 mg versus 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. N. Engl. J. Med. 325, 1261-1266 (1991
    • (1991) N. Engl. J. Med , vol.325 , pp. 1261-1266
  • 45
    • 0026355123 scopus 로고
    • The United Kingdom transient ischaemic attack (UK tia) aspirin trial: Final results
    • Farrell, B., Godwin, J., Richards, S., & Warlow, C. The United Kingdom transient ischaemic attack (UK TIA) aspirin trial: final results. J. Neurol. Neurosurg. Psychiatry 54, 1044-1054 (1991
    • (1991) J. Neurol. Neurosurg. Psychiatry , vol.54 , pp. 1044-1054
    • Farrell, B.1    Godwin, J.2    Richards, S.3    Warlow, C.4
  • 46
    • 0027530664 scopus 로고
    • The gastrointestinal toxicity of aspirin: An overview of randomised controlled trials
    • Roderick, P. J., Wilkes, H. C., & Meade, T. W. The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials. Br. J. Clin. Pharmacol. 35, 219-226 (1993
    • (1993) Br. J. Clin. Pharmacol , vol.35 , pp. 219-226
    • Roderick, P.J.1    Wilkes, H.C.2    Meade, T.W.3
  • 47
    • 0028929443 scopus 로고
    • Prophylactic aspirin and risk of peptic ulcer bleeding
    • Weil, J., et al. Prophylactic aspirin and risk of peptic ulcer bleeding. BMJ 310, 827-830 (1995
    • (1995) BMJ , vol.310 , pp. 827-830
    • Weil, J.1
  • 48
    • 33644837942 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs for cancer prevention: Promise, perils and pharmacogenetics
    • Ulrich, C. M., Bigler, J., & Potter, J. D. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat. Rev. Cancer 6, 130-140 (2006
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 130-140
    • Ulrich, C.M.1    Bigler, J.2    Potter, J.D.3
  • 49
    • 84871747430 scopus 로고    scopus 로고
    • CYP2C9 variants increase risk of colorectal adenoma recurrence and modify associations with smoking but not aspirin treatment
    • Barry, E. L., et al. CYP2C9 variants increase risk of colorectal adenoma recurrence and modify associations with smoking but not aspirin treatment. Cancer Causes Control 24, 47-54 (2013
    • (2013) Cancer Causes Control , vol.24 , pp. 47-54
    • Barry, E.L.1
  • 50
    • 84855534328 scopus 로고    scopus 로고
    • The influence of UGT1A6 variants and aspirin use in a randomized trial of celecoxib for prevention of colorectal adenoma
    • Chan, A. T., Hsu, M., Zauber, A. G., Hawk, E. T., & Bertagnolli, M. M. The influence of UGT1A6 variants and aspirin use in a randomized trial of celecoxib for prevention of colorectal adenoma. Cancer Prev. Res. (Phila.) 5, 61-72 (2012
    • (2012) Cancer Prev. Res. (Phila , vol.5 , pp. 61-72
    • Chan, A.T.1    Hsu, M.2    Zauber, A.G.3    Hawk, E.T.4    Bertagnolli, M.M.5
  • 51
    • 66149123253 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma
    • Chan, A. T., et al. Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma. Gastroenterology 136, 2127-2136 (2009
    • (2009) Gastroenterology , vol.136 , pp. 2127-2136
    • Chan, A.T.1
  • 52
    • 25144438001 scopus 로고    scopus 로고
    • No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARδ and PPAR? Act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma
    • McGreavey, L. E., et al. No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARδ and PPAR? act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. Pharmacogenet. Genom. 15, 713-721 (2005
    • (2005) Pharmacogenet. Genom , vol.15 , pp. 713-721
    • McGreavey, L.E.1
  • 53
    • 84946887537 scopus 로고    scopus 로고
    • Spectral biomarkers for chemoprevention of colonic neoplasia: A placebo-controlled double-blinded trial with aspirin
    • Roy, H. K., et al. Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. Gut http://dx.doi.org/10.1136/gutjnl-2015-309996 (2015
    • (2015) Gut
    • Roy, H.K.1
  • 54
    • 84926318080 scopus 로고    scopus 로고
    • Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial
    • Thomas, S. S., et al. Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial. BMC Med. Genet. 16, 18 (2015
    • (2015) BMC Med. Genet , vol.16 , pp. 18
    • Thomas, S.S.1
  • 55
    • 67650179528 scopus 로고    scopus 로고
    • No association between cyclooxygenase 2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk
    • Thompson, C. L., et al. No association between cyclooxygenase 2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. World J. Gastroenterol. 15, 2240-2244 (2009
    • (2009) World J. Gastroenterol , vol.15 , pp. 2240-2244
    • Thompson, C.L.1
  • 56
    • 84897522332 scopus 로고    scopus 로고
    • The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: Haplotype associations and gene-environment interactions
    • Angstadt, A. Y., et al. The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: haplotype associations and gene-environment interactions. Genes Chromosomes Cancer 53, 454-466 (2014
    • (2014) Genes Chromosomes Cancer , vol.53 , pp. 454-466
    • Angstadt, A.Y.1
  • 57
    • 84899929264 scopus 로고    scopus 로고
    • Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry
    • Scherer, D., et al. Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry. Genes Chromosomes Cancer 53, 568-578 (2014
    • (2014) Genes Chromosomes Cancer , vol.53 , pp. 568-578
    • Scherer, D.1
  • 59
    • 27644555091 scopus 로고    scopus 로고
    • Cyclooxygenase 2: How good is it as a target for cancer chemoprevention
    • Hull, M. A. Cyclooxygenase 2: how good is it as a target for cancer chemoprevention? Eur. J. Cancer 41, 1854-1863 (2005
    • (2005) Eur J. Cancer , vol.41 , pp. 1854-1863
    • Hull, M.A.1
  • 60
    • 84922519182 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors: From pharmacology to clinical read-outs
    • Patrignani, P., & Patrono, C. Cyclooxygenase inhibitors: from pharmacology to clinical read-outs. Biochim. Biophys. Acta 1851, 422-432 (2015
    • (2015) Biochim. Biophys. Acta , vol.1851 , pp. 422-432
    • Patrignani, P.1    Patrono, C.2
  • 61
    • 84916212734 scopus 로고    scopus 로고
    • Current concepts in colorectal cancer prevention with cyclooxygenase inhibitors
    • Ranger, G. S. Current concepts in colorectal cancer prevention with cyclooxygenase inhibitors. Anticancer Res. 34, 6277-6282 (2014
    • (2014) Anticancer Res , vol.34 , pp. 6277-6282
    • Ranger, G.S.1
  • 62
    • 82455188359 scopus 로고    scopus 로고
    • Pharmacology and cellular/molecular mechanisms of action of aspirin and non-Aspirin NSAIDs in colorectal cancer
    • Schror, K. Pharmacology and cellular/molecular mechanisms of action of aspirin and non-Aspirin NSAIDs in colorectal cancer. Best Pract. Res. Clin. Gastroenterol. 25, 473-484 (2011
    • (2011) Best Pract. Res. Clin. Gastroenterol , vol.25 , pp. 473-484
    • Schror, K.1
  • 63
    • 76849095665 scopus 로고    scopus 로고
    • The role of COX 2 in intestinal inflammation and colorectal cancer
    • Wang, D., & Dubois, R. N. The role of COX 2 in intestinal inflammation and colorectal cancer. Oncogene 29, 781-788 (2010
    • (2010) Oncogene , vol.29 , pp. 781-788
    • Wang, D.1    Dubois, R.N.2
  • 65
    • 84899547782 scopus 로고    scopus 로고
    • Aspirin and the risk of colorectal cancer in relation to the expression of 15 hydroxyprostaglandin dehydrogenase (HPGD
    • 233re2
    • Fink, S. P., et al. Aspirin and the risk of colorectal cancer in relation to the expression of 15 hydroxyprostaglandin dehydrogenase (HPGD). Sci. Transl Med. 6, 233re2 (2014
    • (2014) Sci. Transl Med , vol.6
    • Fink, S.P.1
  • 66
    • 34249673868 scopus 로고    scopus 로고
    • Aspirin and the risk of colorectal cancer in relation to the expression of COX 2
    • Chan, A. T., Ogino, S., & Fuchs, C. S. Aspirin and the risk of colorectal cancer in relation to the expression of COX 2. N. Engl. J. Med. 356, 2131-2142 (2007
    • (2007) N. Engl. J. Med , vol.356 , pp. 2131-2142
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 67
    • 84883307169 scopus 로고    scopus 로고
    • High cyclooxygenase 2 expression is associated with advanced stages in colorectal cancer
    • Elzagheid, A., et al. High cyclooxygenase 2 expression is associated with advanced stages in colorectal cancer. Anticancer Res. 33, 3137-3143 (2013
    • (2013) Anticancer Res , vol.33 , pp. 3137-3143
    • Elzagheid, A.1
  • 68
    • 0028261042 scopus 로고
    • Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2
    • Pugh, S., & Thomas, G A. Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2. Gut 35, 675-678 (1994
    • (1994) Gut , vol.35 , pp. 675-678
    • Pugh, S.1    Thomas, G.A.2
  • 69
    • 0034282465 scopus 로고    scopus 로고
    • Genetic disruption of Ptgs 1, as well as Ptgs 2, reduces intestinal tumorigenesis in Min mice
    • Chulada, P. C., et al. Genetic disruption of Ptgs 1, as well as Ptgs 2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60, 4705-4708 (2000
    • (2000) Cancer Res , vol.60 , pp. 4705-4708
    • Chulada, P.C.1
  • 70
    • 0036142927 scopus 로고    scopus 로고
    • Involvement of prostaglandin e receptor subtype EP4 in colon carcinogenesis
    • Mutoh, M., et al. Involvement of prostaglandin E receptor subtype EP4 in colon carcinogenesis. Cancer Res. 62, 28-32 (2002
    • (2002) Cancer Res , vol.62 , pp. 28-32
    • Mutoh, M.1
  • 71
    • 0030606299 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Apcδ716 knockout mice by inhibition of cyclooxygenase 2 (COX 2
    • Oshima, M., et al. Suppression of intestinal polyposis in Apcδ716 knockout mice by inhibition of cyclooxygenase 2 (COX 2). Cell 87, 803-809 (1996
    • (1996) Cell , vol.87 , pp. 803-809
    • Oshima, M.1
  • 72
    • 0034796261 scopus 로고    scopus 로고
    • Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apcδ716 knockout mice
    • Sonoshita, M., et al. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apcδ716 knockout mice. Nat. Med. 7, 1048-1051 (2001
    • (2001) Nat. Med , vol.7 , pp. 1048-1051
    • Sonoshita, M.1
  • 73
    • 0032698210 scopus 로고    scopus 로고
    • Role of the prostaglandin e receptor subtype EP1 in colon carcinogenesis
    • Watanabe, K., et al. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res. 59, 5093-5096 (1999
    • (1999) Cancer Res , vol.59 , pp. 5093-5096
    • Watanabe, K.1
  • 74
    • 84879395305 scopus 로고    scopus 로고
    • Aspirin use and risk of colorectal cancer according to BRAF mutation status
    • Nishihara, R., et al. Aspirin use and risk of colorectal cancer according to BRAF mutation status. JAMA 309, 2563-2571 (2013
    • (2013) JAMA , vol.309 , pp. 2563-2571
    • Nishihara, R.1
  • 76
    • 84989338100 scopus 로고    scopus 로고
    • Genetics of the serrated pathway to colorectal cancer
    • Kedrin, D., & Gala, M. K. Genetics of the serrated pathway to colorectal cancer. Clin. Transl Gastroenterol. 6, e84 (2015
    • (2015) Clin. Transl Gastroenterol , vol.6 , pp. e84
    • Kedrin, D.1    Gala, M.K.2
  • 77
    • 84872670401 scopus 로고    scopus 로고
    • The serrated pathway to colorectal carcinoma: Current concepts and challenges
    • Bettington, M., et al. The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology 62, 367-386 (2013
    • (2013) Histopathology , vol.62 , pp. 367-386
    • Bettington, M.1
  • 78
    • 33747081906 scopus 로고    scopus 로고
    • 15 Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
    • Myung, S. J., et al. 15 Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc. Natl Acad. Sci. USA 103, 12098-12102 (2006
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12098-12102
    • Myung, S.J.1
  • 79
    • 67249157211 scopus 로고    scopus 로고
    • 15 Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors
    • Yan, M., et al. 15 Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. Proc. Natl Acad. Sci. USA 106, 9409-9413 (2009
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9409-9413
    • Yan, M.1
  • 80
    • 84905826523 scopus 로고    scopus 로고
    • Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance
    • Guda, K., et al. Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance. Cancer Prev. Res. (Phila.) 7, 805-812 (2014
    • (2014) Cancer Prev. Res. (Phila , vol.7 , pp. 805-812
    • Guda, K.1
  • 81
    • 5644272862 scopus 로고    scopus 로고
    • Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: Determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer
    • Murphey, L. J., et al. Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal. Biochem. 334, 266-275 (2004
    • (2004) Anal. Biochem , vol.334 , pp. 266-275
    • Murphey, L.J.1
  • 82
    • 84878857014 scopus 로고    scopus 로고
    • Urinary PGE M: A promising cancer biomarker
    • Wang, D., & DuBois, R. N. Urinary PGE M: a promising cancer biomarker. Cancer Prev. Res. (Phila.) 6, 507-510 (2013
    • (2013) Cancer Prev. Res. (Phila , vol.6 , pp. 507-510
    • Wang, D.1    DuBois, R.N.2
  • 83
    • 33750956437 scopus 로고    scopus 로고
    • Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk
    • Cai, Q., et al. Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk. J. Clin. Oncol. 24, 5010-5016 (2006
    • (2006) J. Clin. Oncol , vol.24 , pp. 5010-5016
    • Cai, Q.1
  • 84
    • 84863279448 scopus 로고    scopus 로고
    • Urinary prostaglandin E2 metabolite and risk for colorectal adenoma
    • Shrubsole, M. J., et al. Urinary prostaglandin E2 metabolite and risk for colorectal adenoma. Cancer Prev. Res. (Phila.) 5, 336-342 (2012
    • (2012) Cancer Prev. Res. (Phila , vol.5 , pp. 336-342
    • Shrubsole, M.J.1
  • 85
    • 33750828362 scopus 로고    scopus 로고
    • Urine PGE M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia
    • Johnson, J. C., et al. Urine PGE M: a metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin. Gastroenterol. Hepatol. 4, 1358-1365 (2006
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 1358-1365
    • Johnson, J.C.1
  • 86
    • 84904282333 scopus 로고    scopus 로고
    • Urinary PGE M levels are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs
    • Bezawada, N., et al. Urinary PGE M levels are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs. Cancer Prev. Res. (Phila.) 7, 758-765 (2014
    • (2014) Cancer Prev. Res. (Phila , vol.7 , pp. 758-765
    • Bezawada, N.1
  • 87
    • 84946108246 scopus 로고    scopus 로고
    • Urinary metabolites of prostanoids and risk of recurrent colorectal adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS
    • Fedirko, V., et al. Urinary metabolites of prostanoids and risk of recurrent colorectal adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS). Cancer Prev. Res. (Phila.) 8, 1061-1068 (2015
    • (2015) Cancer Prev. Res. (Phila , vol.8 , pp. 1061-1068
    • Fedirko, V.1
  • 88
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • Wang, D., & Dubois, R. N. Eicosanoids and cancer. Nat. Rev. Cancer 10, 181-193 (2010
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 89
    • 34247587047 scopus 로고    scopus 로고
    • Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors
    • Bigler, J., et al. Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors. Pharmacogenet. Genom. 17, 221-227 (2007
    • (2007) Pharmacogenet. Genom , vol.17 , pp. 221-227
    • Bigler, J.1
  • 90
    • 84862762127 scopus 로고    scopus 로고
    • Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase 1
    • Liu, W., Poole, E. M., Ulrich, C. M., & Kulmacz, R. J. Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase 1. Pharmacogenet. Genom. 22, 525-537 (2012
    • (2012) Pharmacogenet. Genom , vol.22 , pp. 525-537
    • Liu, W.1    Poole, E.M.2    Ulrich, C.M.3    Kulmacz, R.J.4
  • 91
    • 34648836571 scopus 로고    scopus 로고
    • Polymorphisms in PTGS1 PTGS2 and IL 10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial
    • Hubner, R. A., et al. Polymorphisms in PTGS1, PTGS2 and IL 10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. Int. J. Cancer 121, 2001-2004 (2007
    • (2007) Int. J. Cancer , vol.121 , pp. 2001-2004
    • Hubner, R.A.1
  • 92
    • 70350101185 scopus 로고    scopus 로고
    • Cyclooxygenase 2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence-data from a randomized clinical trial
    • Barry, E. L., et al. Cyclooxygenase 2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence-data from a randomized clinical trial. Cancer Epidemiol. Biomarkers Prev. 18, 2726-2733 (2009
    • (2009) Cancer Epidemiol. Biomarkers Prev , vol.18 , pp. 2726-2733
    • Barry, E.L.1
  • 93
    • 76149096488 scopus 로고    scopus 로고
    • Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma
    • Poole, E. M., et al. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol. Biomarkers Prev. 19, 547-557 (2010
    • (2010) Cancer Epidemiol. Biomarkers Prev , vol.19 , pp. 547-557
    • Poole, E.M.1
  • 94
    • 84906833023 scopus 로고    scopus 로고
    • Genetic variation in prostaglandin synthesis and related pathways nsaid use and colorectal cancer risk in the colon cancer family registry
    • Resler, A. J., et al. Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry. Carcinogenesis 35, 2121-2126 (2014
    • (2014) Carcinogenesis , vol.35 , pp. 2121-2126
    • Resler, A.J.1
  • 95
    • 1642617693 scopus 로고    scopus 로고
    • PI3K/Akt signalling pathway and cancer
    • Fresno Vara, J. A., et al. PI3K/Akt signalling pathway and cancer. Cancer Treat. Rev. 30, 193-204 (2004
    • (2004) Cancer Treat. Rev , vol.30 , pp. 193-204
    • Fresno Vara, J.A.1
  • 96
    • 84867817838 scopus 로고    scopus 로고
    • Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    • Liao, X., et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N. Engl. J. Med. 367, 1596-1606 (2012
    • (2012) N. Engl. J. Med , vol.367 , pp. 1596-1606
    • Liao, X.1
  • 97
    • 80052242013 scopus 로고    scopus 로고
    • Location of inhibitor binding sites in the human inducible prostaglandin e synthase MPGES1
    • Prage, E. B., et al. Location of inhibitor binding sites in the human inducible prostaglandin E synthase, MPGES1. Biochemistry 50, 7684-7693 (2011
    • (2011) Biochemistry , vol.50 , pp. 7684-7693
    • Prage, E.B.1
  • 98
    • 79954597286 scopus 로고    scopus 로고
    • Microsomal glutathione transferase 1: Mechanism and functional roles
    • Morgenstern, R., Zhang, J., & Johansson, K. Microsomal glutathione transferase 1: mechanism and functional roles. Drug Metab. Rev. 43, 300-306 (2011
    • (2011) Drug Metab. Rev , vol.43 , pp. 300-306
    • Morgenstern, R.1    Zhang, J.2    Johansson, K.3
  • 99
    • 77953290938 scopus 로고    scopus 로고
    • MPGES 1 as a target for cancer suppression: A comprehensive invited review Phospholipase A2 and lipid mediators
    • Nakanishi, M., Gokhale, V., Meuillet, E J., & Rosenberg, D. W. mPGES 1 as a target for cancer suppression: a comprehensive invited review Phospholipase A2 and lipid mediators. Biochimie 92, 660-664 (2010
    • (2010) Biochimie , vol.92 , pp. 660-664
    • Nakanishi, M.1    Gokhale, V.2    Meuillet, E.J.3    Rosenberg, D.W.4
  • 100
    • 84655166524 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation and the gene expression change in lung cancer
    • Kwon, Y. J., et al. Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. J. Thorac. Oncol. 7, 20-33 (2012
    • (2012) J. Thorac. Oncol , vol.7 , pp. 20-33
    • Kwon, Y.J.1
  • 101
    • 19644363959 scopus 로고    scopus 로고
    • LMO3 interacts with neuronal transcription factor HEN2 and acts as an oncogene in neuroblastoma
    • Aoyama, M., et al. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res. 65, 4587-4597 (2005
    • (2005) Cancer Res , vol.65 , pp. 4587-4597
    • Aoyama, M.1
  • 102
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling: Components, mechanisms, and diseases
    • MacDonald, B. T., Tamai, K., & He, X. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17, 9-26 (2009
    • (2009) Dev. Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 103
    • 33750223793 scopus 로고    scopus 로고
    • Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A
    • Bos, C L., et al. Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A. Oncogene 25, 6447-6456 (2006
    • (2006) Oncogene , vol.25 , pp. 6447-6456
    • Bos, C.L.1
  • 104
    • 84927623385 scopus 로고    scopus 로고
    • Molecular pathways: Aspirin and Wnt signaling-A molecularly targeted approach to cancer prevention and treatment
    • Gala, M. K., & Chan, A. T. Molecular pathways: aspirin and Wnt signaling-A molecularly targeted approach to cancer prevention and treatment. Clin. Cancer Res. 21, 1543-1548 (2015
    • (2015) Clin. Cancer Res , vol.21 , pp. 1543-1548
    • Gala, M.K.1    Chan, A.T.2
  • 105
    • 28544444039 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colon cancer cell growth through a Gs axin-β-catenin signaling axis
    • Castellone, M. D., Teramoto, H., Williams, B. O., Druey, K. M., & Gutkind, J. S. Prostaglandin E2 promotes colon cancer cell growth through a Gs axin-β-catenin signaling axis. Science 310, 1504-1510 (2005
    • (2005) Science , vol.310 , pp. 1504-1510
    • Castellone, M.D.1    Teramoto, H.2    Williams, B.O.3    Druey, K.M.4    Gutkind, J.S.5
  • 106
    • 62149148156 scopus 로고    scopus 로고
    • Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    • Goessling, W., et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136, 1136-1147 (2009
    • (2009) Cell , vol.136 , pp. 1136-1147
    • Goessling, W.1
  • 107
    • 0033615352 scopus 로고    scopus 로고
    • PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • He, T. C., Chan, T. A., Vogelstein, B., & Kinzler, K. W. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99, 335-345 (1999
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 108
    • 0034700110 scopus 로고    scopus 로고
    • Prostacyclin-mediated activation of peroxisome proliferator-Activated receptor delta in colorectal cancer
    • Gupta, R. A., et al. Prostacyclin-mediated activation of peroxisome proliferator-Activated receptor delta in colorectal cancer. Proc. Natl Acad. Sci. USA 97, 13275-13280 (2000
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 13275-13280
    • Gupta, R.A.1
  • 109
    • 1942470331 scopus 로고    scopus 로고
    • Activation of nuclear hormone receptor peroxisome proliferator-Activated receptor-δ accelerates intestinal adenoma growth
    • Gupta, R. A., et al. Activation of nuclear hormone receptor peroxisome proliferator-Activated receptor-δ accelerates intestinal adenoma growth. Nat. Med. 10, 245-247 (2004
    • (2004) Nat. Med , vol.10 , pp. 245-247
    • Gupta, R.A.1
  • 110
    • 4544320012 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-Activated receptor δ
    • Wang, D., et al Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-Activated receptor δ. Cancer Cell 6, 285-295 (2004
    • (2004) Cancer Cell , vol.6 , pp. 285-295
    • Wang, D.1
  • 111
    • 31544463796 scopus 로고    scopus 로고
    • NO donating aspirin isomers downregulate peroxisome proliferator-Activated receptor (PPAR)δ expression in APCmin/+ mice proportionally to their tumor inhibitory effect: Implications for the role of PPARδ in carcinogenesis
    • Ouyang, N., Williams, J. L., & Rigas, B. NO donating aspirin isomers downregulate peroxisome proliferator-Activated receptor (PPAR)δ expression in APCmin/+ mice proportionally to their tumor inhibitory effect: implications for the role of PPARδ in carcinogenesis. Carcinogenesis 27, 232-239 (2006
    • (2006) Carcinogenesis , vol.27 , pp. 232-239
    • Ouyang, N.1    Williams, J.L.2    Rigas, B.3
  • 112
    • 34547498546 scopus 로고    scopus 로고
    • A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
    • Tomlinson, I., et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat. Genet. 39, 984-988 (2007
    • (2007) Nat. Genet , vol.39 , pp. 984-988
    • Tomlinson, I.1
  • 113
    • 34547092701 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
    • Zanke, B. W., et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat. Genet. 39, 989-994 (2007
    • (2007) Nat. Genet , vol.39 , pp. 989-994
    • Zanke, B.W.1
  • 114
    • 68149180901 scopus 로고    scopus 로고
    • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
    • Pomerantz, M. M., et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat. Genet. 41, 882-884 (2009
    • (2009) Nat. Genet , vol.41 , pp. 882-884
    • Pomerantz, M.M.1
  • 115
    • 84891449924 scopus 로고    scopus 로고
    • Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations
    • Nan, H., et al. Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations. J. Natl Cancer Inst. 105, 1852-1861 (2013
    • (2013) J. Natl Cancer Inst , vol.105 , pp. 1852-1861
    • Nan, H.1
  • 116
    • 34547121725 scopus 로고    scopus 로고
    • A common genetic risk factor for colorectal and prostate cancer
    • Haiman, C. A., et al. A common genetic risk factor for colorectal and prostate cancer. Nat. Genet. 39, 954-956 (2007
    • (2007) Nat. Genet , vol.39 , pp. 954-956
    • Haiman, C.A.1
  • 117
    • 84920389109 scopus 로고    scopus 로고
    • The role of PGE2 in intestinal inflammation and tumorigenesis
    • Montrose, D. C., et al. The role of PGE2 in intestinal inflammation and tumorigenesis. Prostaglandins Other Lipid Mediat. 116-117, 26-36 (2015
    • (2015) Prostaglandins Other Lipid Mediat , vol.116-117 , pp. 26-36
    • Montrose, D.C.1
  • 118
    • 84942903147 scopus 로고    scopus 로고
    • Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment that amplify inflammation and tumor growth
    • Ma, X., Aoki, T., Tsuruyama, T., & Narumiya, S. Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment that amplify inflammation and tumor growth. Cancer Res. 75, 2822-2832 (2015
    • (2015) Cancer Res , vol.75 , pp. 2822-2832
    • Ma, X.1    Aoki, T.2    Tsuruyama, T.3    Narumiya, S.4
  • 119
    • 79952284479 scopus 로고    scopus 로고
    • Inflammatory markers are associated with risk of colorectal cancer and chemopreventative response to anti-inflammatory drugs
    • Chan, A. T., Ogino, S., Giovannucci, E. L., & Fuchs, C. S. Inflammatory markers are associated with risk of colorectal cancer and chemopreventative response to anti-inflammatory drugs. Gastroenterology 140, 799-808 (2011
    • (2011) Gastroenterology , vol.140 , pp. 799-808
    • Chan, A.T.1    Ogino, S.2    Giovannucci, E.L.3    Fuchs, C.S.4
  • 120
    • 84878616260 scopus 로고    scopus 로고
    • A prospective study of plasma inflammatory markers and risk of colorectal cancer in men
    • Song, M., et al. A prospective study of plasma inflammatory markers and risk of colorectal cancer in men. Br. J. Cancer 108, 1891-1898 (2013
    • (2013) Br. J. Cancer , vol.108 , pp. 1891-1898
    • Song, M.1
  • 121
    • 58249122522 scopus 로고    scopus 로고
    • Associations of circulating C reactive protein and interleukin 6 with cancer risk: Findings from two prospective cohorts and a meta-Analysis
    • Heikkila, K., et al. Associations of circulating C reactive protein and interleukin 6 with cancer risk: findings from two prospective cohorts and a meta-Analysis. Cancer Causes Control 20, 15-26 (2009
    • (2009) Cancer Causes Control , vol.20 , pp. 15-26
    • Heikkila, K.1
  • 122
    • 84941425687 scopus 로고    scopus 로고
    • Interleukin 6 and risk of colorectal cancer: Results from the CLUE II cohort and a meta-Analysis of prospective studies
    • Kakourou, A., et al. Interleukin 6 and risk of colorectal cancer: results from the CLUE II cohort and a meta-Analysis of prospective studies. Cancer Causes Control 26, 1449-1460 (2015
    • (2015) Cancer Causes Control , vol.26 , pp. 1449-1460
    • Kakourou, A.1
  • 123
    • 84873413504 scopus 로고    scopus 로고
    • The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG 1/GDF15) in cancer
    • Wang, X., Baek, S. J., & Eling, T. E. The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG 1/GDF15) in cancer. Biochem. Pharmacol. 85, 597-606 (2013
    • (2013) Biochem. Pharmacol , vol.85 , pp. 597-606
    • Wang, X.1    Baek, S.J.2    Eling, T.E.3
  • 124
    • 80052907593 scopus 로고    scopus 로고
    • The TGF-β superfamily cytokine, MIC 1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism
    • Breit, S. N., et al. The TGF-β superfamily cytokine, MIC 1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth Factors 29, 187-195 (2011
    • (2011) Growth Factors , vol.29 , pp. 187-195
    • Breit, S.N.1
  • 125
    • 84898920630 scopus 로고    scopus 로고
    • A prospective study of macrophage inhibitory cytokine 1 (MIC 1/GDF15) and risk of colorectal cancer
    • Mehta, R. S., et al. A prospective study of macrophage inhibitory cytokine 1 (MIC 1/GDF15) and risk of colorectal cancer. J. Natl Cancer Inst. 106, dju016 (2014
    • (2014) J. Natl Cancer Inst , vol.106 , pp. dju016
    • Mehta, R.S.1
  • 127
    • 33749434835 scopus 로고    scopus 로고
    • Expression of COX 2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling
    • Dixon, D. A., et al. Expression of COX 2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J. Clin. Invest. 116, 2727-2738 (2006
    • (2006) J. Clin. Invest , vol.116 , pp. 2727-2738
    • Dixon, D.A.1
  • 128
    • 68849123400 scopus 로고    scopus 로고
    • Aspirin use and survival after diagnosis of colorectal cancer
    • Chan, A. T., Ogino, S., & Fuchs, C. S. Aspirin use and survival after diagnosis of colorectal cancer. JAMA 302, 649-658 (2009
    • (2009) JAMA , vol.302 , pp. 649-658
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 129
    • 78649854163 scopus 로고    scopus 로고
    • Effect of aspirin and NSAIDs on risk and survival from colorectal cancer
    • Din, F. V., et al. Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut 59, 1670-1679 (2010
    • (2010) Gut , vol.59 , pp. 1670-1679
    • Din, F.V.1
  • 130
    • 84918592217 scopus 로고    scopus 로고
    • Post-operative aspirin use and colorectal cancer-specific survival in patients with stage I-III colorectal cancer
    • Goh, C. H., et al. Post-operative aspirin use and colorectal cancer-specific survival in patients with stage I-III colorectal cancer. Anticancer Res. 34, 7407-7414 (2014
    • (2014) Anticancer Res , vol.34 , pp. 7407-7414
    • Goh, C.H.1
  • 131
    • 84941278479 scopus 로고    scopus 로고
    • Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: A meta-Analysis
    • Li, P., et al. Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-Analysis. Gut 64, 1419-1425 (2015
    • (2015) Gut , vol.64 , pp. 1419-1425
    • Li, P.1
  • 132
    • 84926518325 scopus 로고    scopus 로고
    • Aspirin and COX 2 inhibitor use in patients with stage III colon cancer
    • Ng, K., et al. Aspirin and COX 2 inhibitor use in patients with stage III colon cancer. J. Natl Cancer Inst. 107, 345 (2015
    • (2015) J. Natl Cancer Inst , vol.107 , pp. 345
    • Ng, K.1
  • 133
    • 0025998557 scopus 로고
    • Aspirin use and reduced risk of fatal colon cancer
    • Thun, M. J., Namboodiri, M. M., & Heath, C. W. Jr. Aspirin use and reduced risk of fatal colon cancer. N. Engl. J. Med. 325, 1593-1596 (1991
    • (1991) N. Engl. J. Med , vol.325 , pp. 1593-1596
    • Thun, M.J.1    Namboodiri, M.M.2    Heath, C.W.3
  • 134
    • 84860467522 scopus 로고    scopus 로고
    • Effects of regular aspirin on long-Term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials
    • Algra, A. M., & Rothwell, P. M. Effects of regular aspirin on long-Term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 13, 518-527 (2012
    • (2012) Lancet Oncol , vol.13 , pp. 518-527
    • Algra, A.M.1    Rothwell, P.M.2
  • 135
    • 84863399038 scopus 로고    scopus 로고
    • Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials
    • Rothwell, P. M., et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 379, 1591-1601 (2012
    • (2012) Lancet , vol.379 , pp. 1591-1601
    • Rothwell, P.M.1
  • 137
    • 84892843686 scopus 로고    scopus 로고
    • Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer
    • Domingo, E., et al. Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. J. Clin. Oncol. 31, 4297-4305 (2013
    • (2013) J. Clin. Oncol , vol.31 , pp. 4297-4305
    • Domingo, E.1
  • 138
    • 84897978063 scopus 로고    scopus 로고
    • Expression of HLA class i antigen, aspirin use, and survival after a diagnosis of colon cancer
    • Reimers, M. S., et al. Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer. JAMA Intern. Med. 174, 732-739 (2014
    • (2014) JAMA Intern. Med , vol.174 , pp. 732-739
    • Reimers, M.S.1
  • 139
    • 84925446564 scopus 로고    scopus 로고
    • Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation
    • Kothari, N., et al. Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation. Acta Oncol. 54, 487-492 (2015
    • (2015) Acta Oncol , vol.54 , pp. 487-492
    • Kothari, N.1
  • 140
    • 84927138420 scopus 로고    scopus 로고
    • Relationship between aspirin use after diagnosis of colorectal cancer and patient survival: A meta-Analysis of observational studies
    • Ye, X. F., Wang, J., Shi, W. T., & He, J. Relationship between aspirin use after diagnosis of colorectal cancer and patient survival: a meta-Analysis of observational studies. Br. J. Cancer 111, 2172-2179 (2014
    • (2014) Br. J. Cancer , vol.111 , pp. 2172-2179
    • Ye, X.F.1    Wang, J.2    Shi, W.T.3    He, J.4
  • 142
    • 66249090583 scopus 로고    scopus 로고
    • Association between rectal optical signatures and colonic neoplasia: Potential applications for screening
    • Roy, H. K., et al. Association between rectal optical signatures and colonic neoplasia: potential applications for screening. Cancer Res. 69, 4476-4483 (2009
    • (2009) Cancer Res , vol.69 , pp. 4476-4483
    • Roy, H.K.1
  • 143
    • 84945967448 scopus 로고    scopus 로고
    • Rectal optical markers for in vivo risk stratification of premalignant colorectal lesions
    • Radosevich, A. J., et al. Rectal optical markers for in vivo risk stratification of premalignant colorectal lesions. Clin. Cancer Res. 21, 4347-4355 (2015
    • (2015) Clin. Cancer Res , vol.21 , pp. 4347-4355
    • Radosevich, A.J.1
  • 144
    • 84955270177 scopus 로고    scopus 로고
    • Aspirin reduces plasma concentrations of the oncometabolite 2 hydroxyglutarate: Results of a randomized, double-blind, crossover trial
    • Liesenfeld, D. B., et al. Aspirin reduces plasma concentrations of the oncometabolite 2 hydroxyglutarate: results of a randomized, double-blind, crossover trial. Cancer Epidemiol. Biomarkers Prev. 25, 180-187 (2015
    • (2015) Cancer Epidemiol. Biomarkers Prev , vol.25 , pp. 180-187
    • Liesenfeld, D.B.1
  • 145
    • 61349140122 scopus 로고    scopus 로고
    • Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation
    • Gerner, E. W., & Meyskens, F. L. Jr. Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation. Clin. Cancer Res. 15, 758-761 (2009
    • (2009) Clin. Cancer Res , vol.15 , pp. 758-761
    • Gerner, E.W.1    Meyskens, F.L.2
  • 146
    • 34248228763 scopus 로고    scopus 로고
    • Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
    • Casero, R. A. Jr. & Marton, L. J. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat. Rev. Drug Discov. 6, 373-390 (2007
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 373-390
    • Casero, R.A.1    Marton, L.J.2
  • 147
    • 4944242891 scopus 로고    scopus 로고
    • Polyamines and cancer: Old molecules, new understanding
    • Gerner, E. W., & Meyskens, F. L. Jr. Polyamines and cancer: old molecules, new understanding. Nat. Rev. Cancer 4, 781-792 (2004
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 781-792
    • Gerner, E.W.1    Meyskens, F.L.2
  • 148
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00983580 (2015
    • (2015) US National Library of Medicine
  • 149
    • 55549132996 scopus 로고    scopus 로고
    • Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial
    • Meyskens, F. L. Jr, et al. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev. Res. (Phila.) 1, 32-38 (2008
    • (2008) Cancer Prev. Res. (Phila , vol.1 , pp. 32-38
    • Meyskens, F.L.1
  • 150
    • 0037934362 scopus 로고    scopus 로고
    • Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene
    • Martinez, M. E., et al. Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. Proc. Natl Acad. Sci. USA 100, 7859-7864 (2003
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7859-7864
    • Martinez, M.E.1
  • 151
    • 33750205691 scopus 로고    scopus 로고
    • Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention
    • Barry, E. L., et al. Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. J. Natl Cancer Inst. 98, 1494-1500 (2006
    • (2006) J. Natl Cancer Inst , vol.98 , pp. 1494-1500
    • Barry, E.L.1
  • 152
    • 42249097559 scopus 로고    scopus 로고
    • Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention
    • Hubner, R. A., et al. Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention. Clin. Cancer Res. 14, 2303-2309 (2008
    • (2008) Clin. Cancer Res , vol.14 , pp. 2303-2309
    • Hubner, R.A.1
  • 153
    • 77957824343 scopus 로고    scopus 로고
    • Ornithine decarboxylase 1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients
    • Zell, J. A., et al. Ornithine decarboxylase 1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients. J. Natl Cancer Inst. 102, 1513-1516 (2010
    • (2010) J. Natl Cancer Inst , vol.102 , pp. 1513-1516
    • Zell, J.A.1
  • 154
    • 83055195220 scopus 로고    scopus 로고
    • Variants downstream of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention
    • Barry, E. L., Mott, L. A., Sandler, R. S., Ahnen, D. J., & Baron, J. A. Variants downstream of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention. Cancer Prev. Res. (Phila.) 4, 2072-2082 (2011
    • (2011) Cancer Prev. Res. (Phila , vol.4 , pp. 2072-2082
    • Barry, E.L.1    Mott, L.A.2    Sandler, R.S.3    Ahnen, D.J.4    Baron, J.A.5
  • 155
    • 84930402629 scopus 로고    scopus 로고
    • Aspirin and NSAID chemoprevention, gene-environment interactions, and risk of colorectal cancer
    • Wender, R. C. Aspirin and NSAID chemoprevention, gene-environment interactions, and risk of colorectal cancer. JAMA 313, 1111-1112 (2015
    • (2015) JAMA , vol.313 , pp. 1111-1112
    • Wender, R.C.1
  • 156
    • 84880946220 scopus 로고    scopus 로고
    • A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the nhs bowel cancer screening programme (the seafood polyp prevention trial): Study protocol for a randomized controlled trial
    • Hull, M. A., et al. A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): study protocol for a randomized controlled trial. Trials 14, 237 (2013
    • (2013) Trials , vol.14 , pp. 237
    • Hull, M.A.1
  • 157
    • 84876237830 scopus 로고    scopus 로고
    • Gastrointestinal adverse effects of short-Term aspirin use: A meta-Analysis of published randomized controlled trials
    • Baron, J. A., et al. Gastrointestinal adverse effects of short-Term aspirin use: a meta-Analysis of published randomized controlled trials. Drugs R D 13, 9-16 (2013
    • (2013) Drugs R D , vol.13 , pp. 9-16
    • Baron, J.A.1
  • 158
    • 78649823909 scopus 로고    scopus 로고
    • ACCF/acg/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: A focused update of the ACCF/acg/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and nsaid use
    • Abraham, N. S., et al. ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am. J. Gastroenterol. 105, 2533-2549 (2010
    • (2010) Am. J. Gastroenterol , vol.105 , pp. 2533-2549
    • Abraham, N.S.1
  • 159
    • 79952061809 scopus 로고    scopus 로고
    • Aspirin: A historical and contemporary therapeutic overview
    • Fuster, V., & Sweeny, J. M. Aspirin: a historical and contemporary therapeutic overview. Circulation 123, 768-778 (2011
    • (2011) Circulation , vol.123 , pp. 768-778
    • Fuster, V.1    Sweeny, J.M.2
  • 160
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane, J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 231, 232-235 (1971
    • (1971) Nat. New Biol , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 161
    • 0023687241 scopus 로고
    • Colorectal cancer risk, chronic illnesses, operations, and medications: Case control results from the melbourne colorectal cancer study
    • Kune, G. A., Kune, S., & Watson, L. F. Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res. 48, 4399-4404 (1988
    • (1988) Cancer Res , vol.48 , pp. 4399-4404
    • Kune, G.A.1    Kune, S.2    Watson, L.F.3
  • 162
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-Tumor development
    • Vogelstein, B., et al. Genetic alterations during colorectal-Tumor development. N. Engl. J. Med. 319, 525-532 (1988
    • (1988) N. Engl. J. Med , vol.319 , pp. 525-532
    • Vogelstein, B.1
  • 163
    • 0028556801 scopus 로고
    • Aspirin use and the risk for colorectal cancer and adenoma in male health professionals
    • Giovannucci, E., et al. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann. Intern. Med. 121, 241-246 (1994
    • (1994) Ann. Intern. Med , vol.121 , pp. 241-246
    • Giovannucci, E.1
  • 164
    • 0029150934 scopus 로고
    • Aspirin and the risk of colorectal cancer in women
    • Giovannucci, E., et al. Aspirin and the risk of colorectal cancer in women. N. Engl. J. Med. 333, 609-614 (1995
    • (1995) N. Engl. J. Med , vol.333 , pp. 609-614
    • Giovannucci, E.1
  • 165
    • 60749128400 scopus 로고    scopus 로고
    • Aspirin for the chemoprevention of colorectal adenomas: Meta-Analysis of the randomized trials
    • Cole, B. F., et al. Aspirin for the chemoprevention of colorectal adenomas: meta-Analysis of the randomized trials. J. Natl Cancer Inst. 101, 256-266 (2009
    • (2009) J. Natl Cancer Inst , vol.101 , pp. 256-266
    • Cole, B.F.1


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