-
1
-
-
77954563464
-
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease
-
Finger EC, Giaccia AJ. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev 2010; 29: 285-293
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 285-293
-
-
Finger, E.C.1
Giaccia, A.J.2
-
2
-
-
84655161946
-
HIF1alpha and HIF2alpha: Sibling rivalry in hypoxic tumour growth and progression
-
Keith B, Johnson RS, Simon MC. HIF1alpha and HIF2alpha: Sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2012; 12: 9-22
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
3
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012; 148: 399-408
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
4
-
-
84867420094
-
Cancer and altered metabolism: Potential importance of hypoxiainducible factor and 2-oxoglutarate-dependent dioxygenases
-
Kaelin Jr. WG. Cancer and altered metabolism: Potential importance of hypoxiainducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol 2011; 76: 335-345
-
(2011)
Cold Spring Harb Symp Quant Biol
, vol.76
, pp. 335-345
-
-
Kaelin Jr., W.G.1
-
6
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg J, Darnell Jr. JE. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000; 19: 2468-2473
-
(2000)
Oncogene
, vol.19
, pp. 2468-2473
-
-
Bromberg, J.1
Darnell Jr., J.E.2
-
7
-
-
0036075424
-
Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: A study of incidence and its association with pathological features and clinical outcome
-
Horiguchi A, Oya M, Shimada T, Uchida A, Marumo K, Murai M. Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: A study of incidence and its association with pathological features and clinical outcome. J Urol 2002; 168: 762-765
-
(2002)
J Urol
, vol.168
, pp. 762-765
-
-
Horiguchi, A.1
Oya, M.2
Shimada, T.3
Uchida, A.4
Marumo, K.5
Murai, M.6
-
8
-
-
1042302005
-
The stats of cancer-new molecular targets come of age
-
Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004; 4: 97-105
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
9
-
-
0034306290
-
STAT proteins and transcriptional responses to extracellular signals
-
Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 2000; 25: 496-502
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 496-502
-
-
Horvath, C.M.1
-
10
-
-
33646527342
-
Phosphorylation and activation of STAT proteins by hypoxia in breast cancer cells
-
Lee MY, Joung YH, Lim EJ, Park JH, Ye SK, Park T, et al. Phosphorylation and activation of STAT proteins by hypoxia in breast cancer cells. Breast 2006; 15: 187-195
-
(2006)
Breast
, vol.15
, pp. 187-195
-
-
Lee, M.Y.1
Joung, Y.H.2
Lim, E.J.3
Park, J.H.4
Ye, S.K.5
Park, T.6
-
11
-
-
65449154326
-
The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis
-
Noman MZ, Buart S, Van Pelt J, Richon C, Hasmim M, Leleu N, et al. The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. J Immunol 2009; 182: 3510-3521
-
(2009)
J Immunol
, vol.182
, pp. 3510-3521
-
-
Noman, M.Z.1
Buart, S.2
Van Pelt, J.3
Richon, C.4
Hasmim, M.5
Leleu, N.6
-
12
-
-
70249099280
-
Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3
-
Selvendiran K, Bratasz A, Kuppusamy ML, Tazi MF, Rivera BK, Kuppusamy P. Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. Int J Cancer 2009; 125: 2198-2204
-
(2009)
Int J Cancer
, vol.125
, pp. 2198-2204
-
-
Selvendiran, K.1
Bratasz, A.2
Kuppusamy, M.L.3
Tazi, M.F.4
Rivera, B.K.5
Kuppusamy, P.6
-
13
-
-
23444449093
-
STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
-
Jung JE, Lee HG, Cho IH, Chung DH, Yoon SH, Yang YM, et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. Faseb J 2005; 19: 1296-1298
-
(2005)
Faseb J
, vol.19
, pp. 1296-1298
-
-
Jung, J.E.1
Lee, H.G.2
Cho, I.H.3
Chung, D.H.4
Yoon, S.H.5
Yang, Y.M.6
-
14
-
-
77958512917
-
Activated STAT3 regulates hypoxia-induced angiogenesis and cell migration in human glioblastoma
-
discussion 95
-
Kang SH, Yu MO, Park KJ, Chi SG, Park DH, Chung YG. Activated STAT3 regulates hypoxia-induced angiogenesis and cell migration in human glioblastoma. Neurosurgery 2010; 67: 1386-1395, discussion 95
-
(2010)
Neurosurgery
, vol.67
, pp. 1386-1395
-
-
Kang, S.H.1
Yu, M.O.2
Park, K.J.3
Chi, S.G.4
Park, D.H.5
Chung, Y.G.6
-
15
-
-
18844444774
-
Hif-1alpha, stat3, cbp/p300 and ref-1/ape are components of a transcriptional complex that regulates src-dependent hypoxia-induced expression of vegf in pancreatic and prostate carcinomas
-
Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, et al. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 2005; 24: 3110-3120
-
(2005)
Oncogene
, vol.24
, pp. 3110-3120
-
-
Gray, M.J.1
Zhang, J.2
Ellis, L.M.3
Semenza, G.L.4
Evans, D.B.5
Watowich, S.S.6
-
16
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002; 21: 2000-2008
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
Song, L.4
Haura, E.5
Turkson, J.6
-
17
-
-
84864389212
-
A novel regulation of VEGF expression by HIF-1alpha and STAT3 in HDM2 transfected prostate cancer cells
-
Rathinavelu A, Narasimhan M, Muthumani P. A novel regulation of VEGF expression by HIF-1alpha and STAT3 in HDM2 transfected prostate cancer cells. J Cell Mol Med 2012; 16: 1750-1757
-
(2012)
J Cell Mol Med
, vol.16
, pp. 1750-1757
-
-
Rathinavelu, A.1
Narasimhan, M.2
Muthumani, P.3
-
18
-
-
41849120867
-
Ectopic decorin expression up-regulates VEGF expression in mouse cerebral endothelial cells via activation of the transcription factors Sp1, HIF1alpha, and Stat3
-
Santra M, Santra S, Zhang J, Chopp M. Ectopic decorin expression up-regulates VEGF expression in mouse cerebral endothelial cells via activation of the transcription factors Sp1, HIF1alpha, and Stat3. J Neurochem 2008; 105: 324-337
-
(2008)
J Neurochem
, vol.105
, pp. 324-337
-
-
Santra, M.1
Santra, S.2
Zhang, J.3
Chopp, M.4
-
19
-
-
79953171126
-
Hypoxia-inducible factor-1alpha enhances haptoglobin gene expression by improving binding of STAT3 to the promoter
-
Oh MK, Park HJ, Kim NH, Park SJ, Park IY, Kim IS. Hypoxia-inducible factor-1alpha enhances haptoglobin gene expression by improving binding of STAT3 to the promoter. J Biol Chem 2011; 286: 8857-8865
-
(2011)
J Biol Chem
, vol.286
, pp. 8857-8865
-
-
Oh, M.K.1
Park, H.J.2
Kim, N.H.3
Park, S.J.4
Park, I.Y.5
Kim, I.S.6
-
20
-
-
35848938945
-
The N-Terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha
-
Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-Terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell 2007; 18: 4528-4542
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4528-4542
-
-
Hu, C.J.1
Sataur, A.2
Wang, L.3
Chen, H.4
Simon, M.C.5
-
21
-
-
0345491599
-
Differential roles of hypoxiainducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxiainducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003; 23: 9361-9374
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
22
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindauassociated renal cell carcinoma
-
Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindauassociated renal cell carcinoma. Mol Cell Biol 2005; 25: 5675-5686
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
Sowter, H.M.4
Mandriota, S.J.5
Li, J.L.6
-
23
-
-
9444283176
-
Differentiating the functional role of hypoxia-inducible factor (hif)-1alpha and hif-2alpha (epas-1) by the use of rna interference: Erythropoietin is a hif-2alpha target gene in hep3b and kelly cells
-
Warnecke C, Zaborowska Z, Kurreck J, Erdmann VA, Frei U, Wiesener M, et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. Faseb J 2004; 18: 1462-1464
-
(2004)
Faseb J
, vol.18
, pp. 1462-1464
-
-
Warnecke, C.1
Zaborowska, Z.2
Kurreck, J.3
Erdmann, V.A.4
Frei, U.5
Wiesener, M.6
-
24
-
-
0141927332
-
Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231
-
Bando H, Toi M, Kitada K, Koike M. Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231. Biomed Pharmacother 2003; 57: 333-340
-
(2003)
Biomed Pharmacother
, vol.57
, pp. 333-340
-
-
Bando, H.1
Toi, M.2
Kitada, K.3
Koike, M.4
-
25
-
-
77950800322
-
Role of hypoxia and autophagy in MDA-MB-231 invasiveness
-
Indelicato M, Pucci B, Schito L, Reali V, Aventaggiato M, Mazzarino MC, et al. Role of hypoxia and autophagy in MDA-MB-231 invasiveness. J Cell Physiol 2010; 223: 359-368
-
(2010)
J Cell Physiol
, vol.223
, pp. 359-368
-
-
Indelicato, M.1
Pucci, B.2
Schito, L.3
Reali, V.4
Aventaggiato, M.5
Mazzarino, M.C.6
-
26
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygendependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygendependent proteolysis. Nature 1999; 399: 271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
27
-
-
38449111737
-
The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
-
Zia MK, Rmali KA, Watkins G, Mansel RE, Jiang WG. The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells. Int J Mol Med 2007; 20: 605-611
-
(2007)
Int J Mol Med
, vol.20
, pp. 605-611
-
-
Zia, M.K.1
Rmali, K.A.2
Watkins, G.3
Mansel, R.E.4
Jiang, W.G.5
-
28
-
-
58249092980
-
Activation of Src and Src-Associated signaling pathways in relation to hypoxia in human cancer xenograft models
-
Pham NA, Magalhaes JM, Do T, Schwock J, Dhani N, Cao PJ, et al. Activation of Src and Src-Associated signaling pathways in relation to hypoxia in human cancer xenograft models. Int J Cancer 2009; 124: 280-286
-
(2009)
Int J Cancer
, vol.124
, pp. 280-286
-
-
Pham, N.A.1
Magalhaes, J.M.2
Do, T.3
Schwock, J.4
Dhani, N.5
Cao, P.J.6
-
29
-
-
33749055594
-
Molecular cross-Talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma
-
Squarize CH, Castilho RM, Sriuranpong V, Pinto Jr. DS, Gutkind JS. Molecular cross-Talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia 2006; 8: 733-746
-
(2006)
Neoplasia
, vol.8
, pp. 733-746
-
-
Squarize, C.H.1
Castilho, R.M.2
Sriuranpong, V.3
Pinto Jr., D.S.4
Gutkind, J.S.5
-
30
-
-
84862776933
-
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase
-
Gao X, Wang H, Yang JJ, Liu X, Liu ZR. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol Cell 2012; 45: 598-609
-
(2012)
Mol Cell
, vol.45
, pp. 598-609
-
-
Gao, X.1
Wang, H.2
Yang, J.J.3
Liu, X.4
Liu, Z.R.5
-
31
-
-
0042704747
-
VEGF differentially activates STAT3 in microvascular endothelial cells
-
Bartoli M, Platt D, Lemtalsi T, Gu X, Brooks SE, Marrero MB, et al. VEGF differentially activates STAT3 in microvascular endothelial cells. FASEB J 2003; 17: 1562-1564
-
(2003)
FASEB J
, vol.17
, pp. 1562-1564
-
-
Bartoli, M.1
Platt, D.2
Lemtalsi, T.3
Gu, X.4
Brooks, S.E.5
Marrero, M.B.6
-
32
-
-
84863174774
-
VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression
-
Wang H, Byfield G, Jiang Y, Smith GW, McCloskey M, Hartnett ME. VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression. Am J Pathol 2012; 180: 1243-1253
-
(2012)
Am J Pathol
, vol.180
, pp. 1243-1253
-
-
Wang, H.1
Byfield, G.2
Jiang, Y.3
Smith, G.W.4
McCloskey, M.5
Hartnett, M.E.6
-
33
-
-
79960894174
-
Prognostic significance of IL-8-STAT-3 pathway in astrocytomas: Correlation with IL-6 VEGF and microvessel morphometry
-
Piperi C, Samaras V, Levidou G, Kavantzas N, Boviatsis E, Petraki K, et al. Prognostic significance of IL-8-STAT-3 pathway in astrocytomas: Correlation with IL-6, VEGF and microvessel morphometry. Cytokine 2011; 55: 387-395
-
(2011)
Cytokine
, vol.55
, pp. 387-395
-
-
Piperi, C.1
Samaras, V.2
Levidou, G.3
Kavantzas, N.4
Boviatsis, E.5
Petraki, K.6
-
34
-
-
33646248422
-
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells
-
Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol 2006; 26: 3514-3526
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3514-3526
-
-
Hu, C.J.1
Iyer, S.2
Sataur, A.3
Covello, K.L.4
Chodosh, L.A.5
Simon, M.C.6
-
35
-
-
51649096739
-
Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-Associated myeloid cells
-
Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, et al. Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-Associated myeloid cells. Mol Cancer Res 2008; 6: 1099-1105
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1099-1105
-
-
Niu, G.1
Briggs, J.2
Deng, J.3
Ma, Y.4
Lee, H.5
Kortylewski, M.6
-
36
-
-
34247631690
-
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
-
Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL, et al. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 2007; 21: 1037-1049
-
(2007)
Genes Dev
, vol.21
, pp. 1037-1049
-
-
Lum, J.J.1
Bui, T.2
Gruber, M.3
Gordan, J.D.4
DeBerardinis, R.J.5
Covello, K.L.6
-
37
-
-
79952666779
-
A stat3-mediated metabolic switch is involved in tumour transformation and stat3 addiction
-
Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, et al. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging 2010; 2: 823-842
-
(2010)
Aging
, vol.2
, pp. 823-842
-
-
Demaria, M.1
Giorgi, C.2
Lebiedzinska, M.3
Esposito, G.4
D'Angeli, L.5
Bartoli, A.6
-
38
-
-
70350500225
-
Stats in cancer inflammation and immunity: A leading role for stat3
-
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer 2009; 9: 798-809
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
39
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177-185
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
40
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3: 187-197
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
41
-
-
0034352334
-
Regulation of Bcl-xL: A little bit of this and a little bit of STAT
-
Grad JM, Zeng XR, Boise LH. Regulation of Bcl-xL: A little bit of this and a little bit of STAT. Curr Opin Oncol 2000; 12: 543-549
-
(2000)
Curr Opin Oncol
, vol.12
, pp. 543-549
-
-
Grad, J.M.1
Zeng, X.R.2
Boise, L.H.3
-
42
-
-
77952888131
-
Stat3 inhibitor wp1066 as a novel therapeutic agent for renal cell carcinoma
-
Horiguchi A, Asano T, Kuroda K, Sato A, Asakuma J, Ito K, et al. STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma. Br J Cancer 2010; 102: 1592-1599
-
(2010)
Br J Cancer
, vol.102
, pp. 1592-1599
-
-
Horiguchi, A.1
Asano, T.2
Kuroda, K.3
Sato, A.4
Asakuma, J.5
Ito, K.6
-
43
-
-
34147205531
-
P66Shc is involved in promoting HIF-1alpha accumulation and cell death in hypoxic T cells
-
Carraro F, Pucci A, Pellegrini M, Pelicci PG, Baldari CT, Naldini A. p66Shc is involved in promoting HIF-1alpha accumulation and cell death in hypoxic T cells. J Cell Physiol 2007; 211: 439-447
-
(2007)
J Cell Physiol
, vol.211
, pp. 439-447
-
-
Carraro, F.1
Pucci, A.2
Pellegrini, M.3
Pelicci, P.G.4
Baldari, C.T.5
Naldini, A.6
-
44
-
-
0033520422
-
Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
-
Paulson M, Pisharody S, Pan L, Guadagno S, Mui AL, Levy DE. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J Biol Chem 1999; 274: 25343-25349
-
(1999)
J Biol Chem
, vol.274
, pp. 25343-25349
-
-
Paulson, M.1
Pisharody, S.2
Pan, L.3
Guadagno, S.4
Mui, A.L.5
Levy, D.E.6
-
45
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
Yuan ZL, Guan YJ, Chatterjee D, Chin YE. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 2005; 307: 269-273
-
(2005)
Science
, vol.307
, pp. 269-273
-
-
Yuan, Z.L.1
Guan, Y.J.2
Chatterjee, D.3
Chin, Y.E.4
-
46
-
-
0035917876
-
Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation
-
Schuringa JJ, Schepers H, Vellenga E, Kruijer W. Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation. FEBS Lett 2001; 495: 71-76
-
(2001)
FEBS Lett
, vol.495
, pp. 71-76
-
-
Schuringa, J.J.1
Schepers, H.2
Vellenga, E.3
Kruijer, W.4
-
47
-
-
0029803552
-
An essential role for p300/CBP in the cellular response to hypoxia
-
Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, et al. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93: 12969-12973
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12969-12973
-
-
Arany, Z.1
Huang, L.E.2
Eckner, R.3
Bhattacharya, S.4
Jiang, C.5
Goldberg, M.A.6
-
48
-
-
0031835957
-
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
-
Ebert BL, Bunn HF. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol 1998; 18: 4089-4096
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4089-4096
-
-
Ebert, B.L.1
Bunn, H.F.2
-
49
-
-
77449159578
-
Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300
-
Ruas JL, Berchner-Pfannschmidt U, Malik S, Gradin K, Fandrey J, Roeder RG, et al. Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. J Biol Chem 2010; 285: 2601-2609
-
(2010)
J Biol Chem
, vol.285
, pp. 2601-2609
-
-
Ruas, J.L.1
Berchner-Pfannschmidt, U.2
Malik, S.3
Gradin, K.4
Fandrey, J.5
Roeder, R.G.6
-
50
-
-
34047156190
-
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007; 11: 335-347
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
51
-
-
57349168511
-
STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination
-
Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, et al. STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination. Exp Mol Med 2008; 40: 479-485
-
(2008)
Exp Mol Med
, vol.40
, pp. 479-485
-
-
Jung, J.E.1
Kim, H.S.2
Lee, C.S.3
Shin, Y.J.4
Kim, Y.N.5
Kang, G.H.6
-
52
-
-
84869500586
-
Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma
-
Adachi M, Cui C, Dodge CT, Bhayani MK, Lai SY. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma. Oral Oncol 2012; 48: 1220-1226
-
(2012)
Oral Oncol
, vol.48
, pp. 1220-1226
-
-
Adachi, M.1
Cui, C.2
Dodge, C.T.3
Bhayani, M.K.4
Lai, S.Y.5
-
53
-
-
84861711607
-
Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxia
-
Liu T, Li Y, Lin K, Yin H, He B, Zheng M, et al. Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxia. Int J Biochem Cell Biol 2012; 44: 1337-1345
-
(2012)
Int J Biochem Cell Biol
, vol.44
, pp. 1337-1345
-
-
Liu, T.1
Li, Y.2
Lin, K.3
Yin, H.4
He, B.5
Zheng, M.6
-
54
-
-
84857922759
-
Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration
-
Bai L, Yang JC, Ok JH, Mack PC, Kung HJ, Evans CP. Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration. Int J Cancer 2012; 130: 2693-2702
-
(2012)
Int J Cancer
, vol.130
, pp. 2693-2702
-
-
Bai, L.1
Yang, J.C.2
Ok, J.H.3
Mack, P.C.4
Kung, H.J.5
Evans, C.P.6
-
55
-
-
37049002653
-
Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells
-
Belaiba RS, Bonello S, Zahringer C, Schmidt S, Hess J, Kietzmann T, et al. Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells. Mol Biol Cell 2007; 18: 4691-4697
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4691-4697
-
-
Belaiba, R.S.1
Bonello, S.2
Zahringer, C.3
Schmidt, S.4
Hess, J.5
Kietzmann, T.6
-
56
-
-
0037461934
-
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
-
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 2003; 22: 319-329
-
(2003)
Oncogene
, vol.22
, pp. 319-329
-
-
Wei, D.1
Le X Zheng, L.2
Wang, L.3
Frey, J.A.4
Gao, A.C.5
-
57
-
-
0030965156
-
The carboxyl-Terminal region of STAT3 controls gene induction by the mouse haptoglobin promoter
-
Kim H, Baumann H. The carboxyl-Terminal region of STAT3 controls gene induction by the mouse haptoglobin promoter. J Biol Chem 1997; 272: 14571-14579
-
(1997)
J Biol Chem
, vol.272
, pp. 14571-14579
-
-
Kim, H.1
Baumann, H.2
-
58
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996; 16: 4604-4613
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
-
59
-
-
0031016301
-
Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for Src kinase
-
Gleadle JM, Ratcliffe PJ. Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for Src kinase. Blood 1997; 89: 503-509
-
(1997)
Blood
, vol.89
, pp. 503-509
-
-
Gleadle, J.M.1
Ratcliffe, P.J.2
-
60
-
-
0028840908
-
Hypoxia, a novel inducer of acute phase gene expression in a human hepatoma cell line
-
Wenger RH, Rolfs A, Marti HH, Bauer C, Gassmann M. Hypoxia, a novel inducer of acute phase gene expression in a human hepatoma cell line. J Biol Chem 1995; 270: 27865-27870
-
(1995)
J Biol Chem
, vol.270
, pp. 27865-27870
-
-
Wenger, R.H.1
Rolfs, A.2
Marti, H.H.3
Bauer, C.4
Gassmann, M.5
-
61
-
-
84868702904
-
USF2 and HIF2alpha cooperatively activate HIF2 target genes during hypoxia
-
Pawlus MR, Wang L, Ware K, Hu CJ. USF2 and HIF2alpha cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol 2012; 32: 4595-4610
-
(2012)
Mol Cell Biol
, vol.32
, pp. 4595-4610
-
-
Pawlus, M.R.1
Wang, L.2
Ware, K.3
Hu, C.J.4
-
62
-
-
33644787084
-
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program
-
Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev 2006; 20: 601-612.
-
(2006)
Genes Dev
, vol.20
, pp. 601-612
-
-
Gomes, N.P.1
Bjerke, G.2
Llorente, B.3
Szostek, S.A.4
Emerson, B.M.5
Espinosa, J.M.6
|